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11. 发明公开

EP0018605A3 Enterosoluble capsule and methods for its preparation 有权
标题翻译：肠溶胶囊及其制备方法
公开(公告)号：EP0018605A3
公开(公告)日：1981-06-03
申请号：EP80102229
申请日：1980-04-25
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Onda, Yoshiro , Muto, Hiroaki , Maruyama, Kazumasa
IPC分类号： A61K09/22 , A61K09/52 , A61K09/36
CPC分类号： A61K9/4816 , A61K9/2866
摘要： The invention provides a novel enterosoluble capsule for containing a medicament, which is shaped with a hitherto not used novel cellulose derivative. The cellulose derivative is a mixed ester of an alkyl-, hydroxyalkyl- or hydroxyalkyl alkylcellulose esterified with succinyl anhydride and an aliphatic monocarboxylic acid anhydride. The enterosoluble capsules have excellent enterosolubility behavior as well as sufficient pliability even without the addition of a plasticizer which is almost indispensable in the prior art materials. The cellulose derivative can be shaped into capsules not only by the conventional dipping method but also by the plastic deformation at an elevated temperature under pressure such as compression molding, vacuum forming, matchedmold forming and the like.

12. 发明申请

WO1997004752A1 PHARMACEUTICAL COMPOSITIONS OF CONJUGATED ESTROGENS AND METHODS FOR THEIR USE 审中-公开
标题翻译：结合雌激素的药物组合物及其使用方法
公开(公告)号：WO1997004752A1
公开(公告)日：1997-02-13
申请号：PCT/US1996011797
申请日：1996-07-16
申请人： DURAMED PHARMACEUTICALS, INC.
发明人： DURAMED PHARMACEUTICALS, INC. , HUBER, Harold, E. , RYAN, Mary, K.
IPC分类号： A61K09/36
CPC分类号： A61K31/568 , A61K9/2018 , A61K9/2054 , A61K9/209 , A61K9/2866 , A61K31/565 , A61K31/566 , A61K31/57 , Y10S514/96 , A61K2300/00
摘要： This invention relates to novel pharmaceutical compositions containing conjugated estrogens for the treatment of peri-menopausal, menopausal and post-menopausal disorders in women. The novel pharmaceutical compositions comprise a carrier base material and conjugated estrogens formed into a solid unit dosage form possessing a regular incremental release of the medicament upon oral administration. Further, the invention comprises the combination of conjugated estrogens with progestogens in a solid, shaped dosage unit. Specifically, the invention comprises the use of an organic excipient such as high molecular weight hydroxyalkyl alkylcelluloses. The use of an organic excipient such as hydroxypropylmethylcellulose in a stable, solid dosage formulation containing either conjugated estrogens alone or in combination with a progestogen is described.
摘要翻译：本发明涉及含有用于治疗妇女围绝经期，绝经期和绝经后疾病的结合性雌激素的新型药物组合物。新型药物组合物包含形成固体单位剂型的载体基质材料和结合型雌激素，其在口服给药时具有药物的常规增量释放。此外，本发明包括在固体，成形剂量单位中结合的雌激素与孕激素的组合。具体地，本发明包括使用有机赋形剂如高分子量羟烷基烷基纤维素。描述了将有机赋形剂如羟丙基甲基纤维素在含有单独的或与孕激素组合的结合雌激素的稳定的固体剂量制剂中的用途。

13. 发明申请

WO1993006821A1 SUSTAINED-RELEASE TABLET 审中-公开
标题翻译：可持续发布的平板电脑
公开(公告)号：WO1993006821A1
公开(公告)日：1993-04-15
申请号：PCT/JP1992001287
申请日：1992-10-05
申请人： YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. , JAPAN TOBACCO INC. , HAYASHIDA, Tomohiro , KADOYA, Kikumaru , OMURA, Tomoyuki;
发明人： YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. , JAPAN TOBACCO INC.
IPC分类号： A61K09/36
CPC分类号： A61K9/2054 , A61K9/2866
摘要： A sustained-release tablet comprising a base tablet containing a water-swellable gelling agent and a pharmaceutically active ingredient dispersed homogeneously in said gelling agent, said base tablet being coated with a coating agent prepared by dissolving ethylcellulose and/or acetylcellulose in an organic solvent. This preparation is a sustained-release tablet which is capable of zero-order dissolution and applicable to any of water-soluble and difficultly soluble medicines, and can be prepared readily at a low cost.
摘要翻译：一种持续释放片剂，其包含含有水溶胀性胶凝剂和均匀分散在所述胶凝剂中的药物活性成分的碱性片剂，所述碱性片剂包被通过将乙基纤维素和/或乙酰纤维素溶解在有机溶剂中制备的包衣剂。该制剂是能够零级溶解并适用于任何水溶性和难溶性药物的缓释片剂，并且可以以低成本容易地制备。

14. 发明申请

WO1998032426A1 TIME-SPECIFIC CONTROLLED RELEASE DOSAGE FORMULATIONS AND METHOD OF PREPARING SAME 审中-公开
标题翻译：时间特异性控制释放剂量制剂及其制备方法
公开(公告)号：WO1998032426A1
公开(公告)日：1998-07-30
申请号：PCT/IB1997001646
申请日：1997-12-16
申请人： POLIN INDUSTRIA CHIMICA S.P.A. , BUSETTI, Cesare , CRIMELLA, Tiziano
发明人： POLIN INDUSTRIA CHIMICA S.P.A.
IPC分类号： A61K09/36
CPC分类号： A61K9/5078 , A61K9/2866 , A61K9/2886 , A61K9/4891
摘要： The present invention provides a method of achieving the time-specific delivery of a pharmaceutically active agent to a patient in need of the therapeutic effects of the pharmaceutically active agent. The method includes administering a pharmaceutical formulation comprising (a) a core including the pharmaceutically active agent to be delivered, and (b) a swellable polymeric coating layer substantially surrounding the core. The swellable polymeric coating layer delays the release of the pharmaceutically active agent from the core for a predetermined period of time dependent upon the thickness of the swellable polymeric coating layer. The swellable polymeric coating layer surrounding the core is provided by a new method which includes alternately (I) wetting the core with a binder solution, and (ii) coating the core with powdered polymeric particles a sufficient number of times to produce a time-specific dosage formulation having the desired thickness of swellable polymeric coating layer.
摘要翻译：本发明提供了一种实现药物活性剂对需要药物活性剂的治疗作用的患者的时间特异性递送的方法。该方法包括施用药物制剂，其包含（a）包含待递送的药物活性剂的核心和（b）基本上围绕核心的可溶胀聚合物涂层。可膨胀聚合物涂层根据可溶胀聚合物涂层的厚度延迟药物活性剂从芯中释放预定时间段。通过新的方法提供围绕芯的可溶胀聚合物涂层，其包括交替地（I）用粘合剂溶液润湿芯，和（ii）用粉末状聚合物颗粒将核心涂覆足够多的次数以产生时间特异性剂量制剂具有所需的可溶胀聚合物涂层的厚度。

15. 发明申请

WO1994025007A1 STABLE, INGESTABLE AND ABSORBABLE NADH AND NADPH THERAPEUTIC COMPOSITIONS 审中-公开
标题翻译：稳定，可吸收和可吸收的NADH和NADPH治疗组合物
公开(公告)号：WO1994025007A1
公开(公告)日：1994-11-10
申请号：PCT/US1994003290
申请日：1994-03-25
申请人： BIRKMAYER U.S.A.
发明人： BIRKMAYER U.S.A. , BIRKMAYER, Joerg, G., D.
IPC分类号： A61K09/36
CPC分类号： A61K31/70 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2866 , Y10S514/959
摘要： A stable, ingestable and intestine-absorbable therapeutic composition comprising NADH or NADPH, or physiologically acceptable salts thereof, in a pill form. The pill has an outer surface covered by an acid stable protective coating. This oral form of NADH/NADPH may be taken for a variety of known therapeutic effects.
摘要翻译：包含药丸形式的包含NADH或NADPH或其生理学上可接受的盐的稳定，可摄取和可肠道吸收的治疗组合物。药丸具有被酸性稳定保护涂层覆盖的外表面。这种NADH / NADPH的口服形式可以用于各种已知的治疗效果。

16. 发明申请

WO1996040080A1 CONTROLLED RELEASE FORMULATION HAVING A PREFORMED PASSAGEWAY 审中-公开
标题翻译：具有预先选择的控制释放配方
公开(公告)号：WO1996040080A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008869
申请日：1996-06-05
申请人： ANDRX PHARMACEUTICALS, INC.
发明人： ANDRX PHARMACEUTICALS, INC. , CHEN, Chih-Ming
IPC分类号： A61K09/36
CPC分类号： A61K9/0004
摘要： A controlled release pharmaceutical tablet having at least one passageway, said tablet having: (a) a compressed core which comprises: (i) a medicament; (ii) an amount of a water soluble osmotic agent which is effective to cause the medicament to be delivered from said passageway in the presence of aqueous media; (iii) a water-swellable pharmaceutically acceptable polymer; and (b) a membrane coating around said core tablet which comprises a water insoluble pharmaceutically acceptable polymer.
摘要翻译：一种具有至少一个通道的控释片剂，所述片剂具有：（a）压缩芯，其包含：（i）药物; （ii）一定量的水溶性渗透剂，其有效地使得药物在水介质存在下从所述通道输送; （iii）水溶胀性药学上可接受的聚合物; 和（b）围绕所述芯片的膜包衣，其包含水不溶性的药学上可接受的聚合物。

17. 发明申请

WO1986000226A1 DRAGEE AND METHOD FOR ITS MANUFACTURE 审中-公开
标题翻译：其制造方法及其方法
公开(公告)号：WO1986000226A1
公开(公告)日：1986-01-16
申请号：PCT/EP1985000284
申请日：1985-06-14
申请人： FERRERO S.p.A. , FERRERO, Pietro
发明人： FERRERO S.p.A.
IPC分类号： A61K09/36
CPC分类号： A23G3/42 , A23G3/26 , A23G3/34 , A23G3/38 , A23G3/54 , A61K9/2826
摘要： The dragée which is dietetic and substantially non-karyogenic has a core and a shell adhering to the core, based on sorbitol with an additive of the methyl ester of L-aspartyl-L-phenyl-alanine (aspartame) in the proportion of not more than 0.5 % by weight. Also described is a tumbling method for making the shell.
摘要翻译：基于具有L-天冬氨酰-L-苯基 - 丙氨酸（阿斯巴甜）的甲酯的添加剂的山梨糖醇，具有饮食和基本上不含核的烟草具有核心和壳附着在核心上，比例不超过大于0.5重量％。还描述了制造壳的翻滚方法。

18. 发明申请

WO1997004753A1 PHARMACEUTICAL COMPOSITIONS OF CONJUGATED ESTROGENS AND METHODS FOR THEIR USE 审中-公开
标题翻译：结合雌激素的药物组合物及其使用方法
公开(公告)号：WO1997004753A1
公开(公告)日：1997-02-13
申请号：PCT/US1996012295
申请日：1996-07-26
申请人： DURAMED PHARMACEUTICALS, INC.
发明人： DURAMED PHARMACEUTICALS, INC. , HUBER, Harold, E. , RYAN, Mary, K.
IPC分类号： A61K09/36
CPC分类号： A61K31/568 , A61K9/2018 , A61K9/2054 , A61K9/209 , A61K9/2866 , A61K31/565 , A61K31/566 , A61K31/57 , Y10S514/96 , A61K2300/00
摘要： This invention relates to novel pharmaceutical compositions and methods for their preparation containing conjugated estrogens for the treatment of peri-menopausal, menopausal and post-menopausal disorders in women. The novel pharmaceutical compositions comprise a carrier base material and conjugated estrogens formed into a solid unit dosage form possessing a regular incremental release of the medicament upon oral administration. Further, the invention comprises the combination of conjugated estrogens with progestogens in a solid, shaped dosage unit. Specifically, the invention comprises the use of an organic excipient such as high molecular weight hydroxyalkyl alkylcelluloses. The use of an organic excipient such as hydroxypropylmethylcellulose in a stable, solid dosage formulation containing either conjugated estrogens alone or in combination with a progestogen is described.
摘要翻译：本发明涉及新型药物组合物及其制备方法，其含有用于治疗妇女围绝经期，绝经期和绝经后疾病的结合性雌激素。新型药物组合物包含形成固体单位剂型的载体基质材料和结合型雌激素，其在口服给药时具有药物的常规增量释放。此外，本发明包括在固体，成形剂量单位中结合的雌激素与孕激素的组合。具体地，本发明包括使用有机赋形剂如高分子量羟烷基烷基纤维素。描述了将有机赋形剂如羟丙基甲基纤维素在含有单独的或与孕激素组合的结合雌激素的稳定的固体剂量制剂中的用途。

19. 发明申请

WO1981001100A1 PROCESS FOR HARD COATING WITH SORBITOL AND PRODUCTS OBTAINED THEREBY 审中-公开
标题翻译：使用SORBITOL硬化涂层的工艺和获得的产品
公开(公告)号：WO1981001100A1
公开(公告)日：1981-04-30
申请号：PCT/FR1980000151
申请日：1980-10-16
申请人： ROQUETTE FRERES , DEVOS F , BUSSIERE G , HUCHETTE M
发明人： ROQUETTE FRERES
IPC分类号： A61K09/36
CPC分类号： A61K9/2826
摘要： Process for hard coating with sorbitol. On the one hand, a sorbitol syrup having a concentration of 60 to 85% by weight is supplied on a moving bed of cores to be coated and, on the other hand, the temperature prevailing in the bed is kept at a value comprised between 50 and 10`C. The present coating process applies conveniently to cores of the "without sugar" type in the field of confectionery and pharmaceutical products.
摘要翻译：用山梨糖醇硬涂层的方法。一方面，将浓度为60〜85重量％的山梨醇糖浆供给到要被涂覆的芯的移动床上，另一方面，床中的温度保持在50 和10'C。本涂料方法适用于糖果和药品领域的“无糖”型核心。

20. 发明申请

WO1996010995A1 ENTERIC FILM COATING COMPOSITIONS, METHOD OF COATING THEREWITH, AND COATED FORMS 审中-公开
标题翻译：电镀膜组合物，涂层方法和涂层形式
公开(公告)号：WO1996010995A1
公开(公告)日：1996-04-18
申请号：PCT/US1995012934
申请日：1995-10-06
申请人： BERWIND PHARMACEUTICAL SERVICES, INC. , MEHRA, Dev, K. , RAMIREDDY, Chittamuru , TANG, Li-Juan , PORTER, Stuart, C.
发明人： BERWIND PHARMACEUTICAL SERVICES, INC.
IPC分类号： A61K09/36
CPC分类号： A61K9/2813 , A61K9/284 , A61K9/2866
摘要： A non-toxic edible enteric film coating dry powder composition for use in making an aqueous enteric coating suspension which may be used in coating pharmaceutical tablets and the like comprises an enteric film forming polymer, a detackifier, a viscosity modifier, and an alkalizing/anti-coagulating agent. Advantageously, the inventive dry powder compositions may include a solid plasticizer, a lubricant, an anti-caking agent, a liquid plasticizer, and a pigment.
摘要翻译：用于制备可用于包衣药片等的水性肠溶衣悬浮液的无毒可食性肠溶薄膜包衣干粉组合物包括肠溶成膜聚合物，防粘剂，粘度调节剂和碱化/抗凝固剂。有利地，本发明的干粉组合物可包括固体增塑剂，润滑剂，抗结块剂，液体增塑剂和颜料。

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