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21. 发明申请

WO2017139539A3 ELECTRONIC MESSAGE INFORMATION RETRIEVAL SYSTEM 审中-公开
公开(公告)号：WO2017139539A3
公开(公告)日：2017-08-17
申请号：PCT/US2017/017318
申请日：2017-02-10
申请人： ZHANG, Yong , LIU, Ning
发明人： ZHANG, Yong , LIU, Ning
IPC分类号： G06F17/27
摘要： A computer system for parsing bulk message information into intelligent question retrieval models receives text-based data associated with a particular user. The system encodes the word into a context-dependent vector, wherein the context-dependent vector indicates the meaning of the word across a semantic space. The system also identifies within a context-independent database a context-independent vector that is associated with the word. Further, the system generates an objective output by combining the context-dependent vector and the context-independent vector. Further still, the system generates a sentence encoding representation by processing at least a portion of the text-based data through a high-level feature embedded convolutional semantic model to generate numerical representations of questions and answers within the text-based dataset. The sentence encoding representation is generated at least in part based upon the objective output.

22. 发明申请

WO2017112617A1 4-AMINO-2-(1H-PYRAZOLO[3,4-B]PYRIDIN-3-YL)-6-OXO-6,7-DIHYDRO-5H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AND THE RESPECTIVE (1H-INDAZOL-3-YL) DERIVATIVES AS CGMP MODULATORS FOR TREATING CARDIOVASCULAR DISEASES 审中-公开
标题翻译： 4-氨基-2-（1H-吡唑并[3,4-b]吡啶-3-基）-6-氧代-6,7-二氢-5H-吡咯并[2,3-d]嘧啶衍生物和其相应的（ 1H-INDAZOL-3-YL）衍生物作为用于治疗心血管疾病的CGMP调节剂
公开(公告)号：WO2017112617A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/067654
申请日：2016-12-20
申请人： MERCK SHARP & DOHME CORP. , BERGER, Raphelle , CHEN, Yi-Heng , LI, Guoqing , GARFUNKLE, Joie , LI, Hong , MIAO, Shouwu , RAGHAVAN, Subharekha , SMITH, Cameron, J. , STELMACH, John , WHITEHEAD, Alan , ZHANG, Rui , ZHANG, Yong , FU, Jianmin , JI, Gang , JIANG, Falong
发明人： BERGER, Raphelle , CHEN, Yi-Heng , LI, Guoqing , GARFUNKLE, Joie , LI, Hong , MIAO, Shouwu , RAGHAVAN, Subharekha , SMITH, Cameron, J. , STELMACH, John , WHITEHEAD, Alan , ZHANG, Rui , ZHANG, Yong , FU, Jianmin , JI, Gang , JIANG, Falong
IPC分类号： C07D487/04 , A61K31/519 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/04
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , C07D519/00
摘要： The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R 1 , R 2 , R 4 , R a , and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate ("cGMP"), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance, such as cardiovascular disease, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, heart failure, pulmonary hypertension (WHO groups I, II, III, IV), angina pectoris, thrombosis, restenosis, myocardial infarction, stroke, cardiac insufficiency, fibrosis, pulmonary hypertonia, erectile dysfunction, asthma, acute respiratory distress syndrome (ARDS), chronic kidney disease, cystic fibrosis, sickle cell anemia, scleroderma, Raynaud's Syndrome, diabetes, diabetic retinopathy, cirrhosis of the liver, chronic obstructive pulmonary disease (COPD), acute lung injury, pulmonary fibrosis or interstitial lung disease. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to the compounds or their pharmaceutically acceptable salts for use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose.
摘要翻译：本发明提供式（I）的化合物或其药学上可接受的盐，其中X，Y，Z，R 1，R 2， R 4，R a和下标m，p和q如本文所述。所述化合物或其药学上可接受的盐可调节身体产生环鸟苷单磷酸（“cGMP”），并且通常适用于治疗和预防与干扰的cGMP平衡有关的疾病，例如心血管疾病，内皮功能障碍，心脏衰竭，肺动脉高压（WHO组I，II，III，IV），心绞痛，血栓形成，再狭窄，心肌梗塞，中风，心功能不全，纤维化，肺高血压，勃起功能障碍，哮喘，急性呼吸窘迫综合征（ARDS），慢性肾病，囊性纤维化，镰状细胞贫血，硬皮病，雷诺氏综合征，糖尿病，糖尿病视网膜病变，肝硬化，慢性阻塞性肺病（COPD），急性肺损伤，肺纤维化或间质肺部疾病。本发明还提供了包含式（I）化合物或其药学上可接受的盐的药物组合物。本发明还涉及用于治疗和预防上述疾病以及为此目的制备药物的化合物或其药学上可接受的盐。

23. 发明申请

WO2016023103A1 METHODS OF EXTRACTION AND PURIFICATION FROM STEVIA REBA UDIANA OF COMPOSITIONS WITH ENHANCED REBAUDIOSIDE-M CONTENT, USES OF SAID COMPOSITION AND NATURAL SWEETENER COMPOSITIONS WITH SAID COMPOSITION 审中-公开
标题翻译：提取和纯化来自具有增强的重氮化物-M含量的组合物的STEVIA REBA UDIANA的方法，含有组合物的组合物的使用和具有合成组合物的天然固体组合物
公开(公告)号：WO2016023103A1
公开(公告)日：2016-02-18
申请号：PCT/CA2015/000462
申请日：2015-08-12
申请人： ZHANG, Yong Luke , LI, Cunbiao Kevin
发明人： ZHANG, Yong Luke
IPC分类号： C07H15/256 , A23L1/236 , A23L2/60 , A61K36/28 , C07H15/24
CPC分类号： C07H15/256 , A23L2/60 , A23L27/36 , A61K36/28 , A61K2236/00 , C07H1/08
摘要： A method for purifying Reb M includes preparing a crude mother liquor/ Stevia rebaudiana primary extract, passing a solution of this primary extract through a multi-column system including a plurality of columns, in series, packed with a porous adsorbent resin to provide at least one column having adsorbed Reb M and eluting fractions with Reb M content from a final/last column in the series to provide an eluted solution with Reb M content.
摘要翻译：纯化Reb M的方法包括制备粗制母液/甜叶菊初级提取物，使该初级提取物的溶液通过包含多个柱的多塔系统串联填充多孔吸附树脂，至少提供一列吸附了Reb M，并从该系列的最终/最后一列得到Reb M含量的洗脱级分，以提供具有Reb M含量的洗脱溶液。

24. 发明申请

WO2015088886A1 SOLUBLE GUANYLATE CYCLASE ACTIVATORS 审中-公开
标题翻译：可溶性冠状动脉激素
公开(公告)号：WO2015088886A1
公开(公告)日：2015-06-18
申请号：PCT/US2014/068689
申请日：2014-12-05
申请人： MERCK SHARP & DOHME CORP. , HAN, Xiaoqing , WHITEHEAD, Alan , RAGHAVAN, Subharekha , CERNAK, Timothy, A. , DREHER, Spencer , GROEPER, Jonathan , GUO, Jian , ZHANG, Yong
发明人： HAN, Xiaoqing , WHITEHEAD, Alan , RAGHAVAN, Subharekha , CERNAK, Timothy, A. , DREHER, Spencer , GROEPER, Jonathan , GUO, Jian , ZHANG, Yong
IPC分类号： A61K31/519 , A61K31/52 , C07D473/00
CPC分类号： C07D519/00 , A61K31/519 , A61K31/52 , A61K45/06 , C07B2200/05 , A61K2300/00
摘要： A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (" cGMP") and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceuticall acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula I or a pharmaceutically acceptable salt thereof.
摘要翻译：式I化合物或其药学上可接受的盐能够调节身体产生环鸟苷酸（“cGMP”），并且通常适用于治疗和预防与受干扰的cGMP平衡有关的疾病。本发明还涉及用于制备式I化合物或其药学上可接受的盐的方法，用于治疗和预防上述疾病和用于制备用于此目的的药物以及包含式I化合物的药物制剂或其药学上可接受的盐。

25. 发明申请

WO2013037058A1 DRILL PIPE WITH REPLACEABLE TOOL JOINTS 审中-公开
标题翻译：带可更换工具接头的钻杆管
公开(公告)号：WO2013037058A1
公开(公告)日：2013-03-21
申请号：PCT/CA2012/050629
申请日：2012-09-12
申请人： ATLAS COPCO CANADA INC. , ZHANG, Yong , PUDSEY, Mike , STEENKAMP, Danie
发明人： ZHANG, Yong , PUDSEY, Mike , STEENKAMP, Danie
IPC分类号： E21B17/04 , E21B17/042
CPC分类号： E21B17/046 , E21B17/042
摘要： A drill string includes tool assembly, wherein the tool assembly includes a tool joint adapter and a tool joint coupled to the tool joint adapter through a faceted pin. The faceted pin includes a faceted fitting having a fitting face. The drill string includes a locking pin which extends through the tool joint adapter and tool joint, wherein the locking pin extends through a locking pin groove of the fitting face. The locking pin locks the tool joint adapter and tool joint together.
摘要翻译：钻柱包括工具组件，其中工具组件包括工具接头适配器和通过小平头连接到工具接头适配器的工具接头。小面销包括具有配合面的小面配件。钻柱包括延伸穿过工具接头适配器和工具接头的锁定销，其中锁定销延伸穿过配合面的锁定销槽。锁定销将工具接头适配器和工具接头锁定在一起。

26. 发明申请

WO2012094752A1 PROCESSES OF PURIFYING STEVIOL GLYCOSIDES REB C 审中-公开
标题翻译：纯化葡萄糖苷的方法
公开(公告)号：WO2012094752A1
公开(公告)日：2012-07-19
申请号：PCT/CA2012/000048
申请日：2012-01-16
申请人： GLG LIFE TECH CORPORATION , ZHANG, Yong Luke , LI, Cunbiao Kevin
发明人： ZHANG, Yong Luke , LI, Cunbiao Kevin
IPC分类号： C07H15/24 , A23L1/236 , C07H13/08
CPC分类号： C13B50/00 , A23L27/36 , C07H15/24
摘要： A process for producing a natural sweetening enhancer composition comprising at least an Rebaudioside C (RC) extract, said process comprises the steps of preparing a saccharide mother liquor comprising an RC mass content of at least 15%; preparing feed liquid from about 8-25 mg/L of the mother liquor; flowing feed liquid through a porous adsorption column, having a pore size of between about 0.001 to 0,.2 micron, and at a flow rate of between 25 to 35 L/m2h and at a pH of between 6 to 8; eluting RC extract with alcohol, said RC extract having a mass concentration of at least 10%; fractionally collecting eluate based on chromatographic critical point for RC extract; concentrating the RC extract and drying the extract so formed. Another process for preparing a crude RC extract which comprises the steps of preparing a saccharide mother liquor into a feedstock solution with a mass concentration of about 0.5-1%; passing the solution through an ultrafiltration membrane device at a flow rate of 25-35 L/m2h, with a molecular weight cut-off at about 5500-6500 DA and at a pH of between about 6.5-7.5, collecting and then concentrating the RC filtrate from about 55°C to 65°C„ drying solid and liquid fractions obtained from the concentrate separately to provide a crude RC extract. Extracts obtained from processes above are further refined by crystallization from water-alcohols (e.g. ethanol and methanol)-acetone mixed solvents to provide a crystalline solid comprising high content of RC.
摘要翻译：一种生产包含至少一种雷鲍迪甙C（RC）提取物的天然甜味增强剂组合物的方法，所述方法包括以下步骤：制备包含至少15％的RC质量含量的糖母液; 从约8-25mg / L的母液制备饲料液; 流动的进料液体通过多孔吸附塔，孔径为约0.001至0.2微米，流速为25至35升/平方米，pH为6至8; 用乙醇洗脱RC提取物，所述RC提取物的质量浓度至少为10％; 基于RC提取物的色谱临界点分馏收集洗脱液; 浓缩RC提取物并干燥所形成的提取物。制备粗制RC提取物的另一种方法，其包括以下步骤：将糖母液制备成质量浓度为约0.5-1％的原料溶液; 将溶液通过超滤膜装置，流速为25-35L / m2h，分子量截止值在约5500-6500DA，pH值在约6.5-7.5之间，收集然后浓缩RC 从约55℃至65℃的滤液“，分离从浓缩物中得到的固体和液体组分，以提供粗制的RC提取物。通过从水醇（例如乙醇和甲醇） - 丙酮的结晶进一步精制得到的提取物混合溶剂以提供包含高含量RC的结晶固体。

27. 发明申请

WO2012088593A1 SWEETENER COMPOSITIONS AND METHODS OF MAKING SAME 审中-公开
标题翻译：触发剂组合物及其制备方法
公开(公告)号：WO2012088593A1
公开(公告)日：2012-07-05
申请号：PCT/CA2011/001409
申请日：2011-12-29
申请人： GLG LIFE TECH CORPORATION , ZHANG, Yong Luke , LI, Cunbiao Kevin
发明人： ZHANG, Yong Luke , LI, Cunbiao Kevin
IPC分类号： A23L1/236 , A23L1/212 , C07H1/08 , C07H15/24
CPC分类号： A23L1/2363 , A23L2/60 , A23L27/33 , A23L27/34 , A23L27/36 , A23L27/88 , C07H15/24
摘要： Natural steviol glycosides sweetener compositions comprise a blend of Rebaudioside C extract and at least one of Rebaudioside A extract and STV extract including methods for producing the same and uses thereof in foods, beverages, functional foods and nutraceuticals.
摘要翻译：天然甜菊糖苷甜味剂组合物包含雷鲍迪苷C提取物和雷鲍迪甙A提取物和STV提取物中的至少一种的混合物，包括其制备方法及其在食品，饮料，功能性食品和营养品中的用途。

28. 发明申请

WO2011019538A1 SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 审中-公开
标题翻译：取代的环丙基化合物，包含这些化合物的组合物和处理方法
公开(公告)号：WO2011019538A1
公开(公告)日：2011-02-17
申请号：PCT/US2010/044181
申请日：2010-08-03
申请人： MERCK SHARP & DOHME CORP. , WOOD, Harold, B. , ADAMS, Alan, D. , SZEWCZYK, Jason, W. , ZHANG, Yong , YANG, Meng
发明人： WOOD, Harold, B. , ADAMS, Alan, D. , SZEWCZYK, Jason, W. , ZHANG, Yong , YANG, Meng
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： C07D401/14 , C07D401/04 , C07D413/14
摘要： Substituted cyclopropyl compounds of the formula I: are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.
摘要翻译：式I的取代的环丙基化合物被公开用于治疗或预防2型糖尿病和类似病症。也包括药学上可接受的盐。该化合物可用作g-蛋白偶联受体GPR-119的激动剂。

29. 发明申请

WO2010093733A3 DETECTING DEFECTS ON A WAFER 审中-公开
标题翻译：检测晶圆上的缺陷
公开(公告)号：WO2010093733A3
公开(公告)日：2010-10-28
申请号：PCT/US2010023802
申请日：2010-02-10
申请人： KLA TENCOR CORP , HUANG JUNQING , ZHANG YONG , CHEN STEPHANIE , LUO TAO , GAO LISHENG , WALLINGFORD RICHARD
发明人： HUANG JUNQING , ZHANG YONG , CHEN STEPHANIE , LUO TAO , GAO LISHENG , WALLINGFORD RICHARD
IPC分类号： H01L21/66 , G01N21/88
CPC分类号： G01N21/9501 , G01N21/8806 , H01L22/12 , H01L2924/0002 , H01L2924/00
摘要： Methods and systems for detecting defects on a wafer are provided.
摘要翻译：提供了用于检测晶片上的缺陷的方法和系统。

30. 发明申请

WO2009111676A8 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：含硼的小分子作为抗炎剂
公开(公告)号：WO2009111676A8
公开(公告)日：2010-09-30
申请号：PCT/US2009036250
申请日：2009-03-05
申请人： ANACOR PHARMACEUTICALS INC , AKAMA TSUTOMU , ZHANG YONG-KANG , DING CHARLES Z , PLATTNER JACOB J , MAPLES KIRK R , FREUND YVONNE , SANDERS VIRGINIA , XIA YI , BAKER STEPHEN J , NIEMANN JAMES A , LU XIAOSONG , SALES MARCELO , SHARMA RASHMI , SINGH RAJESHWAR , JACOBS ROBERT , CHEN DAITAO , ALLEY MICHAEL RICHARD KEVIN
发明人： AKAMA TSUTOMU , ZHANG YONG-KANG , DING CHARLES Z , PLATTNER JACOB J , MAPLES KIRK R , FREUND YVONNE , SANDERS VIRGINIA , XIA YI , BAKER STEPHEN J , NIEMANN JAMES A , LU XIAOSONG , SALES MARCELO , SHARMA RASHMI , SINGH RAJESHWAR , JACOBS ROBERT , CHEN DAITAO , ALLEY MICHAEL RICHARD KEVIN
IPC分类号： A61K31/69
CPC分类号： C07F5/025
摘要： Compounds and methods of treating anti-inflammatory conditions are disclosed.
摘要翻译：公开了治疗抗炎症的化合物和方法。

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