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21. 发明申请

WO2012024415A3 DURABLE CERAMIC NANOCOMPOSITE THERMAL BARRIER COATINGS FOR METALS AND REFRACTORIES 审中-公开
公开(公告)号：WO2012024415A3
公开(公告)日：2012-02-23
申请号：PCT/US2011/048106
申请日：2011-08-17
申请人： TEXAS STATE UNIVERSITY SAN MARCOS, A COMPONENT OF THE TEXAS STATE UNIVERSITY SYSTEM , MASSINGILL, John, L., Jr. , POWELL, Clois, E. , HABINGREITHER, Robert, B. , COOK, Ray, G.
发明人： MASSINGILL, John, L., Jr. , POWELL, Clois, E. , HABINGREITHER, Robert, B. , COOK, Ray, G.
IPC分类号： C09D183/16 , C04B41/81 , C09D5/00 , C09D7/12
摘要： A coating composition for metal or refractories includes a polysilazane resin; and one or more additives that alter the thermal conductivity and/or the abrasion resistance of the cured polysilazane resin. The coating composition may be applied to a metal or refractory material substrate and heated to form a ceramic layer on the substrate. The ceramic layer exhibits lower thermal conductivity and increased abrasion resistance.

22. 发明申请

WO2010050939A1 IMPROVED HCV VACCINES AND METHODS FOR USING THE SAME 审中-公开
标题翻译：改进的HCV疫苗及其使用方法
公开(公告)号：WO2010050939A1
公开(公告)日：2010-05-06
申请号：PCT/US2008/081627
申请日：2008-10-29
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , VGX PHARMACEUTICALS, LLC , WEINER, David, B. , LANG, Krystle, A. , YAN, Jian , DRAGHIA-AKLI, Ruxandra , KHAN, Amir
发明人： WEINER, David, B. , LANG, Krystle, A. , YAN, Jian , DRAGHIA-AKLI, Ruxandra , KHAN, Amir
IPC分类号： C07H21/00 , C07K14/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55 , C12N7/00 , C12N9/506 , C12N15/86 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234
摘要： Improved anti-HCV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HCV genotype l a/l b NS3 and NS4A. Pharmaceutical composition, recombinant vaccines comprising and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HCV are disclosed.
摘要翻译：公开了改进的抗HCV免疫原和编码它们的核酸分子。所公开的免疫原包括那些具有一致的HCV基因型l a / lb NS3和NS4A的那些。公开了药物组合物，包含减毒活疫苗和减毒活疫苗的重组疫苗，并公开了针对HCV个体诱导免疫应答的方法。

23. 发明申请

WO2009158584A1 DUAL ADHESIVE TECHNOLOGY 审中-公开
标题翻译：双胶粘技术
公开(公告)号：WO2009158584A1
公开(公告)日：2009-12-30
申请号：PCT/US2009/048802
申请日：2009-06-26
申请人： WYETH , LIU, Xiuying , KRESEVIC, John
发明人： LIU, Xiuying , KRESEVIC, John
IPC分类号： A61K9/24 , A61K9/62 , A61K31/565 , A61P19/10
CPC分类号： A61K9/006 , A61K9/0034 , A61K9/0036 , A61K9/2054 , A61K9/2086 , A61K9/2853 , A61K31/565
摘要： A dual adhesive layer dosage form for delivery of active agent to and across, the mucosa is disclosed. Particularly, bioadhesive tablets for administration at the vaginal mucosa are disclosed as having a central active layer sandwiched between two bioadhesive layers.
摘要翻译：公开了用于将活性剂递送至粘膜和穿过粘膜的双粘合剂层剂型。特别地，在阴道粘膜上施用的生物粘附片剂被公开为具有夹在两个生物粘附层之间的中心活性层。

24. 发明申请

WO2009100335A1 PHOSPHATE DERIVATIVES OF SUBSTITUTED BENZOXAZOLES 审中-公开
标题翻译：取代苯甲酸的磷酸盐衍生物
公开(公告)号：WO2009100335A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/033398
申请日：2009-02-06
申请人： WYETH , BAUDY, Reinhardt , TRYBULSKI, Eugene, J. , MAGOLDA, Ronald , KHAFIZOVA, Gulnaz , FAWZI, Mahdi, B. , YANG, Cuijian
发明人： BAUDY, Reinhardt , TRYBULSKI, Eugene, J. , MAGOLDA, Ronald , KHAFIZOVA, Gulnaz , FAWZI, Mahdi, B. , YANG, Cuijian
IPC分类号： C07F9/653 , A61K31/675 , A61P29/00
CPC分类号： C07F9/65324
摘要： The present invention relates to phosphate derivatives of estrogen receptor beta agonists, compositions thereof, preparations thereof, and uses thereof. Formula (I).
摘要翻译：本发明涉及雌激素受体β激动剂的磷酸酯衍生物，其组合物，制剂及其用途。式（I）。

25. 发明申请

WO2009042698A2 SYSTEMS AND METHODS OF PREPARING A COMPOSITION USED IN MULTIPLE PROCESSING TOOLS 审中-公开
标题翻译：制备用于多种加工工具的组合物的系统和方法
公开(公告)号：WO2009042698A2
公开(公告)日：2009-04-02
申请号：PCT/US2008/077543
申请日：2008-09-24
申请人： TRES-ARK, INC. , ANDERSON, Gary, R. , FOWLER, Matt , TIMMONS, Tom
发明人： ANDERSON, Gary, R. , FOWLER, Matt , TIMMONS, Tom
IPC分类号： B01F3/22
CPC分类号： B01F15/0408 , B01F15/0441 , G05D11/131
摘要： There is disclosed a system and method of formulating a batch comprising at least two chemicals. An embodiment is disclosed wherein a feedforward algorithm can be used to control the target blend. Subsequently a feedback closed loop control loop algorithm is provided for a multivariant blend. Use of this approach allows for a continuously autoreplenished and controlled blend. Also disclosed is the ability to control via feedforward and feedback algorithms a fast responding control mode that allows for the elimination of a container. This approach will allow for "one pass" blending with control. The controller implements an automated fault detection and correction system, thereby identifying necessary maintenance prior to failure. If failure does occur the signature recognition allows rapid analysis and correction thus maximizing tool availability.
摘要翻译：公开了一种配制包含至少两种化学品的批料的系统和方法。公开了一种实施例，其中可以使用前馈算法来控制目标混合。随后，为多变量混合提供反馈闭环控制环路算法。使用这种方法允许连续自动补偿和控制混合。还公开了通过前馈和反馈算法控制允许消除容器的快速响应控制模式的能力。这种方法将允许“一次通过”与控制混合。控制器实现自动故障检测和校正系统，从而在故障之前识别必要的维护。如果发生故障，则签名识别允许快速分析和校正，从而最大限度地提高工具可用性。

26. 发明申请

WO2008100769A2 PROCESS FOR SELECTIVE SULFATION OF AROMATIC HYDROXYL GROUPS 审中-公开
标题翻译：芳香羟基选择性硫化方法
公开(公告)号：WO2008100769A2
公开(公告)日：2008-08-21
申请号：PCT/US2008/053276
申请日：2008-02-07
申请人： WYETH , MEGATI, Sreenivasulu , RAVEENDRANATH, Panolil
发明人： MEGATI, Sreenivasulu , RAVEENDRANATH, Panolil
CPC分类号： C07J31/006
摘要： The present invention relates to processes for selective sulfation of an aromatic hydroxyl group over an aliphatic hydroxyl group where both are present in the same molecule. This invention also relates to processes for selective sulfation of the aromatic hydroxyl group of equilin, equilenin, estradiol, estra(1,3,5-triene)- 3,16,17-triol, dihydroequilenin or dihydroequilin. This invention further relates to alkali metal salts of dihydroequilenin sulfates, dihydroequilin sulfates, estradiol sulfates, and estriol sulfates, processes for making thereof, stable compositions comprising thereof, and the use thereof.
摘要翻译：本发明涉及在脂肪族羟基上选择性硫酸化芳族羟基的方法，其中两者都存在于同一分子中。本发明还涉及选择性硫酸化平衡，平衡，雌二醇，雌二醇（1,3,5-三烯）-3,16,17-三醇，二氢马来西林或二氢马雌二醇的芳族羟基的方法。本发明还涉及硫酸二氢马来酰氯，二氢巯基硫酸盐，雌二醇硫酸盐和雌三醇硫酸盐的碱金属盐，其制备方法，包含它们的稳定组合物及其用途。

27. 发明申请

WO2008058074A2 SUGAR COATINGS AND METHODS THEREFOR 审中-公开
标题翻译：糖类涂料及其方法
公开(公告)号：WO2008058074A2
公开(公告)日：2008-05-15
申请号：PCT/US2007/083632
申请日：2007-11-05
申请人： WYETH , KRESEVIC, John , KULKARNI, Sheetal , LIU, Xiuying , BAKSH, Nizamuddin , ENEVER, Robin
发明人： KRESEVIC, John , KULKARNI, Sheetal , LIU, Xiuying , BAKSH, Nizamuddin , ENEVER, Robin
CPC分类号： A61K9/2018 , A23G3/343 , A23G3/54 , A61K9/209 , A61K9/2826 , A61K9/2853 , A61K9/2893
摘要： The invention provides sugar-containing compositions suitable for use in coating solid preparations such as tablets, pills, granules and grains. Methods of using such coatings are provided, as are solid dosage forms coated with the compositions. In some embodiments, the methods provide sugar coated tablets comprising conjugated estrogens, and a progestin, for example medroxyprogesterone acetate.
摘要翻译：本发明提供了适用于涂敷固体制剂如片剂，丸剂，颗粒剂和颗粒剂的含糖组合物。提供使用这种涂层的方法，以及涂覆有组合物的固体剂型。在一些实施方案中，所述方法提供包含结合型雌激素的糖衣片剂和孕激素，例如醋酸甲羟孕酮。

28. 发明申请

WO2008006019A3 GROWTH HORMONE RELEASING HORMONE TREATMENT TO DECREASE CHOLESTEROL LEVELS 审中-公开
公开(公告)号：WO2008006019A3
公开(公告)日：2008-01-10
申请号：PCT/US2007/072851
申请日：2007-07-05
申请人： ADVISYS INC. , DRAGHIA-AKLI, Ruxandra , KHAN, Amir, S. , FIOROTTO, Marta, L.
发明人： DRAGHIA-AKLI, Ruxandra , KHAN, Amir, S. , FIOROTTO, Marta, L.
IPC分类号： A61K38/24
摘要： This invention is related to compositions and methods for decreasing cholesterol levels in a subject. The method utilizes a nucleic acid expression construct that encodes a growth- hormone-releasing-hormone ("GHRH") that is delivered into a tissue of the subject, wherein, GHRH is expressed in vivo in the subject.

29. 发明申请

WO2007147014A2 METHOD AND SYSTEMS FOR USING BIOPOLYMER-BASED BEADS AND HYDROGELS 审中-公开
标题翻译：使用基于生物聚合物的珠粒和水凝胶的方法和系统
公开(公告)号：WO2007147014A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/071142
申请日：2007-06-13
申请人： FMC BIOPOLYMER AS , RAUH, Francis , LEE, Randall, J. , MACIEJEWSKI, Mark
发明人： RAUH, Francis , LEE, Randall, J. , MACIEJEWSKI, Mark
IPC分类号： A61K38/14
CPC分类号： A61L27/24 , A61K38/06 , A61L27/20 , A61L27/225 , A61L27/227 , A61L2400/06 , A61L2430/20 , C08L5/08 , C08L5/04
摘要： Compositions comprising biopolymers such as alginates and cell attachment peptides are disclosed. Compositions may optionally further comprise cells. Methods for repairing or treating a tissues and organs with such compositions and systems for providing such compositions to tissues and organs, and methods for delivering desired proteins to individual with such compositions and systems for providing such compositions are also disclosed. In vitro methods of culturing cells are also disclosed.
摘要翻译：公开了包含生物聚合物如藻酸盐和细胞附着肽的组合物。组合物可以任选地进一步包含细胞。还公开了用这种用于将组合物和组织提供给组织和器官的组合物和系统来修复或治疗组织和器官的方法，以及用于将这些组合物和系统用于提供此类组合物的所需蛋白递送给个体的方法。还公开了体外培养细胞的方法。

30. 发明申请

WO2007084775A2 COMPOSITIONS AND METHODS FOR MODULATION OF SUPPRESSOR T CELL ACTIVATION 审中-公开
标题翻译：用于调节抑制剂T细胞活化的组合物和方法
公开(公告)号：WO2007084775A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/001677
申请日：2007-01-22
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THE CHILDREN'S HOSPITAL OF PHILADELPHIA , WANG, Bin , GREENE, Mark, I. , SAQUAF, Sandra , LI, Bin , ZHANG, Hongtao , HANCOCK, Wayne, W.
发明人： WANG, Bin , GREENE, Mark, I. , SAQUAF, Sandra , LI, Bin , ZHANG, Hongtao , HANCOCK, Wayne, W.
IPC分类号： A61K35/14
CPC分类号： C12N5/0636 , A61K31/19 , A61K35/17 , A61K38/1793 , A61K39/00 , A61K39/0011 , A61K39/39 , A61K49/0008 , C12N15/1137 , C12N2310/14 , A61K2300/00
摘要： Methods of treating autoimmune disorders, coronary artery disease, allergy symptoms, allograft rejection sepsis/toxic shock are disclosed. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3 in combination with a T suppressor stimulus and/or an antigen. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3. Some methods comprise administering soluble GITR or antibodies that bind to GITR ligand. Methods of treating cancer, infectious diseases, and immune deficiency are also disclosed as are vaccination methods. The methods comprise administering one or more regulatory compositions to inactivate the T suppressor cells by reducing the acetylation level and/or protein level of FOXP3. Improved vaccines and vaccination methods are disclosed. Methods of identifying compounds that are useful to modulate acetylation level and/or protein level of FOXP3 and treat diseases are disclosed.
摘要翻译：公开了治疗自身免疫性疾病，冠状动脉疾病，过敏症状，同种异体移植排斥败血症/中毒性休克的方法。一些方法包括施用一种或多种调节组合物以通过与T抑制刺激和/或抗原组合增加FOXP3的乙酰化水平和/或蛋白水平来激活T抑制细胞。一些方法包括施用一种或多种调节组合物以通过增加FOXP3的乙酰化水平和/或蛋白质水平来激活T抑制细胞。一些方法包括施用可结合GITR配体的可溶性GITR或抗体。疫苗接种方法也公开了治疗癌症，感染性疾病和免疫缺陷的方法。所述方法包括施用一种或多种调节组合物以通过降低FOXP3的乙酰化水平和/或蛋白质水平来灭活T抑制细胞。公开了改进的疫苗和疫苗接种方法。公开了鉴定可用于调节FOXP3的乙酰化水平和/或蛋白质水平并治疗疾病的化合物的方法。

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