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21. 发明申请

WO2006082448A1 ASSAYS FOR AGENTS WITH SELECTIVE CYTOTOXICTY TO HDAC RESISTANT CELL LINES 审中-公开
标题翻译：具有选择性细胞毒性的药物对HDAC耐药细胞系的测定
公开(公告)号：WO2006082448A1
公开(公告)日：2006-08-10
申请号：PCT/GB2006/000425
申请日：2006-02-06
申请人： TOPOTARGET UK LIMITED , NIELSEN, Torsten , EDWARDS, Nicholas , SEHESTED, Maxwell
发明人： NIELSEN, Torsten , EDWARDS, Nicholas , SEHESTED, Maxwell
IPC分类号： G01N33/50
CPC分类号： G01N33/5011
摘要： This invention relates to a method of identifying and/or obtaining an agent which is selectively cytotoxic to histone deacetylase inhibitor (HDACi) resistant cells, said method comprising the steps of: a) incubating HDACi resistant cells and HDACi sensitive cells with a test agent, b) determining the cytotoxicity of the test agent for said HDACi resistant cells and the cytotoxicity of the test agent for said HDACi sensitive cells, wherein an increase in cytoxicity of the test agent for said HDACi resistant cells relative to said HDACi sensitive cells is indicative that the test agent is an agent which is selectively cytotoxic to HDACi resistant cells. The invention is based on the recognition that cells which are resistant to inhibitors of histone deacetylases (HDACis) such as PXD101 are hypersensitized to certain anti-cancer agents.
摘要翻译：本发明涉及鉴定和/或获得对组蛋白脱乙酰酶抑制剂（HDACi）抗性细胞选择性细胞毒性的试剂的方法，所述方法包括以下步骤：a）用测试试剂培养HDACi抗性细胞和HDACi敏感细胞， b）确定所述测试剂对所述HDACi抗性细胞的细胞毒性和所述测试剂对所述HDACi敏感细胞的细胞毒性，其中所述HDACi抗性细胞相对于所述HDACi敏感细胞的测试剂的细胞毒性的增加表明测试剂是对HDACi抗性细胞选择性细胞毒性的药剂。本发明是基于认识到对组蛋白脱乙酰酶（HDACis）如PXD101的抑制剂具有抗性的细胞对某些抗癌剂过敏。

22. 发明申请

WO2003081548A1 TRANSACTION AUTHENTICATION 审中-公开
标题翻译：交易认证
公开(公告)号：WO2003081548A1
公开(公告)日：2003-10-02
申请号：PCT/GB2003/001137
申请日：2003-03-18
申请人： BRITISH TELECOMMUNICATIONS PUBLIC LIMITED COMPANY , EDWARDS, Nicholas, Hector , CHAPMAN, James, Christopher, Tydd , GIFFORD, Maurice, Merrick
发明人： EDWARDS, Nicholas, Hector , CHAPMAN, James, Christopher, Tydd , GIFFORD, Maurice, Merrick
IPC分类号： G07F19/00
CPC分类号： G06Q20/16 , G06Q20/04 , G06Q20/10 , G06Q20/20 , G06Q20/32
摘要： In a transaction authorisation arrangement a sales point (1) (an electronic point of sale device or a vending machine, for example) communicates with a transaction application (2) transmitting thereto a transaction value. The telephony platform (3) reserves one of a series of premium rate numbers (5) which can be dialled up by a mobile telephone user to authorise the charging of the transaction against the telephone bill. When a call is received at the premium rate number the telephony platform notifies the transaction application which then authorises the sale.
摘要翻译：在交易授权安排中，销售点（1）（例如，电子销售点设备或自动售货机）与向其传送交易值的交易应用程序（2）进行通信。电话平台（3）保留了一系列附加费率数字（5），可由移动电话用户拨打电话号码，以授权对电话费用进行交易。当按照保费率号码收到呼叫时，电话平台通知交易应用程序，然后授权销售。

23. 发明申请

WO2005096117A1 TRUST TOKENS 审中-公开
标题翻译：信托TOKENS
公开(公告)号：WO2005096117A1
公开(公告)日：2005-10-13
申请号：PCT/GB2005/001064
申请日：2005-03-21
申请人： BRITISH TELECOMMUNICATIONS PUBLIC LIMITED COMPANY , GIFFORD, Maurice, Merrick , EDWARDS, Nicholas, Hector , KEARNEY, Paul, Joseph
发明人： GIFFORD, Maurice, Merrick , EDWARDS, Nicholas, Hector , KEARNEY, Paul, Joseph
IPC分类号： G06F1/00
CPC分类号： G06F21/34 , G06F21/32 , G06F2221/2113 , G06F2221/2137 , G06Q20/4014
摘要： An identity confirmation device comprises a token issuer 4 and an authentication device 5, the token issuer being programmable by a central identity provider 2 to issue certification tokens for use in e-commerce whereby transactions can be certified with suppliers without need for additional communication with a central server.
摘要翻译：身份确认设备包括令牌发行者4和认证设备5，令牌发行者可由中央身份提供商2编程，以发行用于电子商务的认证令牌，其中交易可以被供应商认证，而不需要与中央服务器。

24. 发明申请

WO0237241A3 TRANSACTION AUTHENTICATION 审中-公开
标题翻译：交易认证
公开(公告)号：WO0237241A3
公开(公告)日：2003-09-18
申请号：PCT/GB0104836
申请日：2001-11-01
申请人： BRITISH TELECOMM , YATES MARTIN JOHN , THOMPSON STEPHEN MICHAEL , EDWARDS NICHOLAS HECTOR , GIFFORD MAURICE MERRICK , MCCARTNEY DAVID JOHN
发明人： YATES MARTIN JOHN , THOMPSON STEPHEN MICHAEL , EDWARDS NICHOLAS HECTOR , GIFFORD MAURICE MERRICK , MCCARTNEY DAVID JOHN
IPC分类号： G06F1/00 , G06F19/00 , G06F21/42 , G06F21/43 , G06Q20/00
CPC分类号： G06F21/42 , G06F21/43 , G06Q20/02 , G06Q20/04 , G06Q20/102 , G06Q20/12 , G06Q20/20 , G06Q20/425 , G06Q30/0601 , H04L63/083 , H04L63/18
摘要： In a payment validation system, a mobile phone or other communications terminal associated with a particular user is used. A vending node communicates with a validation platform which either returns a telephone number to be displayed for the user to call or which calls the alleged users phone or terminal for confirmation.
摘要翻译：在支付确认系统中，使用与特定用户相关联的移动电话或其他通信终端。售货节点与验证平台进行通信，该验证平台返回要显示的电话号码以供用户呼叫，或者呼叫被指称的用户电话或终端进行确认。

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