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11. 发明申请

US20180011095A1 MONOCLONAL ANTIBODY FOR THE DIAGNOSIS, TREATMENT AND/OR PREVENTION OF BRAIN TUMORS AND BRAIN LESIONS 审中-公开
公开(公告)号：US20180011095A1
公开(公告)日：2018-01-11
申请号：US15541846
申请日：2015-12-17
申请人： ALTHIA HEALTH, S.L , CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
发明人： Augusto SILVA GONZÁLEZ , José Alberto GARCÍA SANZ
IPC分类号： G01N33/574 , A61K49/18 , G01N33/543 , C07K16/30
CPC分类号： G01N33/574 , A61K49/1875 , A61K2039/505 , C07K16/18 , C07K16/2863 , C07K16/3053 , G01N33/54326 , G01N33/57492 , G01N2446/20 , G01N2446/84
摘要： The invention relates to the use of the monoclonal antibody NILO1 for the diagnosis, treatment and/or prevention of brain tumors and lesions. Particularly, the invention relates to methods for the diagnosis of brain tumors and brain lesions in which cells marked with said antibody, or with immunologically active fragments thereof, are detected. The invention also relates to the use of said monoclonal antibody, or immunologically active fragments thereof, as a medicament for the treatment and/or prevention of brain tumors and brain lesions. In a preferred embodiment of the invention, the monoclonal antibody NILO1, or its immunologically active fragments, are humanized.

12. 发明申请

US20160116464A1 STIMULI-RESPONSIVE MAGNETIC NANOPARTICLES 审中-公开
标题翻译：刺激性磁性纳米粒子
公开(公告)号：US20160116464A1
公开(公告)日：2016-04-28
申请号：US14893926
申请日：2014-05-29
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION , NEXGENIA, INC.
发明人： Patrick S. Stayton , Jriuan Lai , Dagmara Monfort , Barrett James Nehilla
IPC分类号： G01N33/543
CPC分类号： G01N33/54333 , A61K49/1839 , G01N2446/20 , G01N2446/84
摘要： The present disclosure provides stimuli-responsive magnetic nanoparticles, methods of making the magnetic nano-particles, and methods of using the magnetic nanoparticles. The magnetic nanoparticles include a metal oxide core; and a shell that includes a stimuli-responsive polymer having a terminal group that directly coordinates to the metal oxide core. The stimuli-responsive polymer does not include a micelle-forming group, at least at a proximal terminus of the polymer, with respect to the metal oxide core.
摘要翻译：本公开提供了刺激响应磁性纳米颗粒，制备磁性纳米颗粒的方法以及使用磁性纳米颗粒的方法。磁性纳米颗粒包括金属氧化物核; 以及包含具有直接与金属氧化物核心配位的末端基团的刺激响应型聚合物的壳。相对于金属氧化物核，刺激响应性聚合物至少在聚合物的近端处不包括胶束形成基团。

13. 发明授权

US09080933B2 Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates 有权
标题翻译：刺激响应性聚合物诊断测定，其包括磁性纳米颗粒和捕获缀合物
公开(公告)号：US09080933B2
公开(公告)日：2015-07-14
申请号：US13891005
申请日：2013-05-09
申请人： University of Washington through its Center for Commercialization
发明人： Patrick S. Stayton , Jriuan Lai , Barrett J. Nehilla , Selvi Srinivasan
IPC分类号： G01N1/34 , C12Q1/68 , B82Y25/00 , G01N1/00 , B01D21/00 , C12N15/10 , G01N27/74 , G01N33/543 , B03C1/01 , B03C1/28 , G01N1/40
CPC分类号： G01N33/54306 , B01D21/0009 , B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26 , B82Y25/00 , C12N15/1013 , C12Q1/6834 , G01N1/34 , G01N27/745 , G01N33/54333 , G01N33/54346 , G01N33/545 , G01N2001/4038 , G01N2001/4088 , G01N2446/20 , G01N2446/84 , Y02A50/53 , Y02A50/58 , Y10T436/00 , Y10T436/25 , Y10T436/255 , C12Q2563/143 , C12Q2563/155
摘要： The present disclosure utilizes the aggregation of stimuli-responsive polymers to isolate a diagnostic target (e.g., an antigen) from a solution using magnetophoresis. Isolating the diagnostic target provides a route to identify the presence of the diagnostic target in the solution.
摘要翻译：本公开使用刺激响应聚合物的聚集来使用磁电泳从溶液中分离诊断靶（例如抗原）。隔离诊断目标提供了一种路径，用于识别解决方案中诊断目标的存在。

14. 发明申请

US20090001025A1 AGGREGATION AND DISPERSION METHODS OF MAGNETIC PARTICLES, SEPARATION AND DETECTION METHODS USING THE SAME AND DETECTION KIT 有权
标题翻译：磁性颗粒的聚集和分散方法，使用其的分离和检测方法和检测试剂盒
公开(公告)号：US20090001025A1
公开(公告)日：2009-01-01
申请号：US12147216
申请日：2008-06-26
申请人： YUKI TAKAHASHI , NORIYUKI OHNISHI , XIAOMAO XIE
发明人： YUKI TAKAHASHI , NORIYUKI OHNISHI , XIAOMAO XIE
IPC分类号： B03C1/01
CPC分类号： G01N33/54333 , G01N27/745 , G01N2446/84 , Y10T428/2998
摘要： It is intended to provide a method capable of simply aggregating magnetic particles having a surface modified with a thermoresponsive polymer at a given temperature without heating or cooling an aqueous solution containing the magnetic particles, and a separation method and a detection method of a substance to be detected in a sample using the method. The method of separating a substance to be detected from a sample includes the steps of: mixing an adsorbent and the sample in an aqueous solution to adsorb the substance to be detected on the adsorbent, aggregating the adsorbent by changing a salt concentration in the aqueous solution; and collecting the adsorbent from the aqueous solution by a magnetic force, wherein said adsorbent comprises a magnetic particle of an average particle size of 50 to 1000 nm, a surface of which is modified with a thermoresponsive polymer and is immobilized with a substance having an affinity for the substance to be detected.
摘要翻译：本发明的目的是提供一种能够在给定温度下简单地聚集具有用热可聚合物改性的表面的磁性颗粒而不加热或冷却含有磁性颗粒的水溶液的方法，以及物质的分离方法和检测方法使用该方法在样品中检测。从样品中分离待检测物质的方法包括以下步骤：将吸附剂和样品混合在水溶液中以将待检测物质吸附在吸附剂上，通过改变水溶液中的盐浓度来聚集吸附剂 ; 并通过磁力从水溶液中收集吸附剂，其中所述吸附剂包括平均粒径为50-1000nm的磁性颗粒，其表面用热反应性聚合物改性并用具有亲和力的物质固定用于检测物质。

15. 发明授权

US07297405B2 Magnetic particles having core-shell structure 失效
标题翻译：具有核 - 壳结构的磁性颗粒
公开(公告)号：US07297405B2
公开(公告)日：2007-11-20
申请号：US10490742
申请日：2002-10-11
申请人： Hideki Kohno
发明人： Hideki Kohno
IPC分类号： B32B5/16 , B05D7/00
CPC分类号： G01N33/545 , B03C1/01 , C12N11/14 , G01N33/54326 , G01N2446/84 , H01F1/112 , H01F1/14758 , H01F1/36 , Y10S428/90 , Y10T428/2991 , Y10T428/2998
摘要： Magnetic particles each including particulate magnetic material and a readily decomposable or easily soluble polymer coating layer containing a reactive component, the coating layer being disposed on the surface of the magnetic material; and a method for producing a reaction product by use of the magnetic particles.Employment of the magnetic particles of the present invention allows solid phase reaction to proceed efficiently and attains an easy recovery of reaction product.
摘要翻译：每个磁性颗粒包括颗粒磁性材料和容易分解或容易溶解的含有反应性组分的聚合物涂层，涂层设置在磁性材料的表面上; 以及通过使用磁性粒子制造反应产物的方法。使用本发明的磁性颗粒可以使固相反应有效地进行并且容易地恢复反应产物。

16. 发明授权

US06013531A Method to use fluorescent magnetic polymer particles as markers in an immunoassay 失效
标题翻译：荧光磁性聚合物颗粒作为免疫测定中的标记物的方法
公开(公告)号：US06013531A
公开(公告)日：2000-01-11
申请号：US518135
申请日：1995-08-22
申请人： Chaeo-Huej J. Wang , Dinesh O. Shah
发明人： Chaeo-Huej J. Wang , Dinesh O. Shah
IPC分类号： C08F257/02 , C08F285/00 , C12Q1/68 , G01N33/543 , G01N33/58 , G01N33/553 , G01N33/546
CPC分类号： C12Q1/6834 , C08F257/02 , C08F285/00 , G01N33/54326 , G01N33/582 , G01N33/585 , G01N2446/10 , G01N2446/40 , G01N2446/84 , G01N2446/86 , Y10S435/967
摘要： This invention provides a novel process of using magnetically responsive fluorescent polymer particles comprising polymeric core particles coated evenly with a layer of polymer containing magnetically responsive metal oxide as highly sensitive quantitative reagents for biochemical and immunological studies, wherein the fluorescent magnetic particles can serve as a marker for the number of particles. A wide variety of polymeric particles with sizes ranging from 1 to 100 microns can be used a core particles and transformed into magnetically responsive polymer particles. The surface of these magnetically responsive polymer particles can be coated further with another layer of functionalized polymer. These magnetically responsive fluorescent polymer particles can be used for passive or covalent coupling of biological material such as antigens, antibodies, enzymes or DNA/RNA hybridization and used as solid phase for various types of immunoassays, DNA/RNA hybridization probes assays, affinity purification, cell separation and other medical, diagnostic, and industrial applications.
摘要翻译：本发明提供了一种使用磁响应荧光聚合物颗粒的新方法，其包括均匀包被含有磁响应金属氧化物的聚合物层的聚合物芯颗粒，作为生物化学和免疫学研究的高灵敏度定量试剂，其中荧光磁性颗粒可以作为标记对于颗粒数量。尺寸范围为1至100微米的多种聚合物颗粒可用于核心颗粒并转化为磁响应聚合物颗粒。这些磁响应聚合物颗粒的表面可以进一步被另一层官能化聚合物涂覆。这些磁响应荧光聚合物颗粒可用于生物材料如抗原，抗体，酶或DNA / RNA杂交的被动或共价偶联，并用作各种类型的免疫测定的固相，DNA / RNA杂交探针测定，亲和纯化，细胞分离等医疗，诊断和工业应用。

17. 发明授权

US5698271A Methods for the manufacture of magnetically responsive particles 失效
标题翻译：用于制造磁响应颗粒的方法
公开(公告)号：US5698271A
公开(公告)日：1997-12-16
申请号：US482448
申请日：1995-06-07
申请人： Paul A. Liberti , Galla C. Rao , Joseph N. Chiarappa
发明人： Paul A. Liberti , Galla C. Rao , Joseph N. Chiarappa
IPC分类号： C12Q1/04 , A61K9/50 , A61K39/02 , A61K39/44 , B03C1/01 , C12Q1/68 , G01N33/543 , G11B5/842 , G11B5/848 , H01F1/34 , H01F1/44 , H01F1/00 , B01J19/08 , B05D1/36 , B29C35/08
CPC分类号： B03C1/01 , A61K9/5094 , G01N33/5434 , G01N33/54393 , G11B5/842 , G11B5/848 , H01F1/445 , G01N2333/765 , G01N2446/20 , G01N2446/80 , G01N2446/84 , Y10T428/2982
摘要： The invention relates to an improved method for the manufacture of magnetically responsive particles, also called ferrofluids. The improved method involves a heat treatment step, which may occur at various times during the preparation of the materials, including during subdivision of the magnetic starting material, during the addion of a coating material, after formation of a magnetically responsive particle, or some combination thereof. The materials formed by such a process have numerous advantages over materials formed by other processes, including enhanced salt stability, increased coating uptake, and increased binding capacity. These ferrofluids have applications in a variety of preparative and diagnostic techniques, including immunoassay, cell separations, toxicity testing, food testing, environmental analysis, and MRI.
摘要翻译：本发明涉及用于制造也称为铁磁流体的磁响应颗粒的改进方法。改进的方法包括热处理步骤，其可以在制备材料期间的不同时间发生，包括在磁性起始材料的分割期间，在涂覆材料的加入期间，在形成磁响应性颗粒之后，或某些组合其中。通过这种方法形成的材料与由其它方法形成的材料相比具有许多优点，包括增强的盐稳定性，增加的涂层吸收和增加的结合能力。这些铁磁流体可用于多种制备和诊断技术，包括免疫测定，细胞分离，毒性测试，食品测试，环境分析和MRI。

18. 发明申请

US20060035388A1 High-sensitivity magnetic marker used for immune response measurement 审中-公开
标题翻译：用于免疫反应测量的高灵敏度磁标记
公开(公告)号：US20060035388A1
公开(公告)日：2006-02-16
申请号：US10534262
申请日：2003-05-08
申请人： Kohji Yoshinaga , Keiji Enpuku
发明人： Kohji Yoshinaga , Keiji Enpuku
IPC分类号： G01N33/553
CPC分类号： G01N33/5434 , G01N2446/84 , G01N2446/86
摘要： Disclosed are a highly-sensitive magnetic marker for use in measuring an immunoreaction with a SQUID magnetic sensor and the preparation thereof. The magnetic marker is composed of a magnetic fine particle and a polymer encapsulating the particle, wherein the particle diameter of the magnetic fine particle (preferably ferrite Fe3O4) is 20 to 40 nm and the external the diameter of the magnetic marker is 40 to 100 nm, the polymer having carboxyl groups on the surface thereof. The magnetic maker for a SQUID magnetic sensor is prepared by causing the surface of a magnetic fine particle to adsorb a hydrophilic macromonomer (preferably polyvinylpyrrolidone) having a polymerizable vinyl group at the terminal thereof and having a molecular weight of 500 to 1000, and then adding a monomer of a hydrophilic vinyl compound having carboxyl group and a crosslinking agent for carrying out copolymerization reaction.
摘要翻译：公开了用于测量与SQUID磁传感器的免疫反应及其制备的高灵敏度磁性标记。磁性标记物由磁性微粒和包封颗粒的聚合物组成，其中磁性细颗粒（优选铁素体Fe 3 O 4 O 4）的粒径为20 至40nm，外部的磁性标记物的直径为40〜100nm，其表面具有羧基的聚合物。通过使磁性细颗粒的表面在其末端吸附具有可聚合乙烯基的亲水性大分子单体（优选聚乙烯吡咯烷酮）并分子量为500至1000，然后加入具有羧基的亲水性乙烯基化合物的单体和用于进行共聚反应的交联剂。

19. 发明申请

US20040241428A1 Magnetic particles 失效
标题翻译：磁性颗粒
公开(公告)号：US20040241428A1
公开(公告)日：2004-12-02
申请号：US10490742
申请日：2004-04-09
发明人： Hideki Kohno
IPC分类号： B32B005/16
CPC分类号： G01N33/545 , B03C1/01 , C12N11/14 , G01N33/54326 , G01N2446/84 , H01F1/112 , H01F1/14758 , H01F1/36 , Y10S428/90 , Y10T428/2991 , Y10T428/2998
摘要： Magnetic particles each including particulate magnetic material and a readily decomposable or easily soluble polymer coating layer containing a reactive component, the coating layer being disposed on the surface of the magnetic material; and a method for producing a reaction product by use of the magnetic particles. Employment of the magnetic particles of the present invention allows solid phase reaction to proceed efficiently and attains an easy recovery of reaction product.
摘要翻译：每个磁性颗粒包括颗粒磁性材料和容易分解或容易溶解的含有反应性组分的聚合物涂层，涂层设置在磁性材料的表面上; 以及通过使用磁性粒子制造反应产物的方法。使用本发明的磁性颗粒可以使固相反应有效地进行并且容易地恢复反应产物。

20. 发明授权

US06638494B1 Super-paramagnetic particles with increased R1 relaxivity, process for producing said particles and use thereof 失效
标题翻译：具有增加的R1松弛度的超顺磁性颗粒，用于制备所述颗粒的方法及其用途
公开(公告)号：US06638494B1
公开(公告)日：2003-10-28
申请号：US09716709
申请日：2000-11-20
申请人： Herbert Pilgrimm
发明人： Herbert Pilgrimm
IPC分类号： A61B5055
CPC分类号： B82Y25/00 , A61K9/5094 , A61K49/1836 , A61K49/186 , G01N33/5434 , G01N2446/20 , G01N2446/84 , H01F1/0054 , H01F1/36 , H01F1/445
摘要： The invention relates to super-paramagnetic single domain particles with increased R1 relaxivity and with surface-stabilizer substances. The particles are characterized in that they consist of iron hydroxide, ferric hydrate, iron oxide, iron mixed oxide or iron; are between 1 and 10 nm in size, the mean particle diameter d50 being 2-4 nm; and have increased R1 relaxivity of between 2 and 50, the ratio of the relaxivities R2/R1 being less than 5. Stabilizer substances of special carboxylic acids are bound to the particle surfaces; these prevent aggregation and sedimentation under gravity or in a magnetic field. If necessary, the particles can also contain further known stabilizer substances and other pharmacological substances. The novel particles can be used for attacking tumors, boosting immunity, for cell fusion, gene transfer, or as contrasting agents in magnetic resonance diagnostics using magnetic fields where necessary.
摘要翻译：本发明涉及具有增加的R1松弛度和表面稳定剂物质的超顺磁性单结构域颗粒。其特征在于它们由氢氧化铁，水合铁，氧化铁，铁混合氧化物或铁组成; 尺寸为1〜10nm，平均粒径d50为2-4nm; 并且R1松弛度增加在2到50之间，松弛度R2 / R1的比例小于5.特殊羧酸的稳定剂物质结合到颗粒表面; 这些防止在重力或磁场中聚集和沉淀。如果需要，颗粒还可以含有另外已知的稳定剂物质和其它药物物质。该新型颗粒可用于攻击肿瘤，增强免疫力，用于细胞融合，基因转移，或作为对比剂在磁共振诊断中使用必要的磁场。

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