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11. 发明申请

US20210047658A1 Magnetic Nanoparticles for use in Assisted Reproduction 有权
公开(公告)号：US20210047658A1
公开(公告)日：2021-02-18
申请号：US16980364
申请日：2019-02-26
申请人： Universidad de Murcia
发明人： Francisco Alberto GARCIA VAZQUEZ , Maria JIMENEZ MOVILLA , Maria CABALLERO SASTRE
IPC分类号： C12N15/873 , A61K35/54 , C12N5/073 , C12N5/075 , C12N5/00
摘要： The present invention relates to a method of preparing magnetic oocytes and/or embryos by means of nanoparticles for assisted reproduction techniques and to the use in assisted reproduction techniques of non-human oocytes and/or embryos prepared with said method. Said method comprises: a step in which magnetic nanoparticles are conjugated with oviduct recombinant protein, OVGP1r; a step in which it is verified that the nanoparticle-OVGP1r conjugation attaches to the ZP of oocytes/embryos after being incubated together; and a step in which the number of oocytes/embryos having nanoparticles attached to them distributed around the ZP without being endocytosed is verified; and it is assessed if the amount of magnetic nanoparticles attached to the ZP of oocytes/embryos is enough to be attracted by a magnetic field.

12. 发明授权

US09277981B2 Device and method for inserting or obtaining a fluid with gametes, embryos or any other type of solution in the oviduct of a sow 有权
标题翻译：在母猪输卵管中插入或获得配子，胚胎或任何其他类型溶液的流体的装置和方法
公开(公告)号：US09277981B2
公开(公告)日：2016-03-08
申请号：US13132518
申请日：2009-09-24
申请人： Juan Maria Vazquez Rojas , Emilio Martinez Garcia , Jose Luis Vazquez Rojas , Jorge Roca Aleu
发明人： Juan Maria Vazquez Rojas , Emilio Martinez Garcia , Jose Luis Vazquez Rojas , Jorge Roca Aleu
IPC分类号： A61D19/04 , A61D19/02 , A61B10/00 , A61B10/02 , A61B17/34 , A61B19/08
CPC分类号： A61D19/04 , A61B10/0045 , A61B10/0291 , A61B17/3478 , A61B46/13 , A61D19/027
摘要： The device comprises an injection system, which is made up of a rigid external tubular body (1) that enables it to be inserted into the abdominal cavity of a sow. This body is, in turn, covered by a sterile sleeve (2) that enables it to be used in different animals. A flexible duct (3) runs coaxially and its distal end connects with a bevelled needle (4) that permits insertion in the oviduct (12) at an angle of 45°. The proximal end of the flexible tube connects with a device (6) that includes a sheath (7) closed at the other end by a piston (8) that slides along the inside of the sheath and that enables the precision insertion of low-volume liquids.
摘要翻译：该装置包括注射系统，该注射系统由刚性的外部管状体（1）构成，使其能够插入到母猪的腹腔中。这个身体又被一个无菌套管（2）所覆盖，使其能够用于不同的动物。柔性管道（3）同轴运行，其远端与倾斜的针头（4）连接，该针头允许以45°的角度插入输卵管（12）中。柔性管的近端与包括由另一端封闭的护套（7）的装置（6）连接，活塞（8）沿着护套的内部滑动，并且能够精确地插入低体积液体。

13. 发明申请

US20130265544A1 INSTRUMENT FOR RAPID MEASUREMENT OF THE OPTICAL PROPERTIES OF THE EYE IN THE ENTIRE FIELD OF VISION 有权
标题翻译：用于快速测量眼睛在整个视野范围内的光学性质的仪器
公开(公告)号：US20130265544A1
公开(公告)日：2013-10-10
申请号：US13823121
申请日：2011-09-13
申请人： Bart Jaeken , Pablo Artal Soriano
发明人： Bart Jaeken , Pablo Artal Soriano
IPC分类号： A61B3/103 , A61B3/00
CPC分类号： A61B3/103 , A61B3/0008 , A61B3/0083 , A61B3/1015
摘要： An instrument measuring optical properties of an eye in an entire field of vision, including refraction and aberrations, including: a frame mounted on an ophthalmologic table that can be oriented in three perpendicular directions X, Y, Z; a support surface for a head of the subject; a hot mirror; a long mirror; an illumination sub-assembly including a fiber optic head; a lens; a diaphragm; a beam splitter; and a measurement sub-assembly with two lens and two mirrors; a camera including a matrix of micro-lenses on the inlet of camera, the camera being placed on the focal plane of the micro-lenses; the frame including a motor, a shaft of which rotates in the Y direction, to which an arm is attached that can rotate on the shaft; components of the illumination sub-assembly, components of a measurement sub-assembly, and the camera with the matrix of micro-lenses being mounted on the arm.
摘要翻译：测量整个视野中的眼睛的光学特性的仪器，包括折射和像差，其包括：安装在眼科台上的框架，其可沿三个垂直方向X，Y，Z取向; 主体的头部的支撑表面; 一个热镜子长镜子照明子组件，包括光纤头; 镜头隔膜分束器; 以及具有两个镜头和两个镜子的测量子组件; 相机包括在相机入口上的微透镜矩阵，相机被放置在微透镜的焦平面上; 所述框架包括马达，其轴在Y方向上旋转，臂可以安装在所述轴上，所述臂可以在所述轴上旋转; 照明子组件的组件，测量子组件的组件以及安装在臂上的具有微透镜矩阵的摄像机。

14. 发明申请

US20120154742A1 OPHTHALMIC INSTRUMENT FOR THE MEASUREMENT OF OCULAR REFRACTION AND VISUAL SIMULATION, AND ASSOCIATED METHODS OF MEASUREMENT OF OCULAR REFRACTION, SIMULATION OF OPHTHALMIC ELEMENTS, VISUAL SIMULATION AND FOR OBTAINING OPTICAL PARAMETERS 有权
标题翻译：用于测量眼压和视觉模拟的眼科仪器，以及相关的眼压测量方法，光学元件的模拟，视觉模拟和获得光学参数
公开(公告)号：US20120154742A1
公开(公告)日：2012-06-21
申请号：US13392723
申请日：2010-07-07
申请人： Enrique J. Fernandez Martinez , Pedro Prieto Corrales , Pablo Artal Soriano
发明人： Enrique J. Fernandez Martinez , Pedro Prieto Corrales , Pablo Artal Soriano
IPC分类号： A61B3/08
CPC分类号： A61B3/0025 , A61B3/1015 , A61B3/103 , A61B3/107
摘要： An ophthalmic instrument for measurement of ocular refraction and visual simulation and a method of measurement obtaining the ocular refraction in a binocular manner, which incorporates a digitally controlled phase modulator for generating best ophthalmic correction in each subject. The instrument enables measuring refraction, not only associated with blurring and astigmatism, but also optical aberration of any order. The phoropter can simulate vision by any phase profile, including those of a diffractive or discontinuous type. The instrument also incorporates a subsystem for presentation of stimuli that produces stereoscopic vision of the same, enabling the subject to enjoy a three dimensional perception during the process, and two output pupils. The instrument, by its electro-optical features, enables simulation of vision as it would be modified after submitting an eye to different surgical techniques, such as refractive surgery or interocular lens implantation.
摘要翻译：一种用于眼睛折射和视觉模拟测量的眼科仪器和一种以双目方式获得眼睛屈光度的测量方法，其包括用于在每个受试者中产生最佳眼科校正的数字控制相位调制器。该仪器能够测量折射，不仅与模糊和散光相关，而且与任何顺序的光学像差有关。扫帚机可以通过任何相位轮廓来模拟视觉，包括衍射或不连续类型。该仪器还包含一个用于呈现刺激物的子系统，产生立体视觉，使受试者在该过程中享受三维感知，以及两个输出学生。该仪器通过其电光学特征，能够对视力进行仿真，因为在将眼睛提交给不同的手术技术（例如屈光手术或眼内透镜植入）后将被修改。

15. 发明公开

US20230168258A1 MONOCLONAL ANTIBODY AND POLYCLONAL ANTIBODY AND OXYTOCIN QUANTIFICATION METHOD BASED ON SAME 审中-公开
公开(公告)号：US20230168258A1
公开(公告)日：2023-06-01
申请号：US17995125
申请日：2021-03-30
申请人： UNIVERSIDAD DE MURCIA
发明人： José Joaquín CERÓN MADRIGAL , Silvia MARTÍNEZ SUBIELA , Marina LÓPEZ ARJONA
IPC分类号： G01N33/74 , C07K16/26
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/565
摘要： The present invention relates to an in vitro method for the quantification of free oxytocin, protein-bound oxytocin that can be released in a reduction/alkylation treatment, and protein-bound oxytocin, in a sample, without performing a reduction/alkylation treatment, wherein said method comprising carrying out a first assay using a monoclonal antibody that binds specifically to free oxytocin and to protein-bound oxytocin that can be released in a reduction/alkylation treatment, and carrying out a second assay using a polyclonal antibody that binds specifically to protein-bound oxytocin. The invention also relates to the monoclonal antibody and polyclonal antibody, and to a composition and kit comprising same.

16. 发明授权

US10898073B2 Optoelectronic binocular instrument for the correction of presbyopia and method for the binocular correction of presbyopia 有权
公开(公告)号：US10898073B2
公开(公告)日：2021-01-26
申请号：US16325001
申请日：2017-06-16
申请人： UNIVERSIDAD DE MURCIA
发明人： Pablo Artal Soriano , Juan Mompean Esteba , Juan Luis Aragón
IPC分类号： A61B3/11 , A61B3/00 , G02C7/08
摘要： Optoelectronic binocular instrument for the automatic correction of presbyopia and method for the binocular correction of the presbyopia. The instrument has two optoelectronic lenses (103, 110; 203, 204) and a capturing subsystem for taking images of the eye. By means of the pupil tracking, which performs the processing of the eye's images, the system determines the distance where the subject is looking at. The pupil tracking works at a very high speed, using a high-performance graphic processor and a highly parallelized algorithm for pupil tracking. The method consists of two phases. In the first one a calibration is accomplished, the subject is asked to look at targets at different distances and the size and position of the pupil is measured. In the second phase the correction is performed by the instrument, the system continuously captures and processes images to calculate the correction to apply and, finally, corrects the presbyopia by applying said correction.

17. 发明授权

US09572490B2 Method and system for measuring intraocular scattering 有权
标题翻译：用于测量眼内散射的方法和系统
公开(公告)号：US09572490B2
公开(公告)日：2017-02-21
申请号：US14114354
申请日：2012-04-11
申请人： Pablo Artal Soriano , Guillermo Perez Sanchez , Juan Manuel Bueno Garcia , Harilaos Ginis
发明人： Pablo Artal Soriano , Guillermo Perez Sanchez , Juan Manuel Bueno Garcia , Harilaos Ginis
IPC分类号： A61B3/14 , A61B3/00 , A61B3/10 , A61B3/12 , A61B3/103
CPC分类号： A61B3/12 , A61B3/10 , A61B3/103
摘要： The present invention relates to a method for measuring ocular scattering, comprising the steps of: sequentially projecting images from an extensive light source, corresponding to different visual angles, onto the retina; recording the output light in a camera or detector once it has passed through the eye twice; calculating the intensity at the center of each recorded image; calculating the PSF for each angle from the previous intensities; and calculating the average of the value of the PSF between the angles. The invention also relates to a system for carrying out said method. The invention can be used to measure the intensity of the scattered light in an objective manner.
摘要翻译：本发明涉及一种用于测量眼睛散射的方法，包括以下步骤：将对应于不同视角的广泛光源的图像顺序地投射到视网膜上; 将输出光记录在相机或检测器中，一旦它通过眼睛两次; 计算每个记录图像中心的强度; 从以前的强度计算每个角度的PSF; 并计算角度之间的PSF值的平均值。本发明还涉及一种用于执行所述方法的系统。本发明可以用于以客观的方式测量散射光的强度。

18. 发明申请

US20150366660A1 VARIABLE-POWER ACCOMMODATIVE INTRAOCULAR LENS AND ASSEMBLY OF VARIABLEPOWER ACCOMMODATIVE INTRAOCULAR LENS AND CAPSULAR RING 审中-公开
标题翻译：可变功率住院镜片和可变电容器内窥镜镜片和囊体环组件
公开(公告)号：US20150366660A1
公开(公告)日：2015-12-24
申请号：US14439619
申请日：2013-07-26
申请人： UNIVERSIDAD DE MURCIA
发明人： Enrique Josua FERNÁNDEZ MARTÍNEZ , Pablo ARTAL SORIANO
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2/16015 , A61F2/1624 , A61F2/1694 , A61F2002/1682 , A61F2002/169 , A61F2250/0053
摘要： The new variable power accommodative intraocular lens is comprised by a central body or optical zone that has at least four refracting interfaces that separate different materials. These are connected by means of a substrate that holds them in an equatorial manner, and which includes the bases of the fasteners of the lens embedded in its core. The lens changes its power in response to variations in the equatorial diameter of the materials that comprise the optical zone. Thanks to its design, the lens can achieve variations in the optical powers greater than one dioptre per micrometre of equatorial compression. This is achieved through the real change of the curvature radii of the refracting interfaces that comprise the optical zone, as well as the central thicknesses along the length of the optical axis of the different materials that limit said refracting interfaces. Preferably the intraocular lens works in combination with a capsular ring, to which the haptics are fixed and whose external diameter determines the power of the lens. The change of power mechanism in the lens initiates with the contraction of the ciliary muscle of the patient in response to the accommodative force.
摘要翻译：新的可变动力调节眼内透镜由具有至少四个分离不同材料的折射界面的中心体或光学区域组成。它们通过以赤道方式保持它们的基板连接，并且其包括嵌入其芯中的透镜的紧固件的基部。镜片根据构成光学区域的材料的赤道直径的变化而改变其功率。由于其设计，透镜可以实现大于一微秒的每微米赤道压缩的光功率的变化。这通过包括光学区域的折射界面的曲率半径的真实变化以及沿着限制所述折射界面的不同材料的光轴的长度的中心厚度来实现。优选地，眼内透镜与荚膜组合起来，襻被固定到其上，并且其外径决定透镜的力量。透镜中功率机制的变化开始于患者的睫状肌受到调节力的收缩。

19. 发明申请

US20130124850A1 SMART GRID AND METHOD FOR OPERATING A SMART GRID 有权
标题翻译：智能网格和操作智能网格的方法
公开(公告)号：US20130124850A1
公开(公告)日：2013-05-16
申请号：US13807769
申请日：2011-01-31
申请人： Felix Gomez Marmol , Christoph Sorge , Osman Ugus , Gregorio Martinez Perez , Alban Hessler
发明人： Felix Gomez Marmol , Christoph Sorge , Osman Ugus , Gregorio Martinez Perez , Alban Hessler
IPC分类号： H04L9/28 , H04L9/08
CPC分类号： H04L9/28 , H04L9/008 , H04L9/08 , H04L9/0833 , H04L9/0891 , H04L63/0428 , H04L63/065 , H04L2209/42 , Y04S40/24
摘要： Method for operating a smart grid including a plurality of smart meters configured to monitor at least one physical measured quantity and to provide measurement results of the at least one physical measured quantity to a central entity, includes the following steps: partitioning the smart grid into groups of smart meters, such that each of the smart meters belongs to exactly one group, all smart meters of one of the groups encrypt their measured value by applying a bihomomorphic encryption scheme and send it to the central entity, one smart meter per group is designated as key aggregator to which all smart meters of that group send their key employed for the encryption, the key aggregator computes the aggregation of all received keys and sends the aggregated key to the central entity, the central entity aggregates all received encrypted measured values and decrypts the aggregation by employing the aggregated key.
摘要翻译：包括配置成监视至少一个物理测量量的多个智能电表并将至少一个物理测量量的测量结果提供给中央实体的智能电网的操作方法包括以下步骤：将智能电网划分成组的智能电表，使得每个智能电表都属于一个组，其中一个组的所有智能电表通过应用生态变形加密方案加密其测量值，并将其发送到中央实体，每组指定一个智能电表作为该组的所有智能电表发送用于加密的密钥的关键聚合器，密钥聚合器计算所有接收到的密钥的聚合并将聚合密钥发送到中央实体，中心实体聚合所有接收到的加密测量值并解密通过采用聚合密钥进行聚合。

20. 发明申请

US20110294172A1 USE OF IONIC LIQUIDS FOR IMPLEMENTING A PROCESS FOR THE PREPARATION OF BIODIESEL 有权
标题翻译：使用离子液体来实施生物物质的制备过程
公开(公告)号：US20110294172A1
公开(公告)日：2011-12-01
申请号：US13130463
申请日：2009-11-20
申请人： Pedro Lozano , Teresa De Diego , Jose Luis Iborra , Michel Vaultier
发明人： Pedro Lozano , Teresa De Diego , Jose Luis Iborra , Michel Vaultier
IPC分类号： C12P9/00 , C12N9/00 , C12P7/64
CPC分类号： C12P7/649 , Y02E50/13
摘要： The use of a combination of—at least one ionic liquid which is lipophilic, and non miscible with water, and—at least one enzyme, for the implementation of an esterification and/or transesterification process of a substrate with at least one alcohol, the substrate consisting of oils, fats, fatty acids, or a mixture thereof, wherein the ionic liquid, the substrate, and the alcohol form a single homogeneous liquid phase at the temperature at which the esterification and/or transesterification process is performed.
摘要翻译：使用至少一种亲脂性离子液体和与水不混溶的至少一种离子液体和至少一种酶的组合来实施底物与至少一种醇的酯化和/或酯交换过程，由油，脂肪，脂肪酸或其混合物组成的底物，其中离子液体，底物和醇在进行酯化和/或酯交换过程的温度下形成单一的均匀液相。

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