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21. 发明申请

US20110277632A1 Electrostatic Aerosol Concentrator 有权
标题翻译：静电气雾浓缩器
公开(公告)号：US20110277632A1
公开(公告)日：2011-11-17
申请号：US11831613
申请日：2007-07-31
申请人： Kapil Pant , Shivshakar Sundaram , Yi Wang
发明人： Kapil Pant , Shivshakar Sundaram , Yi Wang
IPC分类号： B03C3/45 , B03C3/00
CPC分类号： B03C3/68 , B03C3/025 , B03C3/06 , B03C3/41 , B03C3/49
摘要： Disclosed is an electrostatic aerosol concentrator for the concentration of aerosol particles and their collection for subsequent analysis. The concentrator comprises an airflow chamber that includes alternately energized and grounded electrode elements that work in concert to impart radial inward motion to charged aerosol particles and focusing them toward an enriched aerosol outlet. If desired, filtered air inlets may be used to provide a sheath of aerosol-free air along the chamber periphery and prevent deposition of particles onto electrode surfaces. Aerosol particles entering the airflow chamber may carry a positive or negative charge naturally, or a charge may be induced on the particles using a charging section located upstream of the aerosol inlet. Natural or induced charges on the aerosol particles may be used to selectively concentrate subpopulations of aerosol particles from a mixture of particles. For example, bacterial spores or aerosolized viruses may be selectively enriched without concentrating other aerosol particles. The particles of interest are focused and collected at an aerosol rich outlet in a small air volume, while the majority of the airflow, stripped of particles of interest, is purged to the atmosphere through an aerosol lean outlet.
摘要翻译：公开了一种用于浓缩气溶胶颗粒的静电气溶胶浓缩器及其收集用于随后的分析。集中器包括气流室，其包括交替地供电和接地的电极元件，其一致地工作以向带电气溶胶颗粒进行径向向内运动并将它们聚焦到富集的气溶胶出口。如果需要，可以使用过滤的空气入口来沿着室周边提供无气溶胶空气的护套，并防止颗粒沉积到电极表面上。进入气流室的气溶胶颗粒可以自然携带正电荷或负电荷，或者可以使用位于气溶胶入口上游的充电部分在颗粒上诱导电荷。气雾剂颗粒上的天然或诱导电荷可用于从颗粒混合物中选择性地浓缩气溶胶颗粒的亚群。例如，细菌孢子或气雾化病毒可以选择性富集而不浓缩其它气溶胶颗粒。将感兴趣的颗粒聚焦并收集在小气泡体积的气溶胶浓缩出口处，而大部分气流被汽提的感兴趣的颗粒通过气溶胶倾倒出口被吹扫到大气中。

22. 发明授权

US07842006B2 Thrombectomy microcatheter 有权
标题翻译：血栓切除微导管
公开(公告)号：US07842006B2
公开(公告)日：2010-11-30
申请号：US11561303
申请日：2006-11-17
申请人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
发明人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
IPC分类号： A61B17/22
CPC分类号： A61B17/2202 , A61B2017/00778 , A61B2017/22001 , A61B2017/22021
摘要： The present invention is an ultrasonic thrombectomy catheter that produces physical forces (shear rates) strong enough to emulsify obstructions such as thrombi and emboli without causing damage to arterial walls. This is accomplished by properly arranging piezoelectric transducers within a catheter and a tubular catheter head separated by a gap to generate acoustic streaming that simultaneously emulsifies the obstruction and sweeps resulting debris into a catheter lumen for removal. The open gap may be formed by supporting struts that connect the catheter to the catheter head. The design of the catheter tip allows the fabrication of catheters capable of removing partial or complete blockages from arteries and other vessels having diameters as small as 2 mm.
摘要翻译：本发明是一种超声波血栓切除术导管，其产生足够强的物理力（剪切速率）以乳化阻塞物如血栓和栓塞，而不会对动脉壁造成损伤。这是通过将压电换能器适当地布置在导管内的管状导管头和由间隙分开的管状导管头来实现的，以产生声流，其同时乳化阻塞物并将所得碎片扫入导管腔以便移除。开放间隙可以通过将导管连接到导管头上的支柱支撑而形成。导管尖端的设计允许制造能够从直径小至2mm的动脉和其他容器中去除部分或完全阻塞的导管。

23. 发明授权

US07810990B2 Apparatus and method for gelling liquefied gasses 有权
标题翻译：液化气体凝胶化装置及方法
公开(公告)号：US07810990B2
公开(公告)日：2010-10-12
申请号：US11584954
申请日：2006-10-23
申请人： Adam Elliott , Roberto DiSalvo , Phillip Shepherd , Ryan Kosier
发明人： Adam Elliott , Roberto DiSalvo , Phillip Shepherd , Ryan Kosier
IPC分类号： B01F11/00
CPC分类号： C06B47/12 , C06B47/04 , F17C2221/03 , F17C2227/0348 , F17C2227/0388 , F17C2265/025 , F17C2270/0194
摘要： The present invention is a method and apparatus for gelling liquid propane and other liquefied gasses. The apparatus includes a temperature controlled churn mixer, vacuum pump, liquefied gas transfer tank, and means for measuring amount of material entering the mixer. The method uses gelling agents such as silicon dioxide, clay, carbon, or organic or inorganic polymers, as well as dopants such as titanium, aluminum, and boron powders. The apparatus and method are particularly useful for the production of high quality rocket fuels and propellants.
摘要翻译：本发明是用于胶化液体丙烷和其它液化气体的方法和装置。该装置包括温度控制的搅拌混合器，真空泵，液化气体转移罐和用于测量进入混合器的材料量的装置。该方法使用诸如二氧化硅，粘土，碳或有机或无机聚合物的胶凝剂，以及掺杂剂如钛，铝和硼粉末。该装置和方法对于生产高品质的火箭燃料和推进剂特别有用。

24. 发明申请

US20100226847A1 Method for direct, chirality-selective synthesis of semiconducting or metallic single-walled carbon nanotubes 审中-公开
标题翻译：用于直接，手性选择性合成半导体或金属单壁碳纳米管的方法
公开(公告)号：US20100226847A1
公开(公告)日：2010-09-09
申请号：US12398332
申请日：2009-03-05
申请人： Aleksey V. Vasenkov
发明人： Aleksey V. Vasenkov
IPC分类号： D01F9/12 , D01F9/10 , C23C16/00
CPC分类号： B82Y40/00 , B82Y30/00 , C01B32/15
摘要： The present invention is a method comprising a direct chirality-selective nucleation and synthesis of single-walled carbon nanotubes from carbon-containing gases using catalytic nanoparticles of uniform size heated by ultra-short laser pulses of selected frequency to temperatures sufficient for carbon nanotube nucleation and synthesis.
摘要翻译：本发明是一种包括直接手性选择性成核和使用含有均匀尺寸的催化纳米颗粒从含碳气体合成单壁碳纳米管的方法，所述催化纳米颗粒通过选定频率的超短激光脉冲加热至足以使碳纳米管成核的温度，合成。

25. 发明授权

US07631487B2 Constant volume rocket motor 有权
标题翻译：恒定体积火箭发动机
公开(公告)号：US07631487B2
公开(公告)日：2009-12-15
申请号：US11553899
申请日：2006-10-27
申请人： Roberto DiSalvo , Mark Ostrander , Adam Elliott
发明人： Roberto DiSalvo , Mark Ostrander , Adam Elliott
IPC分类号： F02K5/02
CPC分类号： F02K9/94 , F02K9/58 , F02K9/805
摘要： The present invention is a constant volume rocket motor that uses a non-detonating constant-volume, bipropellant combustion process in pulse-mode operation. Opening and closing of the combustion chamber exhaust outlet is controlled by an actuated reciprocating thrust valve (RTV). Fuel enters the combustion chamber at low pressure with the RTV closed. The valve opens after or during combustion when combustion chamber pressure is at or near maximum. The motor has applications in reaction control systems and attitude control systems in spacecraft.
摘要翻译：本发明是在脉冲模式操作中使用非引爆恒定体积的双组元推进剂燃烧过程的恒定体积火箭发动机。燃烧室排气出口的打开和关闭由致动往复推力阀（RTV）控制。燃料在RTV关闭时以低压进入燃烧室。当燃烧室压力处于或接近最大值时，阀门或燃烧期间打开阀门。电机在航天器的反应控制系统和姿态控制系统中有应用。

26. 发明申请

US20080202655A1 High Performance, Low Toxicity Hypergolic Fuel 有权
标题翻译：高性能，低毒性全燃料
公开(公告)号：US20080202655A1
公开(公告)日：2008-08-28
申请号：US11679672
申请日：2007-02-27
申请人： Debasis Sengupta
发明人： Debasis Sengupta
IPC分类号： C06B25/34
CPC分类号： C10L1/232 , A24C5/601 , C06B43/00 , C06B47/02
摘要： Disclosed is a group of tertiary amine azides useful as hypergolic fuels for hypergolic bipropellant mixtures. The fuels provide higher density impulses than monomethyl hydrazine (MMH) but are less toxic and have lower vapor pressures that MMH. In addition, the fuels have shorter ignition delay times than dimethylaminoethylazide (DMAZ) and other potential reduced toxicity replacements for MMH.
摘要翻译：公开了一组可用作高血压双组元推进剂混合物的高凝燃料的叔胺叠氮化物。燃料提供比单甲基肼（MMH）更高的密度脉冲，但是毒性较小并且具有较低的MMH蒸气压。此外，燃料具有比二甲基氨基乙基叠氮化物（DMAZ）更短的点火延迟时间和其他潜在的MMH毒性替代品。

27. 发明申请

US20070209940A1 Self-cleaning and mixing microfluidic elements 有权
标题翻译：自清洁和混合微流体元件
公开(公告)号：US20070209940A1
公开(公告)日：2007-09-13
申请号：US11516358
申请日：2006-09-06
申请人： Sivaramakrishnan Krishnamoorthy , Jianjun Feng
发明人： Sivaramakrishnan Krishnamoorthy , Jianjun Feng
IPC分类号： B01D57/02 , B03C5/00
CPC分类号： B08B7/0064 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B08B9/00 , F04B19/006 , F04B19/24 , Y10S366/04 , Y10T137/0329 , Y10T137/034 , Y10T137/0391
摘要： Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.
摘要翻译：公开了用于基于电热诱导流体流动的微流体系统中的混合和自清洁元件的装置和方法。该装置和方法提供了在微流体系统中的组件之间和之间的流体流动的控制，以便除去不期望的液体和微粒或混合液体。调节电极的几何形状和位置，以在液体中产生温度梯度，从而导致液体内介电性质的不均匀分布。电介质非均匀性在溶液中产生体力和流动，其由元件和电极几何形状，电极布置以及施加电压的频率和波形控制。

28. 发明公开

US20240344127A1 ASYMMETRIC PROBE-ENHANCED LOOP-MEDIATED ISOTHERMAL AMPLIFICATION 审中-公开
公开(公告)号：US20240344127A1
公开(公告)日：2024-10-17
申请号：US18632071
申请日：2024-04-10
申请人： CFD Research Corporation
发明人： David Edwin Gaddes, III , Kyleigh Raye Jones
IPC分类号： C12Q1/6876 , C12Q1/6853
CPC分类号： C12Q1/6876 , C12Q1/6853 , C12Q2600/16
摘要： A method of performing an asymmetric loop-mediated isothermal amplification (LAMP) assay can include: providing the asymmetrical primer set of one of the embodiments; providing a reagent composition having a polymerase; combining the asymmetrical primer set and reagent composition with a sample having the target nucleic acid to form an amplification mixture; heating the amplification mixture to an amplification temperature within an amplification temperature range; maintaining the amplification temperature to amplify the target nucleic acid having the target sequence; and obtaining an amplified amount of the target nucleic acid having the target sequence. The asymmetrical primer set can include one primer of a primer pair to be at a lower (e.g., 10%) amount of the other primer.

29. 发明公开

US20240203290A1 VITRO MODEL DEVICE FOR CORNEA BARRIER 审中-公开
公开(公告)号：US20240203290A1
公开(公告)日：2024-06-20
申请号：US18541346
申请日：2023-12-15
申请人： CFD Research Corporation
发明人： Carrie Lynn German , Balabhaskar Prabhakarpandian , Ketan Harendrakumar Bhatt
IPC分类号： G09B23/30
CPC分类号： G09B23/303
摘要： A microfluidic in vitro cornea device is provided, which can include a tear flow chamber, stromal chamber, endothelial chamber, and aqueous humor chamber. The stromal chamber is adjacent to and porously coupled with the tear flow chamber. The endothelial chamber is adjacent to and porously coupled with the stromal chamber. The aqueous humor chamber adjacent to and porously coupled with the endothelial chamber. A first porous wall is positioned between the tear flow chamber and the stromal chamber. A second porous wall is positioned between the stromal chamber and the endothelial chamber. The third porous wall is positioned between the endothelial chamber and the aqueous humor chamber. The device is configured as a microfluidic in vitro model of a cornea.

30. 发明公开

US20240169859A1 COMPUTATIONAL IN SILICO MODEL FOR PLACENTAL BARRIER 审中-公开
公开(公告)号：US20240169859A1
公开(公告)日：2024-05-23
申请号：US18511367
申请日：2023-11-16
申请人： CFD Research Corporation
发明人： Carrie Lynn German , Balabhaskar Prabhakarpandian , Ketan Harendrakumar Bhatt , Ashley Gilbert Helser
IPC分类号： G09B23/28 , G09B23/30
CPC分类号： G09B23/281 , G09B23/303
摘要： The method involves computationally modeling a placenta by simulating physical placenta models with computational in silico models. The simulated data is compared with actual data from the physical models, and the simulation is iterated until a match is achieved. The method may also include calibrating diffusion parameters for testing substances, and configuring the models for analyzing instances of fluid-induced shear and substance transport. The simulated data may be used to obtain maternal-fetal pharmacokinetic in silico placenta models, and the method may be used to obtain predictions for time-dependent concentrations of molecules in fetal circulation. The computational models may consider instances of fluid-diffusive transport and carrier-mediated transport in calculations and determinations of transport characteristics and values of different testing substances.

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