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    • 29. 发明公开
    • 오고닌을 유효성분으로 함유하는 천식 예방 또는 치료용 약학적 조성물
    • 用于预防或治疗含有WOGONIN作为有效成分的烟草的药物组合物
    • KR1020140026588A
    • 2014-03-05
    • KR1020140007319
    • 2014-01-21
    • 한국생명공학연구원
    • 오세량안경섭이형규장하영권옥경김정희박지원
    • A61K31/352A61K31/35A61P11/06
    • The present invention relates to a pharmaceutical composition containing wogonin as an active ingredient for preventing or treating asthma. The wogonin of the present invention exhibits superior effects in that the wogonin relieves a hypersensitivity of airways which may cause asthma in vivo; restricts an amount of active oxygen produced in the airways; and inhibits an infiltration of inflammatory cells into bronchial tubes. Further, the wogonin inhibits the generation of egg albumin, particularly IgE, in a fluid for bronchoalveolar lavage and in a serum; and inhibits an expression of Th2 cytokine in the lungs. Thus, the wogonin may be valuably used as a composition for the prevention, treatment, and alleviation of asthma. [Reference numerals] (AA) Weight (g); (BB) Normal control group (NC); (CC) Induced asthma group (OVA); (DD) Comparative group 1 (DEXA); (EE) Comparative group 2 (Monte); (FF) Preparation example 1 (wogonin)
    • 本发明涉及含有wogonin作为预防或治疗哮喘的活性成分的药物组合物。 本发明的肌钙蛋白具有优异的效果,因为肌钙蛋白减轻了可能在体内引起哮喘的气道超敏反应; 限制气道中产生的活性氧的量; 并抑制炎症细胞浸润到支气管中。 此外,沃莫辛抑制用于支气管肺泡灌洗液和血清中的卵清蛋白,特别是IgE的产生; 并抑制肺中Th2细胞因子的表达。 因此,沃可素可以有价值地用作预防,治疗和缓解哮喘的组合物。 (附图标记)(AA)重量(g); (BB)正常对照组(NC); (CC)诱发哮喘组(OVA); (DD)比较组1(DEXA); (EE)比较组2(Monte); (FF)制备实施例1(wogonin)