专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US07699767B2 Multiple laminar flow-based particle and cellular separation with laser steering 有权
公开(公告)号：US07699767B2
公开(公告)日：2010-04-20
申请号：US12213109
申请日：2008-06-13
申请人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Harris Rosenbaum
发明人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Harris Rosenbaum
IPC分类号： B04B7/08
CPC分类号： G03H1/0005 , A61L2/08 , B01D21/0009 , B01D21/01 , B01D21/262 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0454 , B03C1/00 , B03C1/002 , B03C1/288 , B03C5/005 , B04B13/00 , G01N15/0205 , G01N21/6486 , G01N27/447 , G01N27/44756 , G01N33/487 , G01N33/5091 , G01N2015/0053 , G01N2201/061 , G01N2458/00 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , G21K5/08 , H05H3/04
摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

22. 发明申请

US20080039502A1 EP4 receptor antagonists 失效
标题翻译： EP4受体拮抗剂
公开(公告)号：US20080039502A1
公开(公告)日：2008-02-14
申请号：US11889570
申请日：2007-08-14
申请人： Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark , David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Christopher Newton
发明人： Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark , David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Christopher Newton
IPC分类号： A61K31/34 , A61K31/341 , A61K31/4155 , A61K31/443 , A61P25/06 , C07D231/12 , C07D231/18 , C07D307/68 , C07D307/77 , C07D405/12 , C07D413/12
CPC分类号： C07D307/54 , A61K31/34 , A61K31/341 , A61K31/4155 , A61K31/443 , C07D307/64 , C07D307/68 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; (iv) tetrazol-5-yl.
摘要翻译：式（I）的化合物：其中：R 2是H或任选取代的C 1-4烷基; Y是 - （CH 2）n -X-，其中n是1或2，X是O，S，S（-O），S（-O ）N 2，或NR 11，其中R 0,1选自H或任选取代的C 1-4烷基，或Y是-C（-O）NR N2 - ，其中R N2选自H和任选取代的C 1-7 - 烷基或C 5-20-20芳基; R 3是与另外任选取代的C 6 -C 6芳基连接的任选取代的C 6-14芳基，其中如果两个C 6 芳基是苯环，两个环之间可能有一个氧桥，与两个环上的连接相邻; A是单键或C 1-3-3亚烷基; 和R 5是：（i）羧基; （ii）式（II）的基团：（iii）式（III）的基团：其中R是任选取代的C 1-7烷基，C 5〜20 其中R“N 3”和“R”N 4“独立地选自任选取代的C 1 -C 6烷基，烷基; （ⅳ）四唑-5-基。

23. 发明申请

US20070135503A1 Furan derivatives as ep4 receptor antagonists 失效
标题翻译：呋喃衍生物作为ep4受体拮抗剂
公开(公告)号：US20070135503A1
公开(公告)日：2007-06-14
申请号：US10576095
申请日：2004-10-15
申请人： David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark
发明人： David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark
IPC分类号： A61K31/41 , A61K31/34 , A61K31/405 , C07D307/02
CPC分类号： C07D307/68
摘要： A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R2 and R5 is: (i) H or an optionally substituted C1-4 alkyl group; or (ii) an optionally substituted C5-7 aryl; and the other of R2 and R5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 RN is H or optionally substituted C1-4 alkyl R3 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; or (iv) tetrazol-5-yl.
摘要翻译：式（I）化合物或其盐，溶剂合物和化学保护形式，其中R 2和R 5中的一个为：（i）H或任选地取代的C 1-4烷基; 或（ii）任选取代的C 5-7芳基; R 2和R 5中的另一个是另一个基团; m和n可以是0或1，m + n = 1或2 R N是H或任选取代的C 1-4烷基R 3， SUP>是：（i）羧基; （ii）式（II）的基团：（iii）式（III）的基团：其中R是任选取代的C 1-7烷基，C 5〜20 其中R 3，N 3和R 4各自独立地选自任选取代的C 1 -C 6芳基或NR N 3 N， 1-4个C 1-4烷基; 或（iv）四唑-5-基。

24. 发明授权

US06442282B2 Acoustic devices 失效
标题翻译：声学装置
公开(公告)号：US06442282B2
公开(公告)日：2002-08-27
申请号：US09935576
申请日：2001-08-24
申请人： Henry Azima , Martin Colloms , Neil Harris
发明人： Henry Azima , Martin Colloms , Neil Harris
IPC分类号： H04R2500
CPC分类号： H04R5/02 , G07F9/02 , H04R1/24 , H04R7/045 , H04R2440/07 , H04R2499/15
摘要： Acoustic devices have members extending transversely of thickness and capable of sustaining bending waves causing consequential acoustic action by reason of areal distribution of resonant modes of natural bending wave vibration consonant with required achievable acoustic action of said member over a desired operative acoustic frequency range, Areal distribution of stiffness including variation(s) therein is used to get desired locations for bending wave transducers and/or good resonant mode acoustic action from inherently unfavourable shapes of members. Members with combined pistonic active drive and bending wave excitement at centers of mass and geometry are featured.
摘要翻译：声学装置具有横向厚度延伸的构件，并且能够承受弯曲波，由于在所需操作声频范围内由所述构件的所需可实现的声学作用引起的自然弯曲波振动辅助谐振模的面分布，从而产生相应的声音作用。的刚度包括其中的变化用于获得用于弯曲波传感器的所需位置和/或从固有不利的构件形状的良好谐振模式声学作用。具有在质量和几何中心组合的活塞主动驱动和弯曲波兴奋的构件。

25. 发明授权

US06427016B1 Acoustic devices 有权
标题翻译：声学装置
公开(公告)号：US06427016B1
公开(公告)日：2002-07-30
申请号：US09246967
申请日：1999-02-09
申请人： Henry Azima , Neil Harris , Bijan Djahansouzi
发明人： Henry Azima , Neil Harris , Bijan Djahansouzi
IPC分类号： H04R2500
CPC分类号： H04R29/001 , H04R7/045 , H04R2440/07
摘要： Acoustic devices rely on bending wave action in a panel member, particularly distribution of resonant modes of such bending wave action and related acoustically significant surface vibration over area of said panel member favourable to desired or at least acceptable acoustic device performance. The devices comply with selecting parameters of said panel member affecting said distribution, including configuration/geometry and/or bending stiffness(es), and/or location(s) of bending wave transducer(s) in said area of said panel member; the selecting being in accordance with analytical assessment of power transfer related characteristic(s) of said panel member thus said acoustic device concerned and desiderata therefor correlating with achieving said acoustic device performance.
摘要翻译：声学装置依赖于面板构件中的弯曲波动作用，特别是在所述面板构件的面积上的这种弯曲波作用和相关的声学显着表面振动的共振模式的分布有利于期望的或至少可接受的声学装置性能。所述装置符合选择影响所述分配的所述面板构件的参数，包括所述面板构件的所述区域中的构造/几何形状和/或弯曲刚度和/或弯曲波换能器的位置; 所述选择是根据所述面板构件的功率传递相关特性的分析评估，因此所述声学装置及其所需的设备与实现所述声学装置性能相关。

26. 发明授权

US06327369B1 Loudspeakers comprising panel-form acoustic radiating elements 失效
标题翻译：扬声器包括面板式声辐射元件
公开(公告)号：US06327369B1
公开(公告)日：2001-12-04
申请号：US09029340
申请日：1998-05-13
申请人： Henry Azima , Martin Colloms , Neil Harris
发明人： Henry Azima , Martin Colloms , Neil Harris
IPC分类号： H04R2500
CPC分类号： B42D15/022 , B60R11/0217 , G06F1/1605 , G06F1/1616 , G06F1/1688 , G06F9/02 , G07F9/02 , H04R1/021 , H04R1/025 , H04R1/028 , H04R1/24 , H04R1/26 , H04R1/2811 , H04R3/04 , H04R5/02 , H04R5/027 , H04R7/045 , H04R7/06 , H04R7/08 , H04R9/025 , H04R9/045 , H04R9/066 , H04R17/00 , H04R2201/021 , H04R2307/029 , H04R2440/07 , H04R2499/13 , H04R2499/15
摘要： A panel-form loudspeaker (81) comprising a resonant distributed mode acoustic radiator (2), and drive means (9) mounted to the radiator to excite multi-mode resonance in the radiator, characterised by a baffle (6, 8) surrounding and supporting the radiator.
摘要翻译：一种包括谐振分布模式声辐射器（2）的面板式扬声器（81）和安装在散热器上以激发散热器中的多模共振的驱动装置（9），其特征在于包围和支持散热器。

27. 发明授权

US06198831B1 Panel-form loudspeakers 失效
标题翻译：面板式扬声器
公开(公告)号：US06198831B1
公开(公告)日：2001-03-06
申请号：US09029359
申请日：1998-05-13
申请人： Henry Azima , Martin Colloms , Neil Harris
发明人： Henry Azima , Martin Colloms , Neil Harris
IPC分类号： H04R2500
CPC分类号： B42D15/022 , B60R11/0217 , G06F1/1605 , G06F1/1616 , G06F1/1688 , G06F9/02 , G07F9/02 , H04R1/021 , H04R1/025 , H04R1/028 , H04R1/24 , H04R1/26 , H04R1/2811 , H04R3/04 , H04R5/02 , H04R5/027 , H04R7/045 , H04R7/06 , H04R7/08 , H04R9/025 , H04R9/045 , H04R9/066 , H04R17/00 , H04R2201/021 , H04R2307/029 , H04R2440/07 , H04R2499/13 , H04R2499/15
摘要： A panel form loudspeaker/microphone combination has a distributed resonant bending wave member and two transducers mounred on the member at sites where the number of vibrationally active resonance anti-nodes is relatively high. One transducer is capable of vibrating the member to couple to and excite resonant bending wave modes in the member and cause the member to produce an acoustic output. The other transducer also is capable of coupling to he resonant bending wave modes in the member, but it produces an output signal in response to resonance of the member due to incident acoustic energy. The combination may be part of a loudspeaker system including an amplifier for the source signal coupled to the first transducer, and a signal receiver coupled to the second transducer for treating the output signal.
摘要翻译：面板式扬声器/麦克风组合具有分布式谐振弯曲波形构件和两个振动器在振动有效谐振抗振节数相对较高的部位上振动。一个传感器能够使构件振动以耦合到构件中并激发谐振弯曲波模式并使构件产生声输出。另一个传感器还能够耦合到构件中的共振弯曲波模式，但是它由于入射声能而响应于构件的谐振而产生输出信号。该组合可以是包括用于耦合到第一换能器的源极信号的放大器的扬声器系统的一部分，以及耦合到第二换能器的信号接收器，用于处理输出信号。

28. 发明授权

US08736558B2 Touch-sensitive device 有权
标题翻译：触敏设备
公开(公告)号：US08736558B2
公开(公告)日：2014-05-27
申请号：US12747366
申请日：2008-12-09
申请人： James East , Chris Cowdery , Martin Colloms , Neil Harris , Geoffrey A. Boyd , Timothy Christopher Johnson Whitwell
发明人： James East , Chris Cowdery , Martin Colloms , Neil Harris , Geoffrey A. Boyd , Timothy Christopher Johnson Whitwell
IPC分类号： G06F3/041
CPC分类号： G06F3/0433 , G06F3/016 , H04R7/045
摘要： A user/machine interface comprising a panel having a surface, the panel being capable of supporting bending waves, a touch-sensitive input device associated with the surface, and means including a force transducer for providing force feedback to the input device. The force is in the form of pulses to the panel, the pulses being in the form of a modulated signal shaped as a damped sinusoid whereby a button click sensation is provided to the user's finger tip. The modulated signal may be produced by a narrow-band sine wave having a carrier frequency in the range 150 to 750 Hz and being of a duration of at least 10 ms.
摘要翻译：一种用户/机器接口，包括具有表面的面板，所述面板能够支撑弯曲波，与表面相关联的触敏输入设备，以及包括用于向输入设备提供力反馈的力传感器的装置。力是面向面板的脉冲形式，脉冲是形状为阻尼正弦曲线的调制信号的形式，由此向用户的指尖提供按钮点击感。调制信号可以由具有在150至750Hz范围内的载波频率并且具有至少10ms的持续时间的窄带正弦波来产生。

29. 发明申请

US20120183947A1 MULTIPLE LAMINAR FLOW-BASED PARTICLE AND CELLULAR SEPARATION WITH LASER STEERING 有权
标题翻译：多层次流动粒子和细胞分离与激光转向
公开(公告)号：US20120183947A1
公开(公告)日：2012-07-19
申请号：US13412969
申请日：2012-03-06
申请人： Daniel MUETH , Joseph PLEWA , Jessica SHIREMAN , Amy ANDERSON , Lewis GRUBER , Neil Harris ROSENBAUM
发明人： Daniel MUETH , Joseph PLEWA , Jessica SHIREMAN , Amy ANDERSON , Lewis GRUBER , Neil Harris ROSENBAUM
IPC分类号： A01N1/02 , B01D21/30 , G01N21/55 , C12M1/34 , G01N11/00 , B01D21/24 , C12M1/00
CPC分类号： G03H1/0005 , A61L2/08 , B01D21/0009 , B01D21/01 , B01D21/262 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0454 , B03C1/00 , B03C1/002 , B03C1/288 , B03C5/005 , B04B13/00 , G01N15/0205 , G01N21/6486 , G01N27/447 , G01N27/44756 , G01N33/487 , G01N33/5091 , G01N2015/0053 , G01N2201/061 , G01N2458/00 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , G21K5/08 , H05H3/04
摘要： The invention provides a method, apparatus and system for separating cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One exemplary method includes providing a first flow having a plurality of components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first cellular component of the plurality of components into the second flow while concurrently maintaining a second cellular component of the plurality of components in the first flow. The second flow having the first cellular component is then differentially removed from the first flow having the second cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
摘要翻译：本发明提供一种用于分离细胞成分的方法，装置和系统，并且可以与全息光学捕获操作或其他形式的光学镊子组合。一个示例性方法包括提供具有多个部件的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个部件的第一细胞组分差异沉积到所述第二流中，同时将所述多个组分的第二细胞组分保持在所述第一流中。然后将具有第一细胞组分的第二流与具有第二细胞组分的第一流差异地去除。全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。

30. 发明申请

US20100302184A1 Touch-sensitive device 有权
标题翻译：触敏设备
公开(公告)号：US20100302184A1
公开(公告)日：2010-12-02
申请号：US12747366
申请日：2008-12-09
申请人： James East , Chris Cowdery , Martin Colloms , Neil Harris , Geoffrey A. Boyd , Timothy Christopher Johnson Whitwell
发明人： James East , Chris Cowdery , Martin Colloms , Neil Harris , Geoffrey A. Boyd , Timothy Christopher Johnson Whitwell
IPC分类号： G06F3/041
CPC分类号： G06F3/0433 , G06F3/016 , H04R7/045
摘要： A user/machine interface comprising a panel having a surface, the panel being capable of supporting bending waves, a touch-sensitive input device associated with the surface, and means including a force transducer for providing force feedback to the input device. The force is in the form of pulses to the panel, the pulses being in the form of a modulated signal shaped as a damped sinusoid whereby a button click sensation is provided to the user's finger tip. The modulated signal may be produced by a narrow-band sine wave having a carrier frequency in the range 150 to 750 Hz and being of a duration of at least 10 ms.
摘要翻译：一种用户/机器接口，包括具有表面的面板，所述面板能够支撑弯曲波，与所述表面相关联的触敏输入设备，以及包括用于向所述输入设备提供力反馈的力传感器的装置。力是面向面板的脉冲形式，脉冲是形状为阻尼正弦曲线的调制信号的形式，由此向用户的指尖提供按钮点击感。调制信号可以由具有在150至750Hz范围内的载波频率并且具有至少10ms的持续时间的窄带正弦波来产生。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式