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11. 发明专利

JP2001199892A METHOD FOR ENHANCING ANTITUMOR ACTIVITY OF AMYGDALIN- CONTAINING MATERIAL, COMPOSITION CONTAINING AMYGDALIN- CONTAINING MATERIAL FOR ENHANCING ANTITUMOR ACTIVITY, METHOD FOR EVALUATING ANTITUMOR EFFECTIVENESS OF TREATMENT BY AMYGDALIN-CONTAINING MATERIAL, AND METHOD FOR EVALUATING ANTITUMOR EFFECTIVENESS OF AMYGDALIN- CONTANING MATERIAL 失效
公开(公告)号：JP2001199892A
公开(公告)日：2001-07-24
申请号：JP2000008337
申请日：2000-01-17
申请人： NIWA KOZO
发明人： NIWA KOZO
IPC分类号： A61K31/7028 , A23L7/104 , A61K20060101 , A61K31/70 , A61K31/7034 , A61K35/00 , A61K36/00 , A61K36/185 , A61K36/73 , A61K36/736 , A61K41/00 , A61P35/00 , C12M20060101 , C12M1/42 , C12P1/00 , C12P1/02 , C12P19/00 , C12Q1/02 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To effectively exhibit the antitumor activities of an amygdalin-containing material in internal use, and further evaluate the effectiveness of the antitumor activities at the time when the amygdalin-containing material is used in the internal use and forecast without carrying out a clinical test. SOLUTION: A seed of a loquat is roasted by far infrared rays, and the roasted seed is fermented by adding a malt. The fermented product is formed into an oil to enhance the antitumor activities thereof. The amygdalin-containing material of which the effects are required to be confirmed is inserted to a system for forming a lipid peroxide by irradiating docosahexaenoic acid with ultraviolet rays, and the antitumor activities are evaluated and predicted so that the larger the increasing proportion of the forming amount of the lipid peroxide based on the concentration- increasing proportion of the amygdalin-contaning material is, the larger the antitumor activities may become at the time of the inner use.

12. 发明专利

JPH05504620A 失效
公开(公告)号：JPH05504620A
公开(公告)日：1993-07-15
申请号：JP50022691
申请日：1990-11-27
IPC分类号： B03C5/02 , C12M20060101 , C12M1/34 , C12Q1/04 , C12Q1/06 , G01N21/17 , G01N27/26 , G01N27/447

13. 发明专利

JPS62277550A BIO-ELECTROCHEMICAL CELL AND TEST METHOD OF ACTIVITY OF MICROORGANISM 失效
公开(公告)号：JPS62277550A
公开(公告)日：1987-12-02
申请号：JP6275587
申请日：1987-03-19
申请人： PENA PAUL DE LA LTD
发明人： ANSONII PIITAA FURANSHISU TAAN , AN SUWAIN , GURAHAMU RAMUJII , MARUKO KARUDOOSHI , BAANAADO HENRII SHIYUNAIDAA
IPC分类号： G01N27/416 , C12M20060101 , C12M1/00 , C12Q1/00 , C12Q1/04 , C12R1/01 , C12R1/19 , C12R1/285 , C12R1/385 , C12R1/445 , C12R1/46 , G01N27/327

14. 发明专利

JPS61100261A Sterilization of adsorbing body 失效
标题翻译：吸附体的灭菌
公开(公告)号：JPS61100261A
公开(公告)日：1986-05-19
申请号：JP22186184
申请日：1984-10-22
申请人： Kanegafuchi Chemical Ind
发明人： TANI NOBUTAKA , OKUYAMA TSUTOMU , FURUYOSHI SHIGEO
IPC分类号： A61M1/36 , A61L20060101 , A61L2/06 , A61M1/14 , C12M20060101 , C12N20060101 , C12P20060101

15. 发明公开

EP1885656A4 A METHOD FOR IMPROVING FLUX IN A MEMBRANE BIOREACTOR 审中-公开
标题翻译： VERFAHREN ZUR VERBESSERUNG DES FLUSES在EINEM MEMBRANBIOREAKTOR
公开(公告)号：EP1885656A4
公开(公告)日：2008-12-03
申请号：EP05775803
申请日：2005-07-26
申请人： NALCO CO
发明人： YOON SEONG-HOON , COLLINS JOHN H , KOPPES JEROEN A , HUISMAN INGMAR H
IPC分类号： C02F3/12 , B01D61/04 , B01D61/16 , C02F1/00 , C02F1/44 , C02F1/56 , C02F5/12 , C12M20060101
CPC分类号： C02F5/12 , B01D61/145 , B01D61/147 , B01D61/16 , B01D2311/04 , B01D2311/12 , B01D2311/16 , B01D2321/168 , C02F1/001 , C02F1/44 , C02F1/56 , C02F3/1268 , C02F3/1273 , C02F3/2853 , Y02W10/15
摘要： The invention pertains to a method of improving flux in a membrane bioreactor (4) having membrane (5) by adding an effective amount of cationic, amphoteric, and zwitterionic polymers, or a combination thereof. The membrane bioreactor (4) is in a system also including an aerobic reactor (2) and anaerobic digester (3).
摘要翻译：本发明涉及通过添加有效量的阳离子，两性和两性离子聚合物或其组合来改善具有膜（5）的膜生物反应器（4）中的通量的方法。膜生物反应器（4）处于也包括好氧反应器（2）和厌氧消化器（3）的系统中。

16. 发明公开

EP1086205A4 METHODS OF MONITORING DISEASE STATES AND THERAPIES USING GENE EXPRESSION PROFILES 审中-公开
标题翻译：疾病状态的监测和治疗过程中使用基因表达谱
公开(公告)号：EP1086205A4
公开(公告)日：2004-11-17
申请号：EP99930385
申请日：1999-06-17
申请人： ROSETTA INPHARMATICS INC
发明人： FRIEND STEPHEN H , STOUGHTON ROLAND
IPC分类号： G01D1/16 , A01N43/04 , A01N61/00 , C07H21/04 , C12M20060101 , C12M1/34 , C12M3/00 , C12N15/09 , C12P21/06 , C12Q1/02 , C12Q1/68 , G01N33/48 , G01N33/53 , G01N37/00 , G06G7/48
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： The present invention provides methods for monitoring disease states in a subject, as well as methods for monitoring the levels of effect of therapies upon a subject having one or more disease states. The methods involve: (i) measuring abundances of cellular constituents in a cell from a subject so that a diagnostic profile is obtained, (ii) measuring abundances of cellular constituents in a cell of one or more analogous subjects so that perturbation response profiles are obtained which correlate to a particular disease or therapy, and (iii) determining the interpolated perturbation response profile or profiles which best fit the diagnostic profile according to some objective measure. In other aspects, the invention also provides a computer system capable of performing the methods of the invention, data bases comprising perturbation response profiles for one or more diseases and/or therapies, and kits for determining levels of disease states and/or therapeutic effects according to the methods of the invention.

17. 发明授权

US06973388B2 Methods of diagnosing disease states using gene expression profiles 失效
标题翻译：使用基因表达谱诊断疾病状态的方法
公开(公告)号：US06973388B2
公开(公告)日：2005-12-06
申请号：US09783474
申请日：2001-02-14
申请人： Stephen H. Friend , Roland Stoughton
发明人： Stephen H. Friend , Roland Stoughton
IPC分类号： G01D1/16 , A01N43/04 , A01N61/00 , C07H21/04 , C12M20060101 , C12M1/34 , C12M3/00 , C12N15/09 , C12P21/06 , C12Q1/02 , C12Q1/68 , G01N33/48 , G01N33/53 , G01N37/00 , G06G7/48
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： The present invention provides methods for monitoring disease states in a subject, as well as methods for monitoring the levels of effect of therapies upon a subject having one or more disease states. The methods involve: (i) measuring abundances of cellular constituents in a cell from a subject to obtain a diagnostic profile, (ii) measuring abundances of cellular constituents in a cell of one or more analogous subjects to obtain perturbation response profiles which correlate to a particular disease or therapy, and (iii) determining the interpolated perturbation response profile or profiles which best fit the diagnostic profile. In other aspects, the invention also provides a computer system capable of performing the methods of the invention, databases comprising perturbation response profiles for one or more diseases and/or therapies, and kits for determining levels of disease states and/or therapeutic effects according to the methods of the invention.
摘要翻译：本发明提供了用于监测受试者的疾病状态的方法，以及用于监测治疗对具有一种或多种疾病状态的受试者的疗效水平的方法。所述方法包括：（i）测量来自受试者的细胞中的细胞成分的丰度以获得诊断特征，（ii）测量一个或多个类似受试者的细胞中细胞成分的丰度，以获得与a相关的扰动反应曲线特定疾病或治疗，以及（iii）确定最适合诊断特征的内插扰动响应曲线或轮廓。在其他方面，本发明还提供一种能够执行本发明的方法的计算机系统，包括用于一种或多种疾病和/或治疗的扰动反应概况的数据库，以及用于确定根据本发明的疾病状态和/或治疗效果水平的试剂盒本发明的方法。

18. 发明授权

US5707859A Two-dimensional microcarriers for anchorage dependent cells 失效
标题翻译：用于锚定依赖细胞的二维微载体
公开(公告)号：US5707859A
公开(公告)日：1998-01-13
申请号：US107713
申请日：1993-12-01
申请人： Alain O. A. Miller , Guy De Hollain , Dominique Masquelier
发明人： Alain O. A. Miller , Guy De Hollain , Dominique Masquelier
IPC分类号： C12M3/00 , C12M20060101 , C12M3/02 , C12N5/00 , C12N5/06 , C12N11/00 , C12N11/08 , C12M1/00 , C12N11/06 , C12N11/14
CPC分类号： C12N5/0075 , C12M25/06 , C12N2533/30
摘要： Two-dimensional microcarriers for culture of anchorage dependent cells are formed having two opposed and parallel anchorage surfaces and a thickness so thin that cells attach only to the surfaces and not between the surfaces. Preferably, each of the surfaces is less than about 500 microns in each of its two dimensions, the thickness is not more than about 35 microns, the microcarriers have a shape resulting from the orthogonal or oblique intersection of two parallel planes separated by a distance of not more than 35 microns with a solid cylinder and the microcarriers are made from a hydrophobic polymeric material such as polystyrene, polycarbonate or polyterephthalate. The microcarriers can be microdisks having a density of between 0.90 and 1.10 g/cm.sup.3. The anchorage surfaces may be treated to enable cell attachment by applying a thin metallic deposit such as a titanium deposit or by electrical corona discharge. The microcarriers may be transparent to light waves and capable of withstanding sterilization. To form the microcarriers, the surfaces of a thin film of the polymeric material having a thickness of not more than about 35 microns are treated to be suitable for cell attachment, and the film is cut such as with a laser or by punching to provide the microcarriers.
摘要翻译： PCT No.PCT / BE91 / 00012 Sec。 371日期：1993年12月1日 102（e）日期1993年12月1日PCT 1991年2月18日提交PCT公布。出版物WO92 / 14814 PCT 日期1992年9月3日形成具有两个相对且平行的锚固表面的厚度依赖性细胞培养的二维微载体，其厚度非常薄，使细胞仅附着在表面而不附着在表面之间。优选地，每个表面在其两个维度的每一个中小于约500微米，厚度不大于约35微米，微载体具有由两个平行平面的正交或倾斜交点形成的形状，不超过35微米的固体圆筒，微载体由疏水性聚合材料如聚苯乙烯，聚碳酸酯或聚对苯二甲酸酯制成。微载体可以是密度在0.90至1.10g / cm 3之间的微盘。可以通过施加诸如钛沉积物的薄金属沉积物或通过电晕放电来处理锚固表面以使细胞附着。微载体对于光波可以是透明的并且能够耐受灭菌。为了形成微载体，将具有不大于约35微米厚度的聚合物材料的薄膜的表面处理成适合于细胞附着，并且用激光或冲孔来切割膜以提供微载体。

19. 发明授权

US5610070A Sterile or specific pathogen free environment methods 失效
标题翻译：无菌或特异性病原体自由环境的方法
公开(公告)号：US5610070A
公开(公告)日：1997-03-11
申请号：US237719
申请日：1994-04-29
申请人： Michael Wilson , Philip Monro
发明人： Michael Wilson , Philip Monro
IPC分类号： A61L2/00 , A01G31/00 , A61M20060101 , A61M5/14 , A61M37/00 , A61M39/02 , B65B25/00 , B65B55/18 , C12M20060101 , C12M1/12 , C12M1/34 , C12M3/00 , G01N33/50 , G01N21/75
CPC分类号： C12M23/00 , A01G31/00 , A61M5/1407 , B65B25/008 , B65B55/18 , C12M37/00 , Y10T436/25
摘要： Methods of maintaining or providing sterile or specific pathogen free environments are disclosed. The methods involve the use of semi-permeable membrane materials between the sterile or pathogen free environment and surrounding potentially hostile environments.
摘要翻译：公开了维持或提供无菌或特异性无病原体环境的方法。该方法涉及在无菌或无病原体环境和周围潜在敌对环境之间使用半透膜材料。

20. 发明授权

US4789634A Carrier for the cultivation of human and/or animal cells in a fermenter 失效
标题翻译：在发酵罐中培养人和/或动物细胞的载体
公开(公告)号：US4789634A
公开(公告)日：1988-12-06
申请号：US875545
申请日：1986-06-18
申请人： Wolfgang G. K. Muller-Lierheim , Andreas H. Beiter
发明人： Wolfgang G. K. Muller-Lierheim , Andreas H. Beiter
IPC分类号： A61F2/14 , A61L27/22 , A61L27/38 , A61L27/54 , C12M20060101 , C12M3/00 , C12N20060101 , C12N5/00 , C12M1/40
CPC分类号： C12M25/14 , A61F2/14 , A61L15/425 , C12M23/04 , C12M25/00 , C12M25/16 , C12M29/04
摘要： A carrier for the cultivation of animal and/or human cells in a fermenter, comprises a polymer base body of a solid formed into a pressure-resistant matrix, with a capillary system for carrying the liquid cell culture medium therethrough, with no cell growth occurring therein, and with interstices for three-dimensional cell growth therein, growth factors for the cells being covalently bonded to the boundary surfaces of the interstices. The carrier can provide a high level of cell density of the order of magnitude of 10.sup.9 cells/ml, by three-dimensional cell growth.
摘要翻译：用于在发酵罐中培养动物和/或人细胞的载体包括形成耐压基质的固体的聚合物基体，具有用于携带液体细胞培养基的毛细管系统，其中没有细胞生长并且其中具有用于三维细胞生长的间隙，细胞的生长因子共价键合到间隙的边界表面。通过三维细胞生长，载体可以提供高达109个细胞/ ml数量级的高水平的细胞密度。

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