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21. 发明申请

US20090130120A1 ANTI-RSV G PROTEIN ANTIBODIES 有权
标题翻译：抗RSV G蛋白抗体
公开(公告)号：US20090130120A1
公开(公告)日：2009-05-21
申请号：US12258260
申请日：2008-10-24
申请人： Lawrence M. KAUVAR , Ellen J. Collarini , Bruce Keyt , Orit Foord
发明人： Lawrence M. KAUVAR , Ellen J. Collarini , Bruce Keyt , Orit Foord
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N5/06 , C12N5/04 , C12P21/04 , A01K67/027 , A01H5/00
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/76 , C07K2317/92 , C12N2740/11011
摘要： Individual monoclonal antibodies and fragments that bind a conserved epitope of the G protein of RSV and which are minimally immunogenic when administered to a human subject, are useful in treating RSV infections.
摘要翻译：单独的单克隆抗体和结合RSV的G蛋白的保守表位并且当施用于人受试者时具有最低免疫原性的片段可用于治疗RSV感染。

22. 发明授权

US07504230B2 Method of identifying a useful set of signal transduction proteins from a multiplicity of potentially useful proteins 失效
标题翻译：从多种潜在有用的蛋白质中鉴定有用的一组信号转导蛋白的方法
公开(公告)号：US07504230B2
公开(公告)日：2009-03-17
申请号：US10714163
申请日：2003-11-13
申请人： Lawrence M. Kauvar
发明人： Lawrence M. Kauvar
IPC分类号： G01N33/53
CPC分类号： G01N33/5014 , Y10T436/12
摘要： The present invention is a cell-based method of identifying a set of signal transduction proteins having an intracellular localization pattern responsive to toxic compounds. The method requires identifying and screening an initial set of signal transduction proteins against a set of toxic compounds, and determining changes in intracellular localization pattern of each of the proteins. Proteins whose changes in intracellular localization pattern are redundant are discarded from the initial set, and new proteins are added to provide a new set of proteins. I repeat the method steps with new sets of proteins until the set of proteins provides me at least 5 principal components with respect to the range of compounds marketed as small organic molecules.
摘要翻译：本发明是鉴定具有对有毒化合物有响应的细胞内定位模式的一组信号转导蛋白的基于细胞的方法。该方法需要鉴定和筛选针对一组有毒化合物的初始信号转导蛋白，并确定每种蛋白质的细胞内定位模式的变化。蛋白质的细胞内定位模式的变化是冗余的，从初始集合中被丢弃，并添加新的蛋白质以提供一组新的蛋白质。我重复使用新的蛋白质组的方法步骤，直到蛋白质集合相对于作为小有机分子销售的化合物的范围至少提供了5个主要成分。

23. 发明授权

US07413868B2 Use of particulate labels in bioanalyte detection methods 有权
标题翻译：在生物分析仪检测方法中使用颗粒标签
公开(公告)号：US07413868B2
公开(公告)日：2008-08-19
申请号：US10981130
申请日：2004-11-03
申请人： Lawrence M. Kauvar , Remy Cromer , William D. Harriman , Ellen J. Collarini
发明人： Lawrence M. Kauvar , Remy Cromer , William D. Harriman , Ellen J. Collarini
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N15/0625 , G01N21/6428 , G01N21/6458 , G01N27/44726 , G01N30/74 , G01N30/88 , G01N33/505 , G01N33/5052 , G01N33/54313 , G01N33/585 , G01N2021/6441 , G01N2030/8813 , G01N2030/8827 , Y10T436/112499 , Y10T436/13 , Y10T436/25125 , Y10T436/25375
摘要： New applications for the use of distinguishable particulate labels available in a variety of hues and sized in the submicron range are described. These applications include profiling of cellular components, obtaining secretion patterns, identifying a multiplicity of components in chromatographic or electrophoretic techniques and identification of desired immunoglobulin secreting cells.
摘要翻译：描述了使用可用于各种色调并且在亚微米范围内尺寸的可区分颗粒标签的新应用。这些应用包括细胞组分的分析，获得分泌模式，在色谱或电泳技术中鉴定多种组分并鉴定所需的免疫球蛋白分泌细胞。

24. 再颁专利

USRE39866E1 Nonpeptide insulin receptor agonists 失效
标题翻译：非肽胰岛素受体激动剂
公开(公告)号：USRE39866E1
公开(公告)日：2007-10-02
申请号：US11167026
申请日：2005-06-23
申请人： Richard Sportsman , Hugo O. Villar , Lawrence M Kauvar , Wayne R Spevak
发明人： Richard Sportsman , Hugo O. Villar , Lawrence M Kauvar , Wayne R Spevak
IPC分类号： A61K31/655 , A61K31/17 , A61K31/10 , A61K31/015 , C07C245/00
CPC分类号： G01N33/582 , C07C309/34 , C12Q1/34 , C12Q1/48 , G01N2333/62 , G01N2333/72 , G01N2333/9121 , Y10S514/866
摘要： Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula wherein each A is independently a proton-accepting substituent; each R is independently a noninterfering substituent; n is 0, 1, or 2; and each linker is independently an isostere of —NHCONH— or of —N═N— or of —NHCO—. Compounds in the genus of Formula (1) can also be used for structure activity studies to identify features responsible for the relevant activities.
摘要翻译：胰岛素受体的活性调节，细胞葡萄糖摄取的增强以及糖尿病的控制和治疗中显着的其它作用使用下式的化合物来实现：其中每个A独立地是质子受体取代基; 每个R独立地是非干扰取代基; n为0,1或2; 并且每个接头独立地是-NHCONH-或-N-N-或-NHCO-的等排物。式（1）属中的化合物也可用于结构活性研究，以鉴定负责相关活性的特征。

25. 发明授权

US07238490B2 Real time detection of intermolecular interaction 失效
标题翻译：实时检测分子间相互作用
公开(公告)号：US07238490B2
公开(公告)日：2007-07-03
申请号：US11187336
申请日：2005-07-21
申请人： Lawrence M. Kauvar
发明人： Lawrence M. Kauvar
IPC分类号： G01N33/53
CPC分类号： C40B30/04 , G01N33/566 , G01N33/6845 , G01N33/6857
摘要： Intermolecular binding can be detected by formation of a “paratope” which results in an immediate generation of a signal. The substances to be tested for interaction are bound to demitopes, wherein said demitopes are components of a paratope which binds a reporter which provides said signal when bound. Known interactions measured in this way can also be employed to screen for compounds which interfere with the interactions. In addition to testing for individual interactions, the interaction of a compound with a library or library×library interactions can also be determined and the effect of potentially interfering substances evaluated.
摘要翻译：分子间结合可以通过形成导致立即产生信号的“同位素”来检测。待测试的相互作用的物质与分子结合，其中所述分子是与结合时提供所述信号的报告物结合的对位基团的组分。以这种方式测量的已知相互作用也可用于筛选干扰相互作用的化合物。除了测试个体相互作用之外，还可以确定化合物与文库或文库相互作用的相互作用，并评估潜在的干扰物质的影响。

26. 发明授权

US06673554B1 Protein localization assays for toxicity and antidotes thereto 失效
公开(公告)号：US06673554B1
公开(公告)日：2004-01-06
申请号：US09332611
申请日：1999-06-14
申请人： Lawrence M. Kauvar
发明人： Lawrence M. Kauvar
IPC分类号： G01N3353
CPC分类号： G01N33/5014 , Y10T436/12
摘要： Intracellular translocation of proteins, particularly protein kinase C (PKC) isoenzymes, provides a surrogate test system for determining toxicity of candidate compounds. The profile of translocation with respect to at least one and preferably two or more signal transduction proteins can be correlated with that of known toxins. In addition, databases of such profiles with respect to toxins of various types provide a useful set of standards for evaluating toxicity of candidate compounds. Moreover, to the extent that a toxin's profile mimics that found in a diseased state, the toxin can be used to construct screens for compounds alleviating the disease.

27. 发明授权

US5908919A Urethane mediated, GST specific molecular release systems 失效
标题翻译：氨基甲酸酯介导的GST特异性分子释放系统
公开(公告)号：US5908919A
公开(公告)日：1999-06-01
申请号：US476119
申请日：1995-06-07
申请人： Lawrence M. Kauvar , Matthew H. Lyttle , Apparao Satyam
发明人： Lawrence M. Kauvar , Matthew H. Lyttle , Apparao Satyam
IPC分类号： A61K38/00 , A61K38/04 , A61P35/00 , C07K5/02 , C07K5/023 , C07K5/037 , C07K5/08 , A61K38/06
CPC分类号： C07K5/0215 , A61K38/00
摘要： Compounds of the formula ##STR1## or of the formula ##STR2## or the amides, esters or salts thereof, wherein: S.sup.x is S.dbd.O, O.dbd.S.dbd.O, S.dbd.NH, HN.dbd.S.dbd.O, Se.dbd.O, O.dbd.Se.dbd.O, Se.dbd.NH, HN.dbd.Se.dbd.O, S.sup.+ R.sup.3 wherein R.sup.3 is alkyl (1-6C) or O--C.dbd.O or HN--C.dbd.O;each R of R.sup.1, and R.sup.2 is independently H or a noninterfering substituent;wherein (conj) represents a conjugated system capable of transmitting electrons;n is 0 or 1;YCO is selected from the group consisting of .gamma.-Glu, .gamma.-Glu-Gly, Glu, Glu-Gly, .beta.Asp, .beta.-Asp-Gly, Asp and Asp-Gly;AA.sub.C is an amino acid linked through a peptide bond to the remainder of said compound of Formula 1; andN(Z) represents a reduced nitrogen-containing leaving group and L represents an electron-withdrawing leaving group,are useful as prodrugs and to generate active components released by the activity of glutathione S-transferase.
摘要翻译：式或式的化合物或其酰胺，酯或盐，其中：Sx为S = O，O = S = O，S = NH，HN = S = O，Se = O，O = Se = O ，Se = NH，HN = Se = O，S + R3，其中R3是烷基（1-6C）或OC = O或HN-C = O; R 1的每个R和R 2独立地为H或非干扰取代基; 其中（conj）表示能够传输电子的共轭系统; n为0或1; YCO选自γ-Glu，γ-Glu-Gly，Glu，Glu-Gly，β-Asp，β-Asp-Gly，Asp和Asp-Gly; AAC是通过肽键与所述式1化合物的剩余部分连接的氨基酸; 并且N（Z）表示还原的含氮离去基团，L表示吸电子离去基团，可用作前药并产生通过谷胱甘肽S-转移酶活性释放的活性成分。

28. 发明授权

US5830918A Nonpeptide insulin receptor agonists 失效
标题翻译：非肽胰岛素受体激动剂
公开(公告)号：US5830918A
公开(公告)日：1998-11-03
申请号：US784857
申请日：1997-01-15
申请人： Richard Sportsman , Hugo O. Villar , Lawrence M. Kauvar
发明人： Richard Sportsman , Hugo O. Villar , Lawrence M. Kauvar
IPC分类号： C07C309/34 , C12Q1/34 , C12Q1/48 , G01N33/58 , A61K31/135
CPC分类号： C12Q1/48 , C07C309/34 , C12Q1/34 , G01N33/582 , G01N2333/62 , G01N2333/72 , G01N2333/9121
摘要： Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula ##STR1## wherein each Ar is independently an aromatic moiety; each A is independently a proton-accepting substituent; each R is independently a noninterfering substituent; m is 0 or 1; n is 4-6; and each linker is independently an isostere of --CH.sub.2 --, --CH.dbd.CH-- or --NCHO--. Compounds in the genus of Formula (1) can also be used for structure activity studies to identify features responsible for the relevant activities.
摘要翻译：胰岛素受体的活性的调节，细胞的葡萄糖摄取增强以及在糖尿病的控制和治疗中显着的其它作用使用式（1）的化合物来实现，其中每个Ar独立地是芳族部分; 每个A独立地是质子接受取代基; 每个R独立地是非干扰取代基; m为0或1; n为4-6; 并且每个连接体独立地是-CH 2 - ， - CH = CH - 或-NCHO - 的等势线。式（1）属中的化合物也可用于结构活性研究，以鉴定负责相关活性的特征。

29. 发明授权

US5763570A Glutathione analogs and paralog panels comprising glutathione mimics 失效
标题翻译：谷胱甘肽类似物和包含谷胱甘肽模拟物的旁系同源片段
公开(公告)号：US5763570A
公开(公告)日：1998-06-09
申请号：US473397
申请日：1995-06-07
申请人： Lawrence M. Kauvar , Matthew H. Lyttle
发明人： Lawrence M. Kauvar , Matthew H. Lyttle
IPC分类号： A61K38/00 , A61K38/06 , C07K5/02 , C07K5/037 , C07K7/06 , C07K7/08 , C07K7/56 , C07K16/00 , C07K16/30 , C07K16/44 , C12N9/10 , G01N30/00 , G01N30/02 , G01N33/53 , G01N33/573 , G01N33/574 , G01N33/68 , C07K5/08
CPC分类号： C12N9/1088 , A61K38/06 , C07K16/00 , C07K16/30 , C07K16/44 , C07K5/0215 , C07K7/06 , C07K7/08 , C07K7/56 , G01N33/53 , G01N33/573 , G01N33/57496 , G01N33/68 , G01N33/6878 , G01N2030/027 , G01N2333/91177 , G01N30/00 , G01N30/02 , G01N30/48 , Y10S435/814
摘要： Compounds of the formula ##STR1## or the alkyl (1-6C), alkenyl (1-6C), or arylalkyl (7-12C) amides or salts including the cycloamido forms thereof; wherein n is 1 or 2; wherein when n is 1, X is a mono- or disubstituted or unsubstituted hydrocarbyl (1-20C) moiety optionally containing 1 or 2 nonadjacent heteroatoms (O, S or N), and wherein said substitution is selected from the group consisting of halo, OR, and SR, wherein R is H or lower alkyl (1-4C); when n is 2, one X is as above defined and the other X is lower alkyl (1-4C); Y is selected from the group consisting of ##STR2## wherein m is 1 or 2; and AA.sub.C is an amino acid coupled through a peptide bond to the remainder of the compound of formula 1, are useful as affinity ligands, elution reagents, solution inhibitors, diagnostic reagents and therapeutics. These compounds and analogous tripeptide glutathione analogs can be used as members of panels to obtain specific characteristic profiles for various glutathione-S-transferases.
摘要翻译：式（1）的化合物或烷基（1-6C），烯基（1-6C）或芳烷基（7-12C）酰胺或包括其环酰胺基的盐; 其中n为1或2; 其中当n为1时，X为任选含有1或2个不相邻杂原子（O，S或N）的单取代或未取代的烃基（1-20C）部分，并且其中所述取代选自卤素， OR和SR，其中R是H或低级烷基（1-4C）; 当n为2时，一个X如上定义，另一个X为低级烷基（1-4C）; Y选自，其中m为1或2; 并且AAC是通过肽键与式1化合物的其余部分偶联的氨基酸，可用作亲和配体，洗脱试剂，溶液抑制剂，诊断试剂和治疗剂。这些化合物和类似的三肽谷胱甘肽类似物可用作面板的成员以获得各种谷胱甘肽-S-转移酶的特定特征。

30. 发明授权

US5674688A Method for analyte classification by SC profiles 失效
标题翻译： SC剖面分析方法
公开(公告)号：US5674688A
公开(公告)日：1997-10-07
申请号：US129413
申请日：1993-09-29
申请人： Lawrence M. Kauvar , Stuart M. Ambler
发明人： Lawrence M. Kauvar , Stuart M. Ambler
IPC分类号： G01N30/02 , G01N33/53 , G01N33/543 , G01N33/566 , G06F17/30
CPC分类号： G01N33/53 , G01N30/02 , Y10S435/975 , Y10S436/808 , Y10S436/815 , Y10S436/816 , Y10S436/817 , Y10S436/901
摘要： The precision of identification of analyte composition in a sample, where the possible analytes each provide a series of values for characteristic parameters; in particular where the parameters are generated by cross-reaction with specific binding reagents, is enhanced by applying pattern recognition techniques. Samples to be tested are evaluated with respect to each survey parameter to obtain a pattern of parameter values with respect to each analyte at a given concentration. In the case of the use of a panel of specific binding reagents, the samples to be tested are reacted with this panel and the affinities at various analyte concentrations are determined. This results in a databank of "SC profiles" for known concentrations of each analyte. This databank is stored in a computationally accessible form, which then can be matched against SC profiles obtained by testing unknown samples.
摘要翻译：样品中分析物组成的鉴定精度，其中可能的分析物各自提供一系列特征参数值; 特别是通过与特异性结合试剂进行交叉反应产生参数时，通过应用模式识别技术得到增强。针对每个测量参数评估要测试的样品，以获得相对于给定浓度的每种分析物的参数值的模式。在使用一组特异性结合试剂的情况下，待测试样品与该面板反应，并确定各种分析物浓度下的亲和力。这导致每个分析物的已知浓度的“SC概况”的数据库。该数据库以计算可访问的形式存储，然后可以与通过测试未知样本获得的SC简档进行匹配。

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