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    • 21. 发明授权
    • Flat bed scanner system and method
    • 平床扫描仪系统及方法
    • US4424589A
    • 1984-01-03
    • US139463
    • 1980-04-11
    • E. Raymond ThomasLysle D. CahillWilliam W. MarshallLuke L. TalleyJohn A. LawsonBrian N. Wilcox
    • E. Raymond ThomasLysle D. CahillWilliam W. MarshallLuke L. TalleyJohn A. LawsonBrian N. Wilcox
    • G02B13/00G02B26/10G02B27/00G03F3/08H04N1/053H04N1/113H04N1/401G06K9/20H04N1/10
    • H04N1/113G02B26/10G02B27/0031H04N1/053H04N1/401H04N2201/0471H04N2201/04775
    • A flat bed scanner system for optically sensing a transparent original image and producing three channels of binary digital data representing the densities of the original image. Each channel produces data in response to one sensing color and sensing of the original image occurs by directing a focused image of a beam of white light onto and across the original image in a pattern of parallel scan lines there being a plurality of sensing positions along each scan line, and producing the digital output data in response to the modulated beam of light transmitted by the original image. There is an optical system which provides for the directing of the beam of white light across the original image and which directs the modulated beam onto sensors. The optical system includes color correction and field flattening of the beam of white light and provides a cylinder condenser lens for the modulated beam of white light. An electronic system receives signals from the sensors and converts them into the desired digital data through analog to digital and logarithmic conversion circuits, base line correction circuits and references compensation circuits. The electronic system also provides a sample clock signal synchronizing the locations of the sensing beam with the locations of the sample positions by way of an optical grating system. An electromechanical system is provided to maintain the optical system in focus from scan line to scan line on both the original image and the optical grating system.
    • 一种用于光学感测透明原始图像并产生表示原始图像的密度的三通道二进制数字数据的平板扫描器系统。 每个通道响应于一个感测颜色产生数据,并且通过以平行扫描线的图案将白光束的聚焦图像引导到原始图像上并跨越原始图像而发生原始图像的感测,其中沿着每个扫描线具有多个感测位置 扫描线,并且响应于由原始图像传输的调制光束产生数字输出数据。 存在一种光学系统,其提供将白光束定向穿过原始图像并将调制光束引导到传感器上。 光学系统包括白光束的颜色校正和场平坦化,并为调制的白光束提供气缸聚光透镜。 电子系统从传感器接收信号,并通过模数转换电路,基线校正电路和基准补偿电路将它们转换成所需的数字数据。 电子系统还提供采样时钟信号,通过光栅系统将感测光束的位置与采样位置的位置同步。 提供了一种机电系统,用于将原始图像和光栅系统上的光学系统保持在扫描线到扫描线的对焦状态。
    • 24. 发明授权
    • Treatment of chemical dependency with substantially nonaddicting normorphine and norcodeine derivatives
    • 治疗化学依赖性与基本上不接受的吗啡和norcodeine衍生物
    • US07629355B2
    • 2009-12-08
    • US10967098
    • 2004-10-14
    • John A. Lawson
    • John A. Lawson
    • A61K31/44
    • A61K31/44
    • A method is provided for treating a drug-dependent individual so as to effect withdrawal from a drug of abuse, e.g., an opiate such as heroin or oxycodone, a stimulant such as cocaine, or alcohol. The method involves substitution therapy wherein a substantially nonaddicting normorphine or norcodeine derivative is substituted for the drug of abuse. The active agent has the structure of formula (I) wherein: R is H, alkyl, or acyl; X is CH(OR′) or C═O, wherein R′ is H or acyl; α is an optional double bond, with the proviso that when α is present, then X is necessarily CH(OH), or an acid addition salt thereof, wherein preferred such agents are in a stereoisomerically pure form that corresponds to that of N-[(1R)-1-cyclopropylethyl]-normorphine (1) which melts at approximately 188° C.-189° C.
    • 提供了一种治疗依赖于药物的个体以便实现从滥用药物中撤出的方法,例如鸦片剂,例如海洛因或羟考酮,兴奋剂如可卡因或酒精。 该方法涉及替代疗法,其中基本上不可接受的吗啡或不可可食衍生物代替滥用药物。 活性剂具有式(I)的结构,其中:R为H,烷基或酰基; X是CH(OR')或C-O,其中R'是H或酰基; α是任选的双键,条件是当存在α时,则X必须是CH(OH)或其酸加成盐,其中优选的这样的试剂是立体异构体纯的形式,其对应于N- [ (1R)-1-环丙基乙基] - 吗啡(1),其在约188℃-189℃熔化