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21. 发明专利

IL143047D0 ASSAY FOR PHOSPHATASE-TARGETING TOXINS 未知
公开(公告)号：IL143047D0
公开(公告)日：2002-04-21
申请号：IL14304799
申请日：1999-11-11
申请人： BIOSENSE LAB AS
IPC分类号： C12Q1/42 , G01N33/53 , G01N33/553 , G01N
摘要： The invention provides an assay method for determining phosphatase targeting toxins which inhibit protein phosphatases comprising contacting a solid support having an immobilized ligand immobilized thereon with: (i) a sample suspected of being contaminated with toxin and (ii) a non-immobilized ligand, wherein said immobilized ligand is capable of generating directly or indirectly detectable signal when uncomplexed, when complexed by said toxin, when complexed by a complex of said toxin and said non-immobilized ligand or when complexed by said non-immobilized ligand or said non-immobilized ligand is capable of generating a directly or indirectly detectable signal when uncomplexed or when complexed, separating a bound fraction from a non-bound fraction; and directly or indirectly determining the non-immobilized ligand bound to the immobilized ligand (the bound fraction) or non-complexed in aqueous solution (the non-bound fraction).

22. 发明专利

HU0104194A2 ASSAY FOR PHOSPHATASE-TARGETING TOXINS 未知
公开(公告)号：HU0104194A2
公开(公告)日：2002-03-28
申请号：HU0104194
申请日：1999-11-11
申请人： BIOSENSE LAB AS
发明人： DOSKELAND STEIN OVE , FLADMARK KARI ESPOLIN , SERRES MARGRETHE HAUGE
IPC分类号： C12Q1/42 , G01N33/53 , G01N33/553
摘要： The invention provides an assay method for determining phosphatase targeting toxins which inhibit protein phosphatases comprising contacting a solid support having an immobilized ligand immobilized thereon with: (i) a sample suspected of being contaminated with toxin and (ii) a non-immobilized ligand, wherein said immobilized ligand is capable of generating directly or indirectly detectable signal when uncomplexed, when complexed by said toxin, when complexed by a complex of said toxin and said non-immobilized ligand or when complexed by said non-immobilized ligand or said non-immobilized ligand is capable of generating a directly or indirectly detectable signal when uncomplexed or when complexed, separating a bound fraction from a non-bound fraction; and directly or indirectly determining the non-immobilized ligand bound to the immobilized ligand (the bound fraction) or non-complexed in aqueous solution (the non-bound fraction).

23. 发明专利

ID30236A 未知
公开(公告)号：ID30236A
公开(公告)日：2001-11-15
申请号：ID20011252
申请日：1999-11-11
申请人： BIOSENSE LAB AS
发明人： OVE DOSKELAND STEIN , HAUGE SERRES MARGRETHE , ESPOLIN FLADMARK KARI
IPC分类号： C12Q1/42 , G01N33/53 , G01N33/553
摘要： The invention provides an assay method for determining phosphatase targeting toxins which inhibit protein phosphatases comprising contacting a solid support having an immobilized ligand immobilized thereon with: (i) a sample suspected of being contaminated with toxin and (ii) a non-immobilized ligand, wherein said immobilized ligand is capable of generating directly or indirectly detectable signal when uncomplexed, when complexed by said toxin, when complexed by a complex of said toxin and said non-immobilized ligand or when complexed by said non-immobilized ligand or said non-immobilized ligand is capable of generating a directly or indirectly detectable signal when uncomplexed or when complexed, separating a bound fraction from a non-bound fraction; and directly or indirectly determining the non-immobilized ligand bound to the immobilized ligand (the bound fraction) or non-complexed in aqueous solution (the non-bound fraction).

24. 发明专利

IL143047A ASSAY FOR PHOSPHATASE-TARGETING TOXINS 未知
公开(公告)号：IL143047A
公开(公告)日：2007-07-04
申请号：IL14304701
申请日：2001-05-08
申请人： BIOSENSE LAB AS
IPC分类号： C12Q1/42 , G01N33/53 , G01N33/553
摘要： The invention provides an assay method for determining phosphatase targeting toxins which inhibit protein phosphatases comprising contacting a solid support having an immobilized ligand immobilized thereon with: (i) a sample suspected of being contaminated with toxin and (ii) a non-immobilized ligand, wherein said immobilized ligand is capable of generating directly or indirectly detectable signal when uncomplexed, when complexed by said toxin, when complexed by a complex of said toxin and said non-immobilized ligand or when complexed by said non-immobilized ligand or said non-immobilized ligand is capable of generating a directly or indirectly detectable signal when uncomplexed or when complexed, separating a bound fraction from a non-bound fraction; and directly or indirectly determining the non-immobilized ligand bound to the immobilized ligand (the bound fraction) or non-complexed in aqueous solution (the non-bound fraction).

25. 发明专利

NZ511757A Assay for phosphatase-targeting toxins 未知
公开(公告)号：NZ511757A
公开(公告)日：2003-10-31
申请号：NZ51175799
申请日：1999-11-11
申请人： BIOSENSE LAB AS
发明人： DOSKELAND STEIN OVE , SERRES MARGRETHE HAUGE , LADMARK KARI ESPOLIN
IPC分类号： C12Q1/42 , G01N33/53 , G01N33/553
摘要： An assay method for determining phosphatase targeting toxins, which inhibit protein phosphatases, comprising contacting a solid support having an immobilized ligand thereon with: (i) a sample suspected of being contaminated with toxin and (ii) a non-immobilized ligand, wherein said immobilized ligand is capable of binding to at least one of said toxins, to said nonimmobilized ligand or to complexes of said toxin and said non-immobilized ligand, and said non-immobilized ligand is capable of binding to at least one of said immobilized ligand, to said toxin or to complexes of said toxin and said immobilized ligand whereby the proportion of said immobilized ligand bound by said toxin, said non-immobilized ligand or complexes of said toxin and said non-immobilized ligand is dependent on the toxin content of said sample and wherein said immobilized ligand is capable of generating directly or indirectly detectable signal when uncomplexed, when complexed by said toxin, when complexed by a complex of said toxin and said nonimmobilized ligand or when complexed by said nonimmobilized ligand or said non-immobilized ligand is capable of generating a directly or indirectly detectable signal when uncomplexed or when complexed, separating a bound fraction from a non-bound fraction; and directly or indirectly determining the nonimmobilized ligand bound to the immobilized ligand (the bound fraction) or non- complexed in aqueous solution (the non-bound fraction); wherein the application of (i) and (ii) to the solid support may be performed separately, sequentially or simultaneously and if separately or sequentially, they can be performed in either order.

26. 发明专利

ZA200103796B Assay for phosphatase-targeting toxins. 未知
公开(公告)号：ZA200103796B
公开(公告)日：2001-11-22
申请号：ZA200103796
申请日：2001-05-10
申请人： BIOSENSE LAB AS
发明人： DOSKELAND STEIN OVE , SERRES MARGRETHE HAUGE , FLADMARK KARI ESPOLIN
IPC分类号： C12Q1/42 , G01N33/53 , G01N33/553 , G01N , C12Q
摘要： The invention provides an assay method for determining phosphatase targeting toxins which inhibit protein phosphatases comprising contacting a solid support having an immobilized ligand immobilized thereon with: (i) a sample suspected of being contaminated with toxin and (ii) a non-immobilized ligand, wherein said immobilized ligand is capable of generating directly or indirectly detectable signal when uncomplexed, when complexed by said toxin, when complexed by a complex of said toxin and said non-immobilized ligand or when complexed by said non-immobilized ligand or said non-immobilized ligand is capable of generating a directly or indirectly detectable signal when uncomplexed or when complexed, separating a bound fraction from a non-bound fraction; and directly or indirectly determining the non-immobilized ligand bound to the immobilized ligand (the bound fraction) or non-complexed in aqueous solution (the non-bound fraction).

27. 发明专利

CA2349942A1 ASSAY FOR PHOSPHATASE-TARGETING TOXINS 未知
公开(公告)号：CA2349942A1
公开(公告)日：2000-05-18
申请号：CA2349942
申请日：1999-11-11
申请人： BIOSENSE LAB AS
发明人： FLADMARK KARI ESPOLIN , DOSKELAND STEIN OVE , SERRES MARGRETHE HAUGE
IPC分类号： C12Q1/42 , G01N33/53 , G01N33/553
摘要： The invention provides an assay method for determining phosphatase targeting toxins which inhibit protein phosphatases comprising contacting a solid support having an immobilized ligand immobilized thereon with: (i) a sample suspected of being contaminated with toxin and (ii) a non-immobilized ligand , wherein said immobilized ligand is capable of generating directly or indirectly detectable signal when uncomplexed, when complexed by said toxin, when complexed by a complex of said toxin and said non-immobilized ligand or when complexed by said non-immobilized ligand or said non-immobilized ligand is capable of generating a directly or indirectly detectable signal when uncomplexed or when complexed, separating a bound fraction from a non-bound fraction; and directly or indirectly determining the non-immobilized ligand bound to the immobilized ligand (the bound fraction) or non-complexed in aqueous solution (the non-bound fraction).

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