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21. 发明申请

WO2003007724A1 YOGURT MANUFACTURE USING HIGH HYDROSTATIC PRESSURE AND THERMAL TREATMENT 审中-公开
标题翻译：使用高水压和热处理的YOGURT制造
公开(公告)号：WO2003007724A1
公开(公告)日：2003-01-30
申请号：PCT/US2002/022713
申请日：2002-07-17
申请人： WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION , HARTE, Federico, M. , BARBOSA-CANOVAS, Gustavo, V. , SWANSON, Barry, G. , LUEDECKE, Lloyd
发明人： HARTE, Federico, M. , BARBOSA-CANOVAS, Gustavo, V. , SWANSON, Barry, G. , LUEDECKE, Lloyd
IPC分类号： A23C9/12
CPC分类号： A23C9/123 , A23C2210/15
摘要： The present invention is directed to methods for manufacturing yogurt using high hydrostatic pressure in combination with thermal processing to obtain gels with desirable firmness and syneresis properties. Another aspect of the invention is directed to milk products manufactured using the methods of the invention.
摘要翻译：本发明涉及使用高静水压力与热加工一起制造酸奶以获得具有期望的坚固度和脱水收缩性质的凝胶的方法。本发明的另一方面涉及使用本发明的方法制造的乳制品。

22. 发明申请

WO2008147826A1 MALARIA LIVER STAGE DRUGS 审中-公开
公开(公告)号：WO2008147826A1
公开(公告)日：2008-12-04
申请号：PCT/US2008/064436
申请日：2008-05-21
申请人： SEATTLE BIOMEDICAL RESEARCH INSTITUTE , KAPPE, Stefan, H. I. , TARUN, Alice , VAUGHAN, Ashley
发明人： KAPPE, Stefan, H. I. , TARUN, Alice , VAUGHAN, Ashley
IPC分类号： A61K31/09 , A61P3/10 , A61P31/00
CPC分类号： A61K31/09 , Y02A50/411
摘要： The invention provides methods for inhibiting the growth of liver stage Plasmodium parasites using inhibitors of apicoplast fatty acid synthesis. The invention further provides methods for preventing malaria and methods for treating Plasmodium infections.
摘要翻译：本发明提供使用抑制阿霉素脂肪酸合成来抑制肝阶段疟原虫寄生虫生长的方法。本发明还提供了预防疟疾的方法和治疗疟原虫感染的方法。

23. 发明申请

WO2007112451A2 COVALENT CONJUGATES BETWEEN ENDOPEROXIDES AND TRANSFERRIN AND LACTOFERRIN RECEPTOR-BINDING AGENTS 审中-公开
标题翻译：内酯与转铁蛋白和LACTOFERRIN受体结合剂之间的共价结合
公开(公告)号：WO2007112451A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/065399
申请日：2007-03-28
申请人： UNIVERSITY OF WASHINGTON , SASAKI, Tomikazu , LAI, Henry, C. , SINGH, Narendra, P. , OH, Steve, J.
发明人： SASAKI, Tomikazu , LAI, Henry, C. , SINGH, Narendra, P. , OH, Steve, J.
IPC分类号： A61K38/20 , A61K38/28 , A61K38/18 , C07D323/04
CPC分类号： C07K7/08 , A61K38/00 , A61K47/64 , A61K47/66 , B82Y5/00 , C07D493/18 , C07D493/20 , C07D519/00 , C07K7/06 , Y02A50/411
摘要： The invention relates to covalent conjugates between endoperoxides and small peptides and organic compounds that bind to molecular cavities on the transferrin or lactoferrin receptor, and the use of compositions comprising these conjugates to treat cancer, hyperproliferative disorders, inflammatory diseases, and infections.
摘要翻译：本发明涉及内过氧化物与结合于转铁蛋白或乳铁蛋白受体上的分子腔的小肽和有机化合物之间的共价缀合物，以及使用包含这些缀合物的组合物来治疗癌症，过度增殖性疾病，炎性疾病和感染。

24. 发明申请

WO2007005720A2 METHODS AND COMPOSITIONS FOR PROMOTING WOUND HEALING 审中-公开
标题翻译：促进愈合的方法和组合
公开(公告)号：WO2007005720A2
公开(公告)日：2007-01-11
申请号：PCT/US2006/025788
申请日：2006-06-29
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , WOOLEY, Richard, E. , RITCHIE, Branson, W. , KEMP, Douglas, T. , CAPOMACCHIA, Anthony, C. , BURNLEY, Victoria, V.
发明人： WOOLEY, Richard, E. , RITCHIE, Branson, W. , KEMP, Douglas, T. , CAPOMACCHIA, Anthony, C. , BURNLEY, Victoria, V.
IPC分类号： A61K31/195 , A61K8/46
CPC分类号： A61K33/38 , A61K9/0014 , A61K9/08 , A61K31/133 , A61K31/195 , A61K31/198 , A61K45/06 , A61L15/18 , A61L15/20 , A61L15/44 , A61L26/00 , A61L26/0004 , A61L26/0066 , A61L2300/406 , A61L2300/412 , Y02A50/475 , Y02A50/478 , Y02A50/479 , Y02A50/481
摘要： The present invention provides methods and compositions that use the combination of Tris and EDTA to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amount of Tris and EDTA applied to a wound or burn can be selected to achieve one or more of the foregoing effects.
摘要翻译：本发明提供使用Tris和EDTA的组合来抑制伤口或烧伤部位的微生物生长和/或促进伤口或烧伤愈合和/或减少感觉的方法和组合物在伤口或烧伤部位的疼痛。可以选择施加到伤口或烧伤上的Tris和EDTA的量以实现一种或多种前述效果。

25. 发明申请

WO2006071933A2 HETERO-OLIGOMERIC HIV ENVELOPE PROTEINS 审中-公开
标题翻译：异位低密度艾滋病毒包膜蛋白
公开(公告)号：WO2006071933A2
公开(公告)日：2006-07-06
申请号：PCT/US2005/047244
申请日：2005-12-28
申请人： SEATTLE BIOMEDICAL RESEARCH INSTITUTE , STAMATATOS, Leonidas
发明人： STAMATATOS, Leonidas
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/57 , C12N2740/16122
摘要： In one aspect, the invention provides an HIV envelope heterotrimer comprising at least two different Env glycoprotein monomers. In some heterotrimers, at least two Env glycoprotein monomers are from different HIV isolates, for example, different HIV-1 isolates. Heterotrimers may contain Env glycoprotein monomers from HIV isolates belonging to the same Glade or to different clades or both. At least one of the Env glycoprotein monomers in a heterotrimer of the invention may be modified in a way that alters its amino acid composition. In another aspect, the invention provides methods for inducing an immune response in a vertebrate host against HIV or an HIV-infected cell, comprising administering to a vertebrate host a prophylactically or therapeutically effective amount of a composition comprising an HIV envelope heterotrimer.
摘要翻译：一方面，本发明提供包含至少两种不同的Env糖蛋白单体的HIV包膜异源三聚体。在一些异源三聚体中，至少两种Env糖蛋白单体来自不同的HIV分离物，例如不同的HIV-1分离物。异源三聚体可能含有属于同一Glade的HIV分离物的Env糖蛋白单体或不同的进化枝或两者。本发明的异源三聚体中的至少一种Env糖蛋白单体可以以改变其氨基酸组成的方式进行修饰。另一方面，本发明提供了在脊椎动物宿主中针对HIV或HIV感染细胞诱导免疫应答的方法，包括向脊椎动物宿主施用预防或治疗有效量的包含HIV包膜异源三聚体的组合物。

26. 发明申请

WO2004037791A1 INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 审中-公开
标题翻译：糖原合成酶激酶抑制剂3
公开(公告)号：WO2004037791A1
公开(公告)日：2004-05-06
申请号：PCT/US2003/033370
申请日：2003-10-20
申请人： CHIRON CORPORATION , NUSS, John, M. , SUBRAMANIAN, Sharadha , WAGMAN, Allan, S.
发明人： NUSS, John, M. , SUBRAMANIAN, Sharadha , WAGMAN, Allan, S.
IPC分类号： C07D213/74
CPC分类号： C07D213/74 , C07D213/85 , C07D401/12
摘要： New carbocyclic compounds of formula (I), compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as in the treatment of diabetes, Alzheimer's disease, other neurodegenerative disorders, such as Parkinson's disease and Huntington's disease, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
摘要翻译：式（I）的新的碳环化合物，体外抑制糖原合酶激酶（GSK3）活性的组合物和方法以及治疗GSK3介导的疾病的方法，在体内提供。本发明的方法，化合物和组合物可以单独使用或与其他药理学活性剂组合用于治疗由GSK3活性介导的病症，例如用于治疗糖尿病，阿尔茨海默氏病，其他神经退行性病症如帕金森病疾病和亨廷顿舞蹈病，肥胖症，动脉粥样硬化心血管疾病，原发性高血压，多囊卵巢综合征，X综合征，局部缺血，创伤性脑损伤，双相型障碍，免疫缺陷或癌症。

27. 发明申请

WO2004018455A1 PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 审中-公开
标题翻译：吡咯基合成酶抑制剂3
公开(公告)号：WO2004018455A1
公开(公告)日：2004-03-04
申请号：PCT/US2003/026625
申请日：2003-08-21
申请人： CHIRON CORPORATION , DESAI, Manoj , NI, Zhi-Jie , NG, Simon , PFISTER, Keith, B. , RAMURTHY, Savithri , SUBRAMANIAN, Sharadha , WAGMAN, Allan, S.
发明人： DESAI, Manoj , NI, Zhi-Jie , NG, Simon , PFISTER, Keith, B. , RAMURTHY, Savithri , SUBRAMANIAN, Sharadha , WAGMAN, Allan, S.
IPC分类号： C07D401/12
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D453/02 , C07D487/08
摘要： New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
摘要翻译：提供了新的基于吡咯的化合物，在体外抑制糖原合酶激酶（GSK3）活性和GSK3介导的疾病的体内治疗的组合物和方法。本发明的方法，化合物和组合物可以单独使用或与其它药理活性剂组合用于治疗由GSK3活性介导的病症，例如糖尿病，阿尔茨海默病和其他神经变性疾病，肥胖症，动脉粥样硬化性心血管疾病，必需的高血压，多囊卵巢综合征，X综合征，缺血，创伤性脑损伤，双相情感障碍，免疫缺陷或癌症。

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