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21. 发明授权

US4255335A Preparation of 5-aroyl-1-loweralkylpyrrole-2-acetic acid derivatives 失效
标题翻译： 5-芳酰基-1-低级烷基吡咯-2-乙酸衍生物的制备
公开(公告)号：US4255335A
公开(公告)日：1981-03-10
申请号：US137046
申请日：1980-04-03
申请人： John R. Carson
发明人： John R. Carson
IPC分类号： A61K31/40 , A61P29/00 , C07D207/32 , C07D207/337
CPC分类号： C07D207/337
摘要： Known types of 5-aroyl-1-loweralkylpyrrole-2-acetic acid derivatives are prepared by the thermal reaction of an aroylcyanide with a 1-alkylpyrrole-2-acetic acid derivative.
摘要翻译：已知类型的5-芳酰基-1-低级烷基吡咯-2-乙酸衍生物通过芳基氰与1-烷基吡咯-2-乙酸衍生物的热反应制备。

22. 发明授权

US4216150A Preparation of pyrrole-2-acetates 失效
标题翻译：制备吡咯-2-乙酸酯
公开(公告)号：US4216150A
公开(公告)日：1980-08-05
申请号：US951559
申请日：1978-10-16
申请人： John R. Carson , Richard J. Carmosin , Anthony T. Stefanski
发明人： John R. Carson , Richard J. Carmosin , Anthony T. Stefanski
IPC分类号： C07D207/32 , C07D207/337
CPC分类号： C07D207/337
摘要： Loweralkyl 1-methylpyrrole-2-acetates are prepared by the recuction of loweralkyl .alpha.-imino-1-methylpyrrole-2-acetates using a divalent sulfur reducing agent.
摘要翻译：通过使用二价硫还原剂回收低级烷基α-亚氨基-1-甲基吡咯-2-乙酸酯来制备1-甲基吡咯-2-乙酸低级烷基酯。

23. 发明授权

US4153176A Meter box having rotatable cover and interlocking means 失效
标题翻译：仪表盒具有可旋转盖和互锁装置
公开(公告)号：US4153176A
公开(公告)日：1979-05-08
申请号：US818949
申请日：1977-09-23
申请人： John R. Carson
发明人： John R. Carson
IPC分类号： H02B1/06 , B65D25/24 , B65D41/06
CPC分类号： H02B1/06
摘要： A meter box and a uniquely designed cover molded out of a substantially rigid plastic material is disclosed. The meter box comprises an open upper top with an upwardly extending rim member. On the inside surface of the meter box are means for supporting a cover forming a ledge member. The cover is arranged and configured to rest on the ledge confronting the rim of the box so as to substantially close the open top of the box. Disposed on the exterior of the meter box are a plurality of anchor tabs. A horizontal member is disposed between two anchor tabs adjacent the top of the meter box which enables the box to be secured in concrete and the like.The cover may be a substantially round member or may comprise first and second sections and means for rotatably joining the first and second sections together. The first section having outwardly extending protrusions which engage slots on the meter box so as to render the first section substantially immovable therein. The second section having an opening which enables the user to lift the second section off the top of the meter box and move it about the rotation means whereby the meter box is selectively opened and closed. The meter box and cover of the present invention have particular utility because of the ease of construction, and beneficial cost versus strength ratios.
摘要翻译：公开了一种仪表盒和由基本上刚性的塑料材料成型的独特设计的盖。仪表盒包括一个敞开的上部顶部，带有向上延伸的边缘部件。在仪表箱的内表面上是用于支撑形成凸缘构件的盖的装置。盖被布置和配置为搁置在面对箱的边缘的突出部上，以便基本上封闭箱的敞开的顶部。设置在仪表箱的外部的是多个锚固片。水平构件设置在邻近仪表箱顶部的两个锚固片之间，使箱体可以固定在混凝土等中。

24. 发明授权

US08350041B2 Tricyclic δ-opioid modulators 有权
标题翻译：三环δ-阿片样物质调节剂
公开(公告)号：US08350041B2
公开(公告)日：2013-01-08
申请号：US13334374
申请日：2011-12-22
申请人： John R. Carson , Ellen Codd , Christine M. Razler , Andrea Works , Mark McDonnell , James J. McNally
发明人： John R. Carson , Ellen Codd , Christine M. Razler , Andrea Works , Mark McDonnell , James J. McNally
IPC分类号： A61K31/4535 , C07D409/04
CPC分类号： C07D405/04 , C07D405/14 , C07D409/14 , C07D471/08
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译：本发明涉及Δ阿片样物质受体调节剂。更具体地，本发明涉及三环δ-阿片样物质调节剂。还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。

25. 发明授权

US08106207B2 Tricyclic δ-opioid modulators 有权
标题翻译：三环δ-阿片样物质调节剂
公开(公告)号：US08106207B2
公开(公告)日：2012-01-31
申请号：US13157846
申请日：2011-06-10
申请人： John R. Carson , Ellen Codd , Christine M. Razler , Andrea Works , Mark McDonnell , James J. McNally
发明人： John R. Carson , Ellen Codd , Christine M. Razler , Andrea Works , Mark McDonnell , James J. McNally
IPC分类号： A61K31/453 , C07D405/04
CPC分类号： C07D405/04 , C07D405/14 , C07D409/14 , C07D471/08
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译：本发明涉及Δ阿片样物质受体调节剂。更具体地，本发明涉及三环δ-阿片样物质调节剂。还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。

26. 发明申请

US20090263322A1 OCTAHYDRO-INDOLIZINE AND QUINOLIZINE AND HEXAHYDRO-PYRROLIZINES 审中-公开
标题翻译：氢化吲哚和喹啉和十六氢吡喃
公开(公告)号：US20090263322A1
公开(公告)日：2009-10-22
申请号：US12494754
申请日：2009-06-30
申请人： Richard Apodaca , Nicholas I. Carruthers , John R. Carson , Wenying Chai , Annette K. Kwok , Xiaobing Li , Timothy W. Lovenberg , Dale A. Rudolph , Chandravadan R. Shah
发明人： Richard Apodaca , Nicholas I. Carruthers , John R. Carson , Wenying Chai , Annette K. Kwok , Xiaobing Li , Timothy W. Lovenberg , Dale A. Rudolph , Chandravadan R. Shah
IPC分类号： A61K31/437 , C07D221/04 , C07D401/14 , A61K31/496 , A61K51/00 , A61P11/00 , A61P25/00
CPC分类号： C07D487/04 , A61K51/0455 , A61K51/0459 , C07D455/00 , C07D471/04
摘要： The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
摘要翻译：本发明具有取代的稠合双环化合物，含有它们的药物组合物，以及使用它们治疗或预防组胺介导的疾病和病症的方法。

27. 发明申请

US20080306111A1 TRICYCLIC DELTA- OPIOID MODULATORS 审中-公开
标题翻译： TRICYCLIC DELTA-OPIOID调制器
公开(公告)号：US20080306111A1
公开(公告)日：2008-12-11
申请号：US12187680
申请日：2008-08-07
申请人： John R. Carson , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James McNally
发明人： John R. Carson , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James McNally
IPC分类号： A61K31/4545 , C07D405/14 , A61K31/4535 , C07D409/04 , A61K31/453
CPC分类号： C07D405/14 , C07D405/04 , C07D409/14 , C07D413/14
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译：本发明涉及Δ阿片样物质受体调节剂。更具体地，本发明涉及三环类阿片样物质调节剂。还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。

28. 发明申请

US20080280990A1 CARBOXAMIDO OPIOID COMPOUNDS 有权
标题翻译： CARBOXAMIDO OPIOID化合物
公开(公告)号：US20080280990A1
公开(公告)日：2008-11-13
申请号：US12182462
申请日：2008-07-30
申请人： John R. Carson , Philip M. Pitis
发明人： John R. Carson , Philip M. Pitis
IPC分类号： A61K31/166 , C07C233/65 , A61P25/00
CPC分类号： C07C237/30 , C07C237/38 , C07C2601/02 , C07C2601/14
摘要： This invention is directed to carboxamido opioid compounds pharmaceutically useful as agents for treating or modulating a central nervous system disorder and methods for treating or modulating a central nervous system disorder.
摘要翻译：本发明涉及药物上可用作治疗或调节中枢神经系统障碍的药物的甲酰胺阿片样物质和治疗或调节中枢神经系统疾病的方法。

29. 发明授权

US06573267B2 Useful aroyl aminoacyl pyrrole compounds 有权
公开(公告)号：US06573267B2
公开(公告)日：2003-06-03
申请号：US09896084
申请日：2001-06-29
申请人： John R. Carson , Philip M. Pitis
发明人： John R. Carson , Philip M. Pitis
IPC分类号： A61K3140
CPC分类号： C07D207/333 , C07D401/06 , C07D409/06
摘要： This invention is directed to aroyl aminoacyl pyrroles pharmaceutically useful as agents and modulators for the treatment of central nervous system disorders and a method for the treatment of central nervous system disorders including, but not limited to, use of the compounds of the present invention as anticonvulsant agents and modulators, antiepileptic agents and modulators, neuroprotective agents and modulators, muscle relaxant agents and modulators and as agents and modulators for the treatment of neuropathic pain.

30. 发明授权

US06492387B2 Isoindolyl and isoquinolinyl aroyl pyrrole compounds 有权
标题翻译：异吲哚基和异喹啉基芳酰基吡咯化合物
公开(公告)号：US06492387B2
公开(公告)日：2002-12-10
申请号：US10015038
申请日：2001-12-11
申请人： John R. Carson , Philip M. Pitis
发明人： John R. Carson , Philip M. Pitis
IPC分类号： C07D40102
CPC分类号： C07D403/06 , C07D401/06
摘要： This invention is directed to isoindolyl and isoquinolinyl aroyl pyrrole compounds pharmaceutically useful as agents or modulators for the treatment of central nervous system disorders and methods for the treatment of central nervous system disorders.
摘要翻译：本发明涉及药学上可用作治疗中枢神经系统病症的药剂或调节剂的异吲哚基和异喹啉基芳酰基吡咯化合物以及治疗中枢神经系统疾病的方法。

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