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21. 发明授权

US08431569B2 Inhibitors of janus kinases 有权
公开(公告)号：US08431569B2
公开(公告)日：2013-04-30
申请号：US12747030
申请日：2008-12-09
申请人： Jonathan R. Young , Jongwon Lim , Michelle R. Machacek , Brandon Mitsuo Taoka , Ryan D. Otte
发明人： Jonathan R. Young , Jongwon Lim , Michelle R. Machacek , Brandon Mitsuo Taoka , Ryan D. Otte
IPC分类号： C07D487/02 , A61K31/503
CPC分类号： C07D471/04
摘要： The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

22. 发明授权

US07763634B2 Inhibitors of janus kinases 有权
标题翻译：痛风激酶抑制剂
公开(公告)号：US07763634B2
公开(公告)日：2010-07-27
申请号：US12227959
申请日：2007-06-05
申请人： Jonathan R. Young , Andrew Haidle , Paul Tempest , Michelle Machacek
发明人： Jonathan R. Young , Andrew Haidle , Paul Tempest , Michelle Machacek
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： The instant invention provides for tetracyclic compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
摘要翻译：本发明提供抑制四种已知的哺乳动物JAK激酶（JAK1，JAK2，JAK3和TYK2）和PDK1的四环化合物。本发明还提供了包含这种抑制化合物的组合物和通过向需要治疗骨髓增生性疾病或癌症的患者施用化合物来抑制JAK1，JAK2，JAK3 TYK2和PDK1的活性的方法。

23. 发明申请

US20090197908A1 Benzocycloheptapyridines as inhibitors of the receptor tyrosine kinase met 有权
标题翻译：作为受体酪氨酸激酶抑制剂的苯并环庚三烯类化合物
公开(公告)号：US20090197908A1
公开(公告)日：2009-08-06
申请号：US11921350
申请日：2006-06-22
申请人： Christopher J. Dinsmore , Ana Esther Gabarda Ortega , David J. Guerin , James P. Jewell , Jason D. Katz , Jongwon Lim , Michelle R. Machacek , Ryan D. Otte , Jonathan R. Young
发明人： Christopher J. Dinsmore , Ana Esther Gabarda Ortega , David J. Guerin , James P. Jewell , Jason D. Katz , Jongwon Lim , Michelle R. Machacek , Ryan D. Otte , Jonathan R. Young
IPC分类号： A61K31/4353 , C07D221/06 , A61P35/00
CPC分类号： C07D471/04 , C07D221/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07D491/10 , C07D491/113 , C07F7/1804
摘要： The present invention relates to 5H-benzo[4,5]cyclohepta[1,2-b]pyridine compounds, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译：本发明涉及可用于治疗细胞增殖性疾病，用于治疗与MET活性相关的疾病和用于抑制受体酪氨酸激酶MET的5H-苯并[4,5]环庚并[1,2-b]吡啶化合物。本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。

24. 发明授权

US07550478B2 Tyrosine kinase inhibitors 有权
标题翻译：酪氨酸激酶抑制剂
公开(公告)号：US07550478B2
公开(公告)日：2009-06-23
申请号：US11473273
申请日：2006-06-22
申请人： Christopher J. Dinsmore , Ana Esther Gabarda Ortega , David J. Guerin , James P. Jewell , Jason D. Katz , Jongwon Lim , Michelle R. Machacek , Ryan D. Otte , Jonathan R. Young
发明人： Christopher J. Dinsmore , Ana Esther Gabarda Ortega , David J. Guerin , James P. Jewell , Jason D. Katz , Jongwon Lim , Michelle R. Machacek , Ryan D. Otte , Jonathan R. Young
IPC分类号： A01N43/42 , A61K31/44 , C07D221/00
CPC分类号： C07D471/04 , C07D221/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07D491/10 , C07D491/113 , C07F7/1804
摘要： The present invention relates to 5H-benzo[4,5]cyclohepta[1,2-b]pyridine compounds, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译：本发明涉及用于治疗细胞增殖性疾病，用于治疗与MET活性相关的疾病和用于抑制受体酪氨酸激酶MET的5H-苯并[4,5]环庚并[1,2-b]吡啶化合物。本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。

25. 发明申请

US20080108689A1 Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists 失效
标题翻译：八氢吡喃[3,4-C]吡咯速激肽受体拮抗剂
公开(公告)号：US20080108689A1
公开(公告)日：2008-05-08
申请号：US11792514
申请日：2005-12-12
申请人： Robert J. Devita , Jinlong Jiang , Sander G. Mills , Jonathan R. Young
发明人： Robert J. Devita , Jinlong Jiang , Sander G. Mills , Jonathan R. Young
IPC分类号： A61K31/407 , C07D491/052 , A61P43/00
CPC分类号： C07D491/04
摘要： The present invention is directed to certain hydropyranopyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译：本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些氢吡喃并吡咯烷化合物。本发明还涉及包含这些化合物作为活性成分的药物组合物和使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。

26. 发明授权

US6147088A Antagonists of gonadotropin releasing hormone 失效
标题翻译：促性腺激素释放激素的拮抗剂
公开(公告)号：US6147088A
公开(公告)日：2000-11-14
申请号：US180645
申请日：1998-11-12
申请人： Mark Goulet , Eric E Allen , Matthew J. Wyvratt, Jr. , Jinlong Jiang , Roy G. Smith , Thomas F Walsh , Yi Tien Yang , Jonathan R Young , Robert J. Devita
发明人： Mark Goulet , Eric E Allen , Matthew J. Wyvratt, Jr. , Jinlong Jiang , Roy G. Smith , Thomas F Walsh , Yi Tien Yang , Jonathan R Young , Robert J. Devita
IPC分类号： A61P5/02 , C07D215/22 , C07D215/36 , C07D215/46 , C07D401/06 , C07D401/12 , C07D413/12 , C07D453/02 , C07D471/08 , A61K31/4704 , A61K31/4709 , C07D215/20 , C07D215/227
CPC分类号： C07D215/22 , C07D215/36 , C07D215/46 , C07D401/06 , C07D401/12 , C07D413/12 , C07D453/02 , C07D471/08
摘要： There are disclosed compounds of formula (I) and pharmaceutical acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related conditions. ##STR1##
摘要翻译： PCT No.PCT / US97 / 08479 Sec。 371日期：1998年11月12日 102（e）1998年11月12日日期PCT提交1997年5月16日PCT公布。 WO97 / 44321 PCT出版物日期1997年11月27日公开了可用作GnRH拮抗剂的式（I）化合物及其药学上可接受的盐，因此可用于治疗各种性激素相关病症。

27. 发明授权

US09493441B2 Acyclic cyanoethylpyrazoles as janus kinase inhibitors 有权
标题翻译：无环氰基乙基吡唑作为甘蔗激酶抑制剂
公开(公告)号：US09493441B2
公开(公告)日：2016-11-15
申请号：US14345977
申请日：2012-09-21
申请人： Jason Brubaker , Joshua T. Close , Joon Jung , Michelle Martinez , Catherine White , Kevin Wilson , Jonathan R. Young , Hongjun Zhang
发明人： Jason Brubaker , Joshua T. Close , Joon Jung , Michelle Martinez , Catherine White , Kevin Wilson , Jonathan R. Young , Hongjun Zhang
IPC分类号： C07D405/08 , C07D403/12 , C07D401/14 , C07D231/38 , C07D401/12 , C07D403/08 , C07D405/12 , C07D409/12 , C07D413/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/14
CPC分类号： C07D405/08 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译：本发明提供了作为JAK抑制剂的式I化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。

28. 发明授权

US09394282B2 Pyrazole carboxamides as Janus kinase inhibitors 有权
标题翻译：吡唑甲酰胺作为Janus激酶抑制剂
公开(公告)号：US09394282B2
公开(公告)日：2016-07-19
申请号：US14345982
申请日：2012-09-21
申请人： Jason Brubaker , Joshua Close , Tony Siu , Graham Frank Smith , Luis E. Torres , Hyun Chong Woo , Jonathan R. Young , Zhongyong Wei , Feng Shi
发明人： Jason Brubaker , Joshua Close , Tony Siu , Graham Frank Smith , Luis E. Torres , Hyun Chong Woo , Jonathan R. Young , Zhongyong Wei , Feng Shi
IPC分类号： C07D401/04 , C07D405/14 , C07D409/04 , C07D417/14 , C07D405/04 , C07D413/14 , C07D401/14 , C07D405/08 , C07D403/12 , C07D231/38 , C07D401/12 , C07D403/08 , C07D405/12 , C07D409/12 , C07D413/12 , C07D403/04 , C07D401/06 , C07D403/06 , C07D405/06
CPC分类号： C07D405/08 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译：本发明提供了作为JAK抑制剂的式I化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。

29. 发明授权

US09328099B2 Cyanomethylpyrazole carboxamides as janus kinase inhibitors 有权
标题翻译：氰基甲基吡唑甲酰胺作为甘蔗激酶抑制剂
公开(公告)号：US09328099B2
公开(公告)日：2016-05-03
申请号：US14345978
申请日：2012-09-21
申请人： Jason Brubaker , Matthew Lloyd Childers , Matthew Christopher , Joshua T. Close , Jason David Katz , Joon Jung , Scott Peterson , Phieng Siliphaivanh , Tony Siu , Graham Frank Smith , Luis E. Torres , Hyun Chong Woo , Jonathan R. Young , Hongjun Zhang
发明人： Jason Brubaker , Matthew Lloyd Childers , Matthew Christopher , Joshua T. Close , Jason David Katz , Joon Jung , Scott Peterson , Phieng Siliphaivanh , Tony Siu , Graham Frank Smith , Luis E. Torres , Hyun Chong Woo , Jonathan R. Young , Hongjun Zhang
IPC分类号： C07D231/38 , C07D405/04 , C07D401/14 , C07D401/04 , C07D403/04 , C07D405/08 , C07D403/12 , C07D401/12 , C07D403/08 , C07D405/12 , C07D409/12 , C07D413/12 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/14
CPC分类号： C07D405/08 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译：本发明提供了作为JAK抑制剂的式I化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。

30. 发明授权

US08602146B2 Vehicle construction method to prevent battery damage in rear impact using optimized bracket separation 有权
标题翻译：车辆施工方法，通过优化支架分离，防止后方碰撞中的电池损坏
公开(公告)号：US08602146B2
公开(公告)日：2013-12-10
申请号：US13443106
申请日：2012-04-10
申请人： Gerritt B. Meyers , Jonathan R. Young , Jesse Buehler , Naipaul Ramoutar , Taichi Yamashita
发明人： Gerritt B. Meyers , Jonathan R. Young , Jesse Buehler , Naipaul Ramoutar , Taichi Yamashita
IPC分类号： B60R16/04
CPC分类号： H01M2/1083 , Y10T29/49826
摘要： A battery attachment bracket and method of assembly for protecting a battery of a motor vehicle from damage during a rear impact. The battery attachment bracket connects the battery to support structure of the motor vehicle in an area subject to deformation during a rear impact. The battery attachment bracket is formed by a body member extending from a battery-engaging surface to a vehicle-support-engaging surface. The vehicle-support-engaging surface has a bolt-receiving aperture, and a notch cut-out adjacent to the bolt-receiving aperture located in a vehicle-front direction with respect to the bolt-receiving aperture to define a narrowed portion of the battery attachment bracket. A gusset having an angled surface is located on a vehicle-front-facing surface of the battery attachment bracket. The gusset resists deformation of the battery attachment bracket and promotes separation of the battery attachment bracket from the support structure of the motor vehicle adjacent the bolt-receiving aperture.
摘要翻译：一种电池附接支架和组装方法，用于保护机动车辆的电池在后部冲击期间不受损坏。电池安装托架将电池连接到在后冲击期间变形的区域中的机动车辆的支撑结构。电池安装支架由从电池接合表面延伸到车辆支撑件接合表面的本体构件形成。车辆支撑接合表面具有螺栓接收孔和邻近螺栓接收孔的切口切口，其相对于螺栓接收孔定位在车辆前方，以限定电池的变窄部分附件支架。具有倾斜表面的角撑板位于电池附接支架的面向车辆的表面上。角撑板抵抗电池附接支架的变形，并促进电池附接支架与邻近螺栓接收孔的机动车辆的支撑结构分离。

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