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21. 发明授权

US06518031B2 Hapten-carrier conjugates for treating and preventing nicotine addiction 失效
公开(公告)号：US06518031B2
公开(公告)日：2003-02-11
申请号：US09784139
申请日：2001-02-16
申请人： Sofiane Ennifar , Ali Ibrahim Fattom , Robert B. Naso
发明人： Sofiane Ennifar , Ali Ibrahim Fattom , Robert B. Naso
IPC分类号： G01N3353
CPC分类号： A61K39/0013 , A61K47/646 , A61K47/6803 , A61K2039/505 , A61K2039/6037 , A61K2039/6068 , C07K16/44 , Y10S435/975 , Y10S436/816 , Y10S530/807
摘要： Novel hapten-carrier conjugates are capable of inducing the production of antibodies, in vivo, that specifically bind to nicotine. These conjugates comprise a nicotine hapten conjugated to an immunogenic carrier protein. The novel conjugates preserve the chirality of nicotine in its native (S)-(−) state, and have good stability properties. The conjugates are useful in formulating vaccines for active immunization, that are used to prevent and treat nicotine addiction. The antibodies raised in response to the nicotine hapten-carrier conjugate are used for passive immunization. These antibodies are administered for prevention and treatment of nicotine addiction.

22. 发明授权

US06294177B1 Staphylococcus aureus antigen-containing whole cell vaccine 有权
标题翻译：含金黄色葡萄球菌抗原的全细胞疫苗
公开(公告)号：US06294177B1
公开(公告)日：2001-09-25
申请号：US09307775
申请日：1999-05-10
申请人： Ali Ibrahim Fattom
发明人： Ali Ibrahim Fattom
IPC分类号： A61K39085
CPC分类号： G01N33/56938 , A61K39/085 , A61K2039/505 , A61K2039/521 , A61K2039/6037 , C07K16/1271
摘要： A negatively-charged S. aureus antigen contains &bgr;-hexosamine as a major carbohydrate component. S. aureus strains that carry the antigen account for nearly all of the clinically significant strains of S. aureus that are not Type 5 or Type 8 strains. The antigen can be used in combination with S. aureus Type 5 polysaccharide antigen and S. aureus Type 8 polysaccharide antigen to provide nearly 100% coverage of S. aureus infection. The antigen and antibodies to the antigen are useful in kits and assays for diagnosing S. aureus infection. A whole cell vaccine of cells that contain the antigen is particularly useful in the treatment of mastitis.
摘要翻译：负电荷的金黄色葡萄球菌抗原含有β-己糖胺作为主要的碳水化合物组分。携带抗原的金黄色葡萄球菌菌株几乎占所有非5型或8型菌株的金黄色葡萄球菌的临床显着菌株。抗原可与金黄色葡萄球菌5型多糖抗原和金黄色葡萄球菌8型多糖抗原组合使用，以提供近100％的金黄色葡萄球菌感染。抗原和抗原抗体可用于诊断金黄色葡萄球菌感染的试剂盒和测定法。含有抗原的细胞的全细胞疫苗特别可用于治疗乳腺炎。

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