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21. 发明授权

US10329541B2 Methods for conversion of the substrate specificity of desaturases 有权
公开(公告)号：US10329541B2
公开(公告)日：2019-06-25
申请号：US15105080
申请日：2014-12-17
申请人： BASF PLANT SCIENCE COMPANY GMBH
发明人： Toralf Senger , Patricia Vrinten , Ze Long Lim
IPC分类号： C12N9/02 , C07K14/46 , C12P7/64
摘要： The present invention relates to methods for the conversion of the substrate specificity of desaturases. Specifically, the present invention pertains to a method for the conversion of the substrate specificity of a Δ5 and/or Δ6 desaturase to the substrate specificity of a Δ4 desaturase, the method comprising: identifying regions and/or amino acid residues which control the substrate specificity of (i) the Δ5 and/or Δ6 desaturase and (ii) the Δ4 desaturase; and replacing in the amino acid sequence of the mentioned Δ5 and/or Δ6 desaturase, the regions and/or amino acid residues which control the substrate specificity of the Δ5 and/or Δ6 desaturase, by the corresponding regions and/or amino acid residues which control the substrate specificity of the Δ4 desaturase, thereby converting the substrate specificity of the Δ5 and/or Δ6 desaturase to the substrate specificity of the Δ4 desaturase. The present invention further concerns a method for the conversion of the substrate specificity of a Δ4 desaturase to the substrate specificity of a Δ5 and/or Δ6 desaturase, the method comprising: identifying regions and/or amino acid residues which control the substrate specificity of (i) the Δ4 desaturase and (ii) the Δ5 and/or Δ6 desaturase; and replacing in the amino acid sequence of the indicated Δ4 desaturase, the regions and/or amino acid residues which control the substrate specificity of the Δ4 desaturase, by the corresponding regions and/or amino acid residues which control the substrate specificity of the Δ5 and/or Δ6 desaturase, thereby converting the substrate specificity of the Δ4 desaturase to the substrate specificity of the Δ5 and/or Δ6 desaturase. In addition, the invention encompasses desaturases with converted substrate specificity.

22. 发明授权

US08318914B2 Elongases and methods for producing polyunsaturated fatty acids in transgenic organisms 有权
标题翻译：在转基因生物体中生产多不饱和脂肪酸的延伸酶和方法
公开(公告)号：US08318914B2
公开(公告)日：2012-11-27
申请号：US12671097
申请日：2008-07-30
申请人： Jörg Bauer , Xiao Qiu , Patricia Vrinten
发明人： Jörg Bauer , Xiao Qiu , Patricia Vrinten
IPC分类号： C07H21/00 , C12N15/74 , C12N1/21 , C12P21/00 , C12P13/06 , C12P9/00 , C12P7/64 , C07K14/00 , C07K16/00 , A01H5/00
CPC分类号： C12N9/1029 , C12N15/8247
摘要： The present invention relates to polynucleotides from Pythium irregulare, Rhizopus oryzae and Euglena gracilis which code for elongases and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotides according to the invention, and to the polypeptides encoded by the polynucleotides. The invention furthermore relates to antibodies against the polypeptides according to the invention. Finally, the invention also relates to production processes for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements.
摘要翻译：本发明涉及编码延长酶并可用于重组生产多不饱和脂肪酸的来自非腐霉的腐霉，米土根霉和小球虫的多核苷酸。本发明还涉及包含根据本发明的多核苷酸的载体，宿主细胞和转基因非人生物以及由多核苷酸编码的多肽。本发明还涉及针对根据本发明的多肽的抗体。最后，本发明还涉及多不饱和脂肪酸和油，脂和脂肪酸组合物的生产方法以及它们作为药物，化妆品，食品，饲料，优选鱼食或食品添加剂的用途。

23. 发明申请

US20120094904A1 FAD4, FAD5, FAD5-2, AND FAD6, NOVEL FATTY ACID DESATURASE FAMILY MEMBERS AND USES THEREOF 有权
标题翻译： FAD4，FAD5，FAD5-2和FAD6，新型脂肪酸脱乙酰酶家族成员及其用途
公开(公告)号：US20120094904A1
公开(公告)日：2012-04-19
申请号：US13339428
申请日：2011-12-29
申请人： Xiao Qiu , Haiping Hong
发明人： Xiao Qiu , Haiping Hong
IPC分类号： A61K38/16 , C12N15/63 , C12N5/10 , C12N1/00 , C12N1/11 , C12N1/15 , C12N1/13 , C12P21/06 , C07K14/00 , C12P7/64 , C12N15/82 , C12N15/74 , A23K1/18 , A61P3/10 , A61P9/00 , A61P35/00 , C07H21/04
CPC分类号： C12N15/8247 , A23K20/158 , A23L33/12 , A23V2002/00 , A61K31/202 , A61K38/00 , C12N9/0071 , C12N9/0083 , C12P7/6427 , C12P7/6472 , C12Y114/19003 , Y02P20/52
摘要： The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., DHA.
摘要翻译：本发明提供编码新型脂肪酸去饱和酶家族成员的分离的核酸分子。本发明还提供了含有去饱和酶核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及大规模生产长链多不饱和脂肪酸（LCPUFA）如DHA的方法。

24. 发明授权

US08088906B2 FAD4, FAD5, FAD5-2, and FAD6, novel fatty acid desaturase family members and uses thereof 有权
标题翻译： FAD4，FAD5，FAD5-2和FAD6，新型脂肪酸去饱和酶家族成员及其用途
公开(公告)号：US08088906B2
公开(公告)日：2012-01-03
申请号：US13150656
申请日：2011-06-01
申请人： Xiao Qiu , Haiping Hong
发明人： Xiao Qiu , Haiping Hong
IPC分类号： C07H21/04 , C12N1/20 , C12N5/10
CPC分类号： C12N15/8247 , A23K20/158 , A23L33/12 , A23V2002/00 , A61K31/202 , A61K38/00 , C12N9/0071 , C12N9/0083 , C12P7/6427 , C12P7/6472 , C12Y114/19003 , Y02P20/52
摘要： The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., DHA.
摘要翻译：本发明提供编码新型脂肪酸去饱和酶家族成员的分离的核酸分子。本发明还提供了含有去饱和酶核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及大规模生产长链多不饱和脂肪酸（LCPUFA）如DHA的方法。

25. 发明授权

US08003853B2 Fatty acid desaturases and uses thereof 有权
标题翻译：脂肪酸去饱和酶及其用途
公开(公告)号：US08003853B2
公开(公告)日：2011-08-23
申请号：US11776219
申请日：2007-07-11
申请人： Dauenpen Meesapyodsuk , Xiao Qiu
发明人： Dauenpen Meesapyodsuk , Xiao Qiu
IPC分类号： A01H5/00 , C12N15/82 , C12N1/20 , C12N5/10 , C07H21/04
CPC分类号： C12P7/6427 , A23D9/00 , A23K20/158 , A23K20/189 , A23L33/115 , A23L33/12 , A61K36/185 , A61K36/28 , A61K36/286 , A61K36/31 , A61K36/47 , A61K36/48 , A61K36/535 , A61K36/55 , A61K36/63 , A61K36/66 , A61K36/889 , C12N9/0083 , C12N15/8247 , C12P7/6472
摘要： The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., SDA, EPA and DHA.
摘要翻译：本发明提供编码新型脂肪酸去饱和酶家族成员的分离的核酸分子。本发明还提供含有去饱和酶核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及大规模生产长链多不饱和脂肪酸（LCPUFA）如SDA，EPA和DHA的方法。

26. 发明申请

US20110162105A1 Nucleic Acids Encoding Desaturases and Modified Plant Oil 有权
标题翻译：编码去饱和酶和改良植物油的核酸
公开(公告)号：US20110162105A1
公开(公告)日：2011-06-30
申请号：US13060458
申请日：2009-08-25
申请人： Jörg Bauer , Toralf Senger , Thorsten Zank , Xiao Qiu , Guohai Wu
发明人： Jörg Bauer , Toralf Senger , Thorsten Zank , Xiao Qiu , Guohai Wu
IPC分类号： A01H1/06 , C07H21/04 , C12N15/63 , C12N5/10 , C12N1/19 , C12N1/15 , A01H5/00 , A01H5/10 , C12N9/02 , C12P7/64 , C07C57/03
CPC分类号： C12N15/8247 , C12N5/14 , C12N9/00 , C12N9/0004
摘要： The present invention relates to nucleic acids derived from Drechslera tritici-repentis, Cylindorcarpon herteronema, Diploida natalensis, Stagonospora nodorum, Microdochium nivalae and Periplaneta americana. The invention also relates to the individual coding sequences and to proteins encoded by these sequences in combination with other sequences as well as to a process for converting oleic acid to linoleic acid to Iinoleic acid and the production of arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid in a plant.
摘要翻译：本发明涉及来自Drechslera tritici-repentis，Cylindorcarpon herteronema，Diploida natalensis，Stagonospora nodorum，Microdochium nivalae和Periplaneta americana的核酸。本发明还涉及个体编码序列和由这些序列与其它序列组合编码的蛋白质以及将油酸转化为亚油酸至亚油酸的方法，以及花生四烯酸，二十碳五烯酸和/或二十二碳六烯酸的生产酸在植物中。

27. 发明申请

US20070192902A1 Flax (Linum usitatissimum I.) seed-specific promoters 有权
标题翻译：亚麻（Linum usitatissimum I.）种子特异性启动子
公开(公告)号：US20070192902A1
公开(公告)日：2007-08-16
申请号：US11655545
申请日：2007-01-19
申请人： Xiao Qiu , Martin Truksa , Zhiyuan Hu
发明人： Xiao Qiu , Martin Truksa , Zhiyuan Hu
IPC分类号： A01H1/00 , C07H21/04 , C12N15/82 , C12N5/04
CPC分类号： C12N15/8234 , C07K14/415 , C12N15/8247
摘要： The present invention is directed to promoters of flax conlinin and ω-3 desaturase genes. The promoters guide high levels of the expression exclusively in flax developing seeds. This specific expression pattern concomitant with the biosynthesis of storage lipids and proteins make these promoters particularly useful for seed-specific modification of fatty acid and protein compositions in plant seeds.
摘要翻译：本发明涉及亚麻精蛋白和ω-3去饱和酶基因的启动子。启动子引导高水平的表达专门在亚麻发育种子。这种特异性表达模式伴随着储存脂质和蛋白质的生物合成，使得这些启动子特别适用于植物种子中脂肪酸和蛋白质组成的种子特异性修饰。

28. 发明申请

US20130323389A1 COMPETITIVE INHIBITORS OF PRO-OXIDANTS IN EDIBLE LONG CHAIN POLYUNSATURATED TRIGLYCERIDE AND ETHYL ESTER OILS 审中-公开
标题翻译：可食用长链聚氧乙烯吡咯烷酮和乙酸酯油中的主要氧化物的竞争性抑制剂
公开(公告)号：US20130323389A1
公开(公告)日：2013-12-05
申请号：US13485765
申请日：2012-05-31
申请人： Fredric James Nugent , Petros Loutas
发明人： Fredric James Nugent , Petros Loutas
IPC分类号： A23D9/013
CPC分类号： C11B5/0035 , A23D9/007 , C11B5/0028 , C11B5/0085
摘要： A composition comprising a competitive inhibitor and an edible long chain polyunsaturated oil or a blend of edible oils, wherein the edible long chain polyunsaturated oil or the blend of edible oils comprises one or more long chain polyunsaturated fatty acids and a pro-oxidant.
摘要翻译：一种组合物，其包含竞争性抑制剂和可食用长链多不饱和油或食用油的混合物，其中所述食用长链多不饱和油或食用油的混合物包含一种或多种长链多不饱和脂肪酸和促氧化剂。

29. 发明授权

US07977469B2 Fad4, fad5, fad5-2, and fad6, novel fatty acid desaturase family members and uses thereof 有权
标题翻译： Fad4，fad5，fad5-2和fad6，新型脂肪酸去饱和酶家族成员及其用途
公开(公告)号：US07977469B2
公开(公告)日：2011-07-12
申请号：US12538227
申请日：2009-08-10
申请人： Xiao Qiu , Haiping Hong
发明人： Xiao Qiu , Haiping Hong
IPC分类号： C07H21/04 , C12N1/20 , C12N5/10
CPC分类号： C12N15/8247 , A23K20/158 , A23L33/12 , A23V2002/00 , A61K31/202 , A61K38/00 , C12N9/0071 , C12N9/0083 , C12P7/6427 , C12P7/6472 , C12Y114/19003 , Y02P20/52
摘要： The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., DHA.
摘要翻译：本发明提供编码新型脂肪酸去饱和酶家族成员的分离的核酸分子。本发明还提供了含有去饱和酶核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及大规模生产长链多不饱和脂肪酸（LCPUFA）如DHA的方法。

30. 发明授权

US07923598B2 Fatty acid hydroxylases and uses thereof 有权
标题翻译：脂肪酸羟化酶及其用途
公开(公告)号：US07923598B2
公开(公告)日：2011-04-12
申请号：US11767115
申请日：2007-06-22
申请人： Dauenpen Meesapyodsuk , Xiao Qiu
发明人： Dauenpen Meesapyodsuk , Xiao Qiu
IPC分类号： C12N15/80 , C12N15/81 , C12N15/82 , C07H21/04 , C12N5/14
CPC分类号： C12P7/6409 , C07C51/42 , C07C51/47 , C07C51/48 , C11B1/025 , C12N9/0071 , C12N15/8247 , C12P7/6463
摘要： The invention provides isolated nucleic acid molecules which encode novel fatty acid hydroxylases. The invention also provides recombinant expression vectors including hydroxylase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for the production of hydroxyl fatty acids such as 12-hydroxyoctadec-9-enoic acid (ricinoleic acid).
摘要翻译：本发明提供编码新型脂肪酸羟化酶的分离的核酸分子。本发明还提供了重组表达载体，包括羟化酶核酸分子，已经引入表达载体的宿主细胞，以及生产羟基脂肪酸如12-羟基十八碳-9-烯酸（蓖麻醇酸）的方法。

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