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21. 发明申请

US20090061072A1 MANDREL AND METHOD FOR COATING OPEN-CELL IMPLANTABLE ENDOVASCULAR STRUCTURES 有权
标题翻译：用于涂覆开放细胞可植入性内膜结构的方法和方法
公开(公告)号：US20090061072A1
公开(公告)日：2009-03-05
申请号：US12199189
申请日：2008-08-27
申请人： Andrew P. Isch , Jeff P. Little , Patrick H. Ruane
发明人： Andrew P. Isch , Jeff P. Little , Patrick H. Ruane
IPC分类号： B05D5/00
CPC分类号： B05D1/02 , A61F2/88 , A61F2220/0033 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2240/001 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2420/02 , B05D1/002 , C08L67/04
摘要： Methods of coating a medical device are provided to improve coating uniformity and reduce coating irregularities while reducing direct coating of the luminal surface of the medical device. Preferably, methods of coating a tubular medical device include the steps of: positioning the tubular medical device around a mandrel coating assembly, mounting the tubular medical device on the mandrel coating assembly and spraying a coating solution including a therapeutic agent and a solvent onto the abluminal surface of the tubular medical device mounted on the mandrel coating assembly. The mandrel coating assembly may include an axial member of a diameter that is less than the diameter of the lumen of the tubular medical device and at least one annular projection extending from the axial member to an outer surface having a diameter greater than or substantially equal to the diameter of the lumen of the medical device. Improved coating uniformity may be achieved by providing an annular space between the luminal surface of the medical device and an axial member. Coating on the luminal surface may be minimized by providing an axial member having an outer diameter that is greater than the maximum width or length of the spray contacting the axial member after passing through the openings in the medical device.
摘要翻译：提供涂覆医疗装置的方法以改善涂层的均匀性并减少涂层不规则，同时减少医疗装置的腔表面的直接涂覆。优选地，涂覆管状医疗装置的方法包括以下步骤：将管状医疗装置定位在心轴涂层组件周围，将管状医疗装置安装在心轴涂层组件上，并将包括治疗剂和溶剂的包衣溶液喷涂在腹腔镜安装在心轴涂层组件上的管状医疗装置的表面。心轴涂层组件可以包括直径小于管状医疗装置的内腔的直径的轴向构件，以及从轴向构件延伸到外表面的至少一个环形凸起，该外表面的直径大于或基本上等于医疗装置的管腔直径。可以通过在医疗装置的腔表面和轴向构件之间提供环形空间来实现改进的涂层均匀性。通过提供具有大于在穿过医疗装置中的开口之后接触轴向构件的喷雾器的最大宽度或长度的外径的轴向构件，腔体表面上的涂层可以最小化。

22. 发明授权

US09474833B2 Stent graft with releasable therapeutic agent and soluble coating 有权
标题翻译：支架移植具有可释放的治疗剂和可溶性涂层
公开(公告)号：US09474833B2
公开(公告)日：2016-10-25
申请号：US11958090
申请日：2007-12-17
申请人： Patrick H. Ruane , Priscilla Reyes , Blayne A. Roeder , Amy M. Vibbert
发明人： Patrick H. Ruane , Priscilla Reyes , Blayne A. Roeder , Amy M. Vibbert
IPC分类号： A61F2/04 , A61F2/06 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , C08L75/04
摘要： Medical devices for implantation within a body vessel comprising a graft material and a releasable therapeutic agent are provided. The graft material preferably comprises a biocompatible polyurethane and a therapeutic agent. Preferably, the medical device is a stent graft formed by attaching a polyurethane graft material comprising an elutable taxane therapeutic agent to a radially expandable frame.
摘要翻译：提供了用于植入包括移植材料和可释放治疗剂的体内容器内的医疗装置。移植材料优选包含生物相容性聚氨酯和治疗剂。优选地，医疗装置是通过将包含可洗脱紫杉烷治疗剂的聚氨酯移植物材料附着到可径向扩张的框架而形成的支架移植物。

23. 发明授权

US08092819B2 Implantable medical device coated with a bioactive agent 有权
标题翻译：涂有生物活性剂的可植入医疗器械
公开(公告)号：US08092819B2
公开(公告)日：2012-01-10
申请号：US11655300
申请日：2007-01-19
申请人： Patrick H. Ruane , Jeff P. Little , Andrew P. Isch
发明人： Patrick H. Ruane , Jeff P. Little , Andrew P. Isch
IPC分类号： A61F13/00 , A61F2/06 , C07H21/04
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/602 , A61L2300/606 , C08L35/04
摘要： The present invention provides an implantable medical device comprising a bioactive agent and poly(alkyl cyanoacrylate) polymer. In one embodiment of the invention, the bioactive agent is a water-soluble material, such as an antisense agent.
摘要翻译：本发明提供了包含生物活性剂和聚（氰基丙烯酸烷基酯）聚合物的可植入医疗装置。在本发明的一个实施方案中，生物活性剂是水溶性物质，例如反义剂。

24. 发明申请

US20080286325A1 CYCLODEXTRIN ELUTION MEDIA FOR MEDICAL DEVICE COATINGS COMPRISING A TAXANE THERAPEUTIC AGENT 审中-公开
标题翻译：用于包含TAXANE治疗剂的医疗装置涂层的环糊精溶液
公开(公告)号：US20080286325A1
公开(公告)日：2008-11-20
申请号：US11774322
申请日：2007-07-06
申请人： Priscilla Reyes , Patrick H. Ruane , Melinda S. Morrell
发明人： Priscilla Reyes , Patrick H. Ruane , Melinda S. Morrell
IPC分类号： A61K9/00 , A61K31/337 , G01N33/15
CPC分类号： A61K31/337 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/416 , Y10T436/142222
摘要： The present disclosure provides methods of measuring the release of a taxane therapeutic agent from a medical device as a function time in contact with a suitable elution medium. The method preferably comprises the step of contacting a coated medical device comprising a taxane therapeutic agent with an elution medium comprising a cyclodextrin to provide an elution profile indicative of the composition or configuration of a medical device coating comprising a taxane therapeutic agent. The elution profile can provide information about the medical device coating that is useful in lot release testing.
摘要翻译：本公开提供了作为与合适的洗脱介质接触的功能时间从医疗装置测量紫杉烷治疗剂的释放的方法。该方法优选包括使包含紫杉烷治疗剂的包被的医疗装置与包含环糊精的洗脱介质接触以提供指示包含紫杉烷治疗剂的医疗装置涂层的组成或构型的洗脱曲线的步骤。洗脱曲线可以提供有关在批量释放测试中有用的医疗器械涂层的信息。

25. 发明申请

US20080199510A1 THERMO-MECHANICALLY CONTROLLED IMPLANTS AND METHODS OF USE 审中-公开
标题翻译：热机械控制的植入物和使用方法
公开(公告)号：US20080199510A1
公开(公告)日：2008-08-21
申请号：US12033586
申请日：2008-02-19
申请人： Patrick H. Ruane , Cameron L. Wilson
发明人： Patrick H. Ruane , Cameron L. Wilson
IPC分类号： A61F2/12 , A61F2/06 , A61F2/02
CPC分类号： A61L31/128 , A61F2/12 , A61F2/28 , A61F2/82 , A61F2210/0004 , A61F2210/0071 , A61F2250/0001 , A61F2250/0004 , A61F2250/0012 , A61F2250/0067 , A61K41/0028 , A61L27/44 , A61L27/54 , A61L27/58 , A61L31/148 , A61L31/16 , A61L2430/04 , B82Y30/00 , G21K5/02
摘要： An implant comprises a structure that may be implanted into tissue and that has a first material property at normal body temperature. The first material property is variable at elevated temperatures above normal body temperature. The implant also has a plurality of particles dispersed in the structure that are adapted to convert incident radiation into heat energy when irradiated with electromagnetic radiation. The particles are in thermal contact with the structure such that exposure of the particles to incident radiation raises the temperature of the structure thereby changing the first material property relative to the first material property at normal body temperature.
摘要翻译：植入物包括可以植入组织中并且在正常体温具有第一材料性质的结构。第一种材料性质在高于正常体温的高温下是可变的。植入物还具有分散在结构中的多个颗粒，其适于在用电磁辐射照射时将入射的辐射转换成热能。颗粒与结构热接触，使得颗粒暴露于入射辐射会提高结构的温度，从而在正常体温下相对于第一材料性质改变第一材料性质。

26. 发明授权

US07122529B2 Compounds that release nitric oxide at controlled rates upon photolysis 有权
标题翻译：在光解后以可控速率释放一氧化氮的化合物
公开(公告)号：US07122529B2
公开(公告)日：2006-10-17
申请号：US10483323
申请日：2002-07-12
申请人： Patrick H. Ruane , John P. Toscano
发明人： Patrick H. Ruane , John P. Toscano
IPC分类号： C07C291/08 , A61K31/655 , A61P7/00
CPC分类号： C07D295/30 , C07C291/08 , C07D295/28
摘要： Chemical compounds which release nitric oxide in a controlled manner upon photolysis with light are provided. These compounds are O2-benzyl, O2-naphthylmethyl and O2-naphthylallyl substituted diazeniumdiolates. Also provided are methods of preparing these novel compounds in high chemical yields as well as methods of using these compounds.
摘要翻译：提供了用光解光以可控方式释放一氧化氮的化合物。这些化合物是O 2 - 苄基，O 2 - 萘基甲基和O 2 - 萘基烯基取代的二氮烯鎓二硫醇盐。还提供了以高化学产率制备这些新化合物的方法以及使用这些化合物的方法。

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