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21. 发明申请

WO2005081825A2 ABUSE RESISTANT OPIOID TRANSDERMAL DELIVERY DEVICE CONTAINING OPIOID ANTAGONIST MICROSPHERES 审中-公开
标题翻译：含有阿片样拮抗剂微生物的耐药性OPIOID TRANSDERMAL DELIVERY DEVICES
公开(公告)号：WO2005081825A2
公开(公告)日：2005-09-09
申请号：PCT/US2005/004741
申请日：2005-02-15
申请人： EURO-CELTIQUE S.A. , REIDENBERG, Bruce , SHEVCHUK, Ihor , TAVARES, Lino , LONG, Kevin , MASKIEWICZ, Richard , SHAMEEM, Mohammed
发明人： REIDENBERG, Bruce , SHEVCHUK, Ihor , TAVARES, Lino , LONG, Kevin , MASKIEWICZ, Richard , SHAMEEM, Mohammed
IPC分类号： A61K9/16 , A61K9/70
CPC分类号： A61K31/485 , A61K9/0014 , A61K9/1611 , A61K9/1647 , A61K9/703 , A61K9/7061 , A61K9/7092 , B09B3/0075 , B09B2220/14
摘要： The present invention provides abuse-resistant transdermal delivery devices containing an opioid agonist intended for analgesic purposes in pain patients.
摘要翻译：本发明提供了在疼痛患者中含有用于止痛目的的阿片样物质激动剂的抗滥用透皮递送装置。

22. 发明申请

WO2004103317A3 TRANSDERMAL BUPRENORPHINE DOSAGE REGIMEN FOR TREATMENT OF DIARRHEA 审中-公开
标题翻译：用于治疗心脏病的转氨酶抑制剂剂量方案
公开(公告)号：WO2004103317A3
公开(公告)日：2005-03-10
申请号：PCT/US2004009335
申请日：2004-03-26
申请人： EURO CELTIQUE SA , REIDENBERG BRUCE E , SPYKER DANIEL A
发明人： REIDENBERG BRUCE E , SPYKER DANIEL A
IPC分类号： A61F13/00 , A61K20060101
CPC分类号： A61K9/0058 , A61K9/4866 , A61K9/4883
摘要： A buprenorphine transdermal dosage regimen is provided that reduces symptoms such as pain and/or diarrhea are effectively reduced in patients suffering from one or more gastrointestinal conditions. The dosage regimen reduces the severity of breakthrough symptoms in a patient treated for symptoms of diarrhea. The gastrointestinal conditions include irritable bowel syndrome (IBS), short gut syndrome, microscopic colitis, and diarrhea associated with VIP-secreting carcinoids.
摘要翻译：提供了一种丁丙诺啡透皮给药方案，其减少了患有一种或多种胃肠病症的患者的症状，例如疼痛和/或腹泻。剂量方案降低了治疗腹泻症状的患者突破症状的严重程度。胃肠道疾病包括肠易激综合征（IBS），短肠综合征，微观结肠炎和与VIP分泌类癌有关的腹泻。

23. 发明申请

WO2005011579A2 TREATMENT OF DEPENDENCE WITHDRAWAL 审中-公开
标题翻译：治疗依赖撤回
公开(公告)号：WO2005011579A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/024010
申请日：2004-07-26
申请人： EURO-CELTIQUE S.A. , REIDENBERG, Bruce, E. , SPYKER, Daniel, A.
发明人： REIDENBERG, Bruce, E. , SPYKER, Daniel, A.
IPC分类号： A61K
CPC分类号： A61K9/7023 , A61K31/485 , A61L15/00 , B09B2220/14
摘要： Dosage regimens of buprenorphine to treat withdrawal or abstinence syndrome in a drug dependent or opioid tolerant patient who is pregnant are described. The method includes treating withdrawal or abstinence syndrome of the patient by transdermal administration of an amount of buprenorphine effective to reduce withdrawal symptoms. For example, a first buprenorphine-containing transdermal dosage form can be administered for a first dosing period that is no more than about 5 days; a second buprenorphine-containing transdermal dosage form for a second dosing period that is no more than about 5 days, the second dosage form comprising the same or a greater dosage of buprenorphine than the first dosage form; and a third buprenorphine-containing transdermal dosage form for a third dosing period that is at least 2 days, the third dosage form comprising the same or a greater dosage of buprenorphine than the second dosage form.
摘要翻译：描述了丁丙诺啡的剂量方案以治疗怀孕的药物依赖或阿片类药物耐受患者的戒断或戒断综合征。该方法包括通过透皮施用有效减少戒断症状的量的丁丙诺啡来治疗患者的戒断或戒断综合征。例如，第一次含有丁丙诺啡的透皮剂型可以在不超过约5天的第一次给药期内给药; 第二剂量的丁丙诺啡的透皮剂型持续不超过约5天，第二剂型包含与第一剂型相同或更高剂量的丁丙诺啡; 和第三次含有丁丙诺啡的透皮剂型，持续至少2天的第三次给药期，第三剂型包含与第二剂型相同或更高剂量的丁丙诺啡。

24. 发明申请

WO2004103317A2 TRANSDERMAL BUPRENORPHINE DOSAGE REGIMEN FOR TREATMENT OF DIARRHEA 审中-公开
标题翻译：用于治疗心脏病的转氨酶抑制剂剂量方案
公开(公告)号：WO2004103317A2
公开(公告)日：2004-12-02
申请号：PCT/US2004/009335
申请日：2004-03-26
申请人： EURO-CELTIQUE S.A. , REIDENBERG, Bruce, E. , SPYKER, Daniel, A.
发明人： REIDENBERG, Bruce, E. , SPYKER, Daniel, A.
IPC分类号： A61K
CPC分类号： A61K9/0058 , A61K9/4866 , A61K9/4883
摘要： A buprenorphine transdermal dosage regimen is provided that reduces symptoms such as pain and/or diarrhea are effectively reduced in patients suffering from one or more gastrointestinal conditions. The dosage regimen reduces the severity of breakthrough symptoms in a patient treated for symptoms of diarrhea. The gastrointestinal conditions include irritable bowel syndrome (IBS), short gut syndrome, microscopic colitis, and diarrhea associated with VIP-secreting carcinoids.
摘要翻译：提供了一种丁丙诺啡透皮给药方案，其减少了患有一种或多种胃肠病症的患者的症状，例如疼痛和/或腹泻。剂量方案降低了治疗腹泻症状的患者突破症状的严重程度。胃肠道疾病包括肠易激综合征（IBS），短肠综合征，微观结肠炎和与VIP分泌类癌相关的腹泻。

25. 发明申请

WO03070191A3 TAMPER-RESISTANT TRANSDERMAL OPIOID DELIVERY DEVICES 审中-公开
标题翻译：防篡改传感器输送装置
公开(公告)号：WO03070191A3
公开(公告)日：2004-09-10
申请号：PCT/US0304999
申请日：2003-02-19
申请人： EURO CELTIQUE SA , SHEVCHUK IHOR , CASSIDY JAMES P , REIDENBERG BRUCE , SHARP DALE E , KUPPER ROBERT J
发明人： SHEVCHUK IHOR , CASSIDY JAMES P , REIDENBERG BRUCE , SHARP DALE E , KUPPER ROBERT J
IPC分类号： A61K9/70 , A61K31/485 , A61K45/06 , A61P25/04 , A61P25/36 , C07D489/08 , A61K31/4468 , A61K31/55 , C07D221/26 , C07D221/28
CPC分类号： A61K9/7084 , A61K31/485 , A61K45/06 , C07D489/08 , A61K2300/00
摘要： This invention relates to a tamper-resistant transdermal-delivery device comprising an opioid, or a pharmaceutically acceptable salt thereof, and an acyl opiod antagonist, or a pharmaceutically acceptable salt thereof. The transdermal-delivery device allows an analgesically effective amount of the opioid, or a pharmaceutically acceptable salt thereof, to be transdermally administered to a patient. The invention further relates to methods for treating or preventing pain in a patient comprising contacting the skin of a patient in need thereof with the transdermal-delivery device of the invention for an amount of time sufficient to treat or prevent pain. The invention further relates to acyl opioid antagonists.
摘要翻译：本发明涉及包含阿片样物质或其药学上可接受的盐和酰基阿片剂拮抗剂或其药学上可接受的盐的抗篡改透皮递送装置。透皮递送装置允许将止痛有效量的阿片样物质或其药学上可接受的盐透皮给药给患者。本发明还涉及用于治疗或预防患者疼痛的方法，包括将有需要的患者的皮肤与本发明的透皮递送装置接触足以治疗或预防疼痛的时间量。本发明还涉及酰基阿片样物质拮抗剂。

26. 发明申请

WO2004054553A1 TRANSDERMAL BUPRENORPHINE DOSAGE REGIMEN FOR ANALGESIA 审中-公开
标题翻译：用于治疗的转铁蛋白抑制剂
公开(公告)号：WO2004054553A1
公开(公告)日：2004-07-01
申请号：PCT/US2003/039792
申请日：2003-12-15
申请人： EURO-CELTIQUE S.A. , REIDENBERG, Bruce, E. , SPYKER, Daniel, A.
发明人： REIDENBERG, Bruce, E. , SPYKER, Daniel, A.
IPC分类号： A61K9/70
CPC分类号： A61K31/485 , A61K9/7023
摘要： Dosage regimens of buprenorphine achieving rapid pain relief without increasing nausea, vomiting, or other adverse effects, are described. Also described are buprenorphine dosage regimens for treating chronic pain comprising administering to the patient (1) a first buprenorphine-containing transdermal dosage form for a first dosing period that is no more than about 5 days; (2) a second buprenorphine-containing transdermal dosage form for a second dosing period that is no more than 5 days, the second dosage form comprising the same dosage of buprenorphine as, or a greater dosage of buprenorphine than, the first dosage form; and (3) a third buprenorphine-containing transdermal dosage form for a third dosing period, the third dosage form comprising a greater dosage of buprenorphine than the second dosage form.
摘要翻译：描述了丁丙诺啡在不增加恶心，呕吐或其他副作用的情况下快速缓解疼痛缓解的剂量方案。还描述了用于治疗慢性疼痛的丁丙诺啡剂量方案，包括向患者施用（1）第一给药期不超过约5天的含有丁丙诺啡的透皮剂型; （2）第二给药期间不超过5天的第二种含丁丙诺啡的透皮剂型，所述第二剂型包含与第一剂型相同的丁丙诺啡剂量或更大剂量的丁丙诺啡; 和（3）第三给药期的含有丁丙诺啡的透皮剂型，所述第三剂型包含比所述第二剂型更大剂量的丁丙诺啡。

27. 发明申请

WO2003070191A1 TAMPER-RESISTANT TRANSDERMAL OPIOID DELIVERY DEVICES 审中-公开
标题翻译：防篡改透明阿片类物质递送装置
公开(公告)号：WO2003070191A1
公开(公告)日：2003-08-28
申请号：PCT/US2003/004999
申请日：2003-02-19
申请人： EURO-CELTIQUE, S.A. , SHEVCHUK, Ihor , CASSIDY, James, P. , REIDENBERG, Bruce , SHARP, Dale, E. , KUPPER, Robert, J.
发明人： SHEVCHUK, Ihor , CASSIDY, James, P. , REIDENBERG, Bruce , SHARP, Dale, E. , KUPPER, Robert, J.
IPC分类号： A61K
摘要： This invention relates to a tamper-resistant transdermal-delivery device comprising an opioid, or a pharmaceutically acceptable salt thereof, and an acyl opiod antagonist, or a pharmaceutically acceptable salt thereof. The transdermal-delivery device allows an analgesically effective amount of the opioid, or a pharmaceutically acceptable salt thereof, to be transdermally administered to a patient. The invention further relates to methods for treating or preventing pain in a patient comprising contacting the skin of a patient in need thereof with the transdermal-delivery device of the invention for an amount of time sufficient to treat or prevent pain. The invention further relates to acyl opioid antagonists.
摘要翻译：本发明涉及包含阿片样物质或其药学上可接受的盐和酰基阿片类拮抗剂或其药学上可接受的盐的抗篡改透皮递送装置。透皮递送装置允许镇痛有效量的阿片样物质或其药学上可接受的盐透皮施用于患者。本发明进一步涉及治疗或预防患者疼痛的方法，其包括使有需要的患者的皮肤与本发明的透皮递送装置接触足以治疗或预防疼痛的时间量。本发明进一步涉及酰基阿片样物质拮抗剂。

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