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11. 发明授权

US08246951B2 Collagenolytic active enzyme containing compositions, and their use in the dental field 有权
标题翻译：含有胶原分解活性酶的组合物及其在牙科领域中的应用
公开(公告)号：US08246951B2
公开(公告)日：2012-08-21
申请号：US12132315
申请日：2008-06-03
申请人： Oliver Kappler , Ingo R. Haeberlein
发明人： Oliver Kappler , Ingo R. Haeberlein
IPC分类号： A61K38/48
CPC分类号： A61K38/488 , A61K38/482 , C12N9/52 , C12N9/54 , C12Y304/2111 , A61K6/0029 , C08L3/00 , C08L39/06 , C08L1/28 , A61K2300/00
摘要： The invention relates to a composition comprising at least one collagenolytic active enzyme with enzymatic activity at acidic pH for drilless enzymatic caries removal. Furthermore, the present invention relates to a process of producing this collagenolytic active enzyme comprising composition and to processes of removing caries. The invention also relates to the use of collagenolytic active enzyme comprising compositions for producing a treatment agent for dental applications.
摘要翻译：本发明涉及一种组合物，其包含至少一种在酸性pH下具有酶活性的胶原分解活性酶，用于无花果酶龋齿去除。此外，本发明涉及生产该胶原分解活性酶的方法，其包含组合物和去除龋齿的方法。本发明还涉及包含用于制备用于牙科应用的治疗剂的组合物的胶原分解活性酶的用途。

12. 发明授权

US5846547A Streptococcal C5a peptidase vaccine 失效
标题翻译：链球菌C5a肽酶疫苗
公开(公告)号：US5846547A
公开(公告)日：1998-12-08
申请号：US589756
申请日：1996-01-22
申请人： Paul Patrick Cleary
发明人： Paul Patrick Cleary
IPC分类号： A61K39/09 , A61K38/48 , A61K39/00 , A61P31/04 , A61P31/10 , C12N9/52 , A61K39/02
CPC分类号： C12N9/52 , A61K39/092 , C12Y304/2111 , A61K39/00
摘要： Novel vaccines for use against .beta.-hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of streptococcal C5a peptidase, or a fragment or mutant thereof. Also disclosed is a method of protecting a susceptible mammal against .beta.-hemolytic Streptococcus colonization or infection by administering such a vaccine.
摘要翻译：公开了用于抗β-溶血性链球菌定居或感染的新型疫苗。疫苗含有免疫原性量的链球菌C5a肽酶，或其片段或突变体。还公开了通过施用这样的疫苗来保护易感染哺乳动物免受β-溶血性链球菌定殖或感染的方法。

13. 发明授权

EP1600141B1 Collagenolytic active enzyme containing compositions for the treatment of dental caries 有权
标题翻译：具有用于龋齿的治疗溶胶原活性的酶组合物
公开(公告)号：EP1600141B1
公开(公告)日：2013-04-17
申请号：EP04012256.6
申请日：2004-05-24
申请人： 3M Deutschland GmbH
发明人： Kappler, Oliver, Dr. , Häberlein, Ingo, Dr.
IPC分类号： A61K6/00 , C12N9/52 , C12N9/54 , A61K38/48
CPC分类号： A61K38/488 , A61K38/482 , C12N9/52 , C12N9/54 , C12Y304/2111 , A61K6/0029 , C08L3/00 , C08L39/06 , C08L1/28 , A61K2300/00
摘要： The invention relates to a composition comprising at least one collagenolytic active enzyme with enzymatic activity at acidic pH for drilless enzymatic caries removal. Furthermore, the present invention relates to a process of producing this collagenolytic active enzyme comprising composition and to processes of removing caries. The invention also relates to the use of collagenolytic active enzyme comprising compositions for producing a treatment agent for dental applications.

14. 发明授权

EP0877624B1 STREPTOCOCCAL C5A PEPTIDASE VACCINE 失效
标题翻译：链球菌C5a肽疫苗
公开(公告)号：EP0877624B1
公开(公告)日：2004-03-31
申请号：EP97902076.5
申请日：1997-01-21
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA
发明人： CLEARY, Paul, P.
IPC分类号： A61K39/09
CPC分类号： C12N9/52 , A61K39/00 , A61K39/092 , C12Y304/2111
摘要： Novel vaccines for use against beta -hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of streptococcal C5a peptidase, or a fragment or mutant thereof. Also disclosed is a method of protecting a susceptible mammal against beta -hemolytic Streptococcus colonization or infection by administering such a vaccine.

15. 发明公开

EP0877624A1 STREPTOCOCCAL C5APEPTIDASE VACCINE 失效
标题翻译：链球菌C5a肽疫苗
公开(公告)号：EP0877624A1
公开(公告)日：1998-11-18
申请号：EP97902076.0
申请日：1997-01-21
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA
发明人： CLEARY, Paul, P.
IPC分类号： A61K39 , A61K38 , A61P31 , C12N9
CPC分类号： C12N9/52 , A61K39/00 , A61K39/092 , C12Y304/2111
摘要： Novel vaccines for use against β-hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of streptococcal C5a peptidase, or a fragment or mutant thereof. Also disclosed is a method of protecting a susceptible mammal against β-hemolytic Streptococcus colonization or infection by administering such a vaccine.

16. 发明公开

EP2886142A1 An apparatus for the extracorporeal treatment of blood 有权
标题翻译：一种用于体外血液处理的装置
公开(公告)号：EP2886142A1
公开(公告)日：2015-06-24
申请号：EP14198204.1
申请日：2014-12-16
申请人： University of Limerick
发明人： Cooney, Jakki , Kagawa, Todd Fumio , Magner, Edmond
IPC分类号： A61M1/36 , C12N11/06
CPC分类号： A61M1/3687 , A61L33/0047 , A61M1/3496 , A61M1/3689 , C12N9/52 , C12N11/14 , C12Y304/2111
摘要： An apparatus for the extracorporeal treatment of blood comprising an extracorporeal blood circuit, a pump configured to provide fluid displacement within the extracorporeal blood circuit, and a reaction chamber connected to the extracorporeal blood circuit and configured to receive blood or plasma from the circuit and treat the blood or plasma. The reaction chamber comprises an protease enzyme immobilized to a support, in which the protease enzyme is specific for, and capable of irreversibly cleaving, a human C5a present in the blood or plasma, wherein the abundance of the human C5a in the treated blood or plasma is less than that in the untreated blood or plasma. The apparatus finds utility in the extracorporeal treatment of blood from patients with inflammatory conditions, especially auto-immune disease and sepsis.
摘要翻译：一种用于体外血液处理的装置，包括体外血液回路，构造成在体外血液回路内提供流体位移的泵，以及连接至体外血液回路并配置为从回路接收血液或血浆并且处理血液或血浆。反应室包含固定在载体上的蛋白酶，其中蛋白酶对血液或血浆中存在的人C5a具有特异性并能够不可逆地切割，其中处理过的血液或血浆中人C5a的丰度低于未治疗血液或血浆中的水平。该设备可用于体外治疗患有炎性疾病的患者的血液，特别是自身免疫疾病和败血症。

17. 发明公开

EP2886140A1 An apparatus for the extracorporeal treatment of blood 审中-公开
标题翻译： Vorrichtung zur extrakorporalen Behandlung von Blut
公开(公告)号：EP2886140A1
公开(公告)日：2015-06-24
申请号：EP13197790.2
申请日：2013-12-17
申请人： University of Limerick
发明人： Cooney, Jakki , Kagawa, Todd Fumio , Magner, Edmond
IPC分类号： A61M1/36 , C12N11/06
CPC分类号： A61M1/3687 , A61L33/0047 , A61M1/3496 , A61M1/3689 , C12N9/52 , C12N11/14 , C12Y304/2111
摘要： An apparatus for the extracorporeal treatment of blood comprising an extracorporeal blood circuit (2), a pump (6) configured to provide fluid displacement within the extracorporeal blood circuit, and a reaction chamber (8) connected to the extracorporeal blood circuit and configured to receive blood or plasma from the circuit and treat the blood or plasma. The reaction chamber comprises an protease enzyme immobilized to a support, in which the protease enzyme is specific for, and capable of irreversibly cleaving, a human C5a present in the blood or plasma, wherein the abundance of the human C5a in the treated blood or plasma is less than that in the untreated blood or plasma. The apparatus finds utility in the extracorporeal treatment of blood from patients with inflammatory conditions, especially auto-immune disease and sepsis.
摘要翻译：一种用于血液体外处理的装置，包括体外血液回路（2），构造成在体外血液回路内提供流体排量的泵（6）和连接到体外血液回路的反应室（8）血液或等离子体，并对血液或血浆进行治疗。反应室包含固定在载体上的蛋白酶，其中蛋白酶与存在于血液或血浆中的人C5a具有特异性并且能够不可逆地切割，其中经处理的血液或血浆中人C5a的丰度小于未经处理的血液或血浆。该设备可用于体外治疗患有炎症状况的患者的血液，特别是自身免疫疾病和败血症。

18. 发明公开

EP1600141A1 Collagenolytic active enzyme containing compositions, and their use in the dental field 有权
标题翻译： Zusammensetzungen mit kollagenolytisch aktivem Enzym zur Behandlung von Karies
公开(公告)号：EP1600141A1
公开(公告)日：2005-11-30
申请号：EP04012256.6
申请日：2004-05-24
申请人： 3M ESPE AG
发明人： Kappler, Oliver, Dr. , Häberlein, Ingo, Dr.
IPC分类号： A61K6/00 , C12N9/52 , A61K38/48 , A61K7/28
CPC分类号： A61K38/488 , A61K38/482 , C12N9/52 , C12N9/54 , C12Y304/2111 , A61K6/0029 , C08L3/00 , C08L39/06 , C08L1/28 , A61K2300/00
摘要： The invention relates to a composition comprising at least one collagenolytic active enzyme with enzymatic activity at acidic pH for drilless enzymatic caries removal. Furthermore, the present invention relates to a process of producing this collagenolytic active enzyme comprising composition and to processes of removing caries. The invention also relates to the use of collagenolytic active enzyme comprising compositions for producing a treatment agent for dental applications.
摘要翻译：本发明涉及一种包含至少一种在酸性pH下具有酶活性的胶原分解活性酶的组合物，用于无花果酶龋齿去除。此外，本发明涉及生产该胶原分解活性酶的方法，其包含组合物和去除龋齿的方法。本发明还涉及包含用于制备用于牙科应用的治疗剂的组合物的胶原分解活性酶的用途。

19. 发明专利

JP2005336185A Collagenolytic active enzyme-containing composition and application thereof in dental field 审中-公开
标题翻译：胶原酶活性含酶组合物及其在牙科领域的应用
公开(公告)号：JP2005336185A
公开(公告)日：2005-12-08
申请号：JP2005150248
申请日：2005-05-23
申请人： 3M Espe Ag , スリーエムイーエスピーイーアーゲー
发明人： KAPPLER OLIVER , HAEBERLEIN INGO R
IPC分类号： A61K47/12 , A61K6/00 , A61K38/48 , A61P1/02 , A61P43/00 , C12N9/52 , C12N9/54
CPC分类号： A61K38/488 , A61K38/482 , C12N9/52 , C12N9/54 , C12Y304/2111 , A61K6/0029 , C08L3/00 , C08L39/06 , C08L1/28 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To use a collagenolytic active enzyme in the dental field. SOLUTION: A composition comprises at least one collagenolytic active enzyme having an enzymatic activity at an acidic pH for drilless enzymatic caries removal. A process for producing the collagenolytic active enzyme-containing composition and a process for removing the caries are provided. The use of the collagenolytic active enzyme-containing composition for producing a treatment agent for dental applications is provided. COPYRIGHT: (C)2006,JPO&NCIPI

20. 发明专利

JP4361606B2 Streptococcal C5a peptidase vaccine 失效
公开(公告)号：JP4361606B2
公开(公告)日：2009-11-11
申请号：JP52630197
申请日：1997-01-21
申请人：リージェンツオブザユニバーシティオブミネソタ
发明人：ピー．クリアリー，ポール
IPC分类号： A61K39/09 , A61K38/48 , A61K39/00 , A61P31/04 , A61P31/10 , C12N9/52
CPC分类号： C12N9/52 , A61K39/00 , A61K39/092 , C12Y304/2111

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