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21. 发明公开

EP2224983A1 DEVICE AND METHOD FOR DEAGGREGATING POWDER 854 有权
标题翻译：用于粉碎粉末的装置和方法854
公开(公告)号：EP2224983A1
公开(公告)日：2010-09-08
申请号：EP08864465.3
申请日：2008-12-18
申请人： AstraZeneca AB
发明人： LASTOW, Orest , REMMELGAS, Johan
IPC分类号： A61M15/00 , F15D1/00
CPC分类号： A61M15/0065 , A61M15/0025 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/10
摘要： The invention relates to a device (1) for inhalation of at least one air stream carrying a dose of medicament powder (2). The device comprises a flow passage (4) passing a powder-containing cavity (5). A part of said flow passage (4) propagates along a flat surface region (7). The flat surface region (7) comprises a cavity opening (20) into said powder- containing cavity (5). The passing of an air stream along said flat surface region (7) and outside said cavity (5) generates an eddy in the cavity (5) and the generated eddy contributes to deaggregation of the powder (2) in said cavity (5) and emptying of the powder (2) from said cavity (5). Furthermore, the invention relates to the use of a shear driven cavity principle on such a device (1) and a method of releasing medicament powder (2).
摘要翻译：本发明涉及用于吸入携带一定剂量的药物粉末（2）的至少一个空气流的装置（1）。该装置包括经过含粉腔（5）的流动通道（4）。所述流道（4）的一部分沿平坦表面区域（7）传播。平坦表面区域（7）包括进入所述容纳粉末的空腔（5）中的空腔开口（20）。沿着所述平坦表面区域（7）并且在所述空腔（5）外部的空气流的通过在空腔（5）中产生涡流，并且所产生的涡流促成所述空腔（5）中的粉末（2）的解聚集和从所述腔体（5）中排出粉末（2）。此外，本发明涉及在这种装置（1）上使用剪切驱动腔原理和释放药物粉末（2）的方法。

22. 发明公开

EP1879812A1 AN ARRANGEMENT AND A METHOD FOR OPENING A CAVITY, A MEDICAL PACKAGE AND A DISPENSING DEVICE 审中-公开
标题翻译： SYSTEM AND METHOD FOR开口的空腔，医疗器械包装和分销
公开(公告)号：EP1879812A1
公开(公告)日：2008-01-23
申请号：EP06733375.7
申请日：2006-04-28
申请人： AstraZeneca AB
发明人： LASTOW, Orest
IPC分类号： B65D75/34 , B65D75/58 , A61M15/00
CPC分类号： A61M15/0045 , A61M15/0031 , A61M15/0048
摘要： An arrangement for opening a cavity (1, 14) sealed by a sealing sheet (2, 16), the cavity (1, 14) housing a medicament (3), the arrangement comprising a separating element (4, 6.4, 13, 5.13) bondable to the outer surface (5) of the sealing sheet (2, 16) above said cavity (1, 14), and guiding means (6, 12) for guiding said separating element (4, 6.4, 13, 5.13) away from said cavity (1, 14), whereby the sealing sheet lid (15) covering said cavity (1, 14) and bonded to said separating element (4, 6.4, 13, 5.13) is completely separated from the rest of the sealing sheet (2, 16) and removed, and the cavity (1, 14) is opened. A pack for doses of medicament, comprising at least one cavity for housing a dose of medicament, the cavity being sealed by a sealing sheet (16), where the outer surface of the sealing sheet (16) above the cavity is bonded to the above-mentioned separating element (5.13). A dispensing device for dispensing doses of medicament, comprising a dispenser outlet, the dispensing device comprising said arrangement for opening a cavity sealed by a sealing sheet.

23. 发明公开

EP1879798A1 A METHOD FOR FILLING A CAVITY WITH A QUANTITY OF PARTICULATE MATERIAL 审中-公开
标题翻译：方法填充空腔颗粒材料的量
公开(公告)号：EP1879798A1
公开(公告)日：2008-01-23
申请号：EP06733374.0
申请日：2006-04-28
申请人： AstraZeneca AB
发明人： ARVIDSSON, Lars , LASTOW, Orest , ÅKERBERG, Vesna
IPC分类号： B65B1/36 , B65B37/20
CPC分类号： B65B7/162 , B65B1/36 , B65B37/20
摘要： A method for filling a cavity (2, 15.1, 15.2) with a quantity (12.1, 12.2) of particulate material, comprising the steps of filling a chamber (4, 10.1, 10.2) with its open side facing upwards with the quantity (12.1, 12.2) of particulate material, positioning the opening of the cavity (2, 15.1, 15.2) opposite the opening of the filled chamber (4, 10.1, 10.2), and thereafter rotating the chamber (4, 10.1, 10.2) and the cavity (2, 15.1, 15.2) so that the cavity (2, 15.1, 15.2) is positioned with its open side facing upwards and the chamber (4, 10.1, 10.2) with its open side facing downwards, whereby the quantity (12.1, 12.2) of particulate material is emptied into the cavity (2, 15.1, 15.2). A corresponding device comprising a chamber (4, 10.1, 10.2), filling means (22, 23, 24) for filling the chamber (4, 10.1, 10.2) with the quantity (12.1, 12.2) of particulate material, operating means (29) for positioning the opening of the cavity (2, 15.1, 15.2) opposite the opening of the chamber (4, 10.1, 10.2), and conveyor belt (20) for rotating the chamber (4, 10.1, 10.2) and the cavity (2, 15.1, 15.2) so that the cavity (2, 15.1, 15.2) is positioned with its open side facing upwards and the chamber (4, 10.1, 10.2) is positioned with its open side facing downwards.

24. 发明授权

EP2224983B1 DEVICE AND METHOD FOR DEAGGREGATING POWDER 854 有权
标题翻译：用于粉碎粉末的装置和方法854
公开(公告)号：EP2224983B1
公开(公告)日：2017-05-10
申请号：EP08864465.3
申请日：2008-12-18
申请人： AstraZeneca AB
发明人： LASTOW, Orest , REMMELGAS, Johan
IPC分类号： A61M15/00 , F15D1/00
CPC分类号： A61M15/0065 , A61M15/0025 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/10

25. 发明授权

EP2595683B1 Inhaler 有权
标题翻译：气雾
公开(公告)号：EP2595683B1
公开(公告)日：2015-03-04
申请号：EP11735691.5
申请日：2011-07-19
申请人： AstraZeneca AB
发明人： ARVIDSSON, Lars, Rune, Gustav , BAKEWELL, William , BRIANT, John, Philip , CAMPBELL, Patrick , COOKE, Charles Brian Durier , GROOMBRIDGE, Christopher Benjamin James , JOHN, James, Daniel , LASTOW, Orest , PENHALLURICK, Trevor, John , SMARTT, Nicholas , SVENSSON, Sven Mårten Jimmy , ULLBRAND, Björn
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0021 , A61M15/0043 , A61M15/0048 , A61M15/0075 , A61M15/0081 , A61M15/0091 , A61M15/08 , A61M2202/064

26. 发明公开

EP1603665A1 POWDER GENERATING APPARATUS AND METHOD FOR PRODUCING POWDER 有权
标题翻译：制粉设备和方法粉末的制造
公开(公告)号：EP1603665A1
公开(公告)日：2005-12-14
申请号：EP04714533.9
申请日：2004-02-25
申请人： AstraZeneca AB
发明人： LASTOW, Orest
IPC分类号： B01J2/02 , B05B5/025
CPC分类号： B05B5/0255 , B01J2/04 , B05B5/025
摘要： Powder generating apparatus for the generation of a powder in particular but not solely for the production of medicinal drug powder. The apparatus comprises a fluid supply means (13), droplet generation means having a dispensing nozzle (20), a surrounding grounding means and a reactor characterised in that said dispensing nozzle of said droplet generation means is less than 3 millimetres.

27. 发明授权

EP2448623B1 DISPENSER AND METHOD FOR ENTRAINING POWDER IN AN AIRFLOW 有权
标题翻译：用于在气流中粉化粉末的分配器和方法
公开(公告)号：EP2448623B1
公开(公告)日：2017-12-20
申请号：EP10794459.7
申请日：2010-06-30
申请人： AstraZeneca AB
发明人： KJELLGREN, Per Arne , LASTOW, Orest , REMMELGAS, Johan , SVENSSON, Mårten
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0025 , A61M15/0043 , A61M15/0048 , A61M2202/064 , A61M2206/10 , A61M2206/14 , A61M2206/16 , A61M2209/02
摘要： A device for inhalation of at least one air stream carrying a dose of medicament powder having a powder-containing cavity which opens into a flow passage. The flow passage is arranged to direct an inhalation air flow across the cavity opening. A circulating flow is thereby induced in the cavity by the phenomenon of shear driven cavity flow. Powder is entrained in the circulating flow and deaggregated before exiting the cavity and becoming entrained in the flow of air along the flow passage.

28. 发明公开

EP2448623A1 DISPENSER AND METHOD FOR ENTRAINING POWDER IN AN AIRFLOW 有权
标题翻译：供体和方法粉料在气流供给
公开(公告)号：EP2448623A1
公开(公告)日：2012-05-09
申请号：EP10794459.7
申请日：2010-06-30
申请人： AstraZeneca AB
发明人： KJELLGREN, Per Arne , LASTOW, Orest , REMMELGAS, Johan , SVENSSON, Mårten
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0025 , A61M15/0043 , A61M15/0048 , A61M2202/064 , A61M2206/10 , A61M2206/14 , A61M2206/16 , A61M2209/02
摘要： The invention relates to a device (1) for inhalation of at least one air stream carrying a dose of medicament powder (2). The device comprises a powder-containing cavity (5) which opens into a flow passage (4). The flow passage is arranged to direct an inhalation air flow across the cavity opening. A circulating flow is thereby induced in the cavity (5) by the phenomenon of shear driven cavity flow. Powder is entrained in the circulating flow and deaggregated before exiting the cavity and becoming entrained in the flow of air along the flow passage (4).

29. 发明公开

EP2334358A1 INHALATION DEVICE AND METHOD OF DISPENSING MEDICAMENT 失效
标题翻译：吸入装置用于毒品问题
公开(公告)号：EP2334358A1
公开(公告)日：2011-06-22
申请号：EP09819487.1
申请日：2009-10-07
申请人： AstraZeneca AB
发明人： BAKEWELL, William , BRIANT, John , CAMPBELL, Patrick , JOHN, James Daniel , COOKE, Charles , GROOMBRIDGE, Christopher , SMARTT, Nickolas , LASTOW, Orest , HARRISON, Nickolas
IPC分类号： A61M15/00 , B65D83/04
CPC分类号： A61M15/0091 , A61M15/0003 , A61M15/0026 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/0093 , A61M15/0096 , A61M2202/064 , A61M2205/073
摘要： The present invention relates to an inhaler, comprising a base having at least one air-tight, foil-sealed cavity containing medicament. An actuator is engagable with a separating element attached to the foil, the actuator having an energized position in which it is biased towards an unloaded position so as to cause the separating element and attached foil to be moved away from the cavity. A latch has a first position, in which it latches the actuator in said energized position, wherein the latch is at least partly arranged in a flow path such that an inhalation flow through the flow path affects the latch to move from the first position to the second position. The invention also relates to a method of dispensing a medicament from a sealed cavity inside an inhaler.

30. 发明公开

EP2224984A1 DISPENSER AND METHOD FOR ENTRAINING POWDER IN AN AIRFLOW 537 审中-公开
标题翻译：供体和方法粉料在气流供给
公开(公告)号：EP2224984A1
公开(公告)日：2010-09-08
申请号：EP08864819.1
申请日：2008-12-18
申请人： AstraZeneca AB
发明人： BRIANT, John , LASTOW, Orest , REMMELGAS, Johan
IPC分类号： A61M15/00 , F15D1/00
CPC分类号： A61M15/0065 , A61M15/0025 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/10
摘要： The invention relates to a method for entraining in an airflow a medicament powder contained in a cavity having a cavity opening. Large airflow vortices are provided, for instance, by means of an obstacle in a flow passage. The airflow with large vortices is arranged to by-pass the cavity opening, thereby generating an eddy in the cavity which contributes to entraining the powder in said airflow. The invention also relates to a medical dispenser, for instance an inhaler, in which said method may be performed.

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