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21. 发明申请

US20030074035A1 System and method for telemetry of analog and digital data 有权
标题翻译：模拟和数字数据遥测的系统和方法
公开(公告)号：US20030074035A1
公开(公告)日：2003-04-17
申请号：US09968644
申请日：2001-10-01
申请人： Data Sciences International, Inc
发明人： Reid Bornhoft , Brian P. Brockway , Matt Kunz , Gregg Lichtscheidl , Brock Lindstedt , Perry A. Mills
IPC分类号： A61N001/08
CPC分类号： H04L25/493 , A61B5/07 , G08C19/24 , H04B14/026 , H04L25/4902
摘要： A system and method involve transceiving successive first and second synchronization signals defining endpoints of a frame. A digital signal is transceived by a modulating time interval between portions of the first and second synchronization signals. A first data pulse is transceived during the frame. A relative position in the frame of the first data pulse represents a first analog signal.
摘要翻译：系统和方法涉及收发定义帧的端点的连续的第一和第二同步信号。数字信号通过第一和第二同步信号的部分之间的调制时间间隔收发。在帧期间收发第一个数据脉冲。第一数据脉冲的帧中的相对位置表示第一模拟信号。

22. 发明申请

US20020072731A1 Adjustable flow probe 有权
标题翻译：可调式流量探头
公开(公告)号：US20020072731A1
公开(公告)日：2002-06-13
申请号：US09735378
申请日：2000-12-12
申请人： Data Sciences International, Inc.
发明人： Gregory P. Doten , Thomas A. Tedham , Brian P. Brockway
IPC分类号： A61M025/16
CPC分类号： A61B5/6876 , A61B5/6884 , A61B8/06 , A61B8/12
摘要： A flow probe has been described which includes a sensor housing and a coupling member. The sensor housing with one or more sensors mated together with the coupling member form the flow probe. The sensor housing accepts a variety of different sized coupling members to form flow probes of different sizes. The sensor housing is adapted to house one or more transducers. Additionally, a version of the flow probe includes strategically located positioning elements for ease in placement and retrieval of the flow probe.
摘要翻译：已经描述了包括传感器壳体和联接构件的流量探针。具有一个或多个传感器的传感器壳体与联接构件配合在一起形成流量探针。传感器壳体接受各种不同尺寸的联接构件，以形成不同尺寸的流量探头。传感器壳体适于容纳一个或多个换能器。此外，流量探头的一个版本包括有策略地定位的定位元件，便于放置和取回流量探针。

23. 发明申请

US20020058875A1 Respiration monitoring system based on sensed physiological parameters 有权
标题翻译：基于感觉生理参数的呼吸监测系统
公开(公告)号：US20020058875A1
公开(公告)日：2002-05-16
申请号：US10041823
申请日：2001-10-29
申请人： Data Sciences International, Inc.
发明人： Gregory P. Doten , Brian P. Brockway , Robert V. Brockway , Richard A. Fundakowski
IPC分类号： A61B005/02 , A61B005/08
CPC分类号： A61B5/021 , A61B5/02108 , A61B5/0816 , G06F19/00
摘要： A system and method obtains a respiration parameter of an animal or human, such as respiratory rate, from a blood pressure, volumetric blood flow, blood velocity or stroke volume signal from a sensor for the animal or human. Specifically, the signal is processed to develop an amplitude versus time waveform. A sequence of selected features derived from individual cardiac cycles of the amplitude versus time waveform over a selected time interval are extracted from the developed amplitude versus time waveform. A mathematical model is fitted to the extracted sequence of selected features to yield a fitted mathematical model. The physiologic parameter information is computed from the fitted mathematical model.
摘要翻译：系统和方法从动物或人的传感器的血压，体积血流量，血液速度或行程体积信号中获得动物或人的呼吸参数，例如呼吸频率。具体地，处理信号以产生幅度对时间波形。从所开发的振幅对时间波形中提取从所选择的时间间隔内的幅度对时间波形的各个心脏周期导出的所选特征序列。将数学模型拟合到所选特征的提取序列以产生拟合的数学模型。从拟合数学模型计算生理参数信息。

24. 发明申请

US20210321677A1 SYSTEMS AND METHODS FOR TESTING ONE OR MORE SMOKING ARTICLES 有权
公开(公告)号：US20210321677A1
公开(公告)日：2021-10-21
申请号：US17235044
申请日：2021-04-20
申请人： Data Sciences International Inc.
发明人： Aaron Benjamin , Justin R. Van Hee , Craig V. Aardahl
IPC分类号： A24F40/80 , A24F40/40
摘要： This specification generally discloses a system and method configured to generate vapor samples from one or more smoking articles (e.g., cigarette, tobacco product, e-cigarette, or nicotine vapor product), in which such vapor sample may optionally be used for testing purposes. The system may be configured in a manner that reduces the likelihood of exposing particular mechanical components to the smoking article vapor, which may in turn reduce effects of fouling or corroding such components of the system over a period time.

25. 发明申请

US20130303931A1 RESPIRATION MEASUREMENTS AND DOSIMETRY CONTROL IN INHALATION TESTING SYSTEMS 审中-公开
标题翻译：吸入测试系统中的呼吸测量和剂量控制
公开(公告)号：US20130303931A1
公开(公告)日：2013-11-14
申请号：US13923751
申请日：2013-06-21
申请人： Data Sciences International, Inc.
发明人： Paul A. Haefner , Loell Boyce Moon , Steve Hachtman , Scott R. Tiesma , Gary Pritchard
IPC分类号： A61B5/091 , A61M31/00
CPC分类号： A61B5/091 , A61B5/085 , A61M31/00
摘要： Inhalation measurement systems and methods enable, during inhalant exposure, substantially real-time respiratory measurements of a test subject using techniques that obtain measurements of respiration directly from that test subject, instead of from inhalation chamber parameter measurements. Direct test subject respiratory measurements may be, by way of example only, impedance measurements. These respiratory measurements taken directly from the test subject may be transmitted, wirelessly for example, for processing during the course of the test to a processing system to determine a cumulative volume of inhalant inspired by the test subject. From that, a cumulative amount of inhalant (or dose) inspired by the test subject may be determined during the course of the inhalation compound test. In addition, a calibration procedure may be performed before the inhalant exposure to provide correlation needed to translate chest and/or abdominal wall expansion measurements, made during the test, into lung volume measurements.
摘要翻译：吸入测量系统和方法在吸入式暴露过程中可以使用直接从该测试对象而不是从吸入室参数测量获得呼吸测量值的技术，使测试对象基本上实时呼吸测量。直接测试对象呼吸测量可能仅作为示例，阻抗测量。直接从测试对象取得的这些呼吸测量可以以无线方式传送，例如用于在测试过程中进行处理以处理系统以确定由测试对象启发的吸入剂的累积体积。由此可以在吸入化合物测试过程中确定受试者启发的吸入剂（或剂量）的累积量。此外，可以在吸入剂暴露之前进行校准程序，以提供在测试期间将胸部和/或腹壁扩张测量值转换成肺容量测量所需的相关性。

26. 发明申请

US20020111393A1 Biocompatible medical devices with polyurethane surface 有权
标题翻译：具有聚氨酯表面的生物相容性医疗器械
公开(公告)号：US20020111393A1
公开(公告)日：2002-08-15
申请号：US09962727
申请日：2001-09-25
申请人： Data Sciences International, Inc.
发明人： Gregory Jay DelMain
IPC分类号： A01N001/00 , A61M029/00
CPC分类号： C08J7/02 , A61L29/06 , A61L33/068 , C08J2375/04 , C08L75/04
摘要： The present invention provides a method for improving the bio-compatibility of devices, especially medical devices which are invasively present within a patient's body and the improved medical device. The present invention particularly reduces the thrombogenicity of polyurethane materials in contact with the blood of a living patient. The method comprises providing a bio-compatible medical device having polymeric polyurethane components thereon, exposing the polyurethane components of the medical device to polar solvents for said polymeric components while the polar solvents are in the vapor phase, and allowing said vapor phase exposure to continue for a sufficient amount of time as to reduce at least some irregular or sharp features on the surface of the polymeric component. The invention describes a method of improving a medical device having at least one polymeric component, the process comprising the steps of providing a vapor phase comprising a solvent for said polymer component, and exposing said polymeric component to said vapor phase. The process comprises taking a polyurethane component having a surface with a topography (e.g., roughness, grooves, wave patterns, sharp edge features, deviations from planarity and the like), and exposing the polyurethane component to said vapor phase to increase planarity in said topography. This is done without chemical reaction with the polymer component, and because of the control of the amount of solvent which can contact the polymer, the potential for damage to the polymeric component is reduced. In particular, the vapor phase treatment will reduce the dimensions of extrusion markings on the exterior surface of the polyurethane with minimum potential for damage to the structure of the polyurethane, even where the polyurethane is present as thin walls (e.g., less than 0.0762 mm).
摘要翻译：本发明提供一种用于改善设备的生物相容性的方法，特别是医疗设备，其侵入地存在于患者体内和改进的医疗设备中。本发明特别降低与活体患者的血液接触的聚氨酯材料的血栓形成。该方法包括在其上提供具有聚合物聚氨酯组分的生物相容性医疗装置，将所述医疗装置的聚氨酯组分暴露于所述聚合物组分的极性溶剂，同时极性溶剂处于气相中，并允许所述气相暴露持续足够的时间来减少聚合物组分表面上的至少一些不规则或尖锐的特征。本发明描述了改进具有至少一种聚合物组分的医疗装置的方法，该方法包括以下步骤：提供包含所述聚合物组分的溶剂的气相，并将所述聚合物组分暴露于所述气相。该方法包括使具有表面的聚氨酯组分具有形貌（例如，粗糙度，凹槽，波形图案，尖锐边缘特征，与平面度偏差等），并将聚氨酯组分暴露于所述气相以增加所述形貌中的平面度。这完成了与聚合物组分的化学反应，并且由于可以控制可以与聚合物接触的溶剂的量，所以降低了对聚合物组分的损害的可能性。特别地，气相处理将减小聚氨酯外表面上挤出标记的尺寸，即使在聚氨酯以薄壁（例如，小于0.0762mm）存在聚氨酯的结构的情况下，也可能损坏聚氨酯的结构，。

27. 发明申请

US20020065472A1 Catheter with physiological sensor 有权
标题翻译：导管与生理传感器
公开(公告)号：US20020065472A1
公开(公告)日：2002-05-30
申请号：US09825130
申请日：2001-04-03
申请人： Data Sciences International, Inc.
发明人： Brian P. Brockway , Lynn M. Zwiers , Perry A. Mills , Mark J. Drexler
IPC分类号： A61B005/02
CPC分类号： A61B5/036 , A61B5/042
摘要： The disclosed embodiments present improved catheters with physiological sensors. In one embodiment, the catheter includes, generally, a pressure transducer/electronics assembly connected to a pressure transmission catheter. The pressure transmission catheter includes a hollow tube made from a low compliance material. The distal end of the hollow tube is filled with a gel-like material or plug which acts as a barrier between the catheter liquid and the target fluid. The hollow tube is partially filled with a low viscosity liquid and is in fluid communication with the gel-like material and the pressure transducer. The pressure of the target fluid is transmitted to the liquid in the hollow tube through the gel-like material and/or the wall of the distal tip and is fluidically transmitted to the pressure transducer. The pressure transmission catheter is capable of being inserted into a vessel lumen or inserted into a lumen of a therapeutic or diagnostic catheter for biomedical applications. This provides the ability to directly measure the pressure effects of the treatment catheter. In another embodiment, the distal end of the pressure transmission catheter may be electrically conductive so as to detect and transmit an electric signal. Thus, in this embodiment, the catheter can be used to detect a physiological signal.
摘要翻译：所公开的实施例使用生理传感器呈现改进的导管。在一个实施例中，导管通常包括连接到压力传递导管的压力换能器/电子组件。压力传递导管包括由低顺应性材料制成的中空管。中空管的远端填充有凝胶状材料或塞子，其作为导管液体和目标流体之间的屏障。中空管部分地填充有低粘度液体并与凝胶状材料和压力传感器流体连通。目标流体的压力通过凝胶状材料和/或远侧末端的壁传递到中空管中的液体，并且被流体传递到压力传感器。压力传递导管能够插入血管内腔或插入用于生物医学应用的治疗或诊断导管的内腔中。这提供了直接测量治疗导管的压力作用的能力。在另一个实施例中，压力传输导管的远端可以是导电的，以便检测和传输电信号。因此，在本实施例中，导管可用于检测生理信号。

28. 发明公开

US20230263610A1 INHALATION EXPOSURE SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20230263610A1
公开(公告)日：2023-08-24
申请号：US18113441
申请日：2023-02-23
申请人： Data Sciences International Inc.
发明人： UV Shemesh , Michael Tyler
IPC分类号： A61D7/00 , A61D99/00
CPC分类号： A61D7/00 , A61D99/00
摘要： Some embodiments of an inhalation exposure system can deliver a gas, such as an aerosol, to a set of exposure chambers in a controlled manner and can monitor one or more characteristics of the gas at a variety of aerosol delivery rates for output to a user interface. In some implementations, the improved user interface of the system may alert the user to a fitting range of aerosol delivery rates.

29. 发明申请

US20020082506A1 Respiration monitoring system based on sensed blood pressure variations 有权
标题翻译：基于感测血压变化的呼吸监测系统
公开(公告)号：US20020082506A1
公开(公告)日：2002-06-27
申请号：US09927588
申请日：2001-08-10
申请人： Data Sciences International, Inc.
发明人： Brian P. Brockway , Robert V. Brockway , Richard A. Fundakowski
IPC分类号： A61B005/00
CPC分类号： A61B5/0816 , A61B5/021 , A61B5/02108 , A61B5/7239 , G06F19/00
摘要： A system and method obtains physiologic parameter information of an animal or human, such as respiratory rate, from a blood pressure signal from an implanted blood pressure sensor in the animal or human. Specifically, the blood pressure signal is externally signal processed to develop an amplitude versus time waveform. A sequence of selected blood pressure features derived from individual cardiac cycles of the amplitude versus time waveform over a selected time interval are extracted from the developed amplitude versus time waveform. A mathematical model is fitted to the extracted sequence of selected blood pressure features to yield a fitted mathematical model. The physiologic parameter information is computed from the fitted mathematical model.
摘要翻译：系统和方法从动物或人体内植入的血压传感器的血压信号获得动物或人的生理参数信息，例如呼吸频率。具体地说，将血压信号从外部进行信号处理，以产生振幅对时间波形。从所开发的振幅对时间波形中提取从所选择的时间间隔内的幅度对时间波形的各个心脏周期导出的选定血压特征的序列。将数学模型拟合到所选择的血压特征的提取序列以产生拟合的数学模型。从拟合数学模型计算生理参数信息。

30. 发明授权

EP0417171B1 A DEVICE FOR CHRONIC MEASUREMENT OF INTERNAL BODY PRESSURE 有权转让
标题翻译：安排心身压力的持续测量。
公开(公告)号：EP0417171B1
公开(公告)日：1995-08-02
申请号：EP89906622.9
申请日：1989-05-17
申请人： Data Sciences International, Inc.
发明人： BROCKWAY, Brian, P. , MILLS, Perry, A. , MILLER, Jonathan, T.
IPC分类号： A61B5/00
CPC分类号： G01L19/141 , A61B5/0031 , A61B5/0215 , A61B5/03 , A61B5/6882 , G01L19/0061 , G01L19/0084 , G01L19/147 , H01L2224/48091 , H01L2924/16152 , Y10S128/903 , H01L2924/00014
摘要： Measurement of a physiological pressure is accomplished by placement of a pressure transmitting catheter (20) within a blood vessel or other structure within which pressure is to be measured. The catheter (20) is blood-compatible, capable of withstanding handling during distribution and implantation, and provides adequate pressure transmission frequency response in a variety of applications. The catheter (20), which includes a hollow tube filled with a low viscosity fluid (29) and having a plug (30) of a gel-like material at its distal end (22), transmits the pressure signal to a solid-state transducer (16) which is typically connected to amplifying electronics and an implantable radio-transmitter (18) capable of relaying the pressure information from within the body to a radio receiver external to the body.

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