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21. 发明申请

US20110014245A1 THERAPEUTIC METHOD OF ADMINISTERING PHARMACEUTICAL TITANIUM DIOXIDE COMPOSITE AND LIGHT IRRADIATION 有权
标题翻译：管理药物二氧化钛复合材料和光照射的治疗方法
公开(公告)号：US20110014245A1
公开(公告)日：2011-01-20
申请号：US12889753
申请日：2010-09-24
申请人： Shuji SONEZAKI , Koki KANEHIRA , Yumi OGAMI , Toshiaki BANZAI , Yoshinobu KUBOTA
发明人： Shuji SONEZAKI , Koki KANEHIRA , Yumi OGAMI , Toshiaki BANZAI , Yoshinobu KUBOTA
IPC分类号： A61K31/74 , A61K9/14 , A61P35/00
CPC分类号： A61K41/0028 , A61K9/0019 , A61K31/704 , A61K47/58 , A61K47/6923 , A61K47/6929 , B82Y5/00
摘要： A titanium dioxide composite is provided that can be stably dispersed in an aqueous solvent and easily administered into a living body, such as human, and allows elimination of the drug efficacy of a pharmaceutical compound supported thereon by light irradiation and a dispersion thereof. A composite is used in which a pharmaceutical compound is bound to titanium dioxide having photocatalytic activity through a hydrophilic polymer. The composite is stable in an aqueous solvent and easily administered into a living body, and adverse drug reactions of the pharmaceutical compound can be reduced by administering the composite into the body and irradiating the composite with a light to photoexcite the titanium dioxide to decompose the pharmaceutical compound in a region where the drug efficacy of the pharmaceutical composition is not required.
摘要翻译：提供二氧化钛复合体，其可以稳定地分散在水性溶剂中，并且容易地施用到人体等生物体中，并且可以通过光照射及其分散来消除其上负载的药物化合物的药物功效。使用其中药物化合物通过亲水性聚合物与具有光催化活性的二氧化钛结合的复合物。该复合材料在水性溶剂中稳定，容易投入生物体中，通过将复合体投入体内照射复合体，对该复合体进行光照射，可以降低药物化合物的药物不良反应，使二氧化钛分解，在不需要药物组合物的药物功效的区域中的化合物。

22. 发明申请

US20090294305A1 Method for Specifically Detecting Analyte Using Photocurrent, and Electrode, Measuring Cell and Measuring Device for Use Therein 有权
标题翻译：使用光电流特异性检测分析物的方法，电极，测量单元及其使用的测量装置
公开(公告)号：US20090294305A1
公开(公告)日：2009-12-03
申请号：US11992858
申请日：2006-09-28
申请人： Makoto Bekki , Hitoshi Ohara , Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Hiroshi Ishikawa , Yumi Osaki , Hiromasa Tokudome , Yoko Yamada , Masahiro Miyauchi
发明人： Makoto Bekki , Hitoshi Ohara , Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Hiroshi Ishikawa , Yumi Osaki , Hiromasa Tokudome , Yoko Yamada , Masahiro Miyauchi
IPC分类号： G01N27/26 , G01F1/64
CPC分类号： G01N33/5438
摘要： A method, an electrode, a measuring cell, and a measuring device are disclosed which can detect and quantitatively determine an analyte having specific bonding properties, in a highly sensitive, simple and accurate manner using photocurrent. This method comprises contacting a working electrode and a counter electrode with an electrolyte medium, wherein the working electrode has an analyte immobilized thereon through a probe substance and wherein the analyte is bonded to a sensitizing dye; irradiating the working electrode with light to photoexcite the sensitizing dye; and detecting photocurrent flowing between the working electrode and the counter electrode, wherein the photocurrent is generated by transfer of electrons from the photoexcited sensitizing dye to the working electrode. The working electrode comprises an electron accepting layer comprising an electron accepting substance capable of accepting electrons released from the sensitizing dye in response to photoexcitation, wherein the probe substance is supported on a surface of the electron accepting layer. The electron accepting substance is an oxide semiconductor having an energy level lower than that of a lowest unoccupied molecular orbit (LUMO) of the sensitizing dye. The electrolyte medium comprises an electrolyte and at least one solvent selected from an aprotic solvent and a protic solvent, wherein the electrolyte comprises a salt capable of providing an oxidized sensitizing dye with electrons.
摘要翻译：公开了一种方法，电极，测量单元和测量装置，其可以使用光电流以高灵敏度，简单和准确的方式检测和定量地确定具有特定粘合特性的分析物。该方法包括使工作电极和对电极与电解质介质接触，其中工作电极通过探针物质固定在其上的分析物，并且其中分析物与致敏染料结合; 用光照射工作电极对光敏染料进行光刺激; 并且检测在工作电极和对电极之间流动的光电流，其中通过将电子从光激发敏化染料转移到工作电极而产生光电流。工作电极包括电子接受层，其包含能够响应于光激发而从感光染料中释放的电子的受电子物质，其中探针物质被负载在电子接受层的表面上。电子接受物质是具有比敏化染料的最低未占据分子轨道（LUMO）的能级更低的氧化物半导体。电解质介质包括电解质和至少一种选自非质子溶剂和质子溶剂的溶剂，其中电解质包含能够提供氧化的致敏染料与电子的盐。

23. 发明申请

US20080262349A1 Ultrasonic Cancer Treatment Enhancer and Cell Killer 有权
标题翻译：超声波治疗增强剂和细胞杀伤剂
公开(公告)号：US20080262349A1
公开(公告)日：2008-10-23
申请号：US11883208
申请日：2006-10-26
申请人： Koki Kanehira , Shuji Sonezaki , Yumi Ogami , Toshiaki Banzai
发明人： Koki Kanehira , Shuji Sonezaki , Yumi Ogami , Toshiaki Banzai
IPC分类号： A61N7/00
CPC分类号： A61K33/30 , A61K9/0019 , A61K9/19 , A61K33/24 , A61K41/0033 , B82Y5/00
摘要： There is provided an ultrasonic cancer treatment enhancer and cell killer that can significantly improve the effect of treating cancer by ultrasonic irradiation while ensuring a high level of safety. The ultrasonic cancer treatment enhancer and cell killer comprise metal semiconductor particles and can be activated upon ultrasonic irradiation to kill or destruct cancer cells.
摘要翻译：提供超声波治疗增强剂和细胞杀伤剂，其可以通过超声波照射显着改善治疗癌症的效果，同时确保高水平的安全性。超声波治疗增强剂和细胞杀伤剂包含金属半导体颗粒，并且可以在超声波照射下被激活以杀死或破坏癌细胞。

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