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21. 发明申请

WO2005061477A1 BIARYL SULFONAMIDES AS MMP INHIBITORS 审中-公开
标题翻译： BIARYL SULFONAMIDES作为MMP抑制剂
公开(公告)号：WO2005061477A1
公开(公告)日：2005-07-07
申请号：PCT/US2003/040835
申请日：2003-12-22
申请人： WYETH , LEVIN, Jeremy, Ian , RUSH, Thomas, Saltmarsh, III , LOVERING, Frank , HU, Yonghan , LI, Jianchang , LI, Wei , WU, Jun, Jun , HOTCHANDANI, Rajeev , XIANG, Jason, Shaoyun , DU, Xuemei , COLE, Derek, Cecil
发明人： LEVIN, Jeremy, Ian , RUSH, Thomas, Saltmarsh, III , LOVERING, Frank , HU, Yonghan , LI, Jianchang , LI, Wei , WU, Jun, Jun , HOTCHANDANI, Rajeev , XIANG, Jason, Shaoyun , DU, Xuemei , COLE, Derek, Cecil
IPC分类号： C07D307/85
CPC分类号： C07D235/24 , C07D209/42 , C07D231/14 , C07D235/12 , C07D261/18 , C07D263/58 , C07D277/56 , C07D277/64 , C07D277/68 , C07D285/01 , C07D307/68 , C07D307/80 , C07D307/81 , C07D307/82 , C07D307/85 , C07D307/92 , C07D333/34 , C07D333/70 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D491/06 , C07D495/04
摘要： The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors: Formule (I).
摘要翻译：本发明涉及联芳基磺酰胺及其作为例如金属蛋白酶抑制剂：Formule（I）的用途。

22. 发明申请

WO1994016945A1 AN AIRCRAFT PROPULSIVE POWER UNIT 审中-公开
标题翻译：飞机推进动力单元
公开(公告)号：WO1994016945A1
公开(公告)日：1994-08-04
申请号：PCT/GB1994000131
申请日：1994-01-24
申请人： SHORT BROTHERS PLC , COLE, Derek , SHERRY, Philip, David , BLAIR, Alan, John
发明人： SHORT BROTHERS PLC
IPC分类号： B64D29/00
CPC分类号： B64D29/08 , B64D29/00
摘要： An aircraft propulsive power unit (19) comprises a nacelle structure (20) housing an engine and having a forward nacelle portion (21) and a rearward nacelle portion (131). The rearward end of the forward nacelle portion (21) in an operational position adjoins the forward end of the rearward nacelle portion (131) and the forward end of the forward nacelle portion (21) includes an intake opening leading to an intake barrel (28) upstream of the engine for the supply of intake air to the engine. The forward nacelle portion (21) has an uninterrupted or substantially uninterrupted low drag exterior surface thereover and the power unit includes support structure to support the forward nacelle portion (21) while permitting it to be moved forwardly on the support structure from the operational position to a forward position in which it is supported by the support structure forwardly of the operational position to provide access to components of the power unit (19) which are inaccessible with the forward nacelle portion (21) in the operational position.
摘要翻译：飞机推进动力单元（19）包括容纳发动机并具有前部机舱部分（21）和后部机舱部分（131）的机舱结构（20）。前部机舱部分（21）的后端处于操作位置，邻接后部机舱部分（131）的前端，并且前部机舱部分（21）的前端包括通向进气筒（28）的进气口），用于向发动机供应进气。前部机舱部分（21）在其上方具有不间断的或基本上不间断的低阻力外表面，并且动力单元包括支撑结构以支撑前部机舱部分（21），同时允许其在支撑结构上从操作位置向前移动到前部位置，其中由支撑结构向前支撑在操作位置，以提供进入动力单元（19）的部件，这些部件在前部机舱部分（21）处于操作位置时是不可接近的。

23. 发明申请

WO2007146376A2 SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：替代3-氰基吡啶作为蛋白激酶抑制剂
公开(公告)号：WO2007146376A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/013954
申请日：2007-06-13
申请人： WYETH , COLE, Derek, Cecil , BOSCHELLI, Diane, Harris , WANG, Yanong, Daniel , ASSELIN, Magda , JOSEPH-MCARTHY, Diane, Marie , PRASHAD, Amarnauth, Shastrie , WISSNER, Allan , DUSHIN, Russell , WU, Biqi , TUMEY, Lawrence, Nathan , NIU, Chuan, S. , CHEN, Joan
发明人： COLE, Derek, Cecil , BOSCHELLI, Diane, Harris , WANG, Yanong, Daniel , ASSELIN, Magda , JOSEPH-MCARTHY, Diane, Marie , PRASHAD, Amarnauth, Shastrie , WISSNER, Allan , DUSHIN, Russell , WU, Biqi , TUMEY, Lawrence, Nathan , NIU, Chuan, S. , CHEN, Joan
CPC分类号： C07D213/85 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present teachings provide compounds of formula I (I) and their pharmaceutically acceptable salts, hydrates, and esters, wherein R 1 , R 2 , and X are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.
摘要翻译：本发明提供式I（I）化合物及其药学上可接受的盐，水合物和酯，其中R 1，R 2和X如本文所定义。本教导还提供制备式I化合物的方法，以及通过向包括人的哺乳动物施用治疗有效量的式I化合物或化合物来治疗自身免疫性和炎性疾病的方法。

24. 发明申请

WO2007108936A2 N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS 审中-公开
标题翻译： N-取代的氮杂环丙胺作为组胺-3拮抗剂
公开(公告)号：WO2007108936A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/005776
申请日：2007-03-08
申请人： WYETH , COLE, Derek Cecil , ASSELIN, Magda , STOCK, Joseph Raymond , ROBICHAUD, Albert Jean , KIM, Ji-In , SOLVIBILE, William Ronald , GROSS, Jonathan Laird
发明人： COLE, Derek Cecil , ASSELIN, Magda , STOCK, Joseph Raymond , ROBICHAUD, Albert Jean , KIM, Ji-In , SOLVIBILE, William Ronald , GROSS, Jonathan Laird
IPC分类号： C07D401/10 , C07D403/10 , C07D471/04 , C07D471/14 , A61K31/404 , A61P25/00
CPC分类号： C07D403/10 , C07D401/10 , C07D471/04 , C07D471/14
摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.
摘要翻译：本发明提供了式（I）化合物及其用于治疗与组胺-3受体相关或受其影响的中枢神经系统疾病的用途。

25. 发明申请

WO2007078813A2 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR (INSERT BETA SYMBOL)-SECRETASE MODULATION 审中-公开
标题翻译： 2-氨基-5-哌啶基咪唑啉酮化合物及其用途（插入式符号）-SECRETASE调节
公开(公告)号：WO2007078813A2
公开(公告)日：2007-07-12
申请号：PCT/US2006047673
申请日：2006-12-14
申请人： WYETH CORP , ZHOU PING , BERNOTAS RONALD CHARLES , LI YANFANG , NOWAK PAWEL WOJCIECH , COLE DEREK CECIL , MANAS ERIC STEVEN , FAN YI , YAN YINFA
发明人： ZHOU PING , BERNOTAS RONALD CHARLES , LI YANFANG , NOWAK PAWEL WOJCIECH , COLE DEREK CECIL , MANAS ERIC STEVEN , FAN YI , YAN YINFA
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14
摘要： The present invention provides a 2-amino-5-piperidinylimidazolone compound of formula ( I ) The present invention also provides methods and compositions for the inhibition of ß-secretase (BACE) and the treatment of ß-amyloid deposits and neurofibrillary tangles.
摘要翻译：本发明提供式（I）的2-氨基-5-哌啶基咪唑酮化合物本发明还提供抑制β-分泌酶（BACE）和β-淀粉样沉积物和神经原纤维缠结的治疗的方法和组合物。

26. 发明申请

WO2004092155A1 FLUORO-AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF 审中-公开
标题翻译：含氟和含三氟甲磺酸的苯甲酰胺酰胺抑制剂的制备及其衍生物
公开(公告)号：WO2004092155A1
公开(公告)日：2004-10-28
申请号：PCT/US2004/009268
申请日：2004-03-26
申请人： WYETH , KREFT, Anthony, Frank , RESNICK, Lynn , MAYER, Scott, Christian , DIAMANTIDIS, George , COLE, Derek, Cecil , WANG, Tingzhong , GALANTE, Rocco, John , HOKE, Molly , HARRISON, Boyd, Lynn , ZHANG, Minsheng
发明人： KREFT, Anthony, Frank , RESNICK, Lynn , MAYER, Scott, Christian , DIAMANTIDIS, George , COLE, Derek, Cecil , WANG, Tingzhong , GALANTE, Rocco, John , HOKE, Molly , HARRISON, Boyd, Lynn , ZHANG, Minsheng
IPC分类号： C07D333/34
CPC分类号： C07D333/62 , C07D231/18 , C07D333/34
摘要： Compounds of Formula (I), are provided where T is CHO, COR 8 , or C(OH)R 1 R 2 ; R 1 and R 2 are hydrogen, optionally substituted lower alkyl, CF 3 , optionally substituted alkenyl, or optionally substituted alkynyl; R 3 is hydrogen or optionally substituted lower alkyl; R 4 is (CF 3 ) n alkyl, (CF 3 ) n (substitutedalkyl), (CF 3 ) n alkylphenyl, (CF 3 )nalkyl(substitutedphenyl), or (F) n cycloalkyl; n=1-3; R 5 is hydrogen, halogen, CF 3 , diene fused to Y when Y=C, or substituted diene fused to Y when Y=C; W, Y and Z are C, CR 6 or N where at least one of W, Y or Z are C; R 6 is hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO 2 , or NR 7 ; R 7 is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R 8 is lower alkyl, CF 3 , or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.
摘要翻译：提供式（I）化合物，其中T是CHO，COR8或C（OH）R 1 R 2; R 1和R 2是氢，任选取代的低级烷基，CF 3，任选取代的烯基或任选取代的炔基; R3是氢或任选取代的低级烷基; R4是（CF3）n烷基，（CF3）n（取代烷基），（CF3）n烷基苯基，（CF3）n烷基（取代苯基）或（F）n环烷基; N = 1-3; 当Y = C时，R 5为氢，卤素，CF 3，与Y稠合的二烯，或Y = C时与Y稠合的取代二烯; W，Y和Z是C，CR 6或N，其中W，Y或Z中的至少一个是C; R6是氢，卤素或任选取代的低级烷基; X是O，S，SO 2或NR 7; R 7是氢，任选取代的低级烷基，任选取代的苄基或任选取代的苯基; 且R 8为低级烷基，CF 3或任选取代的苯基。还描述了制备和使用这些化合物抑制β-淀粉样蛋白产生和治疗阿尔茨海默病和唐氏综合征的方法。

27. 发明申请

WO1993006005A1 THERMAL ANTI-ICING OF AIRCRAFT STRUCTURES 审中-公开
标题翻译：飞机结构的热防护
公开(公告)号：WO1993006005A1
公开(公告)日：1993-04-01
申请号：PCT/GB1992001710
申请日：1992-09-17
申请人： SHORT BROTHERS PLC , ARNOLD, Michael, John , COLE, Derek
发明人： SHORT BROTHERS PLC
IPC分类号： B64D15/04
CPC分类号： B64D15/04 , B64D33/02 , B64D2033/0206 , B64D2033/0233 , B64D2033/0286 , F02C7/047
摘要： An aircraft structural component comprises a forward compartment (17) formed by a forward bulkhead (19) and a skin structure (21) which extends forwardly of the forward bulkhead (17) and which has an outer surface which requires to be protected from accumulation of ice thereon, and a rear compartment (18) formed between the forward bulkhead (19) and a rear bulkhead (20). A supply duct (25) extends through the rear compartment (18) and into the forward compartment (17) for the delivery thereto of pressurised hot gases for distribution over the inner surface of the skin structure (21) to prevent accumulation of ice on the outer surface of the skin structure (21). A protective shroud duct (31) surrounds the supply duct (25), extends from the rear bulkhead (20) to the forward bulkhead (19) and forms an annular space between the protective shroud duct (31) and the supply duct (25). The annular space is closed off at its rear end at the rear bulkhead (20) and throughout its length within the rear compartment (18) by the protective shroud duct (31) and is open at its forward end to provide gaseous flow communication with the forward compartment (17), whereby leakage of hot gases from the supply duct (25) upon rupture are prevented by the protective shroud duct (31) from entering into the rear compartment (18) and pass into the forward compartment (17). A discharge duct is provided for discharging spent gases from the forward compartment (17) to atmosphere.

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