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21. 发明申请

WO2011056899A2 CHIMERIC RSV-F POLYPEPTIDE AND LENTIVIRUS OR ALPHA-RETROVIRUS GAG-BASED VLPS 审中-公开
标题翻译：嵌合RSV-F多肽和雷氏病或α-Retrovirus基于GAG的VLPS
公开(公告)号：WO2011056899A2
公开(公告)日：2011-05-12
申请号：PCT/US2010/055334
申请日：2010-11-03
申请人： LIGOCYTE PHARMACEUTICALS, INC. , HAYNES, Joel, R.
发明人： HAYNES, Joel, R.
IPC分类号： C07K19/00 , C12N15/62 , C12N15/86 , A61K39/295 , A61P31/14
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , C07K16/087 , C07K16/1027 , C07K2317/76 , C07K2319/00 , C12N2740/11023 , C12N2740/16023 , C12N2740/16222 , C12N2760/00023 , C12N2760/18522 , C12N2760/18534
摘要： The present invention relates to chimeric RSV-F polypeptide and lentivirus or alpha- retrovirus GAG-based virus-like particles (VLPs). The present invention also includes methods of making and using such chimeric VLPs. In certain embodiments, the GAG polypeptide of the chimeric VLPs comprises an HlV or ALV GAG polypeptide.
摘要翻译：本发明涉及嵌合RSV-F多肽和基于慢病毒或α-逆转录病毒GAG的病毒样颗粒（VLP）。本发明还包括制造和使用这种嵌合VLP的方法。在某些实施方案中，嵌合VLP的GAG多肽包含H1V或ALV GAG多肽。

22. 发明申请

WO2011044279A2 MICROBIAL SYSTEMS FOR PRODUCING COMMODITY CHEMICALS 审中-公开
标题翻译：生产商品化学品的微生物系统
公开(公告)号：WO2011044279A2
公开(公告)日：2011-04-14
申请号：PCT/US2010/051687
申请日：2010-10-06
申请人： BIO ARCHITECTURE LAB, INC. , YOSHIKUNI, Yasuo , HERMAN, Asael , WARGACKI, Adam, J.
发明人： YOSHIKUNI, Yasuo , HERMAN, Asael , WARGACKI, Adam, J.
IPC分类号： C12N1/21 , C12P19/02 , C12P7/64 , C12N15/52
CPC分类号： C12P19/02 , C12N1/14 , C12N1/20 , C12N1/22 , C12N9/0006 , C12N9/20 , C12N9/2437 , C12N9/244 , C12N9/88 , C12P5/00 , C12P5/007 , C12P7/065 , C12P7/16 , C12P7/6418 , C12P19/04 , C12Y302/01004 , C12Y302/01091 , Y02E50/10 , Y02E50/13 , Y02E50/17
摘要： Provided are improved recombinant microorganisms, and methods of use thereof, for metabolizing biomolecules and producing commodity chemicals such as ethanol therefrom, and genetic constructs to achieve that end.
摘要翻译：提供了改进的重组微生物及其使用方法，用于代谢生物分子和生产商品化学品，例如乙醇，以及实现该目的的遗传构建体。

23. 发明申请

WO2009140657A3 METHOD OF TREATING CHRONIC HEART FAILURE 审中-公开
公开(公告)号：WO2009140657A3
公开(公告)日：2009-11-19
申请号：PCT/US2009/044247
申请日：2009-05-15
申请人： CORTHERA, INC. , UNEMORI, Elaine , TEICHMAN, Sam, L. , DSCHIETZIG, Thomas , STEWART, Dennis, R. , WHITEHOUSE, Martha, Jo
发明人： UNEMORI, Elaine , TEICHMAN, Sam, L. , DSCHIETZIG, Thomas , STEWART, Dennis, R. , WHITEHOUSE, Martha, Jo
IPC分类号： A61K38/00
摘要： The present disclosure relates to methods for treating human subjects afflicted with chronic heart failure. The methods described herein employ administration of relaxin.

24. 发明申请

WO2009103025A3 REACTOR FOR EXTRACTING METALS FROM METAL SULFIDE CONTAINING MATERIALS AND METHODS OF USE 审中-公开
公开(公告)号：WO2009103025A3
公开(公告)日：2009-08-20
申请号：PCT/US2009/034151
申请日：2009-02-13
申请人： BIOMETALLIX, LLC , KELSO, Jody, R. , CINCILLA, William
发明人： KELSO, Jody, R. , CINCILLA, William
IPC分类号： C22B7/00 , C22B3/08 , C22B9/00
摘要： Described herein are an apparatus and method for extracting one or more metals from metal sulfide-containing materials. The reactor includes: a containment vessel, the containment vessel having a base member and a wall member; a gas injection member configured to introduce a gas into the containment vessel; a liquid injection member configured to introduce a liquid into the containment vessel; and a cellular-confinement medium in contact with the base member, the cellular-confinement medium including aggregate materials and configured to affect liquid-solid separation in the containment vessel. The reactor may be operated as a free drained reactor, a partially saturated reactor, or a flooded reactor.

25. 发明申请

WO2008128000A1 TEFLON REPLACEMENTS AND RELATED PRODUCTION METHODS 审中-公开
标题翻译： TEFLON替代品和相关生产方法
公开(公告)号：WO2008128000A1
公开(公告)日：2008-10-23
申请号：PCT/US2008/059957
申请日：2008-04-10
申请人： ALTAIRNANO, INC. , MOLNAR, Michael
发明人： MOLNAR, Michael
IPC分类号： C23C4/10 , C23C4/18 , C23C24/08
CPC分类号： C23C24/04 , C23C4/11 , C23C4/18 , Y02T50/67 , Y10T428/24413
摘要： The methods and compositions described herein generally relate to methods and compositions for providing a non-stick surface on selected materials. In a method aspect, the methods and compositions described herein provide a method of making a non-stick surface on a metal substrate. The method includes the following steps: a) applying nano structured zirconia or nanostructured titania to a metal substrate; and b) polishing the surface of the metal substrate.
摘要翻译：本文所述的方法和组合物通常涉及用于在所选材料上提供不粘表面的方法和组合物。在方法方面，本文所述的方法和组合物提供了在金属基底上制造不粘表面的方法。该方法包括以下步骤：a）将纳米结构氧化锆或纳米结构二氧化钛应用于金属基底; 和b）抛光金属基底的表面。

26. 发明申请

WO2008036424A3 CHEMICALLY INDUCIBLE CUCUMBER MOSAIC VIRUS PROTEIN EXPRESSION SYSTEM 审中-公开
公开(公告)号：WO2008036424A3
公开(公告)日：2008-03-27
申请号：PCT/US2007/020712
申请日：2007-09-24
申请人： REGENTS OF THE UNIVERSITY OF CALIFORNIA , MCDONALD, Karen, A. , DANDEKAR, Abhaya , FALK, Bryce, W. , SUDARSHANA, Mysore, R. , URATSU, Sandra, L. , PLESHA, Michael, A. , HUANG, Ting-Kuo
发明人： MCDONALD, Karen, A. , DANDEKAR, Abhaya , FALK, Bryce, W. , SUDARSHANA, Mysore, R. , URATSU, Sandra, L. , PLESHA, Michael, A. , HUANG, Ting-Kuo
IPC分类号： C12N15/82 , C12N15/63
摘要： The invention relates to a novel chemically inducible plant viral amplicon (CMViva) expression system that permits controllable, high level expression of foreign genes in plant hosts. This system employs agro-infiltration of plants to provide a transient production of a protein of interest, such as a human blood protein. This system provides a major advantage over existing plant expression systems because it allows for consistent expression of foreign or heterologous proteins in plant hosts.

27. 发明申请

WO2007146420A2 LETTUCE BREEDING METHOD 审中-公开
标题翻译：育儿育种方法
公开(公告)号：WO2007146420A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/014063
申请日：2007-06-15
申请人： PROGENY ADVANCED GENETICS , GIBSON, George, D. , OLIVAS, Nathan , SALM, Peter
发明人： GIBSON, George, D. , OLIVAS, Nathan , SALM, Peter
IPC分类号： A01H5/00
CPC分类号： A01H5/12 , A01H1/02
摘要： Methods for pollinating lettuce and producing hybrid lettuce seed are described. The methods include the steps of providing lettuce plants and releasing Megachile rotundata bees or attracting pollinators. Hybrid lettuce seeds and plants produced using methods of this invention and male sterile lettuce lines used in this invention are also described.
摘要翻译：描述了授粉莴苣和生产杂交莴苣种子的方法。这些方法包括提供莴苣植物和释放Megachile rotundata蜜蜂或吸引传粉者的步骤。还描述了使用本发明的方法和本发明中使用的雄性不育莴苣系产生的杂种莴苣种子和植物。

28. 发明申请

WO2007008673A3 CRYSTALLINE ANHYDROUS CEFDINIR AND CRYSTALLINE CEFDINIR HYDRATES 审中-公开
公开(公告)号：WO2007008673A3
公开(公告)日：2007-01-18
申请号：PCT/US2006/026537
申请日：2006-07-10
申请人： ABBOTT LABORATORIES , LAW, Devalina , HENRY, Rodger, F. , LOU, Xiaochun
发明人： LAW, Devalina , HENRY, Rodger, F. , LOU, Xiaochun
IPC分类号： C07D501/22 , A61K31/546 , A61P31/04
摘要： A novel crystalline cefdinir anhydrate and novel crystalline cefdinir hydrates, ways to make them and use them, compositions comprising them and made with them, and methods of treatment using them are disclosed.

29. 发明申请

WO2007008672A1 CRYSTALLINE CEFDINIR TRIHEMIHYDRATE 审中-公开
标题翻译：晶体蛋白三水合物
公开(公告)号：WO2007008672A1
公开(公告)日：2007-01-18
申请号：PCT/US2006/026536
申请日：2006-07-10
申请人： ABBOTT LABORATORIES , LAW, Devalina , HENRY, Rodger, F. , LOU, Xiaochun
发明人： LAW, Devalina , HENRY, Rodger, F. , LOU, Xiaochun
IPC分类号： C07D501/00 , A61K31/546 , A61P31/04
CPC分类号： C07D501/00
摘要： A novel crystalline cefdinir trihemihydrate , ways to make it and use it, compositions comprising it and made with it, and methods of treatment using it are disclosed.
摘要翻译：公开了一种新颖的结晶头孢地尼三聚水合物，其制备方法和使用方法，包含它并由其制备的组合物，以及使用它的治疗方法。

30. 发明申请

WO2006119438A2 METHODS FOR MEASURING CHOLESTEROL METABOLISM AND TRANSPORT 审中-公开
标题翻译：测量胆固醇代谢和运输的方法
公开(公告)号：WO2006119438A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/017167
申请日：2006-05-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HELLERSTEIN, Marc, K.
发明人： HELLERSTEIN, Marc, K.
IPC分类号： A61K51/00 , A61K49/00
CPC分类号： A61K51/0493
摘要： The present invention relates to biochemical methods for determining reverse cholesterol transport (RCT). Specifically, the three components of RCT (efflux, plasma, and excretion) are measured in vivo by administering an isotope-labeled cholesterol or cholesterol-related molecule or cholesterol-related complex, and then measuring the dilution or appearance of isotopes in the various cholesterol or cholesterol-related molecules or cholesterol-related complexes, as well as recovery in sterol end-products, that are part of RCT. A parameter of Global RCT flux, representing for the first time in living organisms that combined rate of cholesterol efflux from tissues into blood and excretion from blood out of the body, is generated. Such methods find use in drug discovery and development, diagnosis and prognosis of atherosclerosis and other blood vessel diseases and conditions, the selection of proper doses for treating disease, and selecting subjects for therapies targeting RCT flux.
摘要翻译：本发明涉及用于测定反向胆固醇转运（RCT）的生物化学方法。具体来说，通过施用同位素标记的胆固醇或胆固醇相关分子或与胆固醇相关的复合物在体内测量RCT（流出，血浆和排泄物）的三个组分，然后测量各种胆固醇中同位素的稀释或外观或胆固醇相关分子或胆固醇相关复合物，以及作为RCT一部分的甾醇终产物的回收。产生全球RCT通量的参数，这是生物体中首次出现胆固醇从组织向血液中流出并将血液排出体外的结合率。这些方法可用于药物发现和开发，动脉粥样硬化和其他血管疾病和病症的诊断和预后，选择用于治疗疾病的适当剂量，并选择靶向RCT通量的疗法的受试者。

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