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21. 发明授权

US5343426A Data formater/converter for use with solid-state disk memory using storage devices with defects 失效
公开(公告)号：US5343426A
公开(公告)日：1994-08-30
申请号：US897164
申请日：1992-06-11
申请人： Charles Cassidy , Paul Kemp
发明人： Charles Cassidy , Paul Kemp
IPC分类号： G06F11/10 , G11C29/00 , H03M13/00
CPC分类号： G06F11/1044 , G11C29/88
摘要： A computer system includes a main memory that is able to make use of DRAM memory devices having a relatively high level of bad cells (hard faults). An EDC circuit is provided which uses combinatorial logic to perform a BCH code type of error detection and correction. A primary feature is the recognition that due to use of high density integrated circuits--gate arrays--it is no longer necessary to use sequential logic to decode the multiple-bit error correcting codes. An EDC with 128-bits of data and a check bit field 41-bits wide, using a BCH code, constructed in ASIC sea-of-gates technology using about 87,000 logic gates, can correct 5-bits in error and can detect 6-bits in error. By using multiple-bit EDC in the controller for main memory, it is no longer necessary that all DRAM devices be ostensibly "perfect." A certain density of non-functional memory cells can be tolerated, yet the memory system will still return perfect data. The added cost of multiple-bit EDC, including the added cost of extra storage for the check bits and the EDC circuit itself, is more than compensated by reduced cost of the DRAMs. In a addition the computer system includes a solid-state disk type memory for a computer system is able to make use of DRAM memory devices having a relatively high level of bad cells (hard faults). An EDC circuit is employed to perform a Reed-Solomon code type of error detection and correction. A primary feature is the recognition that it is no longer necessary that all DRAM devices be ostensibly "perfect." A certain density of non-functional memory cells can be tolerated, yet the memory system will still return perfect data. The added cost of multiple-bit EDC, including the added cost of extra storage for the check bits and the EDC circuit itself, is more than compensated by reduced cost of the DRAMs. A preferred data formatter circuit to convert between symbol and word data is also described.

22. 发明申请

US20100203135A1 Skin Equivalent Culture 有权
标题翻译：皮肤等效文化
公开(公告)号：US20100203135A1
公开(公告)日：2010-08-12
申请号：US11886113
申请日：2006-03-14
申请人： Paul Kemp , David Shering , Andrew Shering , Penny Johnson , Damian Marshall
发明人： Paul Kemp , David Shering , Andrew Shering , Penny Johnson , Damian Marshall
IPC分类号： A61K9/14 , C07K14/78 , A61K38/39 , C07D233/74 , C07D307/62 , C07C53/128 , C07K7/64 , C07D213/80 , C07D281/10 , C07C255/43 , A61P17/02 , C12P21/02
CPC分类号： C12N5/0698 , A61L27/20 , A61L27/225 , A61L27/24 , A61L27/3687 , A61L27/3691 , A61L27/3804 , A61L27/3839 , A61L27/3886 , A61L27/3895 , A61L27/54 , A61L27/60 , C12N2500/25 , C12N2500/30 , C12N2500/32 , C12N2501/11 , C12N2501/15 , C12N2502/094 , C12N2502/1323 , C12N2533/56
摘要： Methods of forming soft connective tissue compositions such as skin equivalents, compositions made by the methods and their uses. In particular, a method of forming a connective tissue equivalent, comprising the steps of: (i) incubating collagen-producing cells in or on a support matrix; (ii) inducing and/or enhancing collagen production by the collagen-producing cells to form a collagenous construct and degradation and replacement of the support matrix; (iii) freeze-drying the construct; and (iv) re-populating the freeze-dried construct with collagen-producing cells and/or epithelial cells and/or endothelial cells and/or mesenchymal cells, thereby forming a connective tissue equivalent, wherein: (a) the collagen-producing cells are substantially fibroblasts; for example human neonatal dermal fibroblasts; (b) the support matrix is a provisional support matrix in which the support matrix is a fibrin matrix, for example formed by thrombin-mediated polymerisation of fibrinogen; and (c) as a result of the collagen production by the collagen-producing cells the provisional fibrin support matrix is digested by the cells and is replaced by collagen, thereby essentially replacing the provisional fibrin matrix with a collagen matrix synthesised in situ by the cells.
摘要翻译：形成软结缔组织组合物如皮肤当量的方法，通过方法制备的组合物及其用途。特别地，形成结缔组织当量的方法，包括以下步骤：（i）在载体基质中或载体上孵育胶原产生细胞; （ii）诱导和/或增强胶原产生细胞的胶原产生以形成胶原构建物并降解和置换支持基质; （iii）冷冻干燥该构造体; 和（iv）用胶原产生细胞和/或上皮细胞和/或内皮细胞和/或间充质细胞重新填充冷冻干燥的构建体，从而形成结缔组织当量，其中：（a）胶原产生细胞基本上是成纤维细胞; 例如人类新生儿真皮成纤维细胞; （b）载体基质是临时支持基质，其中载体基质是纤维蛋白基质，例如通过凝血酶介导的纤维蛋白原聚合形成; 和（c）作为胶原蛋白产生细胞产生胶原的结果，临床纤维蛋白载体基质被细胞消化并被胶原替代，从而基本上用由细胞原位合成的胶原基质代替临时纤维蛋白基质。

23. 发明授权

US4892243A Air-bearing center-guiding apparatus and method 失效
标题翻译：空气轴承中心导向装置及方法
公开(公告)号：US4892243A
公开(公告)日：1990-01-09
申请号：US247224
申请日：1988-09-21
申请人： Michael Long , Thomas W. Palone , Paul Kemp
发明人： Michael Long , Thomas W. Palone , Paul Kemp
IPC分类号： B65H20/10 , B65H23/02 , B65H23/032 , B65H23/24
CPC分类号： B65H23/02 , B65H23/032 , B65H23/24 , B65H2406/111
摘要： An air-bearing center-guiding apparatus 10 and a method are disclosed for supporting and laterally center-guiding thin flexible webs of paper or plastic under 15 mils in thickness. The apparatus comprises a web support and guide member 22 having an inner surface and an outer web-facing surface. Parallel rows of elongated spaced-apart guide apertures 34 extend longitudinally along edge regions of the web. Each guide aperture 34 is formed from a cylindrical opening in the web support and guide member 22 and extends substantially perpendicular to the web. Within each aperture a flat-sided dowel 60 is mounted to define a flow passage shaped in cross-section like a segment of a circle 62. Each circular-segment guide aperture 34 has a straight side 54 and a curved side 52 for directing a jet of air against the web edge 56. A plurality of the circular-segment guide apertures 34 develop a guiding force for holding lateral movement of the web to plus or minus 0.001 inch (0.0254 mm). A row of web-support apertures 32, separate from the guide apertures 34, is provided between the rows of guide apertures 34 to form an air bearing for supporting the web.
摘要翻译：公开了一种空气轴承中心引导装置10和方法，用于支撑和横向中心地引导厚度小于15密耳的纸或塑料的薄柔性幅材。该装置包括具有内表面和面向外网的表面的腹板支撑件和引导构件22。细长间隔开的引导孔34的平行排沿腹板的边缘区域纵向延伸。每个引导孔34由幅材支撑件和引导构件22中的圆柱形开口形成并基本上垂直于幅材延伸。在每个孔内，平面定位销60被安装以限定如同圆形部分62的横截面形状的流动通道。每个圆形段导向孔34具有直的侧面54和用于引导射流的弯曲侧面52 多个圆形段导向孔34形成用于将幅材的横向运动保持在正或负0.001英寸（0.0254mm）的引导力。与引导孔34分开的一排腹板支撑孔32设置在引导孔34的行之间，以形成用于支撑腹板的空气轴承。

24. 发明授权

US4889269A Web center-guiding apparatus 失效
标题翻译：网络中心引导装置
公开(公告)号：US4889269A
公开(公告)日：1989-12-26
申请号：US254341
申请日：1988-09-21
申请人： Michael Long , Thomas W. Palone , Paul Kemp
发明人： Michael Long , Thomas W. Palone , Paul Kemp
IPC分类号： B65H20/10 , B65H23/02 , B65H23/032 , B65H23/24
CPC分类号： B65H23/24 , B65H23/02 , B65H23/032 , B65H2406/111
摘要： An air-bearing center-guiding apparatus is disclosed for supporting and laterally center-guiding thin, flexible webs of paper or plastic under 15 mils in thickness. The apparatus comprises a web support and guide member 10 having an inner surface 58 and an outer web-facing surface 60. The web support and guide member 10 comprises a base member 14 for supporting an inner ring 22, an end cap 38, and a center ring 28 interposed therebetween. Parallel, circumferentially extending rows of circumferentially elongated and spaced-apart guide apertures 62 are provided in the web support and guide member 10 along edge regions of the web. The guide apertures 62 are formed between end surfaces 46 of the center ring 28 and interengaging end surfaces of the inner ring 22 and end cap rings 38. Each guide aperture 62 extends substantially perpendicular to the surface of the web and defines in cross-section an opening having a straight side and a curved side for directing jets of air against the web edges for developing a guiding force for holding lateral movement of the web to plus or minus 0.001 inch (0.0254 mm). A row of support apertures 56, separate from the guide apertures 62, is provided in the center ring 28 between the rows of guide apertures 62 to form an air-bearing for the web.
摘要翻译：公开了一种空气轴承中心引导装置，用于支撑和横向中心地引导厚度小于15密耳的薄而柔软的纸或塑料幅材。该装置包括腹板支撑件和引导构件10，该构件具有内表面58和外腹板相对表面60.腹板支撑件和导向构件10包括用于支撑内圈22，端盖38和中间环28插入其间。平行的沿周向细长且间隔开的导向孔62的周向延伸的排沿腹板的边缘区域设置在腹板支撑件和引导构件10中。引导孔62形成在中心环28的端面46和内环22和端盖环38的相互接合的端面之间。每个引导孔62基本上垂直于网的表面延伸并且在横截面中限定具有直边和弯曲侧的开口，用于将空气的喷射引导到幅材边缘上，用于形成用于将幅材的横向移动保持在正或负0.001英寸（0.0254mm）的引导力。在引导孔62的行之间的中心环28中设置有与引导孔62分离的一排支撑孔56，以形成腹板的空气轴承。

25. 发明授权

US3997480A Air treating gel 失效
标题翻译：空气处理凝胶
公开(公告)号：US3997480A
公开(公告)日：1976-12-14
申请号：US527168
申请日：1974-11-25
申请人： Alan Singleton , Paul Kemp Montagnat
发明人： Alan Singleton , Paul Kemp Montagnat
IPC分类号： A61L9/04 , A61K7/46 , C11B9/00
CPC分类号： A61L9/048
摘要： An air treating gel comprises an aqueous medium, at least one volatile air treating component and a gelling agent, characterized in that the gelling agent consists of the reaction product of a water soluble cellulose derivative and a metal salt.The invention also covers an apparatus for continuously producing the above air treating gel comprising a pair of containers holding the aqueous solution of said cellulose derivative and the slurry of said metal salt and said volatile air treating component respectively, mixing means connected to the containers for mixing and reacting the aqueous solution and slurry to form the gel, and transfer means for continuously transferring the aqueous solution and slurry in predetermined volume proportion from the containers to the mixing means.
摘要翻译：空气处理凝胶包括水性介质，至少一种挥发性空气处理组分和胶凝剂，其特征在于胶凝剂由水溶性纤维素衍生物和金属盐的反应产物组成。

26. 发明授权

US2212178A Alloy suitable for use as bearing metals 失效
标题翻译：合金适合用作轴承金属
公开(公告)号：US2212178A
公开(公告)日：1940-08-20
申请号：US22056238
申请日：1938-07-21
申请人： PAUL KEMP
发明人： PAUL KEMP
IPC分类号： C22C11/10
CPC分类号： C22C11/10 , Y10T29/49709

27. 发明授权

US08591098B2 Apparatus and method for material blending 有权
标题翻译：用于材料混合的装置和方法
公开(公告)号：US08591098B2
公开(公告)日：2013-11-26
申请号：US13643044
申请日：2011-05-05
申请人： Roger Kemp , Chris Kipp , Paul Kemp , Andrew M. Nelson
发明人： Roger Kemp , Chris Kipp , Paul Kemp , Andrew M. Nelson
IPC分类号： B01F15/02 , B01F15/04
CPC分类号： B01F15/0429 , B01F3/188 , B01F5/0062 , B01F15/0238
摘要： A material blender and method for blending a plurality of ingredient materials to make a single heterogeneous material. The material blender may comprise a blending apparatus, a control system, and a pneumatic delivery system. The pneumatic delivery system may comprise a plurality of conduits each provided with a pneumatic flow therethrough to pneumatically convey one of the ingredient materials to the blending apparatus. The delivery system may also comprise one or more valves configured to independently vary the pneumatic flow through one of the conduits. The control system may be configured to provide signals to the valves, commanding the valves to oscillate between varying degrees of openness based on a desired percentage or ratio of each of the ingredient materials to be output to the blending apparatus. The control system may calculate signals to send to the valves based on stored calibration information.
摘要翻译：一种用于混合多种成分材料以制备单一异质材料的材料混合器和方法。材料混合器可以包括混合装置，控制系统和气动输送系统。气动输送系统可以包括多个导管，每个导管设置有穿过其中的气动流，以将配料中的一种材料气动地输送到混合装置。输送系统还可以包括配置成独立地改变通过其中一个导管的气流的一个或多个阀。控制系统可以被配置为向阀提供信号，基于要输出到混合装置的每种成分材料的期望百分比或比例来指示阀在不同程度的开度之间振荡。控制系统可以基于存储的校准信息计算发送到阀的信号。

28. 发明申请

US20130100760A1 APPARATUS AND METHOD FOR MATERIAL BLENDING 有权
标题翻译：用于材料混合的装置和方法
公开(公告)号：US20130100760A1
公开(公告)日：2013-04-25
申请号：US13643044
申请日：2011-05-05
申请人： Roger Kemp , Chris Kipp , Paul Kemp , Andrew M. Nelson
发明人： Roger Kemp , Chris Kipp , Paul Kemp , Andrew M. Nelson
IPC分类号： B01F15/04
CPC分类号： B01F15/0429 , B01F3/188 , B01F5/0062 , B01F15/0238
摘要： A material blender and method for blending a plurality of ingredient materials to make a single heterogeneous material. The material blender may comprise a blending apparatus, a control system, and a pneumatic delivery system. The pneumatic delivery system may comprise a plurality of conduits each provided with a pneumatic flow therethrough to pneumatically convey one of the ingredient materials to the blending apparatus. The delivery system may also comprise one or more valves configured to independently vary the pneumatic flow through one of the conduits. The control system may be configured to provide signals to the valves, commanding the valves to oscillate between varying degrees of openness based on a desired percentage or ratio of each of the ingredient materials to be output to the blending apparatus. The control system may calculate signals to send to the valves based on stored calibration information.
摘要翻译：一种用于混合多种成分材料以制备单一异质材料的材料混合器和方法。材料混合器可以包括混合装置，控制系统和气动输送系统。气动输送系统可以包括多个导管，每个导管设置有穿过其中的气动流，以将配料中的一种材料气动地输送到混合装置。输送系统还可以包括配置成独立地改变通过其中一个导管的气流的一个或多个阀。控制系统可以被配置为向阀提供信号，基于要输出到混合装置的每种成分材料的期望百分比或比例来指示阀在不同程度的开度之间振荡。控制系统可以基于存储的校准信息计算发送到阀的信号。

29. 发明申请

US20060029986A1 Prevention and treatment of cardiovascular pathologies 审中-公开
标题翻译：预防和治疗心血管病变
公开(公告)号：US20060029986A1
公开(公告)日：2006-02-09
申请号：US11231256
申请日：2005-09-20
申请人： David Grainger , Paul Kemp
发明人： David Grainger , Paul Kemp
IPC分类号： G01N33/542 , G01N33/537
CPC分类号： A61K9/0024 , A61K31/00 , A61K31/135 , A61K31/138 , A61K31/337 , A61K31/38 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K31/715 , A61K47/51 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6831 , A61K47/6843 , A61K47/6927 , A61K47/6937 , A61K47/6957 , C07K14/71 , C07K16/22 , C07K2317/73 , G01N33/6893 , G01N33/74 , G01N2333/495 , G01N2800/32
摘要： A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): wherein Z is C═O or a covalent bond; Y is H or O(C1-C4)alkyl, R1 and R2 are individually (C1-C4)alkyl or together with N are a saturated heterocyclic group, R3 is ethyl or chloroethyl, R4 is H or together with R3 is —CH2—CH2— or —S—, R5 is I, O(C1-C4)alkyl or H and R6 is 1, O(C1-C4)alkyl or H with the proviso that when R4, R5, and R6 are H, R3 is not ethyl; or a pharmaceutically acceptable salt thereof, effective to activate or stimulate production of TGF-beta to treat and/or prevent conditions such as atherosclerosis, thrombosis, myocardial infarction, and stroke is provided. Useful compounds include idoxifene and salts thereof. Further provided is a method for identifying a compound that is a TGF-beta activator or production stimulator is provided. Another embodiment of the invention is an assay or kit to determine TGF-beta in vitro. Also provided is a therapeutic method comprising inhibiting smooth muscle cell proliferation associated with procedural vascular trauma employing the administration of tamoxifen or structural analogs thereof, including compounds of formula (I).
摘要翻译：一种治疗或预防心血管病变的方法，其通过给予式（I）化合物：其中Z为C-O或共价键; Y是H或O（C 1 -C 4）烷基，R 1和R 2各自独立地是（ C 1 -C 4烷基或与N一起为饱和杂环基，R 3是乙基或氯乙基，R 4 H或与R 3一起为-CH 2 - ， - CH 2 - 或-S-，R 5 是（O）（C 1 -C 4 - ）烷基或H，且R 6是1，O（C _{1个C 1 -C 4烷基或H，条件是当R 4，R 5，R 5， 6是H，R 3不是乙基; 提供有效激活或刺激TGF-β的产生以治疗和/或预防诸如动脉粥样硬化，血栓形成，心肌梗死和中风的病症的药学上可接受的盐或其药学上可接受的盐。有用的化合物包括异昔芬及其盐。还提供了鉴定作为TGF-β激活剂或生产刺激剂的化合物的方法。本发明的另一个实施方案是用于在体外测定TGF-β的测定或试剂盒。还提供了一种治疗方法，其包括使用给予他莫昔芬或其结构类似物（包括式（I）的化合物）来抑制与程序性血管创伤相关的平滑肌细胞增殖。}

30. 发明申请

US20060024380A1 Chemical cleaning of biological material 审中-公开
公开(公告)号：US20060024380A1
公开(公告)日：2006-02-02
申请号：US11130018
申请日：2005-05-16
申请人： Ginger Abraham , Robert Carr , Paul Kemp , Ryan Mercer , Linda Baker
发明人： Ginger Abraham , Robert Carr , Paul Kemp , Ryan Mercer , Linda Baker
IPC分类号： A61K35/38 , C12Q1/68
CPC分类号： A61L27/3687 , A61K35/12 , A61K38/39 , A61L27/24 , A61L27/3695 , A61L2430/40 , Y10S623/917 , Y10S623/92
摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.

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