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21. 发明授权

KR101879585B1 하이드로겔 입자의 자동 코팅 장치 및 방법 有权
公开(公告)号：KR101879585B1
公开(公告)日：2018-07-18
申请号：KR1020160128835
申请日：2016-10-06
申请人： 서울대학교산학협력단 , 경희대학교 산학협력단
发明人： 권성훈 , 박욱 , 최영재 , 배형종 , 류태훈 , 송석흥
IPC分类号： B05B17/06 , B05D7/02 , B05C3/02 , C09D1/00
摘要： 본개시내용에서는다양한타입의하이드로겔입자를동일조건하에서균일한코팅이가능하도록하이드로겔입자의자동습식코팅장치및 코팅방법이제공된다.

22. 发明授权

KR101471246B1 고순도 뉴클레오타이드의 대량 생산방법 有权
标题翻译：大量生产高纯度核苷酸的方法
公开(公告)号：KR101471246B1
公开(公告)日：2014-12-10
申请号：KR1020120080601
申请日：2012-07-24
申请人： 서울대학교산학협력단
发明人： 권성훈 , 김효기 , 이호원 , 김성식 , 류태훈
IPC分类号： C12Q1/68 , C12N15/10 , C12N15/11
CPC分类号： C12P19/34 , B01J2219/00315 , B01J2219/00441 , B01J2219/00468 , B01J2219/005 , B01J2219/00596 , B01J2219/00648 , B01J2219/00691 , B01J2219/00693 , B01J2219/00722 , C40B20/02 , C40B50/14 , C40B60/04
摘要： 고체지지체상에존재하는올리고뉴클레오타이드들의복제라이브러리를갖는염기서열분석기판을제공하는단계; 상기복제라이브러리를시퀀싱하는단계; 상기염기서열분석기판상의상기고체지지체의실측위치정보를얻는단계; 상기시퀀싱의결과로주어지는상기고체지지체로부터발생한신호의픽셀정보와상기실측위치정보를맵핑하는단계; 상기맵핑한결과를이용하여원하는염기서열을갖는상기고체지지체를상기염기서열분석기판으로부터추출하는단계; 및상기추출된상기고체지지체상의올리고뉴클레오타이드를증폭하여대량으로복제하는단계를포함하는고순도뉴클레오타이드의대량생산방법이제공된다.

23. 发明公开

KR1020140111224A 이종 DNA 바코딩 방법 有权
标题翻译：异质DNA修复
公开(公告)号：KR1020140111224A
公开(公告)日：2014-09-18
申请号：KR1020140026952
申请日：2014-03-07
申请人： 서울대학교산학협력단
发明人： 권성훈 , 김준회 , 류태훈 , 오동윤 , 고재경
IPC分类号： C12Q1/68
CPC分类号： C12N15/1065 , C12Q1/6837 , C12Q2565/513 , C12Q2565/514 , C12Q1/6834
摘要： Provided is a heterogeneous DNA barcoding method comprising the steps of: (a) providing a DNA microarray including DNA spots which are separated from each other by means of a barcode base sequence; (b) providing a microwell array including microwells corresponding to the spatial position of the DNA spots on the DNA microarray; (c) loading a solution of a sample including target base sequences into the microwells; (d) producing fine reactive spaces, which are formed by spatially separating the DNA spots by means of the microwells, by combining the DNA microarray with the microwell array; and (e) combining the base sequence information of the DNA spots with the base sequence information of the sample by making the target base sequence of the sample reacted with the base sequence of the DNA spots in the fine reaction space; and (f) obtaining a byproduct including the barcode base sequence by separating the DNA microarray and the microwell array.
摘要翻译：提供了一种异源DNA条形码方法，其包括以下步骤：（a）提供包含通过条形码碱基序列彼此分离的DNA斑点的DNA微阵列; （b）提供微孔阵列，其包括对应于DNA微阵列上的DNA斑点的空间位置的微孔; （c）将包含靶基序列的样品溶液加载到微孔中; （d）通过将DNA微阵列与微孔阵列组合而产生通过微孔空间分离DNA斑点而形成的细小反应空间; 和（e）通过使样品的靶碱基序列与微细反应空间中的DNA斑点的碱基序列反应，将DNA斑点的碱基序列信息与样品的碱基序列信息组合; 和（f）通过分离DNA微阵列和微孔阵列获得包括条形码碱基序列的副产物。

24. 发明公开

KR1020130046356A 고순도 뉴클레오타이드의 대량 생산방법 有权
标题翻译：大量生产高纯度核子的方法
公开(公告)号：KR1020130046356A
公开(公告)日：2013-05-07
申请号：KR1020120114103
申请日：2012-10-15
申请人： 서울대학교산학협력단
发明人： 권성훈 , 김효기 , 이호원 , 김성식 , 류태훈
IPC分类号： C12Q1/68 , C12N15/10 , G06F19/10
CPC分类号： C12P19/34 , B01J2219/00315 , B01J2219/00441 , B01J2219/00468 , B01J2219/005 , B01J2219/00596 , B01J2219/00648 , B01J2219/00691 , B01J2219/00693 , B01J2219/00722 , C40B20/02 , C40B50/14 , C40B60/04 , C12Q1/6811 , C12Q1/6834
摘要： PURPOSE: A mass production method of a high purity nucleotide is provided to quickly and accurately isolate a microbead with a predetermined sequence and to amplify the sequence. CONSTITUTION: A mass production method of a high purity nucleotide comprises: a step of providing a sequencing substrate with a replication library of oligonucleotides existing on a solid support(S110); a step of sequencing the replication library(S120); a step of obtaining measured location information of the solid support(S130); a step of mapping pixel information of a signal generated from the solid support and the measured location information(S140); a step of extracting a desired sequence from the sequencing substrate using the mapping result(S150); and a step of amplifying a large amount of oligonucleotides on the solid support(S160). [Reference numerals] (AA) Start; (BB) End; (S110) Provide a sequencing analysis substrate with a replication library of oligos on a solid support; (S120) Sequence the replication library; (S130) Obtain the actual location information of the solid support; (S140) Map pixel information and the actual location information; (S150) Extract the solid support using a mapping result; (S160) Massively replicate by amplifying the oligos of the extracted solid support
摘要翻译：目的：提供高纯度核苷酸的大规模生产方法，以预定的顺序快速准确地分离微珠并扩增序列。构成：高纯度核苷酸的批量生产方法包括：向测序底物提供存在于固体支持物上的寡核苷酸复制文库的步骤（S110）; 对复制库进行排序的步骤（S120）; 获取固体支持物的测量位置信息的步骤（S130）; 映射从固体支持物产生的信号的像素信息和所测量的位置信息的步骤（S140）; 使用映射结果从测序底物提取期望的序列的步骤（S150）; 和在固体支持物上扩增大量寡核苷酸的步骤（S160）。（附图标记）（AA）开始; （BB）结束; （S110）在固体支持物上提供具有寡核苷酸复制文库的测序分析底物; （S120）顺序复制库; （S130）获取实体支持的实际位置信息; （S140）映射像素信息和实际位置信息; （S150）使用映射结果提取固体支持; （S160）通过扩增提取的固体支持物的寡核苷酸大量复制

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