会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 25. 发明授权
    • Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one
inhibitors of cholesterol synthesis
    • 反式-6- [2-(取代 - 吡咯-1-基)烷基]吡喃-2-酮胆固醇合成抑制剂的方法
    • US5280126A
    • 1994-01-18
    • US58349
    • 1993-05-06
    • Donald E. ButlerCarl F. DeeringAlan MillarThomas N. NanningaBruce D. Roth
    • Donald E. ButlerCarl F. DeeringAlan MillarThomas N. NanningaBruce D. Roth
    • C07C235/80C07D207/34C07D319/06C07D319/08C07D405/06
    • C07D319/08C07C235/80C07D207/34C07D319/06C07D405/06
    • An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(.+-.)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide by a novel synthesis where 4-methyl-3-oxo-N-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-.alpha.-[2-methyl-1-oxopropyl]-Y-oxo-N,.beta.-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.
    • 描述了通过新的合成制备反式-6- [2-(取代的 - 吡咯-1-基)烷基]吡喃-2-酮的改进方法,其中将1,6-庚二烯-4-醇转化为8 (2R-反式)和反式 - (+/-) - 5-(4-氟苯基)-2-(1-甲基乙基)-N,4- 二苯基-1- [2-(二氢 - 羟基-6-氧代-2H-吡喃-2-基)乙基] -1H-吡咯-3-甲酰胺,通过新的合成法,其中4-甲基-3-氧代 - N-苯基戊酰胺在八个操作中转化为所需产物,或者4-氟-α-[2-甲基-1-氧代丙基] -Y-氧代-N,β-二苯基苯丁酰胺在一个步骤中转化成所需产物,和 另外,制备(2R-反式)-5-(4-氟苯基)-2-(1-甲基乙基)-N,4-二苯基-1- [2-(四氢-4-羟基-6-氧代 -2H-吡喃-2-基)乙基] -1H-吡咯-3-甲酰胺,由(R)-4-氰基-3 - [[(1,1-二甲基乙基)二甲基甲硅烷基]氧基]丁酸以及其它 有价值的中间体 的过程。
    • 28. 发明授权
    • Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one
inhibitors of cholesterol synthesis
    • 反式-6-(2-取代 - 吡咯-1-基)烷基)吡喃-2-酮胆固醇合成抑制剂的方法
    • US5124482A
    • 1992-06-23
    • US792311
    • 1991-11-14
    • Donald E. ButlerCarl F. DeeringAlan MillarThomas N. NanningaBruce D. Roth
    • Donald E. ButlerCarl F. DeeringAlan MillarThomas N. NanningaBruce D. Roth
    • C07C235/80C07D207/34C07D319/06C07D319/08C07D405/06
    • C07D319/08C07C235/80C07D207/34C07D319/06C07D405/06
    • An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans(.+-.)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide by a novel synthesis where 4-methyl-3-oxo-N-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-.alpha.-[2-methyl-1-oxopropyl]-.gamma.-oxo-N,.beta.-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.
    • 描述了通过新的合成制备反式-6- [2-(取代的 - 吡咯-1-基)烷基]吡喃-2-酮的改进方法,其中将1,6-庚二烯-4-醇转化为8 (2R-反式)和反式(+/-) - 5-(4-氟苯基)-2-(1-甲基乙基)-N,4-二苯基的改进方法 -1- [2-(四氢-4-羟基-6-氧代-2H-吡喃-2-基)乙基] -1H-吡咯-3-甲酰胺的新型合成法,其中4-甲基-3-氧代-N - 苯基戊酰胺在八个操作中转化成所需产物,或者4-氟-α-[2-甲基-1-氧代丙基]-γ-氧代-N,β-二苯基苯丁酰胺在一个步骤中转化成所需产物,另外 ,制备(2R-反式)-5-(4-氟苯基)-2-(1-甲基乙基)-N,4-二苯基-1- [2-(四氢-4-羟基-6-氧代 - (R)-4-氰基-3 - [[(1,1-二甲基乙基)二甲基甲硅烷基]氧基]丁酸,以及其它有价值的(R)-4-氰基-3 - [(1H-吡喃-2-基)乙基] -1H-吡咯-3-甲酰胺 中间体 的过程。
    • 29. 发明授权
    • Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one
inhibitors of cholesterol synthesis
    • 反式-6- [2-(取代 - 吡咯-1-基)烷基]吡喃-2-酮胆固醇合成抑制剂的方法
    • US5097045A
    • 1992-03-17
    • US595461
    • 1990-10-09
    • Donald E. ButlerCarl F. DeeringAlan MillarThomas N. NanningaBruce D. Roth
    • Donald E. ButlerCarl F. DeeringAlan MillarThomas N. NanningaBruce D. Roth
    • C07C235/80C07D207/34C07D319/06C07D319/08C07D405/06
    • C07D319/08C07C235/80C07D207/34C07D319/06C07D405/06
    • An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(.+-.)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]1H-pyrrole-3-carboxamide by a novel synthesis where 4-methyl-3-oxo-N-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-.alpha.-[2-methyl-1-oxopropyl]-.gamma.-oxo-N,.beta.-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.
    • 描述了通过新的合成制备反式-6- [2-(取代的 - 吡咯-1-基)烷基]吡喃-2-酮的改进方法,其中将1,6-庚二烯-4-醇转化为8 (2R-反式)和反 - (+/-) - 5-(4-氟苯基)-2-(1-甲基乙基)-N,4- 二苯基-1- [2-(叔 - 羟基-6-羟基-6-氧代-2H-吡喃-2-基)乙基] -1H-吡咯-3-甲酰胺,通过新的合成法,其中4-甲基-3-氧代-N - 苯基戊酰胺在八个操作中转化成所需产物,或者4-氟-α-[2-甲基-1-氧代丙基]-γ-氧代-N,β-二苯基苯丁酰胺在一个步骤中转化成所需产物,另外 ,制备(2R-反式)-5-(4-氟苯基)-2-(1-甲基乙基)-N,4-二苯基-1- [2-(四氢-4-羟基-6-氧代 - (R)-4-氰基-3 - [[(1,1-二甲基乙基)二甲基甲硅烷基]氧基]丁酸,以及其它有价值的(R)-4-氰基-3 - [(1H-吡喃-2-基)乙基] 中间体使用 d在进程中。