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21. 发明申请

WO2008070222A2 A METHOD OF SURFACE PLASMON RESONANCE (SPR) TECHNOLOGY TO DETECT GENOMIC DISORDERS FOR PRENATAL DIAGNOSIS 审中-公开
标题翻译：表面等离子体共振（SPR）技术检测基因治疗疾病进行临床诊断的方法
公开(公告)号：WO2008070222A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/075930
申请日：2007-08-14
申请人： CYTOTREND BIOTECH ENGINEERING LIMITED USA INC , CHEN, Zhong , LIU, Ning
发明人： CHEN, Zhong , LIU, Ning
IPC分类号： C12Q1/68
CPC分类号： G01N33/54373 , C12Q1/6883 , G01N21/553 , G01N33/553 , G01N2800/385 , Y10T436/143333
摘要： The present invention discloses using SPR technology to prenatally detect specific DNA loss or gain related to some genomic disorders. An efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of DNA markers used for the identification of chromosome numerical abnormalities (such as chromosomes 13, 18, 21, X and Y related anomalies) and chromosome microdeletion syndromes (such as DiGeorge syndrome, etc) is also disclosed.
摘要翻译：本发明公开了使用SPR技术预先检测与某些基因组紊乱相关的特定DNA损失或增益。制备混合SAM的有效配方可以大大增强金属表面在基于SPR的技术中的固定能力，这有助于固定用于鉴定染色体数值异常的DNA标记（如染色体13,18,21 ，X和Y相关异常）和染色体微缺失综合征（如DiGeorge综合征等）也被公开。

22. 发明申请

WO2008067006A3 A METHOD FOR QUANTITATIVE DETECTION OF DIABETES RELATED IMMUNOLOGICAL MARKERS 审中-公开
公开(公告)号：WO2008067006A3
公开(公告)日：2008-06-05
申请号：PCT/US2007/078663
申请日：2007-09-17
申请人： CYTOTREND BIOTECH ENGINEERING LIMITED USA INC , CHEN, Zhong , LIU, Ning , LI, Yancun
发明人： CHEN, Zhong , LIU, Ning , LI, Yancun
IPC分类号： G01N33/553
摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of diabetes related immunological makers in a serum sample, which can be used to diagnose and /or early diagnose diabetes as well as to predict the onset risk of diabetes in first-degree relatives. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antigens and antibodies used for the detection of respective diabetes related immunological makers in a serum sample.

23. 发明申请

WO2008066996A2 A METHOD TO DETECT TREPONEMA PALLIDUM IMMUNOLOGICAL MARKERS FOR THE DIAGNOSIS OF SYPHILIS 审中-公开
标题翻译：检测TREPONEMA PALLIDUM免疫标记物进行SYPHILIS诊断的方法
公开(公告)号：WO2008066996A2
公开(公告)日：2008-06-05
申请号：PCT/US2007077867
申请日：2007-09-07
申请人： CYTOTREND BIOTECH ENGINEERING , CHEN ZHONG , LIU NING , LI YANCUN
发明人： CHEN ZHONG , LIU NING , LI YANCUN
IPC分类号： G01N33/571 , C12M3/00
CPC分类号： G01N33/571 , G01N2333/20
摘要： This invention discloses using SPR technology to detect the presence of Treponema pallidum immunological markers in a serum sample, which can be used for the diagnosis of syphilis. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of representative antigens used to detect the respective Treponema pallidum immunological markers (antibodies) in blood for the diagnosis of syphilis.
摘要翻译：本发明公开了使用SPR技术检测血清样本中梅毒螺旋体免疫标记物的存在，可用于诊断梅毒。它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定用于检测血液中相应的梅毒螺旋体免疫标记物（抗体）的代表性抗原用于诊断梅毒。

24. 发明申请

WO2008066982A2 A METHOD OF SURFACE PLASMON RESONANCE (SPR) TECHNOLOGY TO DETECT GENOMIC ABERRATIONS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA 审中-公开
标题翻译：表面等离子体共振（SPR）技术检测慢性淋巴细胞白血病患者基因型异常的方法
公开(公告)号：WO2008066982A2
公开(公告)日：2008-06-05
申请号：PCT/US2007076472
申请日：2007-08-22
申请人： CYTOTREND BIOTECH ENGINEERING , CHEN ZHONG , LIU NING
发明人： CHEN ZHONG , LIU NING
IPC分类号： C12M3/00 , G06F19/00
CPC分类号： B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00722
摘要： The present invention discloses using SPR technology to detect CLL related genomic aberrations in peripheral blood samples. An efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of DNA markers used for the identification of CLL related genomic aberrations in peripheral blood samples is also disclosed.
摘要翻译：本发明公开了使用SPR技术检测外周血样品中的CLL相关基因组畸变。还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这对于用于鉴定外周血样品中CLL相关基因组畸变的DNA标记物的固定是有利的。

25. 发明申请

WO2008036470A2 A METHOD FOR SCREENING OF INFECTIOUS AGENTS IN BLOOD 审中-公开
标题翻译：一种检测血液中感染性物质的方法
公开(公告)号：WO2008036470A2
公开(公告)日：2008-03-27
申请号：PCT/US2007/074819
申请日：2007-07-31
申请人： CYTOTREND BIOTECH ENGINEERING LIMITED USA INC , CHEN, Zhong , LIU, Ning , LI, Yancun
发明人： CHEN, Zhong , LIU, Ning , LI, Yancun
IPC分类号： C12Q1/70
CPC分类号： G01N33/54373 , B01J19/0046 , B01J2219/00385 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00725 , B01J2219/0074 , G01N33/54353 , Y10S436/805
摘要： This invention discloses using SPR technology to simultaneously and qualitatively detect the presence of infectious agent related antibodies and/or antigens in a serum sample, which can be used to screen for infectious agents in blood. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antigens and antibodies used for the screening of infectious agents in blood.
摘要翻译：本发明公开了使用SPR技术来同时和定性检测血清样品中感染剂相关抗体和/或抗原的存在，其可用于筛选血液中的感染因子。它还公开了一种制备混合SAM的高效配方，该混合SAM可以大大提高金属表面在基于SPR的技术中的固定能力，这对固定用于筛选血液中感染因子的相关抗原和抗体是有利的。

26. 发明申请

WO2006074092A1 HIGH PRECISION VOLTAGE SOURCE FOR ELECTRICAL IMPEDANCE TOMOGRAPHY 审中-公开
标题翻译：高电压电压源用于电阻抗TOMOGRAPHY
公开(公告)号：WO2006074092A1
公开(公告)日：2006-07-13
申请号：PCT/US2005/047477
申请日：2005-12-30
申请人： RENSSELAER POLYTECHNIC INSTITUTE , SAULNIER, Gary, J. , LIU, Ning , ROSS, Alexander, S.
发明人： SAULNIER, Gary, J. , LIU, Ning , ROSS, Alexander, S.
IPC分类号： G01R27/08 , G01R31/08 , G01R35/00 , A61B5/05
CPC分类号： A61B5/0536
摘要： An EIT system includes a plurality of voltage sources for supplying a corresponding plurality of voltages to a corresponding number of other structures, voltage source calibration means for calibrating each voltage source, and switching means for individually connecting the calibration means to each voltage source in succession during a period when each other structure is in an inactive condition. Calibrating respective voltages and currents for each voltage source compensates for shunt impedance of each voltage source. A method for calibrating the system includes individually connecting the calibration means to each voltage source in succession during a period when each other structure is in an inactive condition for calibrating all of said voltage sources in the same way.
摘要翻译： EIT系统包括用于将相应多个电压提供给相应数量的其它结构的多个电压源，用于校准每个电压源的电压源校准装置，以及用于在每个电压源期间连续地将校准装置单独连接到每个电压源的开关装置每个其他结构处于非活动状态的时段。校准每个电压源的各个电压和电流补偿每个电压源的并联阻抗。用于校准系统的方法包括在每个其他结构处于非活动状态的时段内将校准装置连续地连接到每个电压源，以便以相同的方式校准所有所述电压源。

27. 发明申请

WO2006073500A2 LATERAL FLOW SYSTEM AND ASSAY 审中-公开
标题翻译：侧流系统和测定
公开(公告)号：WO2006073500A2
公开(公告)日：2006-07-13
申请号：PCT/US2005/027182
申请日：2005-07-29
申请人： PRAXSYS BIOSYSTEMS LLC , ZHOU, Siliang , RUTTER, William, J. , LIU, Ning
发明人： ZHOU, Siliang , RUTTER, William, J. , LIU, Ning
IPC分类号： G01N33/558
CPC分类号： B82Y5/00 , B82Y10/00 , G01N33/558
摘要： The present invention relates to a lateral flow assay and system, including a test strip, for detection and quantification of analytes in samples, such as samples containing cells and fluid. In general, according to the present invention, a test strip for a lateral flow assay for detection of at least one analyte in a sample comprises: (1) a chromatographic strip, a sample filter, a fluid-impermeable barrier, and means for providing a mobilizable detectable agent that is capable of binding to the at least one analyte or to the capture agent after capturing the analyte to the chromatographic strip such that the mobilizable detectable agent migrates through the chromatographic strip and contacts sample that has passed through the sample filter and also has migrated through the chromatographic strip. The test strip allows detection with or without quantitation of an analyte in a sample containing whole cells.
摘要翻译：本发明涉及一种侧流测定和系统，包括用于检测和定量样品中的分析物的测试条，例如含有细胞和流体的样品。通常，根据本发明，用于检测样品中至少一种分析物的横向流动测定的测试条包括：（1）色谱条，样品过滤器，流体不可渗透屏障和用于提供可移动的可检测试剂，其在将分析物捕获到色谱条之后能够结合至少一种分析物或捕获剂，使得可移动的可检测试剂迁移通过色谱条并接触通过样品过滤器的样品，也已经通过色谱条带迁移。测试条允许在含有全细胞的样品中检测有或没有定量分析物。

28. 发明申请

WO2011064073A1 METHOD, DEVICE AND SYSTEM FOR IMAGE COMPRESSION AND DECOMPRESSION USING SUPPORT VECTOR REGRESSION 审中-公开
标题翻译：使用支持向量回归的图像压缩和解码的方法，装置和系统
公开(公告)号：WO2011064073A1
公开(公告)日：2011-06-03
申请号：PCT/EP2010/066799
申请日：2010-11-04
申请人： SIEMENS AKTIENGESELLSCHAFT , HAO, Hong Wei , LIU, Ning , WEN, Bo , YIN, Xu Cheng
发明人： HAO, Hong Wei , LIU, Ning , WEN, Bo , YIN, Xu Cheng
IPC分类号： G06T9/00 , H04N7/26
CPC分类号： G06T9/00 , G06F19/321 , H04N19/50 , H04N19/90
摘要： The invention discloses an image compression method, which comprises: processing the original image by support vector regression to generate the support vector using the pixel coordinates of said original image as the input sample and using the pixel intensity value as the supervisory signal; calculating the regression image according to said support vector; calculating the residual image according to said original image and the regression image; encoding said support vector and said residual image. The invention further discloses an image decompression method corresponding to the above said image compression method. Further, the invention discloses an image compression device and an image decompression device. The invention utilizes the support vector technology for image prediction to reduce the number of parameters used and achieve a very high compression ratio. In addition, the invention uses the vectors of the X-coordinate and Y-coordinate to represent the pixel values of the medical image, which is more stable in medical image compression processing than conventional compression methods based on image pixel gradient prediction, making the compression method of the invention more stable.
摘要翻译：本发明公开了一种图像压缩方法，包括：通过支持向量回归处理原始图像，使用所述原始图像的像素坐标作为输入样本并使用像素强度值作为监控信号来生成支持向量; 根据所述支持向量计算回归图像; 根据所述原始图像和回归图像计算残差图像; 编码所述支持向量和所述残差图像。本发明还公开了一种对应于上述图像压缩方法的图像解压缩方法。此外，本发明公开了一种图像压缩装置和图像解压缩装置。本发明利用支持向量技术进行图像预测，减少使用的参数数量，实现非常高的压缩比。此外，本发明使用X坐标和Y坐标的向量来表示医学图像的像素值，其在医学图像压缩处理中比基于图像像素梯度预测的常规压缩方法更稳定，使得压缩本发明的方法更加稳定。

29. 发明申请

WO2008070222A3 A METHOD OF SURFACE PLASMON RESONANCE (SPR) TECHNOLOGY TO DETECT GENOMIC DISORDERS FOR PRENATAL DIAGNOSIS 审中-公开
标题翻译：表面等离子体共振（SPR）技术检测基因治疗疾病进行临床诊断的方法
公开(公告)号：WO2008070222A3
公开(公告)日：2009-04-09
申请号：PCT/US2007075930
申请日：2007-08-14
申请人： CYTOTREND BIOTECH ENGINEERING , CHEN ZHONG , LIU NING
发明人： CHEN ZHONG , LIU NING
IPC分类号： C12Q1/68 , C07H21/04 , C12M1/34 , C12M3/00 , C12P19/34
CPC分类号： G01N33/54373 , C12Q1/6883 , G01N21/553 , G01N33/553 , G01N2800/385 , Y10T436/143333
摘要： The present invention discloses using SPR technology to prenatally detect specific DNA loss or gain related to some genomic disorders. An efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of DNA markers used for the identification of chromosome numerical abnormalities (such as chromosomes 13, 18, 21, X and Y related anomalies) and chromosome microdeletion syndromes (such as DiGeorge syndrome, etc) is also disclosed.
摘要翻译：本发明公开了使用SPR技术预先检测与某些基因组紊乱相关的特定DNA损失或增益。制备混合SAM的有效配方可以大大增强金属表面在基于SPR的技术中的固定能力，这有助于固定用于鉴定染色体数值异常的DNA标记（如染色体13,18,21 ，X和Y相关异常）和染色体微缺失综合征（如DiGeorge综合征等）也被公开。

30. 发明申请

WO2008036474A3 A METHOD TO DETECT TUMOR MARKERS AND DIAGNOSIS OF UNDIFFERENCIATED TUMORS 审中-公开
标题翻译：一种检测肿瘤标志物和诊断未分化肿瘤的方法
公开(公告)号：WO2008036474A3
公开(公告)日：2008-11-27
申请号：PCT/US2007075325
申请日：2007-08-07
申请人： CYTOTREND BEIJING BIOTECH ENGI , CHEN ZHONG , LIU NING , LI YANCUM
发明人： CHEN ZHONG , LIU NING , LI YANCUM
IPC分类号： G01N33/53 , C07K1/10 , C07K1/13 , C12M1/34 , G01N33/544 , G01N33/547 , G01N33/548 , G01N33/552 , G01N33/553
CPC分类号： G01N33/57492 , G01N33/54373
摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different tumor markers in a protein sample extracted from tumor tissue, which can be used for the diagnosis of undifferentiated tumors. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of monoclonal antibodies used for detecting tumor markers in a tumor tissue sample and for the diagnosis of undifferentiated tumors.
摘要翻译：本发明公开了使用SPR技术同时和定量测量从肿瘤组织提取的蛋白质样品中不同肿瘤标志物的浓度，其可用于诊断未分化的肿瘤。它还公开了制备混合SAM的高效配方，其能够大大增强金属表面在基于SPR的技术中的固定能力，这对于用于检测肿瘤组织样品中肿瘤标志物的单克隆抗体的固定以及用于诊断未分化的肿瘤。

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