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21. 发明申请

WO1997041208A1 SKIN REGENERATION USING MESENCHYMAL STEM CELLS 审中-公开
标题翻译：使用中胚层干细胞进行皮肤再生
公开(公告)号：WO1997041208A1
公开(公告)日：1997-11-06
申请号：PCT/US1997006760
申请日：1997-04-24
申请人： CASE WESTERN RESERVE UNIVERSITY , SORRELL, J., Michael , CAPLAN, Arnold, I.
发明人： CASE WESTERN RESERVE UNIVERSITY
IPC分类号： C12N05/00
CPC分类号： A61L27/3891 , A61K35/12 , A61L27/3804 , A61L27/3813 , A61L27/3834 , A61L27/3886 , A61L27/3895 , A61L27/60 , C12N5/0656 , C12N5/0698 , C12N2502/094 , C12N2502/1323 , C12N2502/1358 , C12N2533/54
摘要： Disclosed is a multilayer skin equivalent having (i) a scaffold layer incorporated with dermis-forming cells, and (ii) a keratinocyte layer. Also disclosed is a multilayer dermal equivalent having at least one of (i) a first layer of at least one skin-associated extracellular matrix component containing papillary dermal fibroblasts; and, in laminar relationship therewith, (ii) a second layer of at least one skin-associated extracellular matrix component containing reticular dermal fibroblasts. Preferred embodiments include those where the scaffold or dermis-forming layer is a multilayer selected from the group consisting of (a) a layer containing isolated papillary dermis-forming cells and a layer containing isolated reticular dermis-forming cells; (b) a layer containing isolated papillary dermis-forming cells and a layer containing isolated, culture expanded mesenchymal stem cells; and (c) a layer containing isolated reticular dermis-forming cells and a layer containing isolated, culture expanded mesenchymal stem cells. Also enclosed is a multilayer skin equivalent having (i) a scaffold layer comprising a first layer of at least one skin-associated extracellular matrix component containing papillary dermal fibroblasts and, in laminar relationship therewith, a second layer of at least one skin-associated extracellular matrix component containing reticular dermal fibroblasts; and (ii) a keratinocyte layer. Also disclosed is an injectable composition of dermis-forming cells and at least one skin-associated extracellular matrix component in a pharmaceutically acceptable injectable carrier. The injectable composition can further include keratinocytes.
摘要翻译：公开了一种多层皮肤当量，其具有（i）与真皮形成细胞结合的支架层，和（ii）角质形成细胞层。还公开了具有以下至少一种的多层皮肤当量：（i）含有乳头状真皮成纤维细胞的至少一种皮肤相关细胞外基质组分的第一层; 并且与其层状关系，（ii）含有网状真皮成纤维细胞的至少一种皮肤相关的细胞外基质组分的第二层。优选的实施方案包括其中支架或真皮形成层是选自（a）含有分离的乳头状真皮细胞形成细胞层和含有分离的网状真皮形成细胞的层的多层的那些实例; （b）含有分离的乳头状真皮细胞的层和含有分离培养的扩展的间充质干细胞的层; 和（c）含有分离的网状真皮细胞的层和含有分离的培养扩展的间充质干细胞的层。还包括多层皮肤等效物，其具有（i）支架层，其包含含有乳头状真皮成纤维细胞的至少一种皮肤相关细胞外基质组分的第一层，并且与其层叠，具有至少一种皮肤相关细胞外的第二层含有网状真皮成纤维细胞的基质成分; 和（ii）角质形成细胞层。还公开了在药学上可接受的可注射载体中的真皮形成细胞和至少一种与皮肤相关的细胞外基质组分的可注射组合物。可注射组合物还可包含角质形成细胞。

22. 发明申请

WO1996024848A1 MONOCLONAL ANTIBODIES FOR HUMAN OSTEOGENIC CELL SURFACE ANTIGENS 审中-公开
标题翻译：人类肿瘤细胞表面抗原的单克隆抗体
公开(公告)号：WO1996024848A1
公开(公告)日：1996-08-15
申请号：PCT/US1996000370
申请日：1996-01-03
申请人： CASE WESTERN RESERVE UNIVERSITY , BRUDER, Scott, P. , CAPLAN, Arnold, I. , HAYNESWORTH, Stephen, E.
发明人： CASE WESTERN RESERVE UNIVERSITY
IPC分类号： G01N33/567
CPC分类号： C07K16/28
摘要： Monoclonal antibodies specific for normal human osteogenic cell subsets and the monoclonal hybridoma cell lines that synthesize and secrete these monospecific antibodies, as well as the uses of the monoclonal antibodies for diagnostic and/or therapeutic purposes.
摘要翻译：对正常人成骨细胞亚群特异性的单克隆抗体以及合成和分泌这些单特异性抗体的单克隆杂交瘤细胞系以及用于诊断和/或治疗目的的单克隆抗体的用途。

23. 发明申请

WO1992022584A1 MONOCLONAL ANTIBODIES SPECIFIC FOR MARROW-DERIVED MESENCHYMAL CELLS 审中-公开
标题翻译：用于大量衍生的细胞的特异性单克隆抗体
公开(公告)号：WO1992022584A1
公开(公告)日：1992-12-23
申请号：PCT/US1992005187
申请日：1992-06-16
申请人： CAPLAN, Arnold, I. , HAYNESWORTH, Stephen, E.
IPC分类号： C07K15/28
CPC分类号： C07K16/28 , A61F2/28 , A61F2/30756 , A61K35/28 , A61K2035/124 , A61L27/38 , A61L31/005 , A61L2430/10 , C12N5/0068 , C12N5/0663 , C12N2501/23 , C12N2501/39 , C12N2533/18 , A61K2300/00
摘要： The invention relates to a process for producing monoclonal antibodies which are specific to marrow-derived mesenchymal cells (i.e. mesenchymal stem cells), as well as the monoclonal antibodies that are produced by the process of the invention. In addition, the present invention is directed to the hybrid cell lines or hybridomas that synthesize and secrete these monospecific antibodies, and the use of the monoclonal antibodies for diagnostic and/or therapeutic purposes.
摘要翻译：本发明涉及一种生产对骨髓间充质细胞（即间充质干细胞）特异性的单克隆抗体的方法，以及通过本发明的方法生产的单克隆抗体。此外，本发明涉及合成和分泌这些单特异性抗体的杂交细胞系或杂交瘤，以及用于诊断和/或治疗目的的单克隆抗体的用途。

24. 发明专利

AU4601485A PROCESS FOR ADAPTING SOLUBLE BONE PROTEIN FOR USE IN STIMULATING OSTEOINDUCTION 未知
公开(公告)号：AU4601485A
公开(公告)日：1986-02-10
申请号：AU4601485
申请日：1985-07-05
申请人： CAPLAN ARNOLD I , SYFTESTAD GLENN T
发明人： CAPLAN ARNOLD I , SYFTESTAD GLENN T
IPC分类号： A61F2/28 , A61K38/18 , A61L27/22 , A61L27/34 , A61L27/54 , A61K37/00
摘要： A method for treating implants such as biodegradable masses, xenogenic bony implants, allografts and prosthetic devices with soluble bone protein to enhance or stimulate new cartilage and/or bone formation. Substrate immobilization or surface coating techniques retard diffusion of the soluble bone protein away from the implant site so that cartilage and bone growth is initiated.

25. 发明专利

DE69233029D1 未知
公开(公告)号：DE69233029D1
公开(公告)日：2003-06-05
申请号：DE69233029
申请日：1992-06-16
申请人： CAPLAN ARNOLD I , HAYNESWORTH STEPHEN E
发明人： CAPLAN ARNOLD I , HAYNESWORTH STEPHEN E
IPC分类号： G01N33/53 , A61F2/28 , A61F2/30 , A61K35/12 , A61K35/28 , A61K39/395 , A61L27/38 , A61L31/00 , A61P43/00 , C07K16/28 , C12N5/00 , C12N5/0775 , C12N5/20 , C12P21/08 , C12R1/91 , G01N33/577 , C12N5/08

26. 发明专利

AT239072T 未知
公开(公告)号：AT239072T
公开(公告)日：2003-05-15
申请号：AT92914266
申请日：1992-06-16
申请人： CAPLAN ARNOLD I , HAYNESWORTH STEPHEN E
发明人： CAPLAN ARNOLD I , HAYNESWORTH STEPHEN E
IPC分类号： G01N33/53 , A61F2/28 , A61F2/30 , A61K35/12 , A61K35/28 , A61K39/395 , A61L27/38 , A61L31/00 , A61P43/00 , C07K16/28 , C12N5/00 , C12N5/0775 , C12N5/20 , C12P21/08 , C12R1/91 , G01N33/577 , C12N5/08

27. 发明专利

IT1209941B 未知
公开(公告)号：IT1209941B
公开(公告)日：1989-08-30
申请号：IT4783485
申请日：1985-03-20
申请人： CAPLAN ARNOLD I , SYFTESTAD GLEN T
发明人： CAPLAN ARNOLD I , SYFTESTAD GLEN T
IPC分类号： A61K35/36 , A61L24/00 , A61L27/22 , A61L27/38 , C12K
摘要： A process for exposing live cells to a soluble bone protein and transferring the cells into appropriate skeletal sites to initiate or enhance local chondrogenesis or osteogenesis. Isogenic fibroblasts are exposed in vitro to a soluble bone protein capable of stimulating in vitro and/or in vivo a chondrogenic response. The fibroblasts are then transferred in vivo in a manner effective to prevent diffusion away from the implantation site so that the desired chondro/osteogenesis reaction can proceed. Delivery systems include: combining the activated fibroblasts with a biodegradable matrix; suspending the activated fibroblasts in a solution suitable for intra-articular injection; and attaching the fibroblasts to allografts and prosthetic devices.

28. 发明专利

IT1182721B 未知
公开(公告)号：IT1182721B
公开(公告)日：1987-10-05
申请号：IT4783585
申请日：1985-03-20
申请人： CAPLAN ARNOLD I , SYFTESTAD GLEN T
发明人： CAPLAN ARNOLD I , SYFTESTAD GLEN T
IPC分类号： A61K38/00 , C07K14/51 , G01N33/50 , G01N33/68 , C07G
摘要： A process of extracting and purifying a bone protein capable of stimulating chondrogenic expression in undifferentiated cells in culture. The purification process is monitored at various stages by bioassaying the bone protein for chondrogenic activity in embryonic limb bud mesenchymal cell cultures.

29. 发明专利

IT8547835D0 未知
公开(公告)号：IT8547835D0
公开(公告)日：1985-03-20
申请号：IT4783585
申请日：1985-03-20
申请人： CAPLAN ARNOLD I , SYFTESTAD GLEN T
发明人： CAPLAN ARNOLD I , SYFTESTAD GLEN T
IPC分类号： A61K38/00 , C07K14/51 , G01N33/50 , G01N33/68 , C07G
摘要： A process of extracting and purifying a bone protein capable of stimulating chondrogenic expression in undifferentiated cells in culture. The purification process is monitored at various stages by bioassaying the bone protein for chondrogenic activity in embryonic limb bud mesenchymal cell cultures.

30. 发明专利

AU669850B2 Monoclonal antibodies specific for marrow-derived mesenchymal cells 未知
公开(公告)号：AU669850B2
公开(公告)日：1996-06-27
申请号：AU2252492
申请日：1992-06-16
申请人： CAPLAN ARNOLD I , STEPHEN E HAYNESWORTH
发明人： CAPLAN ARNOLD I , HAYNESWORTH STEPHEN E
IPC分类号： G01N33/53 , A61F2/28 , A61F2/30 , A61K35/12 , A61K35/28 , A61K39/395 , A61L27/38 , A61L31/00 , A61P43/00 , C07K16/28 , C12N5/00 , C12N5/0775 , C12N5/20 , C12P21/08 , C12R1/91 , G01N33/577 , C12N5/08 , G01N33/554 , G01N33/567

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