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21. 发明申请

WO1997005195A1 METHOD OF DETECTING LUNG DISEASE 审中-公开
标题翻译：检测肺疾病的方法
公开(公告)号：WO1997005195A1
公开(公告)日：1997-02-13
申请号：PCT/US1996012377
申请日：1996-07-24
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , BOUCHER, Richard, C., Jr.
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
IPC分类号： C08K05/15
CPC分类号： A61K9/0078 , A61K31/66 , A61K33/14 , A61K45/06 , A61K31/70 , A61K31/495 , A61K31/7004 , A61K31/165 , A61K31/14 , A61K2300/00
摘要： A method of facilitating the obtaining of a mucus sample from at least one lung of a subject comprises administering to at least one lung of the subject, in an amount effective to hydrate lung mucus secretions and/or stimulate cilia beat frequency therein, uridine 5'-triphosphate, an active analog thereof, or a pharmaceutically acceptable salt of either thereof, and, optionally, concurrently administering to said at least one lung a physiologically acceptable salt in an amount effective to hydrate lung mucus secretions therein. A sputum or mucus sample is then collected from said at least one lung, which sample can then be analyzed for lung disease. Pharmaceutical compositions useful for carrying out the method comprise UTP or a salt thereof, alone or in combination with a physiologically acceptable salt, or a pharmaceutically acceptable salt of either thereof. The composition may be a liquid/liquid suspension composition or a dry powder composition.
摘要翻译：促进从受试者的至少一个肺获得粘液样品的方法包括以有效水合肺粘液分泌物和/或刺激其中的纤毛节拍频率的剂量给予受试者的至少一个肺，尿苷5' 三磷酸盐，其活性类似物或其药学上可接受的盐，并且任选地，以有效水合物中的肺粘液分泌物的量向所述至少一个肺施用生理上可接受的盐。然后从所述至少一个肺采集痰液或粘液样品，然后可以分析该样品的肺部疾病。可用于实施该方法的药物组合物包含UTP或其盐单独或与其生理学上可接受的盐或其药学上可接受的盐组合。组合物可以是液体/液体悬浮液组合物或干粉组合物。

22. 发明申请

WO9428726A3 METHOD OF TREATING RETAINED PULMONARY SECRETIONS 审中-公开
标题翻译：治疗保留的脉搏分泌的方法
公开(公告)号：WO9428726A3
公开(公告)日：1995-03-02
申请号：PCT/US9406486
申请日：1994-06-08
申请人： WELLCOME FOUND , UNIV NORTH CAROLINA , MOLINA VEDIA LUIS M , STUTTS MONROE JACKSON , BOUCHER RICHARD C JR , HENKE DAVID C
发明人： MOLINA Y VEDIA LUIS M , STUTTS MONROE JACKSON , BOUCHER RICHARD C JR , HENKE DAVID C
IPC分类号： A61K9/12 , A61K31/4409 , A61K31/496 , A61K31/7036 , A61K38/00 , A61K38/04 , A61K38/12 , A61K38/16 , A61K45/00 , A61P11/00 , A61P11/08 , A61P11/12 , A61P31/04 , A61P31/06 , A16K37/02
CPC分类号： A61K38/164 , A61K38/04 , A61K38/12 , Y10S514/826 , Y10S514/851 , Y10S514/924 , A61K2300/00
摘要： A method of facilitating the clearance of retained pulmonary secretions in a subject using lantibiotics is disclosed. The method comprises administering to the lungs of the subject an effective amount of a lantibiotic. The lantibiotic is preferably administered by topically applying it to the respiratory epithelia, such as by generating an aerosol thereof which is then inhaled by the subject. A preferred lantibiotic for carrying out the present invention is duramycin. The method may be used in treating disorders such as cystic fibrosis, chronic bronchitis, and asthma. Also disclosed is a method of combatting tuberculosis comprising administering a lantibiotic to a subject in need of such treatment.

23. 发明申请

WO2014036445A2 NOVEL MUCOLYTIC AGENTS 审中-公开
标题翻译：新型粘胶剂
公开(公告)号：WO2014036445A2
公开(公告)日：2014-03-06
申请号：PCT/US2013/057588
申请日：2013-08-30
申请人： JOHNSON, Michael, R. , THELIN, William, R. , BOUCHER, Richard, C. , VILLALON, Diane , BOYER, Jose, L.
发明人： JOHNSON, Michael, R. , THELIN, William, R. , BOUCHER, Richard, C. , VILLALON, Diane , BOYER, Jose, L.
IPC分类号： A61K31/66
CPC分类号： C07F9/5022 , A61K9/0073 , A61K31/66 , A61K31/663 , C07F9/5004 , Y02A50/406
摘要： Provided is a method of liquefying mucus from mucosal surfaces by administering compounds containing a phosphine group.
摘要翻译：提供了一种通过施用含有膦基的化合物从粘膜表面液化粘液的方法。

24. 发明申请

WO2009049159A1 DELIVERING OSMOLYTES BY NASAL CANNULA 审中-公开
标题翻译：由NASAL CANNULA提供OSMOLYTES
公开(公告)号：WO2009049159A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/079519
申请日：2008-10-10
申请人： PARION SCIENCES, INC. , BOUCHER, Richard, C. , JOHNSON, Michael, R.
发明人： BOUCHER, Richard, C. , JOHNSON, Michael, R.
IPC分类号： A61M15/00 , A61M16/00 , B05D7/14 , B65D83/06
CPC分类号： A61M15/08 , A61M11/001 , A61M11/02 , A61M16/0666 , A61M16/0875 , A61M16/1075 , A61M16/1095 , A61M16/14 , A61M16/18 , A61M2202/0488
摘要： The invention described herein is directed to method of treating chronic obstructive pulmonary disease, comprising administering an effective amount of an osmolyte by at least one nasal cannula to a subject in need thereof. Also provided is a nasal cannula system for delivering an osmolyte, comprising a nebulizer and tubing having two ends, where the first end of the tubing is connected to the nebulizer and the second end of the tubing is tapered to fit in the nostril of a subject.
摘要翻译：本文描述的本发明涉及治疗慢性阻塞性肺疾病的方法，包括通过至少一个鼻插管向有需要的受试者施用有效量的渗透液。还提供了一种用于输送渗透液的鼻插管系统，包括具有两个端部的喷雾器和管道，其中管道的第一端连接到雾化器，并且管道的第二端是锥形的，以适合被摄体的鼻孔。

25. 发明申请

WO2008031028A2 METHODS OF ENHANCING MUCOSAL HYDRATION AND MUCOSAL CLEARANCE BY TREATMENT WITH SODIUM CHANNEL BLOCKERS AND OSMOLYTES 审中-公开
标题翻译：通过用钠通道阻滞剂和OSMOLYTES治疗增加粘膜水肿和粘膜间隙的方法
公开(公告)号：WO2008031028A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/077880
申请日：2007-09-07
申请人： JOHNSON, Michael, R. , BOUCHER, Richard, C. , HIRSCH, Andrew, J.
发明人： JOHNSON, Michael, R. , BOUCHER, Richard, C. , HIRSCH, Andrew, J.
IPC分类号： A61K31/4965 , A61P11/00 , A61P11/06 , A61P11/08 , A61P11/12 , A61P27/00
CPC分类号： A61K31/4965 , Y02A50/406
摘要： The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.
摘要翻译：本发明涉及通过施用有效量的本文所定义的钠通道阻断剂和渗透液向受试者施用需要增加的粘膜纤毛清除和粘膜水合的治疗方法来治疗由于增加的粘膜纤毛清除和粘膜水合而改善的疾病的方法和组合物。

26. 发明申请

WO1996018385A1 METHODS OF TREATING LUNG DISEASE 审中-公开
标题翻译：治疗肺疾病的方法
公开(公告)号：WO1996018385A1
公开(公告)日：1996-06-20
申请号：PCT/US1995016066
申请日：1995-12-11
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , BOUCHER, Richard, C. , STUTTS, Monroe, Jackson
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
IPC分类号： A61K09/12
CPC分类号： A61K31/7076 , A61K9/0073 , A61K31/4965 , A61K31/675 , Y10S514/851 , A61K2300/00
摘要： Methods of hydrating lung mucous secretions in the lungs of a subject are disclosed. The methods involve administering benzamil or phenamil (figures 1 and 2) to the lungs of the subject in an amount effective to hydrate lung mucous secretions. The administratiion step is carried out via aerosol and the method is useful for the treatment of cystic fibrosis and chronic bronchitis.
摘要翻译：公开了在受试者的肺中保湿肺粘液分泌物的方法。所述方法包括以有效水合肺粘膜分泌物的量将受试者的苯甲酰胺或苯胺（图1和2）施用于受试者的肺。施用步骤通过气雾剂进行，该方法可用于治疗囊性纤维化和慢性支气管炎。

27. 发明申请

WO1995010538A1 DNA ENCODING THE HUMAN P2U RECEPTOR AND NULL CELLS EXPRESSING P2U RECEPTORS 审中-公开
标题翻译：编码人P2U受体和表达P2U受体的空细胞的DNA
公开(公告)号：WO1995010538A1
公开(公告)日：1995-04-20
申请号：PCT/US1994011260
申请日：1994-10-04
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , THE CURATORS OF THE UNIVERSITY OF MISSOURI , BOUCHER, Richard, C. , WEISMAN, Gary, A. , TURNER, John, T. , HARDEN, Thomas, K. , PARR, Claude, E. , SULLIVAN, Daniel, M. , ERB, Laura, J. , LUSTIG, Kevin, D.
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , THE CURATORS OF THE UNIVERSITY OF MISSOURI
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , A61K38/00
摘要： Isolated DNAs encoding the human P2U receptor are disclosed, along with vectors and host cells containing the same and methods of using the same. Host cells which are essentially free of endogenous P2U receptor expression, and which express a heterologous P2U receptor such as a murine P2U receptor, are also disclosed, along with methods of using the same.
摘要翻译：公开了编码人P2U受体的分离的DNA，以及含有其的载体和宿主细胞以及使用它们的方法。还公开了基本上不含内源性P2U受体表达并且表达异源P2U受体如鼠P2U受体的宿主细胞，以及使用它们的方法。

28. 发明申请

WO1994028726A2 METHOD OF TREATING RETAINED PULMONARY SECRETIONS 审中-公开
标题翻译：治疗保留的脉搏分泌的方法
公开(公告)号：WO1994028726A2
公开(公告)日：1994-12-22
申请号：PCT/US1994006486
申请日：1994-06-08
申请人： THE WELLCOME FOUNDATION LIMITED , THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , MOLINA y VEDIA, Luis, M. , STUTTS, Monroe, Jackson , BOUCHER, Richard, C., Jr. , HENKE, David, C.
发明人： THE WELLCOME FOUNDATION LIMITED , THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
IPC分类号： A16K37/02
CPC分类号： A61K38/164 , A61K38/04 , A61K38/12 , Y10S514/826 , Y10S514/851 , Y10S514/924 , A61K2300/00
摘要： A method of facilitating the clearance of retained pulmonary secretions in a subject using lantibiotics is disclosed. The method comprises administering to the lungs of the subject an effective amount of a lantibiotic. The lantibiotic is preferably administered by topically applying it to the respiratory epithelia, such as by generating an aerosol thereof which is then inhaled by the subject. A preferred lantibiotic for carrying out the present invention is duramycin. The method may be used in treating disorders such as cystic fibrosis, chronic bronchitis, and asthma. Also disclosed is a method of combatting tuberculosis comprising administering a lantibiotic to a subject in need of such treatment.
摘要翻译：公开了一种利用羊毛硫抗生素促进受试者残留肺分泌物清除的方法。该方法包括向受试者的肺部施用有效量的蓝霉素。羊毛硫抗生素优选通过将其局部施用于呼吸上皮，例如通过产生其随后被受试者吸入的气雾剂来施用。用于实施本发明的优选的羊毛硫抗生素是耐久霉素。该方法可用于治疗诸如囊性纤维化，慢性支气管炎和哮喘等疾病。还公开了一种抗结核病的方法，其包括对需要这种治疗的受试者施用蓝霉素。

29. 发明授权

US3172434A Apparatus for filling containers 失效
标题翻译：用于填充容器的装置
公开(公告)号：US3172434A
公开(公告)日：1965-03-09
申请号：US13003861
申请日：1961-08-08
申请人： BOUCHER RICHARD C
发明人： BOUCHER RICHARD C
IPC分类号： B65B39/14 , B67C3/16
CPC分类号： B67C3/16 , B65B39/145 , Y10T137/86863

30. 发明授权

US3105525A Machine and method for filling containers 失效
标题翻译：机器和填充容器的方法
公开(公告)号：US3105525A
公开(公告)日：1963-10-01
申请号：US1873760
申请日：1960-03-30
申请人： BOUCHER RICHARD C
发明人： BOUCHER RICHARD C
IPC分类号： B67C3/00 , B67C3/16 , B67C3/26
CPC分类号： B67C3/001 , B67C3/16 , B67C2003/2668

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