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21. 发明授权

US06706268B1 Human deficiency virus type-1 (HIV-1) peptide encoded by the VIF gene 失效
标题翻译：由VIF基因编码的人类免疫缺陷病毒1型（HIV-1）肽
公开(公告)号：US06706268B1
公开(公告)日：2004-03-16
申请号：US09709316
申请日：2000-11-13
申请人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
发明人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
IPC分类号： A61K3921
CPC分类号： C07K14/005 , C12N2740/16322
摘要： This invention is in the field of lymphadenopathy virus. This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译：本发明在淋巴结病毒病毒领域。本发明涉及通过使用DNA片段或由所述DNA片段编码的肽来检测与所获得的免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法。本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。

22. 发明授权

US06555112B1 Peptides derived from the lymphadenopathy-associated virus (LAV) envelope coding region 失效
标题翻译：衍生自淋巴结病相关病毒（LAV）包膜编码区的肽
公开(公告)号：US06555112B1
公开(公告)日：2003-04-29
申请号：US08391271
申请日：1995-02-21
申请人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
发明人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
IPC分类号： A61K3921
CPC分类号： A61K38/162 , A61K39/00
摘要： The molecular cloning and characterization of a novel human retrovirus, designated lymphadenopathy-associated virus, or LAV, is disclosed. LAV was originally isolated from a patient with acquired immune deficiency syndrome (AIDS). A cloned LAV complementary DNA (cDNA) was used to screen a library of recombinant phages constructed from the genomic DNA of LAV-infected T lymphocytes. The nucleotide sequence of an insert obtained from the recombinant phage clone &lgr;J19 was ascertained through M13 shotgun cloning and the dideoxy chain termination sequencing method. The env coding region was identified and peptides obtained therefrom. These peptides correspond to amino acids 239-294, 273-317, 300-327, 334-381, 397-424, and 466-500 of the LAV env. These peptides provide suitable diagnostic reagents for the detection LAV-specific antibodies and for the generation of LAV-specific immunological reagents.
摘要翻译：公开了一种新型人类逆转录病毒（称为淋巴结病相关病毒）或LAV的分子克隆和表征。 LAV最初与获得性免疫缺陷综合征（AIDS）的患者分离。使用克隆的LAV互补DNA（cDNA）筛选由LAV感染的T淋巴细胞的基因组DNA构建的重组噬菌体文库。通过M13霰弹枪克隆和双脱氧链终止测序方法确定从重组噬菌体克隆lambdJ19获得的插入物的核苷酸序列。鉴定了env编码区和从其获得的肽。这些肽对应于LAV环境的氨基酸239-294,273-317,300-327,334-381,397-424和466-500。这些肽为检测LAV特异性抗体和产生LAV特异性免疫试剂提供合适的诊断试剂。

23. 发明授权

US06337179B1 Methods and kits for detecting antibodies against an HIV variant 失效
标题翻译：使用HIV-1 eli肽检测HIV-1抗体的方法
公开(公告)号：US06337179B1
公开(公告)日：2002-01-08
申请号：US08423477
申请日：1995-04-19
申请人： Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Luc Montagnier
发明人： Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Luc Montagnier
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16021 , C12N2740/16022 , G01N33/56988 , Y10S435/974 , Y10S435/975 , Y10S530/826
摘要： Methods and kits for the in vitro detection of antibodies of an HIV variant are disclosed. In particular, the detection of HIV-1 variants, such as LAVBRU, LAVELI, LAVMAL, are taught by using an immunologically distinct antigen of these HIV variants to detect the antibodies of these variants. Moreover, the immunological characteristics of the HIV-1 variants of the invention are disclosed.
摘要翻译：公开了用于体外检测HIV变体抗体的方法和试剂盒。特别地，通过使用这些HIV变体的免疫学上不同的抗原来检测HIV-1变体（例如LAVBRU，LAVELI，LAVMAL）的检测来检测这些变体的抗体。此外，公开了本发明的HIV-1变体的免疫学特征。

24. 发明授权

US06322964B1 Synthetic HIV-2 gag and env oligopeptides reactive with HIV-2 specific antibodies 失效
标题翻译：与HIV-2特异性抗体反应的合成HIV-2 gag和env寡肽
公开(公告)号：US06322964B1
公开(公告)日：2001-11-27
申请号：US08268388
申请日：1994-06-30
申请人： Wesley L. Cosand , Andrew J. Watson , Raymond L. Houghton , Luc Montagnier , Marc Alizon , Solange Chamaret
发明人： Wesley L. Cosand , Andrew J. Watson , Raymond L. Houghton , Luc Montagnier , Marc Alizon , Solange Chamaret
IPC分类号： C12Q170
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , C07K14/005 , C12N7/00 , C12N2740/16122 , C12N2740/16222 , C12Q1/703 , G01N33/56988 , G01N2333/162 , G01N2469/20
摘要： Peptide sequences are disclosed which immunologically mimic proteins encoded by the env and gag regions of LAV-2, a retrovirus associated with AIDS. The peptide can be used in various specific binding assays to detect the presence of antibodies to LAV-2 in individuals previously exposed to the virus. The peptides enable one to distinguish the presence of antibodies to LAV-2 from antibodies to HIV-1.
摘要翻译：公开了肽序列，其免疫模拟由与HIV相关的逆转录病毒的LAV-2的env和gag区编码的蛋白质。该肽可用于各种特异性结合测定以检测先前暴露于病毒的个体中LAV-2的抗体的存在。这些肽使得人们能够将抗体与LAV-2的区别从抗体与HIV-1区分开来。

25. 发明授权

US06284454B1 Variant of LAV viruses 失效
标题翻译：用于检测使用免疫球蛋白抗原的HIV特异性抗体的方法和试剂盒
公开(公告)号：US06284454B1
公开(公告)日：2001-09-04
申请号：US09048580
申请日：1998-03-27
申请人： Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Luc Montagnier
发明人： Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Luc Montagnier
IPC分类号： C12Q170
CPC分类号： C12Q1/702 , A61K38/00 , C12N7/00 , C12N2740/16021 , C12N2740/16051 , C12Q1/703 , G01N33/56988
摘要： A variant of a LAV virus, designated LAVMAL and capable of causing AIDS. The cDNA and antigens of the LAVMAL virus can be used for the diagnosis of AIDS and pre-AIDS.
摘要翻译： LAV病毒的一种变体，被指定为LAVMAL并能够引起艾滋病。 LAVMAL病毒的cDNA和抗原可用于艾滋病和艾滋病前期的诊断。

26. 发明授权

US06261762B1 Cloned DNA sequences related to the entire genomic RNA of human immunodeficiency virus II (HIV-2), polypeptides encoded by these DNA sequences and the use of these DNA clones polypeptides in diagnostic kits 失效
标题翻译：与人类免疫缺陷病毒II（HIV-2）的整个基因组RNA相关的克隆DNA序列，由这些DNA序列编码的多肽以及这些DNA克隆多肽在诊断试剂盒中的用途
公开(公告)号：US06261762B1
公开(公告)日：2001-07-17
申请号：US08774736
申请日：1997-01-02
申请人： Marc Alizon , Luc Montagnier , Denise Duetard , Francois Clavel , Pierre Sonigo , Mireille Guyader
发明人： Marc Alizon , Luc Montagnier , Denise Duetard , Francois Clavel , Pierre Sonigo , Mireille Guyader
IPC分类号： C12Q170
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , C07K14/005 , C12N7/00 , C12N2740/15022 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/703 , G01N33/56988 , G01N2333/162 , G01N2469/20 , Y10S435/974 , Y10S435/975 , Y10S530/81
摘要： A method for diagnosing an HIV-2 (LAV-II) infection and a kit containing reagents for the same is disclosed. These reagents include cDNA probes which are capable of hybridizing to at least a portion of the genome of HIV-2. In one embodiment, the DNA probes are capable of hybridizing to the entire genome of HIV-2. These reagents also include polypeptides encoded by some of these DNA sequences.
摘要翻译：公开了用于诊断HIV-2（LAV-II）感染的方法和用于其的试剂盒。这些试剂包括能够与HIV-2的至少一部分基因组杂交的cDNA探针。在一个实施方案中，DNA探针能够与HIV-2的整个基因组杂交。这些试剂还包括由这些DNA序列中的一些编码的多肽。

27. 发明授权

US06037165A Methods for the preparation of human immunodeficiency virus type 2 (HIV-2) and antigens encoped thereby 失效
标题翻译：制备人类免疫缺陷病毒2型（HIV-2）的方法和由此编码的抗原
公开(公告)号：US06037165A
公开(公告)日：2000-03-14
申请号：US470487
申请日：1995-06-06
申请人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , Fran.cedilla.ois Clavel , Mireille Guyader , Pierre Sonigo , Fran.cedilla.oise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
发明人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , Fran.cedilla.ois Clavel , Mireille Guyader , Pierre Sonigo , Fran.cedilla.oise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
IPC分类号： A61K38/00 , A61K39/00 , A61K39/21 , C07H21/02 , C07K7/06 , C07K14/16 , C12N7/00 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/569
CPC分类号： C07K7/06 , C07K14/005 , C12N7/00 , C12Q1/703 , G01N33/56988 , A61K38/00 , A61K39/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , G01N2333/162 , G01N2469/20
摘要： Methods for producing the newly discovered HIV-2 retrovirus and its antigens are provided. The antigens are obtained from various HIV-2 retroviruses. The antigen compositions comprise a lysate of an HIV-2 retrovirus, a protein of an HIV-2 retrovirus, or a glycoprotein of an HIV-2 retrovirus. Specifically, the antigen composition can comprise p12, p16, p26, gp32, gp42, and gp140.
摘要翻译：提供了新发现的HIV-2逆转录病毒及其抗原的制备方法。抗原是从各种HIV-2逆转录病毒获得的。抗原组合物包含HIV-2逆转录病毒的裂解物，HIV-2逆转录病毒的蛋白质或HIV-2逆转录病毒的糖蛋白。具体地，抗原组合物可以包含p12，p16，p26，gp32，gp42和gp140。

28. 发明授权

US5980900A Amino acid DNA sequences related to genomic RNA of human immunodeficiency virus (HIV-1) 失效
标题翻译：与人类免疫缺陷病毒（HIV-1）的基因组RNA相关的氨基酸DNA序列
公开(公告)号：US5980900A
公开(公告)日：1999-11-09
申请号：US751059
申请日：1991-08-28
申请人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
发明人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
IPC分类号： A61K39/00 , A61K39/12 , A61K39/21 , A61K39/38 , A61P31/18
CPC分类号： A61K39/00 , A61K39/12 , A61K39/21 , A61K39/38
摘要： This invention is in the field of lymphadenopathy virus which has been desogmated Human Immunodeficiency Virus Type 1 (HIV-1) This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译：本发明涉及已经脱盐的人类免疫缺陷病毒1型（HIV-1）的淋巴结病毒病毒领域本发明涉及检测与所获得的淋巴结转移病毒逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法免疫缺陷综合征或淋巴腺病综合征，通过使用DNA片段或由所述DNA片段编码的肽。本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。

29. 发明授权

US5824482A Purification, cloning, and characterization of a novel human immunodeficiency virus LAV.sub.MAL 失效
标题翻译：新型人类免疫缺陷病毒LAVMAL的纯化，克隆和表征
公开(公告)号：US5824482A
公开(公告)日：1998-10-20
申请号：US471474
申请日：1995-06-06
申请人： Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Luc Montagnier
发明人： Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Luc Montagnier
IPC分类号： A61K38/00 , A61K39/12 , A61K39/21 , C07H21/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C12N1/00 , C12N5/00 , C12N5/02 , C12N7/00 , C12P21/08 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/537 , G01N33/543
CPC分类号： C12Q1/702 , C12N7/00 , C12Q1/703 , G01N33/56988 , A61K38/00 , C12N2740/16021 , C12N2740/16051
摘要： An HIV isolate, LAV.sub.MAL, has been purified, sequenced, and characterized at the genetic level. The entire nucleic acid sequence of the viral genome, the encoded amino acid sequences, and the open reading frames found in the genome are disclosed. Specific peptides relating to the envelope glycoprotein of the viral genome are discussed. These peptides can be used in diagnostic methods and kits for detecting the presence of an HIV virus.
摘要翻译：艾滋病毒分离株LAVMAL已经在遗传水平上进行了纯化，测序和表征。公开了病毒基因组的全部核酸序列，编码的氨基酸序列和在基因组中发现的开放阅读框。讨论了与病毒基因组的包膜糖蛋白相关的特异性肽。这些肽可用于检测HIV病毒存在的诊断方法和试剂盒中。

30. 发明授权

US08507196B1 Nucleic acid probe of human immunodeficiency virus type 1 (HIV-1), and a method and kit employing this probe for detecting the presence of nucleic acid of HIV-1 失效
标题翻译：人类免疫缺陷病毒1型（HIV-1）的核酸探针，以及采用该探针检测HIV-1核酸存在的方法和试剂盒
公开(公告)号：US08507196B1
公开(公告)日：2013-08-13
申请号：US08051226
申请日：1993-04-23
申请人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
发明人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
IPC分类号： C07H21/02
CPC分类号： C07K14/005 , C12N2740/16022 , C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus. This invention relates to a diagnostic means and method to detect the presence of DNA, RNA, or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them, and the proteins expressed.
摘要翻译：本发明在淋巴结病毒病毒领域。本发明涉及通过使用DNA片段或由所述DNA片段编码的肽来检测与所获得的免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法。本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。

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