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21. 发明申请

WO2003071957A2 SHEATH AND PLUNGER APPARATUS AND METHODS FOR DELIVERING A CLOSURE DEVICE 审中-公开
标题翻译：护套和柱塞装置以及用于输送封闭装置的方法
公开(公告)号：WO2003071957A2
公开(公告)日：2003-09-04
申请号：PCT/US2003/005109
申请日：2003-02-20
申请人： INTEGRATED VASCULAR SYSTEMS, INC.
发明人： PANTAGES, Anthony , JABBA, Ronald, J. , GINN, Richard, S.
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/064 , A61B17/08 , A61B2017/00004 , A61B2017/00637 , A61B2017/00659 , A61B2017/00668 , A61B2017/00672 , A61B2017/0641
摘要： An apparatus for delivering a clip includes an introducer sheath including an outer surface extending between its proximal and distal ends. A clip is carried on the outer surface, e.g., on a carrier assembly that is slidable along the outer surface from the proximal end towards the distal end. A skin overlies the outer surface of the sheath and the carrier assembly that is separable from the outer surface as the carrier assembly is advanced from the proximal end towards the distal end of the sheath. During use, the distal end of the sheath is inserted into an opening through tissue, e.g., into a puncture communicating with a blood vessel. The carrier assembly is advanced towards the distal end of the sheath, causing the skin to separate from the outer surface of the elongate member, and the clip is deployed from the carrier to seal the opening.
摘要翻译：用于递送夹子的设备包括导引器鞘，导引器鞘包括在其近端和远端之间延伸的外表面。夹子被承载在外表面上，例如在可从近端朝向远端沿外表面滑动的载体组件上。皮肤覆盖在护套的外表面上，并且当载体组件从护套的近端向远端推进时，载体组件从外表面可分离。在使用期间，护套的远端插入穿过组织的开口中，例如插入与血管连通的穿刺中。载体组件朝着护套的远端前进，使得皮肤与细长构件的外表面分离，并且夹子从载体展开以密封开口。

22. 发明申请

WO2003071957A3 SHEATH AND PLUNGER APPARATUS AND METHODS FOR DELIVERING A CLOSURE DEVICE 审中-公开
公开(公告)号：WO2003071957A3
公开(公告)日：2003-09-04
申请号：PCT/US2003/005109
申请日：2003-02-20
申请人： INTEGRATED VASCULAR SYSTEMS, INC.
发明人： PANTAGES, Anthony , JABBA, Ronald, J. , GINN, Richard, S.
IPC分类号： A61B17/00
摘要： An apparatus for delivering a clip includes an introducer sheath including an outer surface extending between its proximal and distal ends. A clip is carried on the outer surface, e.g., on a carrier assembly that is slidable along the outer surface from the proximal end towards the distal end. A skin overlies the outer surface of the sheath and the carrier assembly that is separable from the outer surface as the carrier assembly is advanced from the proximal end towards the distal end of the sheath. During use, the distal end of the sheath is inserted into an opening through tissue, e.g., into a puncture communicating with a blood vessel. The carrier assembly is advanced towards the distal end of the sheath, causing the skin to separate from the outer surface of the elongate member, and the clip is deployed from the carrier to seal the opening.

23. 发明申请

WO2003071955A2 CLOSURE DEVICE AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：封闭装置及其制造和使用方法
公开(公告)号：WO2003071955A2
公开(公告)日：2003-09-04
申请号：PCT/US2003/004906
申请日：2003-02-18
申请人： INTEGRATED VASCULAR SYSTEMS, INC.
发明人： CARLEY, Michael, T. , GINN, Richard, S. , SAGASTEGUI, Javier , JABBA, Ronald, J. , ALDRICH, William, N. , BELEF, Martin, W.
IPC分类号： A61B17/00
CPC分类号： A61B17/08 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/083 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00867 , A61B2017/0641 , A61B2017/081 , H03K3/356139 , H03K3/356156
摘要： A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.
摘要翻译：用于接合组织的夹具包括限定平面并围绕垂直于平面延伸的中心轴设置的大致环形的主体。主体包括交替的内部和外部弯曲区域，围绕夹子的周边限定Z字形图案。身体偏向平面构型，该平面构型位于平面内，并可朝向延伸出平面的横向构型偏转。齿从内部弯曲区域延伸，尖齿在平面构型中朝向中心轴线定向，并且在横向构型中平行于中心轴线。尖齿可以包括比主尖齿短的主要尖齿和次要尖齿。主尖齿可以设置在相对的内部弯曲区域上并且朝向彼此定向，使得它们在平面构造中重叠。

24. 发明申请

WO2003047434A1 APPARATUS AND METHODS FOR PROVIDING TACTILE FEEDBACK WHILE DELIVERING A CLOSURE DEVICE 审中-公开
标题翻译：提供闭合装置时提供触觉反馈的装置和方法
公开(公告)号：WO2003047434A1
公开(公告)日：2003-06-12
申请号：PCT/US2002/037698
申请日：2002-11-22
申请人： INTEGRATED VASCULAR SYSTEMS, INC.
发明人： GINN, Richard
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/064 , A61B34/76 , A61B2017/00367 , A61B2017/00637 , A61B2017/00654 , A61B2017/00663 , A61B2017/00668 , A61B2017/00672 , A61B2017/081
摘要： An apparatus for sealing a passage through tissue includes a tubular member, a plug (412), and a locator member (416). The plug is disposed on a distal end of the tubular member and includes an external thread (418). The locator member is inserted into a lumen of the tubular member until a distal portion is disposed beyond the plug. The distal portion includes a helically wound wire and a tether coupled to the wire that is movable for causing the wire to buckle. To seal a passage communicating with a blood vessel, the distal portion of the locator member is inserted into the passage, and the plug is threaded into the passage until the distal portion extends into the vessel. The tether is pulled to buckle the wire, and the plug is unthreaded until the buckled wire contacts a wall of the vessel, whereupon the plug is released to seal the passage.
摘要翻译：用于密封通过组织的通道的装置包括管状构件，插头（412）和定位构件（416）。塞子设置在管状构件的远端上并且包括外螺纹（418）。定位器构件插入到管状构件的内腔中，直到远端部分设置在塞子之外。远侧部分包括螺旋缠绕的线和联接到线的系绳，其可移动以使线扣合。为了密封与血管连通的通道，定位器构件的远端部分插入通道中，并且将塞子拧入通道中，直到远端部分延伸到血管内。系绳被拉动以扣紧线，并且插头是无螺纹的，直到带扣的线接触到容器的壁，然后释放插头以密封通道。

25. 发明申请

WO2002028286A1 APPARATUS AND METHODS FOR POSITIONING A VASCULAR SHEATH 审中-公开
标题翻译：用于定位血管的装置和方法
公开(公告)号：WO2002028286A1
公开(公告)日：2002-04-11
申请号：PCT/US2001/031154
申请日：2001-10-03
申请人： INTEGRATED VASCULAR SYSTEMS, INC.
发明人： GINN, Richard S , BELEF, Martin W
IPC分类号： A61B17/00
CPC分类号： A61M25/0662 , A61B17/0057 , A61B17/3417 , A61B17/3498 , A61B2017/00672 , A61B2017/3454 , A61B2090/062 , A61M25/0693 , A61M2025/0079
摘要： An apparatus for positioning an introducer sheath includes a sheath having a distal end including first and second ports, the second port being located distally from the first port. An obturator is slidable within the sheath that includes a distal region that sealingly engages an interior surface of the sheath. The obturator includes first and second openings in the distal region that are alignable with the first and second ports in the sheath. A housing is slidable on the exterior of the sheath that releasably holds a closure element. The sheath may be inserted into an incision communicating with a blood vessel, the first and second ports providing backbleed indication of the depth of the insertion of the sheath into the vessel. The housing is actuated to deploy the closure element to engage and close the incision.
摘要翻译：用于定位导引鞘的装置包括具有包括第一和第二端口的远端的护套，第二端口位于远离第一端口的位置。密封件可以在护套内滑动，其包括密封地接合护套的内表面的远侧区域。封闭器包括远端区域中的与护套中的第一和第二端口对准的第一和第二开口。壳体可在护套的外部滑动，其可释放地保持闭合元件。护套可插入与血管连通的切口中，第一和第二端口提供将护套插入血管的深度的指示。壳体被致动以展开闭合元件以接合和闭合切口。

26. 发明申请

WO2003071956A2 APPARATUS AND METHODS FOR DELIVERING A CLOSURE DEVICE 审中-公开
标题翻译：用于输送封闭装置的设备和方法
公开(公告)号：WO2003071956A2
公开(公告)日：2003-09-04
申请号：PCT/US2003/005059
申请日：2003-02-18
申请人： INTEGRATED VASCULAR SYSTEMS, INC.
发明人： BELEF, Martin, W. , ALDRICH, William, N , CARLEY, Michael, T , JABBA, Ronald, J , SALMON, Stephen, M , PANTAGES, Anthony , SAGASTEGUI, Javier
IPC分类号： A61B17/00
CPC分类号： A61B17/083 , A61B17/0057 , A61B17/064 , A61B17/128 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00862 , A61B2017/0641
摘要： An apparatus for delivering a clip to close an opening through tissue includes a sheath and a carrier assembly including a clip therein that is slidable on the sheath. An actuator assembly is connectable to the sheath, and telescoping actuator members extend from the handle that are connectable to the carrier assembly for advancing the carrier assembly along the sheath. An obturator on the actuator assembly includes splines that may be deployed beyond a distal end of the sheath, and expanded to a transverse expanded configuration for positioning the sheath before deploying the clip. The actuator members include cooperating detents that selectively release the actuator members as the carrier assembly reaches predetermined positions along the sheath for deploying the clip from the carrier assembly, and that collapse the splines to allow removal of the apparatus after deploying the clip.
摘要翻译：用于递送夹子以闭合穿过组织的开口的装置包括护套和载体组件，载体组件包括其中可在护套上滑动的夹子。致动器组件可连接到护套，伸缩致动器构件从手柄延伸，可连接到载体组件以沿着护套推进载体组件。致动器组件上的阻塞器包括花键，该花键可以被部署在护套的远端之外，并且被展开成横向扩展构造，用于在展开夹子之前定位护套。致动器构件包括协作棘爪，当托架组件沿着护套到达预定位置时，选择性释放致动器构件，以从托架组件展开夹子，并且使花键折叠以允许在展开夹子之后移除设备。

27. 发明授权

EP1679041B1 Surgical clip applier 有权
公开(公告)号：EP1679041B1
公开(公告)日：2017-08-16
申请号：EP06112536.5
申请日：2004-01-20
申请人： Integrated Vascular Systems, Inc.
发明人： Palermo, Thomas , Belef, William M. , Carley, Michael T. , Ginn, Richard S. , Jabba, Ronald J. , Pantages, Anthony , Sagasteguei, Javier
IPC分类号： A61B17/00 , A61B17/064 , A61B17/068 , A61B17/122 , A61B17/128
CPC分类号： A61B17/064 , A61B17/0057 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/1227 , A61B17/1285 , A61B2017/00637 , A61B2017/00672

28. 发明授权

EP2229892B1 Apparatus for delivering a closure device 有权
标题翻译：设备交付的封闭元件
公开(公告)号：EP2229892B1
公开(公告)日：2012-01-18
申请号：EP10005887.4
申请日：2001-11-30
申请人： Integrated Vascular Systems, Inc.
发明人： Roe, Steven N. , Ginn, Richard S. , Belef, W. Martin
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/064 , A61B34/76 , A61B2017/00637 , A61B2017/00654 , A61B2017/00668 , A61B2017/00672

29. 发明公开

EP2095774A2 Apparatus and methods for delivering a closure device 有权
标题翻译： Vorrichtung zur Ausgabe einer Verschlussvorrichtung
公开(公告)号：EP2095774A2
公开(公告)日：2009-09-02
申请号：EP09006392.6
申请日：2001-11-30
申请人： Integrated Vascular Systems, Inc.
发明人： The designation of the inventor has not yet been filed
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/064 , A61B34/76 , A61B2017/00637 , A61B2017/00654 , A61B2017/00668 , A61B2017/00672
摘要： There is described an apparatus for delivering a closure element into a puncture communicating with a blood vessel including an introducer sheath and a locator member disposed within the sheath, the locator member having a distal portion extending distally beyond the distal end of the sheath. A plurality of splines are provided on the distal portion of the locator member, the splines being selectively expandable between an axial collapsed configuration and a transverse expanded configuration. An actuator is coupled to the locator member for controllably expanding the splines. A housing is slidably disposed on the sheath for deploying a closure element, such as a vascular clip. The locator actuator may automatically collapse the splines upon advancement of the housing. Alternatively, the distal portion includes a helically wound wire and a tether coupled to the wire that is movable for causing the wire to buckle instead of the splines.
摘要翻译：描述了一种用于将闭合元件递送到与血管连通的穿刺装置，该血管包括引导器护套和设置在护套内的定位器构件，定位器构件具有向远侧延伸超过鞘的远端的远侧部分。多个花键设置在定位器构件的远侧部分上，花键可在轴向收缩构型和横向膨胀构型之间选择性地膨胀。致动器联接到定位器构件，用于可控地扩展花键。壳体可滑动地设置在护套上，用于展开闭合元件，例如血管夹。定位器致动器可以在壳体前进时自动地折叠花键。或者，远侧部分包括螺旋缠绕的线和连接到线的系绳，该系绳可移动以使导线弯曲而不是花键。

30. 发明授权

EP1322230B1 APPARATUS FOR POSITIONING A VASCULAR SHEATH 有权
标题翻译：设备对准血管套
公开(公告)号：EP1322230B1
公开(公告)日：2009-02-25
申请号：EP01977502.2
申请日：2001-10-03
申请人： Integrated Vascular Systems, Inc.
发明人： GINN, Richard S , BELEF, Martin W
IPC分类号： A61B17/00
CPC分类号： A61M25/0662 , A61B17/0057 , A61B17/3417 , A61B17/3498 , A61B2017/00672 , A61B2017/3454 , A61B2090/062 , A61M25/0693 , A61M2025/0079
摘要： An apparatus for positioning an introducer sheath includes a sheath having a distal end including first and second ports, the second port being located distally from the first port. An obturator is slidable within the sheath that includes a distal region that sealingly engages an interior surface of the sheath. The obturator includes first and second openings in the distal region that are alignable with the first and second ports in the sheath. A housing is slidable on the exterior of the sheath that releasably holds a closure element. The sheath may be inserted into an incision communicating with a blood vessel, the first and second ports providing backbleed indication of the depth of the insertion of the sheath into the vessel. The housing is actuated to deploy the closure element to engage and close the incision.

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