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21. 发明专利

DE60023489T2 未知
公开(公告)号：DE60023489T2
公开(公告)日：2006-07-27
申请号：DE60023489
申请日：2000-05-04
申请人： PROCOGNIA LTD
发明人： MARKMAN OFER
IPC分类号： G01N33/53 , C12M1/40 , C12Q1/34 , C12Q1/48 , G01N33/02 , G01N33/15 , G01N33/50 , G01N33/543 , G01N33/66
摘要： A method for the structural analysis of a saccharide is disclosed, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixture comprising a plurality of fragments of said saccharide; c) washing or otherwise removing unbound saccharide or saccharide fragments; d) adding to the surface obtained in step c) an essentially sequence- and/or site-specific marker, or a mixture of essentially sequence- and/or site-specific markers; e) acquiring one or more images of the markers that are bound to said surface; and f) deriving information related to the identity of the saccharide being analyzed from said image. The invention further provides a solid support comprising in a pre-defined order a plurality of visual or otherwise detectable markers representative of a saccharide or saccharide sequence or fragment, as well as methods and software for choosing a set of essentially sequence-specific markers for use in the method of the invention, methods for obtaining structure-related data of saccharides, and methods and apparatus for analyzing the structure of a saccharide by sequential digestion using a glycosidase or an equivalent thereof.

22. 发明专利

DE60023489D1 未知
公开(公告)号：DE60023489D1
公开(公告)日：2005-12-01
申请号：DE60023489
申请日：2000-05-04
申请人： PROCOGNIA LTD
发明人： MARKMAN OFER
IPC分类号： C12M1/40 , C12Q1/34 , C12Q1/48 , G01N33/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/66
摘要： A method for the structural analysis of a saccharide is disclosed, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixture comprising a plurality of fragments of said saccharide; c) washing or otherwise removing unbound saccharide or saccharide fragments; d) adding to the surface obtained in step c) an essentially sequence- and/or site-specific marker, or a mixture of essentially sequence- and/or site-specific markers; e) acquiring one or more images of the markers that are bound to said surface; and f) deriving information related to the identity of the saccharide being analyzed from said image. The invention further provides a solid support comprising in a pre-defined order a plurality of visual or otherwise detectable markers representative of a saccharide or saccharide sequence or fragment, as well as methods and software for choosing a set of essentially sequence-specific markers for use in the method of the invention, methods for obtaining structure-related data of saccharides, and methods and apparatus for analyzing the structure of a saccharide by sequential digestion using a glycosidase or an equivalent thereof.

23. 发明专利

CA2428150A1 METHODS FOR COMPARITIVE ANALYSIS OF CARBOHYDRATE POLYMERS 未知
公开(公告)号：CA2428150A1
公开(公告)日：2002-05-10
申请号：CA2428150
申请日：2001-11-05
申请人： PROCOGNIA LTD
发明人： ROTHMAN CHANA , MARKMAN OFER , AMOR YEHUDIT , ORON ASSAF , OR EINAT
IPC分类号： C12Q1/02 , C12Q1/34 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/58
摘要： Disclosed is a method for characterizing a carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer is allowed to contact the substrate under conditions that allow for formation of a first complex between the first saccharide-binding agent and the carbohydrate polymer. A second saccharide-binding agent, which preferably includes a label, is also contacted with the carbohydrate polymer under conditions that allow for formation of a second complex between the second binding agent and the first complex. Identification of the first and second binding agent allows for characterization of the polysaccharide.

24. 发明专利

CA2428431C SYSTEM AND METHOD FOR INTEGRATED ANALYSIS OF DATA FOR CHARACTERIZING CARBOHYDRATE POLYMERS 未知
公开(公告)号：CA2428431C
公开(公告)日：2012-05-01
申请号：CA2428431
申请日：2001-11-05
申请人： PROCOGNIA LTD
发明人： ORON ASSAPH PERETZ , OR EINAT , MARKMAN OFER , SHVARTSER LEONID , ZAARUR NAVA
IPC分类号： G06F19/00 , C12Q1/02 , C12Q1/34 , C40B30/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/58 , G06F17/30
摘要： A system and method for characterizing carbohydrate polymers according to maps obtained from experimental data. Preferably, the data is obtained from a plurality of different types of experimental assays for characterizing the carbohydrate polymer. More preferably, at least one such assay involves binding a saccharide-binding agent to the carbohydrate polymer. One or more features of the carbohydrate polymer are then preferably characterized. These features are preferably derived from maps of the data obtained from assays involving the sample carbohydrate polymer. These maps are more preferably analyzed at a plurality of levels, with each level providing more abstract biological information. Most preferably, new types of experimental data are introduced to the process of analysis at each level, in order to support more complex analyses of the data. Optionally and most preferably, maps are eliminated at each level as being inconsistent with the experimental data. New maps are most preferably added at a higher level only if they are derived from the new experimental data which has been introduced at that level, in order to prevent a combinatorial explosion at successive levels of data analysis.

25. 发明专利

CA2548219A1 METHOD FOR ANALYZING A GLYCOMOLECULE 未知
公开(公告)号：CA2548219A1
公开(公告)日：2005-06-30
申请号：CA2548219
申请日：2004-12-20
申请人： PROCOGNIA LTD
发明人： REBE SABINA , BANGIO HAIM , KASUTO IDIL KELSON , KLEINMAN FREDI , GULKO MIRIT KOLOG , MARKMAN OFER , ALERGAND TAL , SAMOKOVLISKY ALBENA , ROSENFELD RAKEFET , AMOR YEHUDIT , MAYA RUTH
IPC分类号： G01N33/53 , G01N33/537 , G01N33/543
摘要： The invention relates generally the structural analysis of glycomolecule- containing macromolecules, such as those that occur either attached to proteins (proteoglycans, glycoproteins), lipids, or as free saccharides.

26. 发明专利

IL155716D0 METHODS FOR COMPARATIVE ANALYSIS OF CARBOHYDRATE POLYMERS 未知
公开(公告)号：IL155716D0
公开(公告)日：2003-11-23
申请号：IL15571601
申请日：2001-11-05
申请人： PROCOGNIA LTD
IPC分类号： C12Q1/02 , C12Q1/34 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/58 , G01N

27. 发明专利

AU2002362903A1 Method of preparing purified biologically active oligosaccharide libraries 未知
公开(公告)号：AU2002362903A1
公开(公告)日：2003-04-28
申请号：AU2002362903
申请日：2002-10-16
申请人： PROCOGNIA LTD
发明人： GULKO MIRIT KOLOG , SAMOKOVLISKY ALBENA , MARKMAN OFER , KELSON IDIL KASUTO , SHVARTSER LEONID , AMOR YEHUDIT , GROSZ-MORAGA ANA
IPC分类号： C12P19/04 , C12P19/14 , F16B21/00 , G01N33/53
摘要： Disclosed are methods of making oligosaccharide libraries whose members have defined structural and/or functional properties, as well as methods of making and using the oligosaccharide libraries.

28. 发明专利

CA2428431A1 SYSTEM AND METHOD FOR INTEGRATED ANALYSIS OF DATA FOR CHARACTERIZING CARBOHYDRATE POLYMERS 未知
公开(公告)号：CA2428431A1
公开(公告)日：2002-06-06
申请号：CA2428431
申请日：2001-11-05
申请人： PROCOGNIA LTD
发明人： ORON ASSAF , OR EINAT , MARKMAN OFER , ZAARUR NAVA , SHVARTSER LEONID
IPC分类号： C12Q1/02 , C12Q1/34 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/58 , G01N33/00
摘要： A system and method for characterizing carbohydrate polymers according to maps obtained from experimental data. Preferably, the data is obtained from a plurality of different types of experimental assays for characterizing the carbohydrate polymer. More preferably, at least one such assay involves binding a saccharide-binding agent to the carbohydrate polymer. One or more features of the carbohydrate polymer are then preferably characterized. These features are preferably derived from maps of the data obtained from assays involving the sample carbohydrate polymer. These maps are more preferably analyzed at a plurality of levels, with each level providing more abstract biological information. Most preferably, new types of experimental data are introduced to the process of analysis at each level, in order to support more complex analyses of the data. Optionally and most preferably, maps are eliminated at each level as being inconsistent with the experimental data. New maps are most preferably added at a higher level only if they are derived from the new experimental data which has been introduced at that level, in order to prevent a combinatorial explosion at successive levels of data analysis.

29. 发明公开

EP1402450A2 SYSTEM AND METHOD FOR INTEGRATED ANALYSIS OF DATA FOR CHARACTERIZING CARBOHYDRATE POLYMERS 审中-公开
标题翻译：系统和方法进行综合数据分析糖类聚合物的表征
公开(公告)号：EP1402450A2
公开(公告)日：2004-03-31
申请号：EP01988283.6
申请日：2001-11-05
申请人： Procognia, Ltd.
发明人： ORON, Assaf , OR, Einat , MARKMAN, Ofer , SHVARTSER, Leonid , ZAARUR, Nava
IPC分类号： G06F19/00
CPC分类号： G01N33/5308 , C12Q1/34
摘要： A system and method for characterizing carbohydrate polymers according to maps obtained from experimental data. Preferably, the data is obtained from a plurality of different types of experimental assays for characterizing the carbohydrate polymer. More preferably, at least one such assay involves binding a saccharide-binding agent to the carbohydrate polymer. One or more features of the carbohydrate polymer are then preferably characterized. These features are preferably derived from maps of the data obtained from assays involving the sample carbohydrate polymer. These maps are more preferably analyzed at a plurality of levels, with each level providing more abstract biological information. Most preferably, new types of experimental data are introduced to the process of analysis at each level, in order to support more complex analyses of the data. Optionally and most preferably, maps are eliminated at each level as being inconsistent with the experimental data. New maps are most preferably added at a higher level only if they are derived from the new experimental data which has been introduced at that level, in order to prevent a combinatorial explosion at successive levels of data analysis.

30. 发明申请

US20120277116A1 Disease diagnosis according to saccharide binding 审中-公开
标题翻译：疾病诊断根据糖结合
公开(公告)号：US20120277116A1
公开(公告)日：2012-11-01
申请号：US13545118
申请日：2012-07-10
申请人： Ofer Markman , Assaf (Assaph) Peretz Oron , Chana Rothmann-Schertz
发明人： Ofer Markman , Assaf (Assaph) Peretz Oron , Chana Rothmann-Schertz
IPC分类号： C40B30/04 , C12Q1/70 , G01N33/574 , G01N33/569 , G01N33/566 , G01N33/53
CPC分类号： G01N33/5308 , G01N2400/00
摘要： Disclosed is a method for characterizing carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer is allowed to contact the substrate under conditions that allow for formation of a first complex between the first saccharide-binding agent and the carbohydrate polymer. In one aspect, the method is used in the diagnosis of a disease, including a viral disease, an autoimmune disease, a bacterial infection, or cancer.
摘要翻译：公开了通过鉴定结合碳水化合物聚合物的至少两种结合剂来表征碳水化合物聚合物的方法。优选通过使碳水化合物聚合物与含有固定在基材上预定位置的多个第一糖结合剂的底物接触来确定结合。允许碳水化合物聚合物在允许在第一糖结合剂和碳水化合物聚合物之间形成第一配合物的条件下接触底物。一方面，该方法用于诊断疾病，包括病毒性疾病，自身免疫疾病，细菌感染或癌症。

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