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11. 发明申请

WO1998025924A1 8-AZABICYCLO[3.2.1]OCTANE-, 8-AZABICYCLO[3.2.1]OCT-6-ENE-, 9-AZABICYCLO[3.3.1]NONANE-, 9-AZA-3-OXABICYCLO[3.3.1]NONANE- AND 9-AZA-3-THIABICYCLO[3.3.1]NONANE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INSECTICIDES 审中-公开
标题翻译： 8-亚氨基双环[3.2.1]十八烷，8-亚氨基二环[3.2.1] OCT-6-ENE-，9-异亚氨基[3.3.1] NONANE-，9-亚氨基-3-氧代羰基[3.3.1] NONANE - 和9-氨基-3-噻唑啉[3.3.1] NONANE衍生物，其制备及其作为杀虫剂的用途
公开(公告)号：WO1998025924A1
公开(公告)日：1998-06-18
申请号：PCT/GB1997003054
申请日：1997-11-06
申请人： ZENECA LIMITED , URCH, Christopher, John , LEWIS, Terence , SUNLEY, Raymond, Leo , SALMON, Raymond , GODFREY, Christopher, Richard, Ayles , BRIGHTWELL, Christopher, Ian , HOTSON, Matthew, Brian
发明人： ZENECA LIMITED
IPC分类号： C07D451/14
CPC分类号： C07D451/02 , A01N43/90 , A01N47/16 , A01N47/18 , C07D451/04 , C07D451/06 , C07D451/14
摘要： A compound of formula (I) wherein A represents a bidentate group of the formula -CH2-X-CH2- (wherein X is methylene, sulfur or oxygen), X'C=CY or X'WC-CYZ (wherein X', W, Y and Z are independently hydrogen, hydroxy, acyloxy, alkoxy, alkylsilyloxy, cyano or halogen, or X' and W or Y and Z together with the carbon to which they are attached form a carbonyl group), provided that A is not CH2-CH2; Ar is an optionally substituted phenyl or 5- or 6-membered heterocyclic ring system containing from 1 to 3 heteroatoms individualy selected from nitrogen, oxygen and sulfur atoms, and at least one unsaturation (double bond) between adjacent atoms in the ring, said heterocyclic ring being optionally fused to a benzene ring, wherein the substituents, if present, are selected from halogen atoms, cyano, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkenyl, alkylthio and alkyl amino groups, any of which groups contain up to six carbon atoms; R is hydrogen or cyano or a group selected from alkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, alkoxycarbonyl, alkanesulfonyl, arenesulfonyl, alkenyloxycarbonyl, aralkylocycarbonyl, aryloxycarbonyl, heterocyclylalkyl, carbamyl, dithiocarboxyl or X''R (where X'' represents oxygen or a group NR ), provided that when R is alkenyl, aralkenyl or alkynyl said group does not have an unsaturated carbon atom bonding directly to the ring nitrogen of formula (I); R is hydrogen, cyano, hydroxy, alkyl, alkoxy, amino, nitro, isocyanato, acylamino, hydroxyalkyl, optionally substituted heteroaryl, alkoxyalkyl, haloalkyl, halohydroxyalkyl, aralkyloxyalkyl, acyloxyalkyl, amidoximido, sulfonyloxyalkyl, aminoalkyl, alkoxycarbonylamino, acylaminoalkyl, cyanoalkyl, imino, formyl, acyl or carboxylic acid or an ester or amide thereof, or alkenyl or alkynyl either of which is optionally substituted by halogen, alkoxy, cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or cyano; R and R are, independently, hydrogen, alkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, heterocyclylalkyl, alkoxycarbonyl or carboxylic acyl; alkyl moieties of R, R and R comprise from 1 to 15 carbon atoms, and are optionally substituted with one or more substituents selected from, halogen, cyano, carboxyl, carboxylic acyl, carbamyl, alkoxycarbonyl, alkoxy, alkylenedioxy, hydroxy, nitro, amino, acylamino, imidate and phosphonato groups; aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, alkoxycarbonyl, alkanesulfonyl, arenesulfonyl, alkanyloxycarbonyl, aralkyloxycarbonyl, aryloxycarbonyl, heterocyclylalkyl, carbamyl, dithiocarboxyl moieties of R, R and R comprise from 1 to 15 carbon atoms, and are optionally substituted with one or more substituents selected from, halogen, cyano, carboxyl, carboxylic acyl, carbamyl, alkoxycarbonyl, alkoxy, alkylenedioxy, hydroxy, nitro, haloalkyl, alkyl, amino, acylamino, imidate and phosphonato groups; or an acid addition salt, quaternary ammonium salt or N -oxide derived therefrom; an insecticidal, acaricidal or nematicidal composition comprising a compound of formula (I) and a suitable carrier or diluent therefor; a method of combating and controlling insect, acarine or nematode pests at a locus which comprises treating the pests or the locus of the pests with an effective amount of a compound of formula (I) or a composition as hereinbefore described.
摘要翻译：式（I）的化合物，其中A表示式-CH 2 -X-CH 2 - （其中X是亚甲基，硫或氧），X'C = CY或X'WC-CYZ（其中X'， W，Y和Z独立地是氢，羟基，酰氧基，烷氧基，烷基甲硅烷氧基，氰基或卤素，或X'和W或Y和Z与它们所连接的碳一起形成羰基），条件是A不是 CH2-CH2; Ar是任选取代的苯基或含有1至3个选自氮，氧和硫原子的杂原子的5或6元杂环系，以及环中相邻原子之间的至少一个不饱和键（双键），所述杂环任选地与苯环稠合，其中取代基（如果存在的话）选自卤素原子，氰基，烷基，烯基，炔基，烷氧基，卤代烷基，卤代烯基，烷硫基和烷基氨基，其中任何一个基团含有最多六个碳原子 R是氢或氰基或选自烷基，芳基，杂芳基，芳烷基，杂芳基烷基，烯基，芳烯基，炔基，烷氧基羰基，链烷磺酰基，芳烃磺酰基，烯氧基羰基，芳烷基羰基，芳氧基羰基，杂环基烷基，氨基甲酰基，二硫代羧基或X'R （其中X“表示氧或基团NR 4），条件是当R是烯基时，所述基团不具有与式（I）的环氮直接键合的不饱和碳原子; R 1是氢，氰基，羟基，烷基，烷氧基，氨基，硝基，异氰酸根合，酰氨基，羟烷基，任选取代的杂芳基，烷氧基烷基，卤代烷基，卤代羟烷基，芳烷氧基烷基，酰氧基烷基，酰氨基亚氨基，磺酰氧基烷基，氨基烷基，烷氧基羰基氨基，酰基氨基烷基，酰基或羧酸或其酯或酰胺，或任选被卤素，烷氧基，环烷基，任选取代的芳基，任选取代的杂芳基或氰基取代的链烯基或炔基; R 3和R 4独立地是氢，烷基，芳基，杂芳基，芳烷基，杂芳基烷基，烯基，芳烯基，炔基，杂环基烷基，烷氧基羰基或羧基酰基。 R 3，R 3和R 4的烷基部分含有1至15个碳原子，并且任选地被一个或多个选自卤素，氰基，羧基，羧酰基，氨基甲酰基，烷氧基羰基，烷氧基，亚烷基二氧基，羟基，硝基，氨基，酰氨基，亚氨基和膦酸基; 芳基，杂芳基，芳烷基，杂芳基烷基，烯基，芳烯基，炔基，烷氧基羰基，烷磺酰基，芳烃磺酰基，烷氧基羰基，芳烷氧基羰基，芳氧基羰基，杂环基烷基，氨基甲酰基，R 3，R 3和R 4的二硫代羧基部分包含1至15个碳任选被一个或多个选自卤素，氰基，羧基，羧基酰基，氨基甲酰基，烷氧基羰基，烷氧基，亚烷基二氧基，羟基，硝基，卤代烷基，烷基，氨基，酰氨基，亚氨酸酯基和膦酸基的取代基取代。或由其衍生的酸加成盐，季铵盐或N，N-氧化物; 杀虫杀螨或杀线虫组合物，其包含式（I）化合物及其合适的载体或稀释剂; 一种防治昆虫，螨虫或线虫害虫的方法，包括用有效量的式（I）化合物或上述组合物处理害虫或害虫的场所。

12. 发明申请

WO1998024065A1 3D IMAGING FROM 2D SCANS 审中-公开
标题翻译：从2D扫描3D成像
公开(公告)号：WO1998024065A1
公开(公告)日：1998-06-04
申请号：PCT/GB1997003250
申请日：1997-11-27
申请人： ZENECA LIMITED
发明人： ZENECA LIMITED , ALLOTT, Christopher, Paul , BARRY, Christopher, David , ARUNDEL, Philip, Anthony , JOHN, Nigel, William , MELLOR, Paul, Maxwell
IPC分类号： G06T17/00
CPC分类号： G01S7/52087 , A61B8/483 , G01S15/8993 , G01S15/8995 , G06T17/00
摘要： There is disclosed a method and apparatus for reconstructing in 3D an image of an object scanned in 2D a plurality of times to produce a plurality of 2D image data slices at different angles of inclination. The slices are recorded and stored on a recording medium e.g. video tape, whereon the slices are recorded in succession together with at least one datum which identifies the image data slices as corresponding to at least one changing physical parameter such as positioning, ECG, and/or respiration cycle. The 2D image data slices are processed to create a 3D grid of points containing data values based on at least part of an object being scanned, with the image data values being inserted at the grid points as a result of processing the 2D image data slices in dependence upon said at least one datum. Preferably the scanning is carried out by feehand ultrasound scanning, and can be employed for the non-invasive determination of a condition inside a mammalian body.
摘要翻译：公开了一种用于在3D中重构在2D中多次扫描的对象的图像以产生不同倾斜角度的多个2D图像数据切片的方法和装置。将切片记录并存储在记录介质上，例如视频磁带，其中片与连续记录的至少一个数据一起记录，所述至少一个数据标识与至少一个改变的物理参数（例如定位，ECG和/或呼吸循环）相对应的图像数据切片。处理2D图像数据切片以创建基于被扫描对象的至少一部分的包含数据值的点的3D网格，其中图像数据值作为处理2D图像数据切片的结果插入网格点依赖于所述至少一个基准。优选地，扫描通过手动超声扫描进行，并且可以用于非侵入式确定哺乳动物体内的状况。

13. 发明申请

WO1998022462A1 8-AZABICYCLO[3.2.1]OCTANE-, 8-AZABICYCLO[3.2.1]OCT-6-ENE-, 9-AZABICYCLO[3.3.1]NONANE-, 9-AZA-3-OXABICYCLO[3.3.1]NONANE-, 9-AZA-3-THIABICYCLO[3.3.1]NONANE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INSECTICIDES 审中-公开
标题翻译： 8-亚氨基双环[3.2.1]十八烷，8-亚氨基二环[3.2.1] OCT-6-ENE-，9-异亚氨基[3.3.1] NONANE-，9-亚氨基-3-氧代羰基[3.3.1] NONANE - ，9-AZA-3-THIABICYCLO [3.3.1] NONANE DORIVATIVES，其制备及其作为杀虫剂的用途
公开(公告)号：WO1998022462A1
公开(公告)日：1998-05-28
申请号：PCT/GB1997002987
申请日：1997-10-30
申请人： ZENECA LIMITED , BISHOP, Nigel, Douglas , URCH, Christopher, John , LEWIS, Terence , SUNLEY, Raymond, Leo , SALMON, Roger , GODFREY, Christopher, Richard, Ayles
发明人： ZENECA LIMITED
IPC分类号： C07D451/02
CPC分类号： C07D519/00 , A01N43/90 , A01N47/38
摘要： A compound of formula (I): P-R -Q, where each of P and Q is, independently, a group of formula (B), wherein J is a bidentate group of formula -CH2-X-CH2- (wherein X is methylene, sulfur or oxygen), X'C=CY or X'WC-CYZ (wherein X', W, Y and Z are independently hydrogen, hydroxy, acyloxy, alkoxy, alkylsilyloxy or halogen); R is an optionally substituted phenyl or 5- or 6-membered heterocyclic ring system containing from 1 to 3 heteroatoms individually selected from nitrogen, oxygen and sulfur atoms, and at least one unsaturation (double bond) between adjacent atoms in the ring, said heterocyclic ring being optionally fused to a benzene ring, wherein the substituents, if present, are selected from halogen atoms, cyano, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkenyl, alkylthio and alkyl amino groups, any of which groups contain up to six carbon atoms; R is a bidentate linking group and is a substituted or unsubstituted alkylene, alkylenearyl, alkyleneheteroaryl, alkenylene, alkylenylarylalkynlenyl, carbonyl or diacyl group, provided that when R is alkenylene or alkylenylarylalkylenyl, said group does not have an unsaturated carbon atom bonding directly to the ring nitrogen of formula (B); R is hydrogen, cyano, hydroxy, alkyl, alkoxy, amino, nitro, isocyanato, acylamino, hydroxyalkyl, optionally substituted heteroaryl, alkoxyalkyl, haloalkyl, halohydroxyalkyl, aralkyloxyalkyl, acyloxyalkyl, amidoximido, sulfonyloxyalkyl, aminoalkyl, alkoxycarbonylamino, acylaminoalkyl, cyanoalkyl, imino, formyl, acyl or carboxylic acid or an ester or amide thereof, or alkenyl or alkynyl either of which is optionally substituted by halogen, alkoxy, cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or cyano; or an acid addition salt, quaternary ammonium salt or N -oxide derived therefrom; an insecticidal, acaricidal or nematicidal composition comprising a compound of formula (I) and a suitable carrier or diluent therefor; a method of combating and controlling insect, acarine or nematode pests at a locus which comprises treating the pests or the locus of the pests with an effective amount of a compound of formula (I) or a composition as hereinbefore described.
摘要翻译：式（I）的化合物：PR 2 -Q，其中P和Q各自独立地是式（B）的基团，其中J是式-CH 2 -X-CH 2 - 的双齿基团（其中 X是亚甲基，硫或氧），X'C = CY或X'WC-CYZ（其中X'，W，Y和Z独立地是氢，羟基，酰氧基，烷氧基，烷基甲硅烷氧基或卤素）; R 1是任选取代的苯基或5-或6-元杂环体系，其含有1-3个分别选自氮，氧和硫原子的杂原子，以及环中相邻原子之间的至少一个不饱和键（双键）所述杂环任选地与苯环稠合，其中所述取代基（如果存在的话）选自卤原子，氰基，烷基，烯基，炔基，烷氧基，卤代烷基，卤代烯基，烷硫基和烷基氨基，最多6个碳原子; R 2是二齿连接基团，并且是取代或未取代的亚烷基，亚烷基硬脂基，亚烷基杂芳基，亚烯基，亚烷基芳基烯烃基，羰基或二酰基，条件是当R 2是亚烯基或亚烷基芳基亚烷基时，所述基团不具有不饱和碳原子直接键合到式（B）的环氮上; R 3是氢，氰基，羟基，烷基，烷氧基，氨基，硝基，异氰酸根合，酰氨基，羟基烷基，任选取代的杂芳基，烷氧基烷基，卤代烷基，卤代羟烷基，芳烷氧基烷基，酰氧基烷基，酰氨基亚氨基，磺酰氧基烷基，氨基烷基，烷氧基羰基氨基，酰基氨基烷基，酰基或羧酸或其酯或酰胺，或任选被卤素，烷氧基，环烷基，任选取代的芳基，任选取代的杂芳基或氰基取代的链烯基或炔基; 或由其衍生的酸加成盐，季铵盐或N，N-氧化物; 杀虫杀螨或杀线虫组合物，其包含式（I）化合物及其合适的载体或稀释剂; 一种防治昆虫，螨虫或线虫害虫的方法，包括用有效量的式（I）化合物或上述组合物处理害虫或害虫的场所。

14. 发明申请

WO1998021188A1 HETEROCYCLE DERIVATIVES WHICH INHIBIT FACTOR Xa 审中-公开
标题翻译：禁忌因子的异构体衍生物Xa
公开(公告)号：WO1998021188A1
公开(公告)日：1998-05-22
申请号：PCT/GB1997003033
申请日：1997-11-04
申请人： ZENECA LIMITED , PRESTON, John , STOCKER, Andrew , TURNER, Paul , SMITHERS, Michael, James , RAYNER, John, Wall
发明人： ZENECA LIMITED
IPC分类号： C07D239/26
CPC分类号： C07D213/73 , A61K31/44 , A61K31/505 , C07D213/56 , C07D213/61 , C07D213/84 , C07D213/89 , C07D237/08 , C07D239/26
摘要： The invention relates to heterocyclic derivatives of the formula (I): A-B-X -T (R )-L -T (R )-X -Q or pharmaceutically acceptable salts thereof, which possess antithrombotic and anticoagulant properties due to their inhibition of Factor Xa and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the heterocyclic derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.
摘要翻译：本发明涉及式（I）的杂环衍生物：ABX 1 -T 1（R 2）-L 1 -T 2（R 3）-X 2 - Q或其药学上可接受的盐，由于其对因子Xa的抑制而具有抗血栓形成和抗凝血性质，因此可用于治疗人或动物的方法。本发明还涉及制备杂环衍生物的方法，含有它们的药物组合物及其在制备用于产生抗血栓形成或抗凝血作用的药物中的用途。

15. 发明申请

WO1998018961A1 METHODS FOR PREPARING ARRAYS OF SINGLE-STRANDED DNA 审中-公开
标题翻译：用于制备单链DNA序列的方法
公开(公告)号：WO1998018961A1
公开(公告)日：1998-05-07
申请号：PCT/GB1997002961
申请日：1997-10-28
申请人： ZENECA LIMITED , CHARLES, Andrew, David
发明人： ZENECA LIMITED
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6837
摘要： A method for preparing an array of single-stranded DNA immobilised on a solid support, which method comprises (i) providing samples of double-stranded DNA chemically modified on the sense or antisense strand for attachment to the solid support, and (ii) linking the DNAs to the solid support and, before or after step (ii), removing the non-modified strand whereby an array of single-stranded DNA is provided on the solid support.
摘要翻译：一种制备固定在固体支持物上的单链DNA阵列的方法，该方法包括（i）提供在有义链或反义链上化学修饰的双链DNA样品以连接到固体支持物上，和（ii）连接在固体支持物上的DNA和步骤（ii）之前或之后，除去未修饰的链，由此在固体支持物上提供单链DNA阵列。

16. 发明申请

WO1998012263A1 AZO DYER FOR INK-JET PRINTING 审中-公开
标题翻译：喷墨打印机的AZO DYER
公开(公告)号：WO1998012263A1
公开(公告)日：1998-03-26
申请号：PCT/GB1997002377
申请日：1997-09-05
申请人： ZENECA LIMITED , MILLARD, Christine , BRADBURY, Roy , GREGORY, Peter
发明人： ZENECA LIMITED
IPC分类号： C09B43/16
CPC分类号： C09D11/328 , C09B43/16
摘要： Azo dyes of Formula (1) have utility as dyes for ink-jet printing, where Formula (1) comprises any suitable form of the compound: such as salt; stereoisomer, zwitterion, polymorph, complex, isotopic form, combinations thereof in the same species and mixtures thereof; where: n represents from 1 to 5 inclusive; R , R , R and R each independently comprises at least one of the following substituents, optionally substituted: H, C1-8alkyl; C1-8alkoxy; -NHCOH, C1-8alkylcarbonylamino; and -NHCONR R where R and R each independently comprises at least one of the following substituents: H, C1-8alkyl and aryl; and R and R each independently comprises at least one of the following substituents, optionally substituted: H; C1-8alkoxy; -NHC1-8alkyleneOH, -SC1-8-alkyleneSO3H; -NHC1-8alkyleneN(C1-8alkyl)2; (a) where X comprises one of the following: -NHC1-8alkylene; -NHphenylSO2NHC1-8alkylene; and a direct link, (b) where X comprises one of the following: -NHC1-8alkylene; -NHphenylSO2NHC1-8alkylene; and a direct link; a moiety of Formula (2) where m and p is each independently from 0 to 5 inclusive, provided that (m + p) is from 1 to 5 inclusive; and R , R , R and R each independently comprises at least one of those optionally substituted substituents as defined herein for R , R , R and R respectively; and any other suitable labile or non-labile substituent not mentioned above; where the optional substituents herein comprise: C alkyl (optionally substituted with at least one halo), C1-4alkoxy (optionally substituted with at least one halo), carboxy, sulpho, hydroxy, amino, mercapto, cyano, nitro and halo.
摘要翻译：式（1）的偶氮染料可用作喷墨印花的染料，其中式（1）包含任何合适形式的化合物：例如盐; 立体异构体，两性离子，多晶型物，复合物，同位素形式，它们在同一物种及其混合物中的组合; 其中：n表示1〜5; R 1，R 1B，R 4和R 4各自独立地包含至少一个如下取代基，任选被取代：H，C 1-8烷基; C 1-8烷氧基; -NHCOH，C 1-8烷基羰基氨基; 和-NHCONR 5 R 6，其中R 5和R 6各自独立地包含至少一个如下取代基：H，C 1-8烷基和芳基; R 2和R 3各自独立地包含至少一个如下取代基，任选被取代：H; C 1-8烷氧基; -NHC1-8亚烷基OH，-SC1-8-亚烷基SO3H; -NHC1-8alkyleneN（C 1-8烷基）2; （a）其中X包括以下之一：-NHC1-8亚烷基; -NHphenylSO2NHC1-8alkylene; 和直接链接，（b）其中X包含以下之一：-NHC1-8亚烷基; -NHphenylSO2NHC1-8alkylene; 和直接联系; 式（2）的部分，其中m和p各自独立地为0至5，其中（m + p）为1至5（包括端值）; R 1A，R 2A，R 4A和R 4C各自独立地包含至少一个如本文定义的R 1，R 2，R 4和 R 4B; 以及上文未提及的任何其他合适的不稳定或非不稳定取代基; 其中本文任选的取代基包含：C 1-4烷基（任选被至少一个卤素取代），C 1-4烷氧基（任选被至少一个卤素取代），羧基，磺基，羟基，氨基，巯基，氰基，硝基和光环。

17. 发明申请

WO1998011228A2 GENETIC CONTROL OF FRUIT RIPENING 审中-公开
标题翻译：水果粕的遗传控制
公开(公告)号：WO1998011228A2
公开(公告)日：1998-03-19
申请号：PCT/GB1997002424
申请日：1997-09-08
申请人： ZENECA LIMITED , SEYMOUR, Graham, Barron , BIRD, Colin, Roger , MEDINA-SUAREZ, Rosybel de Jesús
发明人： ZENECA LIMITED
IPC分类号： C12N15/29
CPC分类号： C12N15/8249
摘要： A method of modulating the ripening and/or senescence characteristics in plants of the genus Musa comprises transforming plants with one or more sequences obtainable from the deposited cDNA library having the accession number 40184, regenerating said plants and selecting from the population of transformants those plants having modulated and/or tissue senescence characteristics.
摘要翻译：调节植物中成熟和/或衰老特性的方法包括用可从保藏号为40184的保藏cDNA文库获得的一个或多个序列转化植物，再生所述植物并从转化体群体中选择具有调节和/或组织衰老特征。

18. 发明申请

WO1998000561A1 REG GENE EXPRESSION IN CANCER TISSUE 审中-公开
标题翻译： REG基因表达在癌组织中
公开(公告)号：WO1998000561A1
公开(公告)日：1998-01-08
申请号：PCT/GB1997001739
申请日：1997-06-30
申请人： ZENECA LIMITED , MARKHAM, Alexander, Fred , GUILLOU, Pierre, John
发明人： ZENECA LIMITED
IPC分类号： C12Q01/68
CPC分类号： G01N33/57484 , C12Q1/6886 , G01N2500/00 , G01N2800/50 , G01N2800/56
摘要： The invention relates to a marker for determining the tendency towards a cancerous condition and/or the aggressive nature of cancer tissue with a view to determining a prognosis and suitable course of action/treatment. More specifically, the invention concerns an investigation for products of the (REG) gene, i.e. the pancreatic protein lithostathine (REG) gene.
摘要翻译：本发明涉及用于确定癌症状态趋势和/或癌组织侵袭性质的标志物，以便确定预后和合适的作用/治疗过程。更具体地说，本发明涉及（REG）基因，即胰腺蛋白物质（REG）基因的产物的研究。

19. 发明申请

WO1998000429A1 PROCESS FOR THE PREPARATION OF PENAM AND PENEM DERIVATIVES 审中-公开
标题翻译：制备PENAM和PENEM衍生物的方法
公开(公告)号：WO1998000429A1
公开(公告)日：1998-01-08
申请号：PCT/GB1997001714
申请日：1997-06-24
申请人： ZENECA LIMITED , GALLAGHER, Timothy, Charles , HALES, Neil, James , WISEDALE, Richard , PLANCHENAULT, Denis
发明人： ZENECA LIMITED
IPC分类号： C07D499/04
CPC分类号： C07D499/88 , C07D499/00 , Y02P20/55
摘要： The invention provides a process for the preparation of compounds of formula (I) wherein R , R , R , R and R are as defined in the specification; and wherein any functional groups are optionally protected; and salts thereof; which process includes the step of reacting the intermediate formed by heating a compound of formula (II), in an inert solvent, with a compound of the formula S=C(R )R wherein R , R , R , R and R are as defined in the specification and functional groups are optionally protected; and thereinafter, if necessary, removing any protecting groups. The compounds of the formula (I) are useful as intermediates in the preparation of penems and may possess antibacterial properties and/or inhibit beta -lactamase in their own right.
摘要翻译：本发明提供了制备式（I）化合物的方法，其中R 1，R 2，R 3，R 4和R 5如说明书中所定义; 并且其中任选的官能团被保护; 及其盐; 该方法包括使在惰性溶剂中加热式（II）化合物形成的中间体与式S = C（R 3）R 4的化合物反应的步骤，其中R 1， R 2，R 3，R 4和R 5如说明书中所定义，官能团任选地被保护; 并且如果需要，移除任何保护组。式（I）的化合物可用作制备青霉烯的中间体，并且可以具有本身的抗菌性和/或抑制β-内酰胺酶。

20. 发明申请

WO1997043286A1 BICYCLIC AMINES AS INSECTICIDES 审中-公开
标题翻译：双酚A作为杀虫剂
公开(公告)号：WO1997043286A1
公开(公告)日：1997-11-20
申请号：PCT/GB1997001259
申请日：1997-05-09
申请人： ZENECA LIMITED , SALMON, Roger , HOTSON, Matthew, Brian
发明人： ZENECA LIMITED
IPC分类号： C07D451/02
CPC分类号： C07D451/02 , A01N43/90
摘要： The invention provides novel compounds of formula (I) and formula (II) wherein R represents a group of formula (A) where each of W, X, Y and Z represents either a group CR or the nitrogen atom, provided that not more than two of W, X, Y, and Z represent the nitrogen atom, and where each R present is independently selected from hydrogen and halogen atoms and cyano, amino, hydrazino, acylamino, hydroxy, alkyl, hydroxyalkyl, alkoxy, haloalkyl, haloalkoxy, alkenyl, alkenyloxy, alkoxyalkenyl, alkynyl, carboxylic acyl, alkoxycarbonyl, aryl and heterocyclyl groups, said groups comprising up to 6 carbon atoms, and wherein R represents a group XR where X represents oxygen or a group NR where R and R are individually selected from hydrogen or a group selected from alkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, heterocyclylalkyl, alkoxycarbonyl, and carboxylic acyl groups, said groups comprising from 1 to 15 carbon atoms, said groups being optionally substituted with one or more substituents selected from, halogen, cyano, carboxyl, carboxylic acyl, carbamyl, alkoxycarbonyl, alkoxy, alkylenedioxy, hydroxy, nitro, haloalkyl and alkyl groups; and acid addition salts and quaternary ammonium salts and N-oxides derived therefrom. The compounds have useful insecticidal properties.
摘要翻译：本发明提供新的式（I）和式（II）化合物，其中R 1表示式（A）中的基团，其中W，X，Y和Z各自表示基团CR或氮原子，条件是不多于两个W，X，Y和Z表示氮原子，并且其中每个R独立地选自氢和卤素原子和氰基，氨基，肼基，酰氨基，羟基，烷基，羟基烷基，烷氧基，卤代烷基，卤代烷氧基，烯基，烯氧基，烷氧基烯基，炔基，羧基酰基，烷氧基羰基，芳基和杂环基，所述基团包含至多6个碳原子，并且其中R 2表示XR 3基团，其中X表示氧或NR 其中R 3和R 4分别选自氢或选自烷基，芳基，杂芳基，芳烷基，杂芳基烷基，烯基，芳烯基，炔基，杂环基烷基，烷氧基羰基和羧酰基的基团，所述基团包含1至15个碳原子，所述基团是选择性的被一个或多个选自卤素，氰基，羧基，羧基酰基，氨基甲酰基，烷氧基羰基，烷氧基，亚烷基二氧基，羟基，硝基，卤代烷基和烷基的取代基取代。和酸加成盐和季铵盐和由其衍生的N-氧化物。该化合物具有有用的杀虫性质。

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