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21. 发明授权

US10725056B2 Biomarkers for assessing HIV 有权
公开(公告)号：US10725056B2
公开(公告)日：2020-07-28
申请号：US15387932
申请日：2016-12-22
申请人： BIOCRATES LIFE SCIENCES AG , IDCGS CLINICA DE DIAGNOSTICOS MEDICOS , CENTRO DE GENOMAS
发明人： Ismael Dale Cotrim Guerreiro Da Silva , Edson Guimaraes Loturco , Ricoardo Soubie Diaz , Therese Koal
IPC分类号： G01N33/92 , G01N33/68 , G01N33/569 , C12Q1/70
摘要： The present invention relates to metabolic biomarker sets for assessing HIV. In preferred embodiments, the present invention relates to the use of biomarker sets for screening and/or diagnosing HIV infection, for prediction of immunologic response of a mammalian subject to antiretroviral therapy and/or prognosis of HIV disease progression, and for monitoring of HIV disease activity in a mammalian subject. In other embodiments, the invention relates to methods for screening and/or diagnosing HIV infection, for prediction of immunologic response of a mammalian subject to antiretroviral therapy and/or prognosis of HIV disease progression, and for monitoring of HIV disease activity in a mammalian subject, as well as to a kit adapted to carry out the methods. By employing the specific biomarkers and the method according to the present invention it becomes possible to more properly and reliably assess HIV. In particular, it becomes possible to screen for and diagnose HIV in a patient with high accuracy and predict early in advance the patient's therapeutic response to antiretroviral therapy.

22. 发明授权

US10054604B2 Biomarkers for assessing HIV 有权
公开(公告)号：US10054604B2
公开(公告)日：2018-08-21
申请号：US15301913
申请日：2015-03-31
申请人： BIOCRATES LIFE SCIENCES AG , IDCGS CLINICA DE DIAGNOSTICOS MEDICOS , CENTRO DE GENOMAS
发明人： Ismael Dale Cotrim Guerreiro Da Silva , Edson Guimaraes Loturco , Ricoardo Soubie Diaz , Therese Koal
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , C12Q1/70 , G01N33/56988 , G01N33/6812 , G01N33/6893 , G01N2333/47 , G01N2405/04 , G01N2405/08 , G01N2560/00 , G01N2800/52
摘要： The present invention relates to metabolic biomarker sets for assessing HIV. In preferred embodiments, the present invention relates to the use of biomarker sets for screening and/or diagnosing HIV infection, for prediction of immunologic response of a mammalian subject to antiretroviral therapy and/or prognosis of HIV disease progression, and for monitoring of HIV disease activity in a mammalian subject. In other embodiments, the invention relates to methods for screening and/or diagnosing HIV infection, for prediction of immunologic response of a mammalian subject to antiretroviral therapy and/or prognosis of HIV disease progression, and for monitoring of HIV disease activity in a mammalian subject, as well as to a kit adapted to carry out the methods. By employing the specific biomarkers and the method according to the present invention it becomes possible to more properly and reliably assess HIV. In particular, it becomes possible to screen for and diagnose HIV in a patient with high accuracy and predict early in advance the patient's therapeutic response to antiretroviral therapy.

23. 发明授权

US08116983B2 Device for quantitative analysis of a drug or metabolite profile 有权
标题翻译：用于定量分析药物或代谢物分布的装置
公开(公告)号：US08116983B2
公开(公告)日：2012-02-14
申请号：US11476657
申请日：2006-06-29
申请人： Steven Lewis Ramsay , Wolfgang Guggenbichler , Klaus Michael Weinberger , Armin Graber , Wolfgang Markus Stoeggl
发明人： Steven Lewis Ramsay , Wolfgang Guggenbichler , Klaus Michael Weinberger , Armin Graber , Wolfgang Markus Stoeggl
IPC分类号： G01N33/48
CPC分类号： G01N33/5038 , G01N33/5005 , G01N33/54366 , G01N33/6848 , G01N35/00594 , G06F19/28 , H01J49/0027
摘要： A device, in particular a sample preparation device for the quantitative analysis of a drug and/or metabolite profile in a biological sample, which includes an insert for such a device being impregnated with at least one internal standard, to the internal standard itself, and to a kit comprising the device. Further, the invention also relates to an apparatus containing the device, and to a method for the quantitative analysis of a drug and/or metabolite profile in a biological sample employing the device.
摘要翻译：一种装置，特别是用于定量分析生物样品中的药物和/或代谢物分布的样品制备装置，其包括用于将至少一种内标浸渍的该装置的插入物与内标物本身，以及包括该装置的套件。此外，本发明还涉及含有该装置的装置以及用于使用该装置的生物样品中的药物和/或代谢物分布的定量分析的方法。

24. 发明授权

US08265877B2 Apparatus and method for analyzing a metabolite profile 有权
标题翻译：用于分析代谢物分布的仪器和方法
公开(公告)号：US08265877B2
公开(公告)日：2012-09-11
申请号：US11476637
申请日：2006-06-29
申请人： Steven Lewis Ramsay , Wolfgang Markus Stoeggl , Klaus Michael Weinberger , Armin Graber , Wolfgang Guggenbichler
发明人： Steven Lewis Ramsay , Wolfgang Markus Stoeggl , Klaus Michael Weinberger , Armin Graber , Wolfgang Guggenbichler
IPC分类号： G01N33/48
CPC分类号： G01N33/5038 , G01N33/5005 , G01N33/54366 , G01N33/6848 , G01N35/00594 , G06F19/28 , H01J49/0027
摘要： An apparatus and method analyzes a metabolic profile in a biological sample. The apparatus includes an input unit for inputting the drugs and/or metabolites to be screened; a controlling unit for determining a parameter set for metabolites preparation and for mass spectrometry analysis depending on the input of the kind of metabolites to be screened; a treatment unit for preparing the metabolites to be screened depending on the determined parameter set; a mass spectrometer for performing mass spectrometry analysis on prepared metabolites depending on the parameter set; a database for storing results of analyzing and parameter sets for metabolite preparation and for mass spectrometry analyses; and an evaluation unit for evaluating the results of mass spectrometry by use of reference results stored in the database to output an analysis of the metabolites profile.
摘要翻译：一种设备和方法分析生物样品中的代谢谱。该装置包括用于输入待筛选的药物和/或代谢物的输入单元; 用于确定用于代谢物制备的参数组和用于质谱分析的控制单元，取决于待筛选的代谢物的种类的输入; 用于根据确定的参数组制备要筛选的代谢物的处理单元; 用于根据参数集对制备的代谢物进行质谱分析的质谱仪; 用于存储分析结果的数据库和用于代谢物制备和质谱分析的参数组; 以及用于通过使用存储在数据库中的参考结果来评估质谱结果以输出代谢物分布的分析的评估单元。

25. 发明申请

US20120208282A1 Method For Normalization in Metabolomics Analysis Methods with Endogenous Reference Metabolites. 审中-公开
标题翻译：用内源性参考代谢物代谢组学分析方法进行正常化的方法。
公开(公告)号：US20120208282A1
公开(公告)日：2012-08-16
申请号：US13381860
申请日：2010-06-23
申请人： Hans-Peter Deigner , Matthias Kohl , Matthias Keller , Therese Koal , David Enot
发明人： Hans-Peter Deigner , Matthias Kohl , Matthias Keller , Therese Koal , David Enot
IPC分类号： G01N27/62 , G01R33/465
CPC分类号： G16B40/00 , G01N2800/60 , Y10T436/163333 , Y10T436/201666
摘要： The present invention relates to the use of endogenous reference metabolites and a method for normalization of intensity data corresponding to amounts and/or concentrations of selected target metabolites in a biological sample of a mammalian subject, wherein said intensity data are obtained by a metabolomics analysis method with one or a plurality of endogenous reference metabolites, comprising carrying out at least one in vitro metabolomics analysis method of said selected target metabolites in said biological sample, simultaneously carrying out in the same sample a quantitative analysis of one or a plurality of endogenous reference metabolites or derivatives thereof, wherein said endogenous reference metabolites are such compounds in the biological sample which are present in the subject at an essentially constant level; and wherein said endogenous reference metabolites or derivatives thereof have a molecular mass less than 1500 Da.
摘要翻译：本发明涉及内源性参考代谢物的使用以及对应于哺乳动物受试者的生物样品中所选靶标代谢物的量和/或浓度的强度数据的归一化方法，其中所述强度数据通过代谢组学分析法与一种或多种内源性参考代谢物，包括在所述生物样品中进行所述选择的目标代谢物的至少一种体外代谢组学分析方法，同时在同一样品中进行一种或多种内源性参考代谢物的定量分析或其衍生物，其中所述内源性参考代谢物是生物样品中以基本恒定水平存在于受试者中的这样的化合物; 并且其中所述内源性参考代谢物或其衍生物具有小于1500Da的分子量。

26. 发明申请

US20120202240A1 Method for Predicting the likelihood of an Onset of an Inflammation Associated Organ Failure 审中-公开
标题翻译：预测炎症相关器官衰竭发生的可能性的方法
公开(公告)号：US20120202240A1
公开(公告)日：2012-08-09
申请号：US13387572
申请日：2010-07-23
申请人： Hans-Peter Deigner , Matthias Kohl , David Enot , Theresa Koal , Matthias Keller
发明人： Hans-Peter Deigner , Matthias Kohl , David Enot , Theresa Koal , Matthias Keller
IPC分类号： G01N27/62 , G01R33/48 , G06F19/00 , H01J49/26 , G01N27/72
CPC分类号： G01N33/6893 , G01N2800/26 , G16B5/00 , G16B40/00 , Y10T436/173845
摘要： The present invention relates to a reliable and statistically significant method for predicting the likelihood of an onset of an inflammation associated organ failure from a biological sample of a mammalian subject in vitro, by means of a subject's quantitative metabolomics profile comprising a plurality of endogenous metabolites, and comparing it with a quantitative reference metabolomics profile of a plurality of endogenous organ failure predictive target metabolites in order to predict whether the subject is likely or unlikely to develop an organ failure. Furthermore, the invention relates to the usefulness of endogenous organ failure predictive target metabolites in such a method.
摘要翻译：本发明涉及用于通过受试者的定量代谢组学谱来预测来自哺乳动物受试者的体外生物样品的炎症相关器官功能衰竭发作的可能性的可靠和统计学上显着的方法，所述定量代谢组学特征包括多种内源性代谢物，并将其与多种内源性器官衰竭预测目标代谢物的定量参考代谢组学谱进行比较，以便预测受试者是否可能或不可能发生器官功能衰竭。此外，本发明涉及在这种方法中内源性器官衰竭预测目标代谢物的有用性。

27. 发明申请

US20090072109A1 HOLDER FOR HOLDING A CARRIER FOR INSERTION INTO A CYLINDRICAL WELL 有权
标题翻译：持有一个承运人进入一个缸体的持有人
公开(公告)号：US20090072109A1
公开(公告)日：2009-03-19
申请号：US12202063
申请日：2008-08-29
申请人： Steven Ramsay , Florian Bichteler , Wolfgang Guggenbichler
发明人： Steven Ramsay , Florian Bichteler , Wolfgang Guggenbichler
IPC分类号： A47F5/00
CPC分类号： B01L3/5085 , B01L2300/0609 , B01L2300/0829
摘要： The invention relates to a holder for holding a carrier, wherein the holder is inserted into a cylinder-shaped well, for example, of a multiwell plate. In addition the invention relates to a multiwell plate with such a holder. In order to provide a possibility for the reliable support of a carrier in a holder, wherein the holder ensures a secure and specified positioning of the carrier in a well and reliably prevents the carrier and the holder from falling out of the well, a holder is proposed for insertion into a cylindrical well and to support the carrier. The holder comprises a support, a holding piece and a connecting piece which connects the supporting piece with the holding piece, wherein the holder together with the lateral external surfaces of the supporting piece, the holding piece and/or connecting piece lies against at least one lateral internal surface of the well, and wherein the carrier is inserted on the support and under the holding piece.
摘要翻译：本发明涉及一种用于保持载体的保持器，其中保持器插入例如多孔板的圆筒状的孔中。此外，本发明涉及具有这种保持器的多孔板。为了提供载体在保持器中的可靠支撑的可能性，其中保持器确保承载件在井中的安全和指定的定位并可靠地防止载体和保持器从井中脱落，提出用于插入圆柱形井并支撑载体。保持器包括支撑件，保持件和将支撑件与保持件连接的连接件，其中保持器与支撑件，保持件和/或连接件的侧面外表面相对于至少一个井的侧向内表面，并且其中载体被插入支撑件上并在保持件下方。

28. 发明公开

US20240192216A1 METABOLIC BIOMARKER SET FOR ASSESSING OVARIAN CANCER 审中-公开
公开(公告)号：US20240192216A1
公开(公告)日：2024-06-13
申请号：US17969834
申请日：2022-10-20
申请人： Biocrates Life Sciences AG
发明人： Udo MÜLLER , Simon SCHAFFERER , Barbara BURWINKEL
IPC分类号： G01N33/574 , G01N33/48 , G01N33/68 , G01N33/92
CPC分类号： G01N33/57449 , G01N33/68 , G01N33/92 , G01N33/48 , G01N33/6848 , G01N2405/04 , G01N2405/08
摘要： The present invention relates to new biomarkers for assessing ovarian cancer being more sensitive, particularly at early stage of disease. Moreover, the present invention relates to a method for assessing ovarian cancer from a patient to be examined, and to a kit for carrying out the method.

29. 发明申请

US20160187339A1 Biomarker and Method for Determining an Oxidative Stress Level 审中-公开
公开(公告)号：US20160187339A1
公开(公告)日：2016-06-30
申请号：US14824984
申请日：2015-08-12
申请人： Biocrates Life Sciences AG
发明人： Klaus Michael Weinberger , Armin Graber , Steven Lewis Ramsay
IPC分类号： G01N33/573 , C07D209/16 , C07D209/20 , C07C229/36 , C07C317/48
CPC分类号： G01N33/5735 , C07C229/36 , C07C317/48 , C07D209/16 , C07D209/20 , C12Q1/26 , G01N2333/90245 , G01N2800/042 , G01N2800/7009
摘要： The present invention relates to a biomarker and a method for determining an oxidative stress level in a biological sample, which employs co-factor-dependent oxidative stress parameters, as well as a kit adapted for carrying out such a method. In one aspect the co-factor is tetrahydrobiopterin.

30. 发明申请

US20120129265A1 NEW BIOMARKERS FOR ASSESSING KIDNEY DISEASES 审中-公开
标题翻译：新生物标记用于评估KIDNEY病
公开(公告)号：US20120129265A1
公开(公告)日：2012-05-24
申请号：US13375553
申请日：2009-06-02
申请人： Ulrika Lundin , Klaus Weinberger
发明人： Ulrika Lundin , Klaus Weinberger
IPC分类号： G01N33/68 , B01L3/00
CPC分类号： G01N33/6893 , G01N2800/347
摘要： The present invention relates to a metabolic biomarker set for assessing kidney disease comprising at least two amino acids, at least two acylcarnitines and at least two biogenic amines. Moreover, the present invention relates to a method for assessing kidney disease in a mammalian subject which comprises obtaining a biological sample, preferably blood and/or urine, from the subject and measuring in the biological sample the amount of at least two amino acids, of at least two acylcarnitines and of at least two biogenic amines, as well as to a kit adapted to carry out the method. By employing the specific biomarkers and the method according to the present invention it becomes possible to more properly and reliably assess kidney disease.
摘要翻译：本发明涉及用于评估肾脏疾病的代谢生物标志物组，其包含至少两种氨基酸，至少两种酰基肉碱和至少两种生物胺。此外，本发明涉及一种用于在哺乳动物受试者中评估肾脏疾病的方法，其包括从受试者获得生物样品，优选血液和/或尿液，并在生物样品中测量至少两个氨基酸的量至少两种酰基肉碱和至少两种生物胺，以及适于实施该方法的试剂盒。通过使用特定的生物标志物和根据本发明的方法，可以更正确和可靠地评估肾脏疾病。

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