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    • 22. 发明授权
    • Diphenyl ether compounds useful in therapy
    • 用于治疗的二苯醚化合物
    • US06448293B1
    • 2002-09-10
    • US09810378
    • 2001-03-16
    • Mark David AndrewsDavid HepworthDonald Stuart MiddletonAlan Stobie
    • Mark David AndrewsDavid HepworthDonald Stuart MiddletonAlan Stobie
    • C07C21758
    • C07D231/38C07C45/71C07C47/55C07C47/575C07C205/44C07C217/58C07C229/38C07C237/28C07C255/43C07C255/59C07C311/05C07C311/08C07C311/37C07C317/32C07C323/20C07C323/32C07C323/67C07C2601/02C07C2601/08C07D231/12C07D233/56C07D249/06C07D249/08C07D295/096C07D295/192
    • A compound of general formula (I), or pharmaceutically acceptable salts, solvates or polymorphs thereof; wherein; R1 and R2, which may be the same or different, are hydrogen, C1-C6alkyl, (CH2)m (C3-C6cycloalkyl) wherein m =0, 1, 2 or 3, or R1 and R2 together with the nitrogen to which they are attached form an azetidine ring; each R3 is independently CF3, OCF3, C1-4alkylthio or C1-C4alkoxy; n is 1, 2 or 3; and R4 and R5, which may be the same or different, are: A—X, wherein A =—CH=CH— or —(CH2)p— where p is 0, 1 or 2; X is hydrogen, F, Cl, Br, I, CONR6R7, SO2NR6R7, SO2NHC(=O)R6, OH, C1-4alkoxy, NR8SO2R9, NO2, NR6R11, CN, CO2R10, CHO, SR10, S(O)R9 or SO2R10; R6, R7, R8 and R10 which may be the same or different, are hydrogen or C1-6alkyl optionally substituted independently by one or more R12; R9 is C1-6 alkyl optionally substituted independently by one or more R12; R11 is hydrogen, C1-6 alkyl optionally substituted independently by one or more R12, C(O)R6, CO2R9, C(O)NHR6 or SO2NR6R7; R12 is F, OH, CO2H, C3-6cycloalkyl, NH2, CONH2, C1-6alkoxy, C1-6alkoxycarbonyl or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O optionally substituted independently by one or more R13; or R6 and R7, together with the nitrogen to which they are attached, form a 4-, 5- or 6-membered heterocyclic ring optionally substituted independently by one or more R13; or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O, optionally substituted independently by one or more R13; wherein R13 is hydroxy, C1-C4alkoxy, F, C1-C6alkyl, haloalkyl, haloalkoxy, —NH2, —NH(C1-C6alkyl) or —N(C1-C6alkyl)2; wherein when R1 and R2 are methyl, R4 and R5 are hydrogen and n is 1, R3is not a —SMe group para to the ether linkage linking rings A and B.
    • 通式(I)的化合物或其药学上可接受的盐,溶剂化物或多晶型物; 其中; R 1和R 2可以相同或不同,为氢,C 1 -C 6烷基,(CH 2)m(C 3 -C 6环烷基),其中m = 0,1,2或3,或R 1和R 2与它们 连接形成氮杂环丁烷环; 每个R 3独立地为CF 3,OCF 3,C 1-4烷硫基或C 1 -C 4烷氧基; n为1,2或3; 并且R 4和R 5可以相同或不同,为:A-X,其中A = -CH = CH-或 - (CH 2)p - ,其中p为0,1或2; X是氢,F,Cl,Br,I,CONR6R7,SO2NR6R7,SO2NHC(= O)R6,OH,C1-4烷氧基,NR8SO2R9,NO2,NR6R11,CN,CO2R10,CHO,SR10,S(O)R9或SO2R10 ; R 6,R 7,R 8和R 10可以相同或不同,是氢或被一个或多个R 12独立地取代的C 1-6烷基; R9是任选被一个或多个R 12独立地取代的C 1-6烷基; R 11是氢,任选地被一个或多个R 12,C(O)R 6,CO 2 R 9,C(O)NHR 6或SO 2 NR 6 R 7取代的C 1-6烷基; R 12是F,OH,CO 2 H,C 3-6环烷基,NH 2,CONH 2,C 1-6烷氧基,C
    • 23. 发明授权
    • Dihydropyran derivatives as viral neuraminidase inhibitors
    • 二氢吡喃衍生物作为病毒神经氨酸酶抑制剂
    • US5919819A
    • 1999-07-06
    • US000149
    • 1998-09-14
    • David AndrewsPaul JonesDavid Humber
    • David AndrewsPaul JonesDavid Humber
    • A61K31/00A61K31/35A61K31/351A61P31/00C07D309/28C07D315/00
    • C07D309/28
    • Compounds of formula (I), wherein R.sup.1 represents NR.sup.5 R.sup.6, wherein R.sup.5 represents H or a hydrocarbon group optionally substituted by one or more of Br, Cl, F, I, CF.sub.3, NR.sup.7 R.sup.8, CO.sub.2 R.sup.9, CONR.sup.7 R.sup.8, COR.sup.9, OR.sup.10 or SR.sup.10, or a heteroaromatic group; and R.sup.6 represents a hydrocarbon group optionally substituted by one or more of Br, Cl, F, I, CF.sub.3, NR.sup.7 R.sup.8, CO.sub.2 R.sup.9, CONR.sup.7 R.sup.8, COR.sup.9, OR.sup.10 or SR.sup.10, or a heteroaromatic group; R.sup.2 represents a group SO.sub.2 R.sup.9 or COR.sup.9 ; R.sup.3 represents H, C.sub.1-6 -alkyl or C(=NR.sup.11)NR.sup.12 R.sup.13 ; R.sup.4 represents H or C.sub.1-6 alkyl; R.sup.7 and R.sup.8 each independently represent H, C.sub.1-6 alkyl or COR.sup.9 ; R.sup.9 represents C.sub.1-6 alkyl optionally substituted by one or more halogen atoms; R.sup.10 represents H, C.sub.1-6 -alkyl or phenyl; R.sup.11, R.sup.12 and R.sup.13 each independently represent H, C.sub.1-6 alkyl, amino, hydroxy, cyano or nitro; and X represents O or S; and their pharmaceutically acceptable derivatives are neuraminidase inhibitors useful in the treatment of viral infections.
    • PCT No.PCT / AU96 / 00495 Sec。 371日期:1998年9月14日 102(e)1998年9月14日PCT PCT 1996年8月7日PCT公布。 公开号WO97 / 06157 日期:1997年2月20日,式(I)的化合物,其中R 1表示NR 5 R 6,其中R 5表示H或任选被Br,Cl,F,I,CF 3,NR 7 R 8,CO 2 R 9,CONR 7 R 8,COR 9, OR10或SR10,或杂芳族基团; 并且R 6表示任选被Br,Cl,F,I,CF 3,NR 7 R 8,CO 2 R 9,CONR 7 R 8,COR 9,OR 10或SR 10中的一个或多个取代的烃基或杂芳基; R2代表基团SO2R9或COR9; R 3表示H,C 1-6 - 烷基或C(= NR 11)NR 12 R 13; R4表示H或C1-6烷基; R 7和R 8各自独立地表示H,C 1-6烷基或COR 9; R9表示任选被一个或多个卤素原子取代的C 1-6烷基; R 10表示H,C 1-6 - 烷基或苯基; R 11,R 12和R 13各自独立地表示H,C 1-6烷基,氨基,羟基,氰基或硝基; X表示O或S; 其药学上可接受的衍生物是可用于治疗病毒感染的神经氨酸酶抑制剂。
    • 25. 发明授权
    • Occupant sensing system
    • 乘员感应系统
    • US08587422B2
    • 2013-11-19
    • US13074830
    • 2011-03-29
    • David AndrewsJason LissemanJerome Bosch
    • David AndrewsJason LissemanJerome Bosch
    • B60Q1/00
    • B60R21/01516B60N2/002B60R21/0152
    • An occupant sensing system for a vehicle includes a pressure sensitive material installed in one or more pressure sensing zones in or around at least one vehicle seat. The pressure sensitive material of each zone is configured to provide an electrical signal to a controller when pressure is applied. The controller determines at least one of occupant presence, position, and classification based on the electrical signal. The pressure sensitive material has at least one of a variable resistance and a variable capacitance based on the amount or type of pressure that is applied to the material. The at least one of a variable resistance and a variable capacitance changes characteristics of the electrical signal.
    • 用于车辆的乘员感测系统包括安装在至少一个车辆座椅内或周围的一个或多个压力感测区域中的压敏材料。 每个区域的压敏材料构造成当施加压力时向控制器提供电信号。 控制器基于电信号确定乘员存在,位置和分类中的至少一个。 基于施加到材料的压力的量或类型,压敏材料具有可变电阻和可变电容中的至少一种。 可变电阻和可变电容中的至少一个改变电信号的特性。
    • 27. 发明授权
    • Method of and apparatus for implementing a decoder
    • 用于实现解码器的方法和装置
    • US08250448B1
    • 2012-08-21
    • US12056193
    • 2008-03-26
    • David Andrews
    • David Andrews
    • H03M13/03
    • H03M13/2957H03M13/2993H03M13/3972H03M13/6502H03M13/6525
    • Method and apparatus for concatenated and interleaved turbo product code decoding are described. The turbo encoder include a plurality of decoders coupled to receive first portion of data, a processor coupled to receive second portion of the data, and a controller providing a plurality of control signals coupled to the plurality of decoders and the processor. A control signal of the plurality of control signals coupled to the processor when enabled configures the processor to pre-calculate the second portion of the data, where the second portion of the data is trellis termination data.
    • 描述了用于级联和交织的涡轮乘积码解码的方法和装置。 所述turbo编码器包括耦合以接收数据的第一部分的多个解码器,耦合以接收所述数据的第二部分的处理器,以及提供耦合到所述多个解码器和所述处理器的多个控制信号的控制器。 当启动时,耦合到处理器的多个控制信号的控制信号使处理器预先计算数据的第二部分,其中数据的第二部分是格状终止数据。