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21. 发明申请

US20130023650A1 FILLER FOR AFFINITY CHROMATOGRAPHY 有权
标题翻译：填充色谱法
公开(公告)号：US20130023650A1
公开(公告)日：2013-01-24
申请号：US13638826
申请日：2011-03-29
申请人： Kouji Tamori , Takayoshi Abe , Yusuke Okano , Masaki Momiyama , Hiroshi Kawai , Satoshi Hyugaji , Yong Wang
发明人： Kouji Tamori , Takayoshi Abe , Yusuke Okano , Masaki Momiyama , Hiroshi Kawai , Satoshi Hyugaji , Yong Wang
IPC分类号： C08F261/04 , B01D15/38 , C07K1/22
CPC分类号： C07K1/18 , B01D15/3804 , B01D15/3809 , B01J20/286 , C07K1/22 , C08F222/1006 , C08F220/20 , C08F2220/325 , C08F2220/281 , C08F220/58
摘要： Provided is a filler for affinity chromatography which is useful for protein purification and contains porous particles that have a high dynamic binding capacity for proteins and excellent pressure characteristics. The filler for affinity chromatography of the present invention is characterized in that it includes a porous particle consisting of a polymer of vinyl monomer including a cross-linkable vinyl monomer that contains hydroxyl group but does not contain epoxy group and an epoxy group-containing non-cross-linkable vinyl monomer, or a cross-linkable vinyl monomer that contains hydroxyl group and epoxy group, ligands bound to the porous particle, and ring-opened epoxy groups.
摘要翻译：提供了用于亲和层析的填充剂，其用于蛋白质纯化，并且包含对于蛋白质具有高动态结合能力和优异的压力特性的多孔颗粒。本发明的亲和层析用填料的特征在于，它包括由包含含有羟基但不含环氧基的可交联乙烯基单体的乙烯基单体的聚合物组成的多孔颗粒，或可交联乙烯基单体，或含有羟基和环氧基的可交联乙烯基单体，与多孔颗粒结合的配体和开环的环氧基。

22. 发明申请

US20110311824A1 NON-SPECIFIC ADSORPTION INHIBITOR, PROBE-BONDED PARTICLES, AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：非特异性吸附抑制剂，探针结合颗粒及其制造方法
公开(公告)号：US20110311824A1
公开(公告)日：2011-12-22
申请号：US13218494
申请日：2011-08-26
申请人： Kouji TAMORI , Eiji TAKAMOTO
发明人： Kouji TAMORI , Eiji TAKAMOTO
IPC分类号： B32B15/02 , C08G73/00
CPC分类号： G01N33/54326 , G01N33/531 , G01N33/54353
摘要： A non-specific adsorption inhibitor of formula (1), wherein n is a real number of 4 to 2,000, R1 and R2 individually represent a hydrogen atom or a group comprising 1 to 11 amino group(s) or imino group(s), or both, provided that the total number of amino groups and imino groups contained in R1 and R2 is 2 to 11. Non-specific adsorption inhibitor composition, probe-bonded particles.
摘要翻译：式（1）的非特异性吸附抑制剂，其中n为4〜2,000的实数，R1和R2分别表示氢原子或含有1〜11个氨基或亚氨基的基团，或两者，条件是R1和R2中所含的氨基和亚氨基的总数为2至11.非特异性吸附抑制剂组合物，探针键合颗粒。

23. 发明申请

US20090014682A1 Carrier Polymer Particle, Process for Producing the Same, Magnetic Particle for Specific Trapping, and Process for Producing the Same 审中-公开
标题翻译：载体聚合物颗粒，其制备方法，用于特定捕集的磁性颗粒及其生产方法
公开(公告)号：US20090014682A1
公开(公告)日：2009-01-15
申请号：US11914986
申请日：2006-05-17
申请人： Masayuki Takahashi , Tetsuo Fukuta , Kiyoshi Kasai , Toshihiro Ogawa , Satoshi Katayose , Kouji Tamori , Kinji Yamada
发明人： Masayuki Takahashi , Tetsuo Fukuta , Kiyoshi Kasai , Toshihiro Ogawa , Satoshi Katayose , Kouji Tamori , Kinji Yamada
IPC分类号： H01F1/01 , B32B27/36
CPC分类号： C08G63/91 , B32B5/16 , G01N33/53 , G01N33/5434 , G01N33/54353 , Y10T428/2982 , Y10T428/2998
摘要： Carrier polymer particles comprising organic polymer particles having a particle diameter of 0.1 to 20 micrometers and a saccharide with which the surface of the organic polymer particles is covered, the organic polymer particles and the saccharide being chemically bonded.
摘要翻译：包含粒径为0.1-20微米的有机聚合物颗粒的载体聚合物颗粒和被覆盖有机聚合物颗粒的表面的糖类，有机聚合物颗粒和化学键合的糖类。

24. 发明申请

US20080224088A1 Emulsion Composition 有权
标题翻译：乳液成分
公开(公告)号：US20080224088A1
公开(公告)日：2008-09-18
申请号：US10583874
申请日：2004-12-14
申请人： Kouji Tamori , Takeshi Mogi , Takuo Sone , Akira Nishikawa
发明人： Kouji Tamori , Takeshi Mogi , Takuo Sone , Akira Nishikawa
IPC分类号： H01G9/025 , C08F2/32
CPC分类号： H01B1/122 , C09D5/022 , C09D5/24 , C09J101/28 , C09J105/14
摘要： The present invention provides an emulsion composition which has been increased in sulfonic group content, yet has sufficient water resistance and has been enhanced in properties such as small resistance, film-forming property, etc. The emulsion composition contains (A) a water-based solvent, (B) an organic solvent, (C) a sulfonic group-containing polymer soluble in the component (A), and (D) a polymer soluble in the component (B) but insoluble in water. This emulsion composition is enhanced in small resistance and yet has sufficient water resistance and film-forming property.
摘要翻译：本发明提供了一种乳液组合物，其磺酸基含量增加，但具有足够的耐水性，并且在耐电阻性，成膜性等性能方面得到提高。乳液组合物含有（A）水性溶剂，（B）有机溶剂，（C）可溶于组分（A）的含磺酸基聚合物，和（D）可溶于组分（B）但不溶于水的聚合物。该乳液组合物的电阻小，耐水性和成膜性好。

25. 发明申请

US20080160167A1 NON-SPECIFIC ADSORPTION INHIBITOR, PROBE-BONDED PARTICLES, AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：非特异性吸附抑制剂，探针结合颗粒及其制造方法
公开(公告)号：US20080160167A1
公开(公告)日：2008-07-03
申请号：US11954289
申请日：2007-12-12
申请人： Kouji Tamori , Eiji Takamoto
发明人： Kouji Tamori , Eiji Takamoto
IPC分类号： A61L33/04 , C08G65/00
CPC分类号： G01N33/54326 , G01N33/531 , G01N33/54353
摘要： A method for producing a non-specific adsorption inhibitor includes reacting (A) a tosylated compound of polyoxyethylene monomethyl ether with (B) a polyamine having either an amino group or imino group (—NH—), or both, in total of 3 to 12.
摘要翻译：非特异性吸附抑制剂的制造方法包括使（A）聚氧乙烯一甲醚的甲苯磺酰化化合物与（B）具有氨基或亚氨基（-NH-）的多胺或二者的总量为3〜 12。

26. 发明申请

US20080078974A1 ORGANIC POLYMER PARTICLES AND PROCESS FOR PRODUCING SAME 有权
标题翻译：有机聚合物颗粒及其生产方法
公开(公告)号：US20080078974A1
公开(公告)日：2008-04-03
申请号：US11773801
申请日：2007-07-05
申请人： Kouji TAMORI , Eiji Takamoto , Takahiro Kawai
发明人： Kouji TAMORI , Eiji Takamoto , Takahiro Kawai
IPC分类号： C08G63/52 , C08G63/181 , C08G63/199
CPC分类号： C08G63/181 , C08G63/199 , C08G63/52 , Y10T428/2991 , Y10T428/2998
摘要： Organic polymer particles having a structure shown by the following formula (1) are disclosed. wherein A represents an alkylidene group, an alkylene group, a cyclohexylene group, or a phenylene group, and B represents a linear or branched alkylene group or an alkylidene group having 1 to 6 carbon atoms.
摘要翻译：公开了具有下式（1）所示结构的有机聚合物颗粒。其中A表示亚烷基，亚烷基，亚环己基或亚苯基，B表示直链或支链亚烷基或碳原子数1〜6的亚烷基。

27. 发明申请

US20080026222A1 MAGNETIC PARTICLES, METHOD FOR PRODUCING SAME, AND PROBE-BONDED PARTICLES 有权
标题翻译：磁性颗粒，其制造方法和探针粘结颗粒
公开(公告)号：US20080026222A1
公开(公告)日：2008-01-31
申请号：US11772616
申请日：2007-07-02
申请人： Kouji TAMORI , Eiji Takamoto , Masaru Ueno , Tetsuo Fukuta , Tomohiro Uetsuhara , Mitsuhiro Murata
发明人： Kouji TAMORI , Eiji Takamoto , Masaru Ueno , Tetsuo Fukuta , Tomohiro Uetsuhara , Mitsuhiro Murata
IPC分类号： B32B5/16 , B05D5/12
CPC分类号： G01N33/5434 , G01N2446/20 , G01N2446/86 , Y10S525/902 , Y10T428/2998
摘要： A method for producing magnetic particles includes forming a hydrophobic first polymer layer on the surface of a mother particle containing superparamagnetic particles, forming a second polymer layer having glycidyl groups at least on its surface on the first polymer layer, and introducing a polar group containing one or more of at least one atom selected from the group consisting of an oxygen atom, a nitrogen atom, and a sulfur atom by chemically modifying the glycidyl groups.
摘要翻译：制造磁性粒子的方法包括在含有超顺磁性粒子的母粒子的表面形成疏水性第一聚合物层，在第一聚合物层上至少在其表面上形成具有缩水甘油基的第二聚合物层，并引入含有一个或更多的选自氧原子，氮原子和硫原子的至少一个原子，通过化学改性缩水甘油基。

28. 发明授权

US06726997B2 Aqueous dispersion and coated product 有权
标题翻译：水分散体和涂层产品
公开(公告)号：US06726997B2
公开(公告)日：2004-04-27
申请号：US10135427
申请日：2002-05-01
申请人： Kouji Tamori , Hirotaka Shida , Kenji Ishizuki
发明人： Kouji Tamori , Hirotaka Shida , Kenji Ishizuki
IPC分类号： B32B904
CPC分类号： C09D183/10 , C08F283/12 , C08L83/04 , C09D151/085 , Y10T428/31663 , C08L2666/06 , C08L2666/02
摘要： An aqueous dispersion which is excellent in storage stability, and can form a coating film excellent in leveling properties, anti-checking properties, water resistance, etc., transparent and high in hardness, which is obtained by mixing and emulsifying (A) at least one selected from an organosilane represented by (R1)4−n—(Si)—(OR2)n, a hydrolysate of the organosilane and a partial condensation product of the hydrolysate, (B) a radical polymerizable monomer, (C) an emulsifier and (D) a hydrolytic catalyst for component (A) to reduce the particle size of an emulsion, as well as to allow hydrolysis of component (A) to proceed, and adding (E) a radical polymerization initiator to allow polymerization of component (B) to proceed, has a concentration of alcohols having a boiling point of 100° C. or less of 0.1 to 2.0 wt %, and further contains (F) a component having ultraviolet absorption and/or light stabilization action as needed.
摘要翻译：一种水性分散体，其储存稳定性优异，可以形成透明且硬度高的流平性，防粘性，耐水性等优异的涂膜，（A）至少选自由（R 1）4 - （Si） - （OR 2）n表示的有机硅烷，有机硅烷的水解产物和水解产物的部分缩合产物，（B）可自由基聚合的单体，（C）乳化剂和（D）用于组分（A）的水解催化剂以降低乳液的粒径，以及使组分（A）进行水解，并加入（E）自由基聚合引发剂为了进行组分（B）的聚合，具有沸点为100℃以下的醇的浓度为0.1〜2.0重量％，进一步含有（F）具有紫外线吸收和/或稳定性的成分根据需要采取行动

29. 发明授权

US09040661B2 Support for affinity chromatography and method for isolating immunoglobulin 有权
标题翻译：支持亲和色谱法和分离免疫球蛋白的方法
公开(公告)号：US09040661B2
公开(公告)日：2015-05-26
申请号：US13996978
申请日：2011-12-20
申请人： Satoshi Nakamura , Tetsuo Fukuta , Yusuke Okano , Tomonori Shiotani , Kouji Tamori , Yu Otani , Shun-Cheng Li , Xing Li , Courtney Voss
发明人： Satoshi Nakamura , Tetsuo Fukuta , Yusuke Okano , Tomonori Shiotani , Kouji Tamori , Yu Otani , Shun-Cheng Li , Xing Li , Courtney Voss
IPC分类号： C07K1/22 , C07K17/08 , C07K16/06
CPC分类号： C07K1/22 , B01D15/3804 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/288 , B01J20/321 , B01J20/3217 , B01J20/3274 , B01J20/3278 , B01J20/3293 , C07K16/065 , C07K17/08
摘要： Provided are a support for affinity chromatography which has excellent alkali resistance, and a method for isolating immunoglobulin. A support for affinity chromatography, containing an immobilized protein ligand represented by the following formula (1): R—R2 (1) wherein R represents a polypeptide consisting of 4 to 30 amino acid residues that contains an amino acid sequence represented by ATK or ASK; and R2 represents a polypeptide consisting of 50 to 500 amino acid residues containing an immunoglobulin-binding domain consisting of an amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 2, the partial sequence thereof, or an amino acid sequence having 70% or more identity to these sequences; with the proviso that a terminus at which R2 binds to R is C-terminus or N-terminus of the immunoglobulin-binding domain.
摘要翻译：提供了具有优异的耐碱性的亲和层析的支持物和分离免疫球蛋白的方法。含有由下式（1）表示的固定化蛋白质配体的亲和层析的载体：R-R2（1）其中R表示由4至30个氨基酸残基组成的多肽，其含有由ATK或ASK表示的氨基酸序列 ; 并且R 2表示由50-500个氨基酸残基组成的多肽，其含有由SEQ ID NO：1或SEQ ID NO：2所示的氨基酸序列组成的免疫球蛋白结合结构域，其部分序列或具有这些序列具有70％以上的同一性; 条件是R 2与R结合的末端是免疫球蛋白结合结构域的C末端或N末端。

30. 发明申请

US20130041135A1 FILLER FOR AFFINITY CHROMATOGRAPHY AND METHOD FOR ISOLATING IMMUNOGLOBULIN 有权
标题翻译：亲和色谱填充剂和分离免疫球蛋白的方法
公开(公告)号：US20130041135A1
公开(公告)日：2013-02-14
申请号：US13636410
申请日：2011-03-23
申请人： Kouji Tamori , Tetsuo Fukuta , Masaaki Miyaji , Yong Wang , Takayoshi Abe , Yusuke Okano , Masaki Momiyama , Takahiro Kawai
发明人： Kouji Tamori , Tetsuo Fukuta , Masaaki Miyaji , Yong Wang , Takayoshi Abe , Yusuke Okano , Masaki Momiyama , Takahiro Kawai
IPC分类号： C07K17/02 , C07K1/22
CPC分类号： C07K1/22 , B01D15/3804 , B01J20/286 , B01J20/288 , B01J20/3219 , B01J20/3274 , C07K2317/10
摘要： Provided are a filler for affinity chromatography which has excellent alkali resistance, and a method for isolating immunoglobulin. The filler for affinity chromatography is a filler in which a protein represented by the following formula (1) is immobilized on a carrier. R—R2 (1) wherein R represents an amino acid sequence consisting of 4 to 300 amino acid residues containing a region consisting of 4 to 20 contiguous histidine residues; and R2 represents an amino acid sequence capable of binding to immunoglobulin, the amino acid sequence consisting of 50 to 500 amino acid residues containing Z domain of Protein A or a fragment thereof, or a variant thereof, provided that the R binds to C-terminus or N-terminus of the R2.
摘要翻译：提供了具有优异的耐碱性的亲和色谱法的填充剂和分离免疫球蛋白的方法。用于亲和层析的填料是其中由下式（1）表示的蛋白质固定在载体上的填料。 R-R2（1）其中R表示由4至300个氨基酸残基组成的氨基酸序列，其含有由4至20个连续组氨酸残基组成的区域; 并且R 2表示能够结合免疫球蛋白的氨基酸序列，所述氨基酸序列由含有蛋白A的Z结构域或其片段的50至500个氨基酸残基或其变体组成，条件是R与C-末端结合或R2的N-末端。

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