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21. 发明授权

US5594108A Human dopamine receptor and its uses 失效
标题翻译：人类多巴胺受体及其用途
公开(公告)号：US5594108A
公开(公告)日：1997-01-14
申请号：US333977
申请日：1994-11-03
申请人： Olivier Civelli , Hubert H. Van Tol
发明人： Olivier Civelli , Hubert H. Van Tol
IPC分类号： C07K14/00 , C07K14/705 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/04 , C12Q1/68 , C12R1/91 , G01N33/50 , G01N33/94
CPC分类号： G01N33/9406 , C07K14/70571 , C12Q1/683 , G01N33/9413 , G01N2500/00 , G01N2800/52
摘要： The present invention is directed toward the isolation, characterization and pharmacological use of the human D.sub.4 dopamine receptor. The nucleotide sequence of the gene corresponding to this receptor is provided by the invention. The invention also includes a recombinant eukaryotic expression vector capable of expressing the human D.sub.4 dopamine receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells which synthesize the human D.sub.4 dopamine receptor.
摘要翻译：本发明涉及人D4多巴胺受体的分离，表征和药理学应用。对应于该受体的基因的核苷酸序列由本发明提供。本发明还包括能够在转化的真核细胞和合成人D4多巴胺受体的转化真核细胞的培养物中表达人D4多巴胺受体的重组真核表达载体。

22. 发明授权

US5569601A Human dopamine receptor and its uses 失效
公开(公告)号：US5569601A
公开(公告)日：1996-10-29
申请号：US928611
申请日：1992-08-10
申请人： Olivier Civelli
发明人： Olivier Civelli
IPC分类号： C07K14/00 , C07K14/705 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/04 , C12Q1/68 , C12R1/91 , G01N33/50 , G01N33/94 , C12N5/00 , C07H17/00 , C12N15/00 , C12P21/06
CPC分类号： G01N33/9406 , C07K14/70571 , C12Q1/683 , G01N33/9413 , G01N2500/00 , G01N2500/10 , G01N2800/52
摘要： The present invention is directed toward the isolation, characterization and pharmacological use of the human D4 dopamine receptor. The nucleotide sequence of the gene corresponding to this receptor and alleleic variant thereof are provided by the invention. The invention also includes recombinant eukaryotic expression constructs capable of expressing the human D4 dopamine receptor in cultures of transformed eukaryotic cells. The invention provides cultures of transformed eukaryotic cells which synthesize the human D4 dopamine receptor, and methods for characterizing novel psychotropic compounds using such cultures.

23. 发明授权

US5516683A Human D4 dopamine receptor and its uses 失效
标题翻译：人类D4多巴胺受体及其用途
公开(公告)号：US5516683A
公开(公告)日：1996-05-14
申请号：US56051
申请日：1993-04-29
申请人： David K. Grandy , James R. Bunzow , Olivier Civelli , Hubert H.-M. Van Tol
发明人： David K. Grandy , James R. Bunzow , Olivier Civelli , Hubert H.-M. Van Tol
IPC分类号： C07K14/705 , C12Q1/68 , G01N33/94 , C12N15/12
CPC分类号： C07K14/70571 , C12Q1/683 , G01N33/9406 , G01N33/9413 , G01N2500/00 , G01N2800/52
摘要： The present invention is directed toward the isolation, characterization and pharmacological use of the human D4 dopamine receptor. The nucleotide sequence of the gene corresponding to this receptor and alleleic variants thereof are provided by the invention. The invention particularly provides recombinant eukaryotic expression constructs capable of expressing the human D4 dopamine receptor at useful levels in cultures of transformed eukaryotic cells. The invention provides cultures of transformed eukaryotic cells which synthesize such useful amounts of human D4 dopamine receptor protein, and methods for characterizing novel psychotropic compounds using such cultures.
摘要翻译：本发明涉及人D4多巴胺受体的分离，表征和药理学应用。对应于该受体的基因的核苷酸序列及其等位变体由本发明提供。本发明特别提供能够在转化的真核细胞的培养物中以有用水平表达人D4多巴胺受体的重组真核表达构建体。本发明提供合成这种有用量的人D4多巴胺受体蛋白质的转化真核细胞的培养物，以及使用这种培养物表征新的精神药物的方法。

24. 发明授权

US5441883A A3 adenosine receptor, DNA, and uses 失效
标题翻译： A3腺苷受体，DNA和用途
公开(公告)号：US5441883A
公开(公告)日：1995-08-15
申请号：US101435
申请日：1993-08-02
申请人： Olivier Civelli , Qun-Yong Zhou
发明人： Olivier Civelli , Qun-Yong Zhou
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention relates to a novel mammalian adenosine receptor. The invention is directed toward the isolation, characterization and pharmacological use of the rat A3 adenosine receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing the rat A3 adenosine receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize the rat A3 adenosine receptor. The invention also provides methods for screening adenosine-receptor agonists and antagonists in vitro using preparations of the rat A3 adenosine receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the rat A3 adenosine receptor gene.
摘要翻译：本发明涉及新型哺乳动物腺苷受体。本发明涉及大鼠A3腺苷受体（对应于该受体的基因）的分离，表征和药理学应用，能够在转化的真核细胞的培养物中表达大鼠A3腺苷受体的重组真核表达构建体，合成大鼠A3腺苷受体的真核细胞。本发明还提供了使用由包含大鼠A3腺苷受体基因的重组真核表达构建体转化的真核细胞的这种培养物中的大鼠A3腺苷受体的制备体外筛选腺苷受体激动剂和拮抗剂的方法。

25. 发明授权

US06437114B1 Human dopamine receptor and uses 失效
标题翻译：人类多巴胺受体和用途
公开(公告)号：US06437114B1
公开(公告)日：2002-08-20
申请号：US09378074
申请日：1999-08-20
申请人： Olivier Civelli , Hubert Henri-Marie Van Tol
发明人： Olivier Civelli , Hubert Henri-Marie Van Tol
IPC分类号： C12N1512
CPC分类号： G01N33/9406 , C07K14/70571 , C12Q1/683 , G01N33/9413 , G01N2500/00 , G01N2500/10 , G01N2800/52
摘要： The present invention is directed toward the isolation, characterization and pharmacological use of the human D4 dopamine receptor. The nucleotide sequence of the gene corresponding to this receptor and alleleic variant thereof are provided by the invention. The invention also includes recombinant eukaryotic expression constructs capable of expressing the human D4 dopamine receptor in cultures of transformed eukaryotic cells. The invention provides cultures of transformed eukaryotic cells which synthesize the human D4 dopamine receptor, and methods for characterizing novel psychotropic compounds using such cultures.
摘要翻译：本发明涉及人D4多巴胺受体的分离，表征和药理学应用。对应于该受体的基因的核苷酸序列及其等位变体由本发明提供。本发明还包括能够在转化的真核细胞的培养物中表达人D4多巴胺受体的重组真核表达构建体。本发明提供合成人D4多巴胺受体的转化真核细胞的培养物，以及使用这种培养物表征新的精神药物的方法。

26. 发明授权

US06342360B1 Dopamine receptors and genes 失效
标题翻译：多巴胺受体和基因
公开(公告)号：US06342360B1
公开(公告)日：2002-01-29
申请号：US09238977
申请日：1999-01-27
申请人： Olivier Civelli , James R. Bunzow , David K. Grandy , Curtis A. Machida
发明人： Olivier Civelli , James R. Bunzow , David K. Grandy , Curtis A. Machida
IPC分类号： G01N3353
CPC分类号： C07K14/70571 , A01K2217/05 , A61K38/00 , C07K16/286 , C12N15/00 , C12Q1/6876 , C12Q2600/158
摘要： A mammalian D2 dopamine receptor gene has been cloned. Thus, DNA sequences encoding all or a part of the dopamine receptor are provided, as well as the corresponding polypeptide sequences and methods for producing the same both synthetically and via expression of a corresponding sequence from a host transformed with a suitable vector carrying the corresponding DNA sequence. The various structural information provided by this invention enables the preparation of labeled or unlabeled immunospecific species, particularly antibodies, as well as nucleic acid probes labeled in conventional fashion. Pharmaceutical compositions and methods of using various products of this invention are also provided.
摘要翻译：已经克隆了哺乳动物D2多巴胺受体基因。因此，提供了编码全部或部分多巴胺受体的DNA序列，以及相应的多肽序列及其制备方法，合成和通过表达相应序列的宿主，所述宿主用携带相应DNA的合适载体转化序列。由本发明提供的各种结构信息使得能够制备标记或未标记的免疫特异性物种，特别是抗体，以及以常规方式标记的核酸探针。还提供了使用本发明的各种产品的药物组合物和方法。

27. 发明授权

US5547845A Aqueous solution containing D.sub.1 dopamine receptor 失效
标题翻译：含有D1多巴胺受体的水溶液
公开(公告)号：US5547845A
公开(公告)日：1996-08-20
申请号：US196523
申请日：1994-02-15
申请人： James R. Bunzow , Olivier Civelli , David K. Grandy , Qun Y. Zhou
发明人： James R. Bunzow , Olivier Civelli , David K. Grandy , Qun Y. Zhou
IPC分类号： C07H21/00 , C07K14/705 , C12N15/12 , C12Q1/68
CPC分类号： C07H21/00 , C07K14/70571 , C12Q1/6876 , C12Q2600/158
摘要： Cloned genes which code for the D.sub.1 dopamine receptor are disclosed. The receptors coded for by these clones bind dopamine ligands with the proper pharmacological profile and, when expressed in the cell membrane of a suitable host and so bound, stimulate adenylyl cyclase. Also disclosed are vectors comprising a cloned gene encoding a D.sub.1 -dopamine receptor, cells transformed with such vectors, and oligonucleotide probes capable of selectively hybridizing to DNA comprising a portion of a gene coding for a D.sub.1 -dopamine receptor. The cloned genes are useful for making proteins and cell membrane preparations which can be used to screen compounds for D.sub.1 -dopamine receptor binding activity, are useful in molecular biology, and are useful as diagnostic probes.
摘要翻译：公开了编码D1多巴胺受体的克隆基因。由这些克隆编码的受体结合具有适当药理学特征的多巴胺配体，并且当在合适的宿主的细胞膜中表达并如此结合时，刺激腺苷酸环化酶。还公开了包含编码D1-多巴胺受体的克隆基因，用这些载体转化的细胞和能够与包含编码D1-多巴胺受体的基因的一部分的DNA选择性杂交的寡核苷酸探针的载体。克隆的基因可用于制备可用于筛选化合物的多巴胺受体结合活性的蛋白质和细胞膜制剂，可用于分子生物学，并且可用作诊断探针。

28. 发明授权

US5427942A Human D5 dopamine recepltor gene and uses 失效
标题翻译：人类D5多巴胺受体基因及用途
公开(公告)号：US5427942A
公开(公告)日：1995-06-27
申请号：US791936
申请日：1991-11-13
申请人： Olivier Civelli , David K. Grandy
发明人： Olivier Civelli , David K. Grandy
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12
CPC分类号： C07K14/70571 , A61K38/00
摘要： The present invention relates to the isolation, characterization and pharmacological uses for the human D5 dopamine receptor, the gene corresponding to this receptor, pseudogenes of this receptor gene, a recombinant eukaryotic expression vector capable of expressing the human D5 dopamine receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize the human D5 dopamine receptor. The invention relates to the biochemical and physiological characterization of the human D5 dopamine receptor and the development and testing of drugs useful for treating or preventing human disease.
摘要翻译：本发明涉及人D5多巴胺受体的分离，表征和药理学应用，与该受体相应的基因，该受体基因的假基因，能够在转化真核生物培养物中表达人D5多巴胺受体的重组真核表达载体细胞和合成人D5多巴胺受体的转化真核细胞的这种培养物。本发明涉及人D5多巴胺受体的生物化学和生理表征以及用于治疗或预防人类疾病的药物的开发和测试。

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