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11. 发明申请

US20170299619A1 CONSUMABLE MANIPULATION FOR THE PURPOSE OF LIQUID HANDLING 审中-公开
公开(公告)号：US20170299619A1
公开(公告)日：2017-10-19
申请号：US15487861
申请日：2017-04-14
申请人： Andrew Alliance S.A.
发明人： Piero Zucchelli
IPC分类号： G01N35/00 , G01N35/02 , B01L9/02 , G01N35/10 , B01L9/00 , B01L3/00
CPC分类号： G01N35/00732 , B01J2219/00364 , B01L3/502715 , B01L9/02 , B01L9/54 , B01L2300/1888 , G01N35/0099 , G01N35/02 , G01N35/10 , G01N35/1081 , G01N2035/041 , G01N2035/0477
摘要： A method and device to perform liquid handling by means of manipulation and transportation of consumables, instead of manipulation and transportation of a liquid handling head, among static or quasi-static liquid handling heads. A quasi-static liquid handling head (or pipette) that doesn't move between the aspiration and dispensing steps.

12. 发明申请

US20070243613A1 Method for producing a cell culture substrate 审中-公开
标题翻译：细胞培养基质的制造方法
公开(公告)号：US20070243613A1
公开(公告)日：2007-10-18
申请号：US11709119
申请日：2007-02-20
申请人： Hideyuki Miyake , Hideshi Hattori , Yoichi Takahashi
发明人： Hideyuki Miyake , Hideshi Hattori , Yoichi Takahashi
IPC分类号： C12N5/02 , B41J2/175
CPC分类号： B01L3/0268 , B01L3/5085 , B01L2200/12 , B01L2300/069 , B01L2300/10 , B01L2300/1888 , B01L2400/0439 , C12M23/20 , C12M25/06 , C12N5/0068 , C12N2533/12 , C12N2535/10
摘要： A main object of the invention is to provide a new method for producing a cell culture substrate used to cause cells to adhere in a highly precise form onto a base material and then culture the cells. To attain the object, the invention provides a method for producing a cell culture substrate comprising: a patterning substrate forming process of forming, on a base material, a cell culture patterning layer wherein a cell adhesion portion having cell adhesive properties and a cell adhesion-inhibiting portion having cell adhesion-inhibiting properties can be formed by action of a photocatalyst by energy irradiation, thereby forming a patterning substrate; an energy irradiating process of irradiating the energy onto the cell culture patterning layer, thereby forming the cell adhesion portion and the cell adhesion-inhibiting portion in a pattern form by action of the photocatalyst; and a cell-containing liquid applying process of applying a cell-containing liquid onto the cell adhesion portion by a region-selecting applying method of applying the cell-containing liquid selectively onto the patterned cell adhesion portion.
摘要翻译：本发明的主要目的是提供一种用于生产细胞培养基质的新方法，该方法用于使细胞以高度精确的形式粘附到基材上，然后培养细胞。为了达到上述目的，本发明提供一种细胞培养基材的制造方法，其特征在于，包括：在基材上形成细胞培养图案形成层的图案形成基板的形成工序，其中，具有细胞粘合性的细胞粘附部，通过能量照射可以通过光催化剂的作用形成具有细胞粘附抑制特性的抑制部分，从而形成图案化衬底; 将能量照射到细胞培养图案化层上的能量照射方法，由此通过光催化剂的作用形成图案形式的细胞粘附部分和细胞粘附抑制部分; 以及通过选择性地将细胞含有液体施加到图案化细胞粘附部分上的区域选择施加方法将含细胞的液体施加到细胞粘附部分上的含细胞的液体施加方法。

13. 发明授权

US06143499A Miniaturized reaction vessel system, method for performing site-specific biochemical reactions and affinity fractionation for use in DNA sequencing 失效
$Miniaturized reaction vessel system, method for performing site-specific biochemical reactions and affinity fractionation for use in DNA sequencing$
标题翻译：小型化反应容器系统，用于进行位点特异性生化反应的方法和用于DNA测序的亲和分离
公开(公告)号：US06143499A
公开(公告)日：2000-11-07
申请号：US99959
申请日：1998-06-19
申请人： Andrei Darievich Mirzabekov , Yuri Petrovich Lysov , Svetlana A. Dubley
发明人： Andrei Darievich Mirzabekov , Yuri Petrovich Lysov , Svetlana A. Dubley
IPC分类号： B01L3/00 , B01L3/02 , C12Q1/68 , C40B40/06 , C40B60/14 , C12P19/34 , C07M21/02 , C07M21/04
CPC分类号： B01L3/0255 , B01L3/0244 , B01L3/5085 , B82Y30/00 , B01J2219/00387 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00617 , B01J2219/00626 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00722 , B01L2200/12 , B01L2300/069 , B01L2300/0893 , B01L2300/0896 , B01L2300/1822 , B01L2300/1888 , C40B40/06 , C40B60/14 , Y10S436/80 , Y10S436/807 , Y10S436/809 , Y10T436/143333
摘要： A method for fractionating and sequencing DNA via affinity interaction is provided comprising contacting cleaved DNA to a first array of oligonucleotide molecules to facilitate hybridization between said cleaved DNA and the molecules; extracting the hybridized DNA from the molecules; contacting said extracted hybridized DNA with a second array of oligonucleotide molecules, wherein the oligonucleotide molecules in the second array have specified base sequences that are complementary to said extracted hybridized DNA; and attaching labeled DNA to the second array of oligonucleotide molecules, wherein the labeled re-hybridized DNA have sequences that are complementary to the oligomers. The invention further provides a method for performing multi-step conversions of the chemical structure of compounds comprising supplying an array of polyacrylamide vessels separated by hydrophobic surfaces; immobilizing a plurality of reactants, such as enzymes, in the vessels so that each vessel contains one reactant; contacting the compounds to each of the vessels in a predetermined sequence and for a sufficient time to convert the compounds to a desired state; and isolating the converted compounds from said array.
摘要翻译：提供了通过亲和相互作用对DNA进行分级和测序的方法，包括将切割的DNA与第一阵列的寡核苷酸分子接触以促进所述切割的DNA与分子之间的杂交; 从分子中提取杂交的DNA; 使所述提取的杂交DNA与第二阵列的寡核苷酸分子接触，其中所述第二阵列中的寡核苷酸分子具有与所述提取的杂交DNA互补的特定碱基序列; 并将标记的DNA附着到第二寡核苷酸分子阵列上，其中标记的再杂交DNA具有与寡聚物互补的序列。本发明还提供了一种用于进行化合物化学结构的多步转化的方法，包括提供由疏水性表面分离的聚丙烯酰胺容器阵列; 将诸如酶的多种反应物固定在容器中，使得每个容器含有一种反应物; 以预定顺序将化合物与每个容器接触并持续足够的时间将化合物转化为所需状态; 并从所述阵列中分离转化的化合物。

14. 发明公开

EP2628786A4 AUTOMATED NUCLEIC ACID PROCESSOR AND AUTOMATED NUCLEIC ACID PROCESSING METHOD USING MULTI FUNCTION DISPENSING UNIT 有权
标题翻译：自动化核酸处理器和自动化核酸过程中利用多功能输出单元
公开(公告)号：EP2628786A4
公开(公告)日：2015-09-30
申请号：EP11832627
申请日：2011-10-14
申请人： UNIVERSAL BIO RESEARCH CO LTD
发明人： TAJIMA HIDEJI
IPC分类号： C12M1/00 , B01L3/02 , B01L7/00 , C12N15/09 , C12Q1/68
CPC分类号： C12Q1/686 , B01L3/0217 , B01L3/0275 , B01L3/523 , B01L3/527 , B01L7/52 , B01L2200/026 , B01L2200/0689 , B01L2200/142 , B01L2300/024 , B01L2300/044 , B01L2300/0654 , B01L2300/0672 , B01L2300/0829 , B01L2300/1822 , B01L2300/1888 , C12Q1/6806 , C12Q2563/143 , C12Q2563/149 , C12Q2565/629 , G01N21/75 , G01N35/00732 , G01N35/04 , G01N35/1065 , G01N2035/00742 , G01N2035/00821 , G01N2035/00851 , G01N2035/0403 , G01N2035/103 , G01N2035/1048 , G01N2035/1055 , G01N2035/1062
摘要： In relation to an automated nucleic acid processor and an automated nucleic acid processing method using a multi function dispensing unit, processing involving extraction and amplification of the nucleic acid, can be consistently, quickly and efficiently conducted at a low cost with the use of a multi function dispensing unit, while saving user's trouble without expanding the scale of the device. The multi function dispensing unit includes: a nozzle head provided with a suction-discharge mechanism and nozzles detachably provided with dispensing tips; a container group having, at the very least housing parts for liquids and reaction containers for housing an amplification solution; a transfer mechanism that makes an interval between the nozzles and the container group relatively movable; a temperature controller whereby temperature control of the interior of the reaction vessels is possible; sealing liquids and/or sealing lids that are transportable to the reaction vessels using the nozzles, and which make the amplification solutions housed in the reaction vessels sealable within the reaction vessels; and a sealing control part that controls the suction-discharge mechanism or the transfer mechanism, such that the sealing liquid and/or the sealing lids seal the amplification solution within the reaction vessels when the housing of the amplification solution in the reaction vessels is completed.
摘要翻译：相对于上自动化核酸处理器和自动核酸处理方法使用多功能分配单元，处理涉及提取和核酸扩增，可以是一致，快速，以低成本与使用多的有效地进行功能分配单元，同时节省了用户的麻烦不扩大装置规模。多功能分配单元包括：设置有抽吸排出机构和可拆卸地设置有分配尖端喷嘴的喷嘴头; 具有容器组，至少是，用于液体和反应容器的扩增溶液壳体的壳体部分; 转移机构做了喷嘴和容器组可相对移动之间的时间间隔的品牌; 温度控制器，由此反应容器的内部的温度控制是可能的; 密封液体和/或密封的盖确实是可运输的，以使用所述的喷嘴的反应容器，并且使在密封的反应容器内的反应容器容纳在所述放大溶液; 和密封控制部确实控制吸入排出机构或转移机构，检查并当完成在反应容器中的扩增溶液的壳体中的密封液和/或密封的盖子密封该反应容器内的扩增溶液。

15. 发明公开

EP2145949A1 TEMPERATURE CONTROL DEVICE, AND TEMPERATURE CONTROL METHOD 审中-公开
标题翻译：温度范围：温度范围
公开(公告)号：EP2145949A1
公开(公告)日：2010-01-20
申请号：EP08739991.1
申请日：2008-04-07
申请人： Universal Bio Research Co., Ltd.
发明人： TAJIMA, Hideji
IPC分类号： C12M1/00 , C12N15/09 , C12Q1/68
CPC分类号： B01L7/525 , B01L3/021 , B01L3/0275 , B01L7/52 , B01L2200/0684 , B01L2200/142 , B01L2200/147 , B01L2300/0636 , B01L2300/0838 , B01L2300/18 , B01L2300/1822 , B01L2300/1844 , B01L2300/1888 , B01L2400/0478 , B01L2400/0487 , G01N2035/00346 , G01N2035/103 , G01N2035/1039 , G01N2035/1062 , Y10T137/0329 , Y10T137/6552
摘要： The present invention relates to a temperature controlling apparatus and the temperature controlling method which can arrest foaming and inflation of the air contained in a liquid, and can perform temperature controlling of a liquid of high reliance, and the present invention is constructed to have one or a plurality of sets of nozzles which can suck and discharge a liquid through a tip, and can retain the sucked liquid, a suction and discharge mechanism which can suck and discharge a gas via the each nozzle, a temperature regulator which can maintain one or two or more set predetermined temperatures for a predetermined time regarding one or two or more predetermined temperature controlling regions set in the each nozzle, a movement mechanism which allows relative movement between one or two or more containers which can accommodate a liquid and a nozzle, and a controlling part which instructs the movement mechanism, the suction and discharge mechanism or the temperature regulator to adjust a liquid to be sucked into the nozzle and a liquid amount thereof, a position of the sucked liquid in the nozzle, and temperature controlling of the liquid.
摘要翻译：本发明涉及一种温度控制装置和温度控制方法，其可以阻止液体中包含的空气的起泡和膨胀，并且可以执行高依赖性的液体的温度控制，并且本发明构造成具有一个或多个能够通过尖端吸取和排出液体并能够保持被吸入的液体的喷嘴组，能够通过各个喷嘴吸入和排出气体的吸引和排出机构，能够保持一个或两个的温度调节器或更多地对预定时间设定关于设置在每个喷嘴中的一个或两个或更多个预定温度控制区域的预定温度;允许一个或两个或更多个可容纳液体和喷嘴的容器之间的相对运动的移动机构，以及控制部分，指示移动机构，吸入和排出机构或温度调节器仅吸入喷嘴的液体及其液体量，吸入液体在喷嘴中的位置，以及液体的温度控制。

16. 发明公开

EP2628786A1 AUTOMATED NUCLEIC ACID PROCESSOR AND AUTOMATED NUCLEIC ACID PROCESSING METHOD USING MULTI FUNCTION DISPENSING UNIT 有权
标题翻译：自动化核酸处理器和自动化核酸过程中利用多功能输出单元
公开(公告)号：EP2628786A1
公开(公告)日：2013-08-21
申请号：EP11832627.1
申请日：2011-10-14
申请人： Universal Bio Research Co., Ltd.
发明人： TAJIMA Hideji
IPC分类号： C12M1/00 , C12N15/09 , C12Q1/68
CPC分类号： C12Q1/686 , B01L3/0217 , B01L3/0275 , B01L3/523 , B01L3/527 , B01L7/52 , B01L2200/026 , B01L2200/0689 , B01L2200/142 , B01L2300/024 , B01L2300/044 , B01L2300/0654 , B01L2300/0672 , B01L2300/0829 , B01L2300/1822 , B01L2300/1888 , C12Q1/6806 , C12Q2563/143 , C12Q2563/149 , C12Q2565/629 , G01N21/75 , G01N35/00732 , G01N35/04 , G01N35/1065 , G01N2035/00742 , G01N2035/00821 , G01N2035/00851 , G01N2035/0403 , G01N2035/103 , G01N2035/1048 , G01N2035/1055 , G01N2035/1062
摘要： In relation to an automated nucleic acid processor and an automated nucleic acid processing method using a multi function dispensing unit, processing involving extraction and amplification of the nucleic acid, can be consistently, quickly and efficiently conducted at a low cost with the use of a multi function dispensing unit, while saving user's trouble without expanding the scale of the device. The multi function dispensing unit includes: a nozzle head provided with a suction-discharge mechanism and nozzles detachably provided with dispensing tips; a container group having, at the very least housing parts for liquids and reaction containers for housing an amplification solution; a transfer mechanism that makes an interval between the nozzles and the container group relatively movable; a temperature controller whereby temperature control of the interior of the reaction vessels is possible; sealing liquids and/or sealing lids that are transportable to the reaction vessels using the nozzles, and which make the amplification solutions housed in the reaction vessels sealable within the reaction vessels; and a sealing control part that controls the suction-discharge mechanism or the transfer mechanism, such that the sealing liquid and/or the sealing lids seal the amplification solution within the reaction vessels when the housing of the amplification solution in the reaction vessels is completed.

17. 发明公开

EP1859868A1 Heatable pipette 审中-公开
标题翻译： Beheizbare移液器
公开(公告)号：EP1859868A1
公开(公告)日：2007-11-28
申请号：EP06405221.0
申请日：2006-05-23
申请人： F.HOFFMANN-LA ROCHE AG
发明人： Hochstrasser, Remo Anton , Voegelin, Dieter , Ran, Fréderic
IPC分类号： B01L3/02 , B01L7/00
CPC分类号： B01L3/021 , B01L2200/147 , B01L2300/1827 , B01L2300/1888 , B01L2400/0487 , G01N35/10 , G01N2035/00425
摘要： A heatable pipette (1) with a needle (2) has an inner channel (23) defined by an inner wall (21). The pipette (1) is arranged to conduct electric current in an essentially longitudinal direction through the inner wall (21) for resistively heating the inner wall (21). By conducting current directly through the inner wall (21), the inner wall (21) itself operates as resistor. Particularly, if the inner wall is made of an appropriate material, for example of stainless steel, the ohmic resistance of the inner wall (21) is not negligible even if the inner wall is very thin. Therefore, the inner wall (21) can directly be used as resistor for resistance heating of the inner wall (21) even if the needle is manufactured in small dimensions.
摘要翻译：具有针（2）的可加热移液管（1）具有由内壁（21）限定的内通道（23）。移液管（1）布置成通过内壁（21）沿基本上纵向的方向传导电流，用于电阻加热内壁（21）。通过直接通过内壁（21）导通电流，内壁（21）本身作为电阻器工作。特别地，如果内壁由适当的材料制成，例如不锈钢，即使内壁非常薄，内壁（21）的欧姆电阻也不能忽略。因此，即使针被制造成小尺寸，内壁（21）也可以直接用作内壁（21）的电阻加热用电阻。

18. 发明公开

EP1281441A3 Liquid ejection device and sample carrier preparation apparatus 审中-公开
标题翻译： Dispensiervorrichtung und Vorrichtung zur Beladung vonProbenträgern
公开(公告)号：EP1281441A3
公开(公告)日：2004-12-01
申请号：EP02255410.9
申请日：2002-08-01
申请人： CANON KABUSHIKI KAISHA
发明人： Inoue, Takashi, c/o Canon Kabushiki Kaisha
IPC分类号： B01L3/02 , G01N35/10
CPC分类号： B01L3/0268 , B01J2219/00317 , B01J2219/00364 , B01J2219/00371 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01L2200/06 , B01L2300/1888 , B01L2400/0442 , C40B60/14 , G01N35/1074 , G01N2035/1039
摘要： A liquid ejection device (1) comprises a flow path having an ejection orifice (2) and a pressure chamber (5) communicating with each other; a pressure control assembly (6) for changing the gas pressure in the pressure chamber; and an ejection energy-generating element (4) for giving the energy for ejection of a liquid in the flow path through the orifice to the liquid, wherein the liquid is introduced through the ejection orifice into the flow path by depressurizing the pressure chamber by the pressure control assembly. A carrier preparation apparatus comprises the liquid ejection device; a first driving assembly for driving the pressure control assembly; a second driving assembly for driving the ejection energy-generating element; a liquid holding portion (23) for holding the liquid containing a sample; a carrier holding member for holding a carrier for fixing the sample; a moving means (22) for moving the ejection orifice in positional relation to the liquid holding portion and the carrier holding member; and a position control assembly for deciding the position of the ejection orifice in the relative movement.
摘要翻译：液体喷射装置（1）包括具有喷射孔（2）和彼此连通的压力室（5）的流路; 用于改变压力室中的气体压力的压力控制组件（6）; 以及喷射能量产生元件（4），用于提供通过所述孔口的液体流向液体的能量，其中所述液体通过所述喷射孔通过所述压力室的压力被引入所述流动通道压力控制组件。载体制备装置包括液体喷射装置; 用于驱动压力控制组件的第一驱动组件; 用于驱动喷射能量产生元件的第二驱动组件; 用于保持含有样品的液体的液体保持部分（23）用于保持用于固定样本的载体的载体保持构件; 移动装置（22），用于使喷射口与液体保持部分和载体保持构件位置关系移动; 以及位置控制组件，用于在相对运动中决定喷射口的位置。

19. 发明专利

JPWO2004068144A1 液体試料の分析方法及び分析装置审中-公开
公开(公告)号：JPWO2004068144A1
公开(公告)日：2006-05-25
申请号：JP2005504765
申请日：2004-01-30
申请人：ユニバーサル・バイオ・リサーチ株式会社
发明人：田島　秀二 , 秀二田島
IPC分类号： G01N35/00 , B01L3/00 , B01L3/02 , G01N21/78 , G01N35/10 , G01N37/00
CPC分类号： B01L3/50851 , B01L3/021 , B01L2300/0636 , B01L2300/1805 , B01L2300/185 , B01L2300/1861 , B01L2300/1888 , G01N35/10 , G01N2035/00425
摘要：それぞれ異なる反応温度で特定の標的物質と反応する複数の反応物質が表面に固定された固体支持体を用いて液体試料の分析を行う際に、全ての反応物質がそれぞれ特定の標的物質と反応できる温度環境を形成することができるとともに、反応から検出に至る一連の操作を自動化することができる液体試料の分析方法及び分析装置を提供することを目的とし、この目的を達成するために、本発明の液体試料の分析方法及び分析装置においては、反応室外にある液体試料を、反応物質のいずれの反応温度よりも高温になるまで加熱する工程(a)と、反応室外にある液体試料を反応室に流入させる工程(b)と、反応室内にある液体試料を反応室から流出させる工程(c)と、液体試料の温度が反応物質のいずれの反応温度をも通過するように、反応室内にある液体試料及び/又は反応室外にある液体試料を冷却する工程(d)と、反応物質のそれぞれの反応温度に冷却された液体試料を反応室に保持する工程(e)とを行うことにより、液体試料を分析する。

20. 发明专利

JP3772990B2 Flow control device 失效
公开(公告)号：JP3772990B2
公开(公告)日：2006-05-10
申请号：JP50127295
申请日：1994-06-03
申请人：グラクソ、グループ、リミテッドGlaxo Group Ltd.
发明人：デービッドベバン、クリストファー , マーティンマトン，イーアン
IPC分类号： G01N1/00 , B01L3/00 , F16L55/10 , F16L55/103 , G01N30/20 , G01N30/30 , G01N30/60 , G01N35/08
CPC分类号： G01N35/1097 , B01L3/502738 , B01L2300/0816 , B01L2300/1888 , B01L2400/0406 , B01L2400/0421 , B01L2400/0677 , F16L55/103 , G01N30/20 , G01N30/6095 , G01N35/08 , G01N2030/3038 , Y10S366/03 , Y10T137/0391 , Y10T436/2575
摘要： The present invention relates to a method and apparatus for managing liquid flow through small bore tubing (1,2,3) or channels (13) by freezing the liquid or thawing the frozen liquid in a small segment of the tube or channel.

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