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21. 发明申请

US20100028382A1 Lentival Vector-Based Vaccine 有权
标题翻译：基于矢量的基于疫苗的疫苗
公开(公告)号：US20100028382A1
公开(公告)日：2010-02-04
申请号：US12083532
申请日：2006-10-17
申请人： Pierre Charneau , Philippe Despres
发明人： Pierre Charneau , Philippe Despres
IPC分类号： A61K39/21 , C12N15/74 , C12N5/07 , A61K39/12 , A61K39/245 , A61P31/12 , A61P31/22
CPC分类号： A61K39/12 , A61K2039/5256 , C07K14/005 , C12N2740/15043 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/394
摘要： Methods of eliciting humoral responses, methods of immunization, and methods of vaccination using lentiviral vector are disclosed. Additionally, immunogenic compositions and vaccines for West Nile Virus are disclosed.
摘要翻译：公开了引起体液应答的方法，免疫方法和使用慢病毒载体的疫苗接种方法。另外，公开了用于西尼罗河病毒的免疫原性组合物和疫苗。

22. 发明申请

US20090214589A1 Recombinant lentiviral vector for expression of a flaviviridae protein and applications thereof as a vaccine 审中-公开
标题翻译：用于表达黄病毒科蛋白的重组慢病毒载体及其作为疫苗的应用
公开(公告)号：US20090214589A1
公开(公告)日：2009-08-27
申请号：US11596675
申请日：2005-05-16
申请人： Philippe Despres , Pierre Charneau , Frederic Tangy , Marie-Pascale Frenkiel
发明人： Philippe Despres , Pierre Charneau , Frederic Tangy , Marie-Pascale Frenkiel
IPC分类号： A61K39/12 , C12N15/867 , C12N5/00 , C12P21/06 , C12Q1/70
CPC分类号： C12N15/86 , A61K2039/53 , C07K14/005 , C12N2740/16043 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/394
摘要： Use of a recombinant lentiviral vector comprising a polynucleotide fragment encoding at least one protein of a virus of the family Flaviviridae or an immunogenic peptide of at least 8 amino acids of said protein, for preparing a pharmaceutical composition intended for the prevention and/or the treatment of a Flaviviridae infection in a sensitive species.
摘要翻译：使用重组慢病毒载体，其包含编码至少一种黄病毒科病毒蛋白的多核苷酸片段或所述蛋白质的至少8个氨基酸的免疫原性肽，用于制备用于预防和/或治疗的药物组合物的敏感物种中的黄病毒科感染。

23. 发明授权

US07419789B2 Method of inhibiting binding of Dengue virus to a human cell with DC-SIGN blockers 失效
标题翻译：用DC-SIGN阻断剂抑制登革热病毒与人细胞结合的方法
公开(公告)号：US07419789B2
公开(公告)日：2008-09-02
申请号：US10700491
申请日：2003-11-05
申请人： Ali Amara , Fernando Arenzana-Seisdedos , Philippe Despres , Jean-Louis Virelizier
发明人： Ali Amara , Fernando Arenzana-Seisdedos , Philippe Despres , Jean-Louis Virelizier
IPC分类号： G01N33/53 , A61K39/12
CPC分类号： G01N33/566 , A61K38/162 , A61K2039/505 , C07K16/2851 , C07K16/2896 , G01N33/6872 , G01N2333/70596 , G01N2500/00 , G01N2500/10 , Y02A50/386 , Y02A50/53
摘要： The present invention relates to methods and compositions for preventing or treating diseases of a mammal, including viral infections, wherein at least one symptom of the disease is mediated at least in part by the binding of an effector molecule to a DC-SIGN receptor present on cells of the mammal to be treated. The invention also provides methods of identifying compositions, wherein the compositions are useful for treating mammalian diseases, including viral infections, for which at least one symptom of the disease is mediated at least in part by the specific binding of an effector molecule to a DC-SIGN receptor present on the cells that express the DC-SIGN receptor, belonging to the mammal to be treated. The invention further relates to compositions and methods for targeting subject molecules to cells that express the DC-SIGN receptor.
摘要翻译：本发明涉及用于预防或治疗哺乳动物疾病（包括病毒感染）的方法和组合物，其中所述疾病的至少一种症状至少部分地通过效应分子与存在于...的DC-SIGN受体结合而介导要治疗的哺乳动物的细胞。本发明还提供鉴定组合物的方法，其中所述组合物可用于治疗哺乳动物疾病，包括病毒感染，至少一种疾病症状至少部分地通过效应子分子与DC- 属于待治疗的哺乳动物的表达DC-SIGN受体的细胞上存在SIGN受体。本发明还涉及将受试者分子靶向表达DC-SIGN受体的细胞的组合物和方法。

24. 发明申请

US20070087354A1 Lentiviral vector-based vaccine 有权
标题翻译：基于慢病毒载体的疫苗
公开(公告)号：US20070087354A1
公开(公告)日：2007-04-19
申请号：US11250616
申请日：2005-10-17
申请人： Pierre Charneau , Philippe Despres
发明人： Pierre Charneau , Philippe Despres
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5256 , C12N2740/15043 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/394
摘要： Methods of eliciting humoral responses, methods of immunization, and methods of vaccination using lentiviral vector are disclosed. Additionally, immunogenic compositions and vaccines for West Nile Virus are disclosed.
摘要翻译：公开了引起体液应答的方法，免疫方法和使用慢病毒载体的疫苗接种方法。另外，公开了用于西尼罗河病毒的免疫原性组合物和疫苗。

25. 发明申请

US20060073164A1 Dengue and West Nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications 有权
公开(公告)号：US20060073164A1
公开(公告)日：2006-04-06
申请号：US11210960
申请日：2005-08-25
申请人： Frederic Tangy , Philippe Despres , Chantal Combredet , Marie Frenkiel
发明人： Frederic Tangy , Philippe Despres , Chantal Combredet , Marie Frenkiel
IPC分类号： C12Q1/68 , G01N33/53 , A61K39/12 , C12N5/06 , C12N5/16
CPC分类号： A61K39/12 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C07K14/1825 , C12N15/86 , C12N2760/18443 , C12N2770/24122 , C12Q1/701 , Y02A50/386 , Y02A50/394 , Y02A50/53
摘要： The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective humoral and cellular immune responses against WNV or Dengue virus infections. More specifically, the present invention relates to three (3) antigens from WNV (the secreted envelope glycoprotein (E), the heterodimer glycoproteins (pre-M-E) and the NSI protein) and from Dengue virus (the secreted envelope glycoprotein (e), the heterodimer glycoproteins (pre- m-e) and the nsl protein) and their use in vaccinal, therapeutic and diagnostic applications.

26. 发明申请

US20050080231A1 Small peptides having apoptotic activities and their applications 有权
标题翻译：具有凋亡活性的小肽及其应用
公开(公告)号：US20050080231A1
公开(公告)日：2005-04-14
申请号：US10608147
申请日：2003-06-30
申请人： Philippe Despres , Adeline Catteau
发明人： Philippe Despres , Adeline Catteau
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/18 , C07K7/08 , C07K7/06
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , C12N2770/24122 , Y02A50/386 , Y02A50/394
摘要： The present invention relates to nine residue peptides (M32-40) from flavivirus M ectodomain able to modulate specifically the apoptotic activity of diverse flavivirus, to pharmaceutical composition comprising the same and their use for the treatment and/or the prevention of flavivirus-linked infections and cancers.
摘要翻译：本发明涉及能够特异性调节多种黄病毒的凋亡活性的黄病毒M胞外域的九个残基肽（M <32-40>），包含其的药物组合物及其用于治疗和/或预防黄病毒连锁的感染和癌症。

27. 发明授权

US08853379B2 Chimeric poly peptides and the therapeutic use thereof against a flaviviridae infection 有权
标题翻译：嵌合多肽及其针对黄病毒科感染的治疗用途
公开(公告)号：US08853379B2
公开(公告)日：2014-10-07
申请号：US13089705
申请日：2011-04-19
申请人： Frederic Tangy , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
发明人： Frederic Tangy , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
IPC分类号： C12N15/62 , C12N15/86 , C07K14/005 , C07K14/08 , A61K39/12 , A61K39/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/165 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , C07K2319/00 , C07K2319/04 , C12N7/00 , C12N15/86 , C12N2760/18434 , C12N2760/18443 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide for producing recombinant viral vectors such as a measles living viral vector is also disclosed.
摘要翻译：本发明涉及构建用于预防或治疗黄病毒科感染的嵌合多肽。还公开了本发明的嵌合多肽用于产生重组病毒载体如麻疹活病毒载体的用途。

28. 发明申请

US20140274762A1 MULTIPLEX IMMUNO SCREENING ASSAY 有权
标题翻译：多重免疫屏蔽测定
公开(公告)号：US20140274762A1
公开(公告)日：2014-09-18
申请号：US13883339
申请日：2012-12-10
申请人： Jean-Claude Manuguerra , Jessica Vanhomwegen , Philippe Despres , Sylvie Paulous
发明人： Jean-Claude Manuguerra , Jessica Vanhomwegen , Philippe Despres , Sylvie Paulous
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , G01N33/54313 , G01N33/54353 , G01N33/564 , G01N33/56983 , G01N33/6845 , G01N2333/18 , G01N2333/185 , G01N2469/20 , Y02A50/51 , Y02A50/53 , Y02A50/56 , Y02A50/58 , Y02A50/60
摘要： The present invention provides kits and assay methods for the early detection of pathogens, precise identification of the etiologic agent, and improved disease surveillance. More specifically, the present invention discloses an immunoassay leading to the rapid and simultaneous detection of antibodies to a wide range of infectious pathogens in biological fluids of infected patients. This immunoassay involves the covalent and oriented coupling of fusion proteins comprising an AGT enzyme and a viral antigen on an identifiable solid support (e.g. fluorescent microspheres), said support being previously coated with an AGT substrate. This coupling is mediated by the irreversible reaction of the AGT enzyme on its substrate. The thus obtained antigen-coupled microspheres show enhanced capture of specific antibodies as compared to antigen-coupled microspheres produced by standard amine coupling procedures. The methods of the invention possess the ability to multiplex, minimize the amount of biological sample, and have enhanced sensitivity and specificity toward target antibodies as compared with classical ELISA or Radio-Immunoprecipitation assays.
摘要翻译：本发明提供用于病原体的早期检测，病原体的精确鉴定和改进的疾病监测的试剂盒和测定方法。更具体地，本发明公开了一种免疫测定，其导致快速和同时检测感染患者生物流体中广泛感染性病原体的抗体。该免疫测定涉及包含AGT酶和病毒抗原的融合蛋白在可识别的固体支持物（例如荧光微球）上的共价和取向偶联，所述载体预先用AGT底物涂覆。该偶联由AGT酶在其底物上的不可逆反应介导。与通过标准胺偶联方法制备的抗原偶联微球相比，由此获得的抗原偶联微球显示出特异性抗体的增强捕获。与传统的ELISA或放射免疫沉淀测定相比，本发明的方法具有复用多样化，最小化生物样品的量并且对靶抗体具有增强的敏感性和特异性的能力。

29. 发明授权

US08716013B2 Recombinant lentiviral vector for expression of a flaviviridae protein and applications thereof as a vaccine 有权
标题翻译：用于表达黄病毒科蛋白的重组慢病毒载体及其作为疫苗的应用
公开(公告)号：US08716013B2
公开(公告)日：2014-05-06
申请号：US12929215
申请日：2011-01-07
申请人： Philippe Despres , Pierre Charneau , Frédéric Tangy , Marie-Pascale Frenkiel
发明人： Philippe Despres , Pierre Charneau , Frédéric Tangy , Marie-Pascale Frenkiel
IPC分类号： C12N15/00 , A61K39/12
CPC分类号： C12N15/86 , A61K2039/53 , C07K14/005 , C12N2740/16043 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/394
摘要： Use of a recombinant lentiviral vector comprising a polynucleotide fragment encoding at least one protein of a virus of the family Flaviviridae or an immunogenic peptide of at least 8 amino acids of said protein, for preparing a pharmaceutical composition intended for the prevention and/or the treatment of a Flaviviridae infection in a sensitive species.
摘要翻译：使用重组慢病毒载体，其包含编码至少一种黄病毒科病毒蛋白的多核苷酸片段或所述蛋白质的至少8个氨基酸的免疫原性肽，用于制备用于预防和/或治疗的药物组合物的敏感物种中的黄病毒科感染。

30. 发明申请

US20120009216A1 EARLY DETECTION OF FLAVIVIRUSES USING THE NS1 GLYCOPROTEIN 有权
标题翻译：使用NS1 GLYCOPROTEIN早期检测FLAVIVIRUSUS
公开(公告)号：US20120009216A1
公开(公告)日：2012-01-12
申请号：US13190547
申请日：2011-07-26
申请人： Marie Flamand , Françoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
发明人： Marie Flamand , Françoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
IPC分类号： A61K39/12 , C07K16/10 , A61P37/04 , C12P19/34 , A61P31/14 , C12P21/00 , A61K31/7088
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/505 , C07K16/1081 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N2333/18 , G01N2469/10 , Y02A50/386 , Y02A50/53 , Y10S435/975
摘要： The invention concerns a method for early detection of a flavivirus-induced infection, comprising the detection of the flavivirus non-structural glycoprotein NS1 in a biological sample during the clinical phase of the infection, by an immunological method using at least two identical or different antibodies, the first antibody consisting of polyclonal or monoclonal antibodies pre-selected for their high affinity for said NS1 protein hexameric in shape.
摘要翻译：本发明涉及一种用于早期检测黄病毒感染的方法，包括在感染的临床阶段通过使用至少两种相同或不同抗体的免疫学方法检测生物样品中的黄病毒非结构性糖蛋白NS1 第一抗体由预先选择的多克隆抗体或单克隆抗体，因为它们对所述NS1蛋白六聚体形状的高亲和力。

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