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21. 发明申请

WO2009085204A2 METHODS AND DEVICES FOR DETECTING, CONTROLLING, AND PREDICTING RADIATION DELIVERY 审中-公开
标题翻译：用于检测，控制和预测辐射传送的方法和装置
公开(公告)号：WO2009085204A2
公开(公告)日：2009-07-09
申请号：PCT/US2008013886
申请日：2008-12-18
申请人： ORAYA THERAPEUTICS INC , GERTNER MICHAEL , ARNOLDUSSEN MARK , CHELL ERIK , HANSEN STEVEN D , HERRON MATT , KORUGA IGOR , LIANG JUNZHONG
发明人： GERTNER MICHAEL , ARNOLDUSSEN MARK , CHELL ERIK , HANSEN STEVEN D , HERRON MATT , KORUGA IGOR , LIANG JUNZHONG
IPC分类号： A61F9/00 , A61N5/10
CPC分类号： A61N5/1067 , A61F9/008 , A61F2009/00844 , A61F2009/00863 , A61N5/1017 , A61N5/1049 , A61N2005/1059 , A61N2005/1072 , A61N2005/1091
摘要： Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina. Particular methods for controlling radiation in response to motion of the target during treatment are described, such as algorithms for gating or interrupting radiation emission, both to ensure treatment goals and to avoid exposure to sensitive structures.
摘要翻译：实施例提供了用于确定诸如眼睛的患者身体部位（例如眼睛）在诸如放射治疗装置的治疗或诊断装置的外部坐标系中的对准的方法和系统，以便限定用于引导装置操作的参考轴。另外的实施例提供了基于图像的方法和系统，用于相对于辐射束轴对准，跟踪和监测身体部位和治疗目标的运动。特别的眼科实施例提供了包括眼睛接触引导装置和成像系统的方法和系统，用于对准和跟踪眼睛和眼部治疗目标相对于正电压X射线束轴线的运动，以便监测辐射对病变的应用，如视网膜的黄斑病变。描述了在处理期间响应于靶的运动来控制辐射的特定方法，例如用于门控或中断辐射发射的算法，以确保治疗目标并避免暴露于敏感结构。

22. 发明申请

WO2008124801A2 ORTHOVOLTAGE RADIOSURGERY 审中-公开
标题翻译： ORTHOVOLTAGE放射外科
公开(公告)号：WO2008124801A2
公开(公告)日：2008-10-16
申请号：PCT/US2008/059808
申请日：2008-04-09
申请人： ORAYA THERAPEUTICS, INC. , GERTNER, Michael , HANSEN, Steven, D.
发明人： GERTNER, Michael , HANSEN, Steven, D.
IPC分类号： A61N5/10 , A61B5/00
CPC分类号： A61N5/1067 , A61B6/506 , A61B6/508 , A61N5/10 , A61N5/1001 , A61N5/1017 , A61N5/1045 , A61N5/1048 , A61N5/1049 , A61N5/1064 , A61N5/1065 , A61N5/1077 , A61N5/1084 , A61N2005/1019 , A61N2005/1022 , A61N2005/105 , A61N2005/1051 , A61N2005/1059 , A61N2005/1091 , A61N2005/1097
摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, an eye is held with force and in alignment with the system. In some embodiments, the device automatically turns off with excessive movement outside of alignment along an axis of the eye. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.
摘要翻译：描述了一种放射外科系统，其被配置为将治疗剂量的辐射递送至患者中的目标结构。在一些实施方案中，治疗炎性眼部病症，特别是黄斑变性。在一些实施方案中，用辐射剂量治疗身体的其他病症或组织。在一些实施例中，基于眼部成像将目标组织放置在全局坐标系统中。在一些实施例中，全局坐标系内的目标组织导致基于坐标系内的目标组织定向的自动定位系统的方向。在一些实施例中，利用治疗计划，其中针对待治疗的特定疾病和/或要避免的结构确定治疗的射束能量和方向以及持续时间。在一些实施例中，使用基准标记来识别目标组织的位置。在一些实施例中，用力保持眼睛并与系统对齐。在一些实施例中，该装置在眼睛的轴线对准之外以过度移动自动关闭。在一些实施例中，描述了放射动力学治疗，其中放射外科手术与其他治疗组合使用，并且可以伴随其他治疗，之前或之后递送。

23. 发明申请

WO2007109496A3 DEVICES AND METHODS FOR TARGETED NASAL PHOTOTHERAPY 审中-公开
标题翻译：靶向性鼻咽癌的装置和方法
公开(公告)号：WO2007109496A3
公开(公告)日：2008-02-21
申请号：PCT/US2007064048
申请日：2007-03-15
申请人： ALLUX MEDICAL INC , ROGERS ERICA , FLOM JAMES R , LECLERC NORBERT H , JOHNSON PETER L , GERTNER MICHAEL
发明人： ROGERS ERICA , FLOM JAMES R , LECLERC NORBERT H , JOHNSON PETER L , GERTNER MICHAEL
IPC分类号： A61N5/06
CPC分类号： A61N5/0603 , A61N2005/0607 , A61N2005/063 , A61N2005/0644 , A61N2005/0647 , A61N2005/0652 , A61N2005/0654 , A61N2005/0661
摘要： The invention is directed to therapy devices for providing therapeutic light to a target region of tissue within a nasal cavity. The devices are adapted to include a light source communicating with a distal end of the first insertion member, wherein light from the light source illuminates a target region of tissue within a nasal cavity posterior to a limen nasi of the nasal cavity, and further wherein the insertion member is configured to prevent illumination of a region of tissue anterior to the limen nasi. The devices are further adapted to be positioned within the nasal cavity by a user without observing the location of the distal tip.
摘要翻译：本发明涉及用于向鼻腔内的组织的靶区域提供治疗光的治疗装置。这些装置适于包括与第一插入构件的远端连通的光源，其中来自光源的光照射鼻腔后面的鼻腔内的组织的目标区域，并且其中，插入构件被构造成防止在所述跛行之前的组织区域的照射。所述装置还适于由用户定位在鼻腔内，而不观察远侧末端的位置。

24. 发明申请

WO2007106856A3 PHOTOTHERAPY DEVICE AND METHOD OF PROVIDING PHOTOTHERAPY TO A BODY SURFACE 审中-公开
标题翻译：摄影装置及向身体表面提供光泽的方法
公开(公告)号：WO2007106856A3
公开(公告)日：2008-02-07
申请号：PCT/US2007063979
申请日：2007-03-14
申请人： ALLUX MEDICAL INC , LECLERC NORBERT H , MORAN BRENDAN JUDE , FLOM JAMES R , GERTNER MICHAEL , PODMORE JONATHAN L , RODE MICHAEL , CROWE JOHN E , ROGERS ERICA
发明人： LECLERC NORBERT H , MORAN BRENDAN JUDE , FLOM JAMES R , GERTNER MICHAEL , PODMORE JONATHAN L , RODE MICHAEL , CROWE JOHN E , ROGERS ERICA
IPC分类号： A61N5/06
CPC分类号： A61N5/0616 , A61B2017/00026 , A61B2017/00057 , A61B2018/00642 , A61B2018/00702 , A61B2018/00785 , A61N5/062 , A61N2005/007 , A61N2005/0628 , A61N2005/063 , A61N2005/0645 , A61N2005/0652
摘要： A method and apparatus is described for treating a target body surface using a radiation applicator. The therapeutic treatment apparatus adapted to conform to a patients body. The treatment apparatus comprises a plurality of light sources coupled with a flexible substrate, a light integrator in at least a portion of the optical path between the light source and the patient's body surface, a power supply, and a controller.
摘要翻译：描述了使用辐射施加器来治疗目标体表的方法和装置。该治疗设备适于符合患者身体。处理装置包括与柔性基板耦合的多个光源，在光源和患者体表之间的光路的至少一部分中的光积分器，电源和控制器。

25. 发明申请

WO2007145638A1 MEDICAL DEVICES WITH INTEGRAL MAGNETS AND USES THEREOF 审中-公开
标题翻译：具有整体磁铁的医疗器械及其用途
公开(公告)号：WO2007145638A1
公开(公告)日：2007-12-21
申请号：PCT/US2006/023743
申请日：2006-06-16
申请人： GERTNER, Michael
发明人： GERTNER, Michael
IPC分类号： A61B5/05
CPC分类号： A61M25/0158 , A61B34/70 , A61B34/73 , A61M25/0127
摘要： In one embodiment, an elongate body with a proximal end and a distal end is disclosed and which is controllable by an operator at the proximal end; in one embodiment, the elongate body is a catheter and the catheter tip is located at the distal end. The body contains numerous magnets along its length, at least one of which is an electromagnet, controllable by means of a current delivered by the operator of the body at the proximal end of the body. The magnets are placed such that a force is created at the distal end of the elongate body. The magnetic forces which control the distal end of the body originate from the controllable magnets placed on the body.
摘要翻译：在一个实施例中，公开了具有近端和远端的细长主体，并且其可由近端的操作者控制; 在一个实施例中，细长主体是导管，并且导管尖端位于远端。身体沿其长度包含许多磁体，其中至少一个是电磁体，可通过身体操作者在身体的近端传递的电流来控制。磁体被放置成使得在细长体的远端产生力。控制身体远端的磁力源于放置在身体上的可控磁体。

26. 发明申请

WO2007114905A2 PERICARDIAL INSERTS AND METHODS OF USE 审中-公开
标题翻译： PERICARDIAL插入物和使用方法
公开(公告)号：WO2007114905A2
公开(公告)日：2007-10-11
申请号：PCT/US2007008184
申请日：2007-03-30
申请人： GEM BIOSYSTEMS INC , GERTNER MICHAEL
发明人： GERTNER MICHAEL
IPC分类号： G06T7/20
CPC分类号： A61F2/2481 , A61N1/0587 , A61N1/3627
摘要： Devices, systems and methods are provided which are capable of applying pressure and constraint to the heart and use the pericardium to assist in the application of the pressure and force to the heart.
摘要翻译：提供的装置，系统和方法能够对心脏施加压力和约束，并且使用心包来帮助将心脏施加压力和力。

27. 发明申请

WO2007067206A3 OBESITY TREATMENT SYSTEMS 审中-公开
公开(公告)号：WO2007067206A3
公开(公告)日：2007-06-14
申请号：PCT/US2006/015881
申请日：2006-04-26
申请人： GERTNER, Michael
发明人： GERTNER, Michael
IPC分类号： A61F2/00 , A61F2/02 , A61B5/00 , A61N1/00 , A61K9/22
摘要： In one embodiment, a pressure sensing system is described which transmits data to a patient management system external to a patient. The pressure sensing system can rigidly couple to an implantable port or flexibly couple to an implantable port. In some embodiments, the pressure sensing system communicates with a hydraulic actuating system. In some embodiments, the pressure sensing system is implantable and comprises a circuit capable of wireless transmission through the skin of a patient to an external receiver which is part of a patient management system. A patient management system is described which receives up to date as well as historical data form the pressure sensing system and manages the data in the context of a patient database.

28. 发明申请

WO2005094447A3 DEVICES AND METHODS TO TREAT A PATIENT 审中-公开
标题翻译：用于治疗患者的装置和方法
公开(公告)号：WO2005094447A3
公开(公告)日：2007-03-01
申请号：PCT/US2005009322
申请日：2005-03-19
申请人： MINIMUS SURGICAL SYSTEMS INC , GERTNER MICHAEL , BROMMER ROBERT , SHEEHAN NEIL
发明人： GERTNER MICHAEL , BROMMER ROBERT , SHEEHAN NEIL
IPC分类号： A61F2/00 , A61B17/00 , A61B17/04 , A61B17/06 , A61B17/08 , A61B17/28 , A61F5/00
CPC分类号： A61B17/0401 , A61B17/00234 , A61B17/0469 , A61B17/0487 , A61B17/29 , A61B2017/00398 , A61B2017/00827 , A61B2017/00871 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0445 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0464 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61F5/0076 , A61F5/0086
摘要： Disclosed are methods and apparatus for implantation into the walls or an organ such as the stomach. Deformable or inflatable anchors with a connector between are used to pull the walls of the organ together, or to implant devices in the wall of the organ. Also disclosed are surgical instruments useful in practicing the disclosed methods.
摘要翻译：公开了用于植入壁或诸如胃的器官的方法和装置。具有连接器的可变形或可充气的锚固件用于将器官的壁拉到一起，或将器械植入器官壁。还公开了可用于实践所公开的方法的外科器械。

29. 发明申请

WO2006099413A2 DEVICES, METHODS AND KITS FOR RADIATION TREATMENT VIA A TARGET BODY SURFACE 审中-公开
标题翻译：用于通过目标身体表面进行辐射治疗的装置，方法和工具
公开(公告)号：WO2006099413A2
公开(公告)日：2006-09-21
申请号：PCT/US2006009122
申请日：2006-03-14
申请人： ALLUX MEDICAL INC , GERTNER MICHAEL , ROGERS ERICA
发明人： GERTNER MICHAEL , ROGERS ERICA
IPC分类号： A61H33/00
CPC分类号： A61N5/0616 , A61N2005/0645 , A61N2005/0652 , A61N2005/0661
摘要： A method and apparatus is described for treating a target body surface using a radiation applicator. The radiation applicator includes a radiation source in combination with a delivery applicator. The applicator has a low profile enable the patient to apply the applicator to a target area underneath, for example, clothing. The applicator can be configured to use one or more radiation sources to apply one or more types of radiation for one or more periods of time. Additionally, the applicator can be configured with a feedback loop to determine when a therapeutically desirable amount of radiation has been delivered.
摘要翻译：描述了使用辐射施加器来治疗目标体表的方法和装置。辐射施加器包括与输送施用器组合的辐射源。施用器具有低的轮廓，使得患者能够将施用器施加到下方的目标区域，例如衣服。施用器可以被配置为使用一个或多个辐射源将一种或多种类型的辐射施加一个或多个时间段。另外，施用器可以配置有反馈回路，以确定治疗期望量的辐射何时已被输送。

30. 发明申请

WO2008118198A3 OCULAR RADIOSURGERY 审中-公开
标题翻译：眼科放射科医师
公开(公告)号：WO2008118198A3
公开(公告)日：2009-02-19
申请号：PCT/US2007081569
申请日：2007-10-16
申请人： ORAYA THERAPEUTICS INC , GERTNER MICHAEL
发明人： GERTNER MICHAEL
IPC分类号： A61N5/10 , A61B5/00
CPC分类号： A61N5/1049 , A61B6/506 , A61B2017/306 , A61F9/009 , A61N5/1017 , A61N5/103 , A61N2005/105 , A61N2005/1056 , A61N2005/1091
摘要： A radiosurgery system describes a therapeutic radiation delivery to a target structure in a patient. The radiosurgery system treats inflammatory ocular disorders; places ocular structures in a global coordinate system based on ocular imaging; automates ocular structures inside the global coordinate system to direction of a positioning system that is directed based on ocular structures within the coordinate system; tracks and relates the position of ocular structures to the status of the radiosurgery system; determines beam energy and direction and duration of time for treatment for a specific disease to be treated and/or structures to be avoided; tracks structure of an eye; holds and fixes the eye is in place; places a fiducial is on the eye to aid in positioning; positions the eye off the refelction; and combines with other treatments and can be delivered concomitant with, prior to, or following other treatments.
摘要翻译：放射外科系统描述了对患者的靶结构的治疗性辐射递送。放射外科系统治疗炎症性眼部疾病; 将眼部结构置于基于眼睛成像的全局坐标系中; 将全局坐标系内的眼结构自动化到基于坐标系内眼睛结构的定位系统的方向; 跟踪并将眼部结构的位置与放射外科手术系统的状态相关联; 确定要治疗的特定疾病和/或要避免的结构的束能量和治疗时间的方向和持续时间; 轨道结构的眼睛; 保持和修复眼睛到位; 放置基准在眼睛上帮助定位; 将眼睛放在反光面上; 并结合其他治疗方法，并可在其他治疗之前，之前或之后进行交付。

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