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11. 发明专利

GB202014880D0 Detection of biomarkers 未知
公开(公告)号：GB202014880D0
公开(公告)日：2020-11-04
申请号：GB202014880
申请日：2020-09-21
申请人： REFEYN LTD
摘要： A method and kit is described for the detection of a biomarker in a sample, by light scattering microscopy. The invention is particularly useful for the detection of low abundance biomarker in complex samples, and is suitable for use in a point of care setting. In an embodiment, the method of the invention describes detection of a biomarker in a sample using mass photometry.

12. 发明专利

GB201914669D0 Methods and apparatus for optimised interferometric scattering microscopy 未知
公开(公告)号：GB201914669D0
公开(公告)日：2019-11-27
申请号：GB201914669
申请日：2019-10-10
申请人： REFEYN LTD
摘要： The application discloses a method and apparatus for imaging a sample by interferometric scattering microscopy, the method comprising illuminating a sample with at least one coherent light source, the sample being held at a sample location comprising an interface having a refractive index change, detecting a backpropagating signal from the sample comprising light reflected at the interface and light scattered by the sample, splitting the backpropagating signal into first and second signals, passing at least one of the backpropagating, the first, and the second signals through a spatial filter, the spatial filter being configured to effect a reduction in intensity on incident radiation, the reduction in intensity being greater within a predetermined numerical aperture, directing the first and second signals onto first and second detectors to generate, respectively, first and second images and comparing, by a processor, the first and second images to determine one or more characteristics of the sample.

13. 发明专利

GB202211801D0 Improvements in or relating to an illumination device 未知
公开(公告)号：GB202211801D0
公开(公告)日：2022-09-28
申请号：GB202211801
申请日：2022-08-12
申请人： REFEYN LTD

14. 发明专利

GB202112523D0 Improvements in or relating to storage containers 未知
公开(公告)号：GB202112523D0
公开(公告)日：2021-10-20
申请号：GB202112523
申请日：2021-09-02
申请人： REFEYN LTD

15. 发明专利

GB202110264D0 Method 未知
公开(公告)号：GB202110264D0
公开(公告)日：2021-09-01
申请号：GB202110264
申请日：2021-07-16
申请人： REFEYN LTD

16. 发明专利

GB202100697D0 Refeyn Ltd 未知
公开(公告)号：GB202100697D0
公开(公告)日：2021-03-03
申请号：GB202100697
申请日：2021-01-19
申请人： REFEYN LTD

17. 发明专利

GB2593194B Methods and apparatus for optimised interferometric scattering microscopy 未知
公开(公告)号：GB2593194B
公开(公告)日：2022-09-07
申请号：GB202003946
申请日：2020-03-18
申请人： REFEYN LTD
发明人： JOSIAH KANE , MAX FELIX HANTKE , LEWIS CAMEY
IPC分类号： G02B21/14 , G01N15/14 , G02B21/36
摘要： A method of imaging a sample by interferometric scattering microscopy (IScat), the method comprising illuminating a sample with at least one light source, the sample being held at a sample location comprising a reflective surface, such that a reflected signal is formed; the reflected signal comprising light from the light source and light scattered by the sample; detecting the output light over a first time window for a first frame N1; detecting the output light over a second time window for a second frame N2; calculating a ratiometric signal R which is the ratio of N1 and N2 minus 1; estimating the ratiometric motion signature S = (Sx, Sy) from frames N1 and N2 with S defined as the ratiometric image which would be measured from an invariant sample moving along x and y for a given motion vector m = (mx, my); estimating m as the most consistent vector such that R is approximated using S and m;calculating the corrected ratiometric contrast image R* from R, S and m. An interferometric scattering microscope configured to carry out the method comprises a spatial filter positioned to filter the output light. Figure shows image where motion correction has been applied

18. 发明专利

GB2588378A Methods and apparatus for optimised interferometric scattering microscopy 未知
公开(公告)号：GB2588378A
公开(公告)日：2021-04-28
申请号：GB201914669
申请日：2019-10-10
申请人： REFEYN LTD , UNIV OXFORD INNOVATION LTD
发明人： MATTHIAS KARL FRANZ LANGHORST , DANIEL RICHARD COLE , DAVID JOHN LEHAR GRAHAM
IPC分类号： G01B9/02 , G01N21/00 , G01N21/01 , G02B21/14 , G02B21/18 , G02B21/36
摘要： The application discloses a method and apparatus for imaging a sample by interferometric scattering microscopy, the method comprising illuminating a sample with at least one coherent light source, the sample being held at a sample location comprising an interface having a refractive index change, detecting a backpropagating signal from the sample comprising light reflected at the interface and light scattered by the sample, splitting the backpropagating signal into first and second signals, passing at least one of the backpropagating, the first, and the second signals through a spatial filter, the spatial filter being configured to effect a reduction in intensity on incident radiation, the reduction in intensity being greater within a predetermined numerical aperture, directing the first and second signals onto first and second detectors to generate, respectively, first and second images and comparing, by a processor, the first and second images to determine one or more characteristics of the sample.

19. 发明专利

GB202003946D0 Methods and apparatus for optimised interferometric scattering microscopy 未知
公开(公告)号：GB202003946D0
公开(公告)日：2020-05-06
申请号：GB202003946
申请日：2020-03-18
申请人： REFEYN LTD
摘要： A method of imaging a sample by interferometric scattering microscopy (IScat), the method comprising illuminating a sample with at least one light source, the sample being held at a sample location comprising a reflective surface, such that a reflected signal is formed; the reflected signal comprising light from the light source and light scattered by the sample; detecting the output light over a first time window for a first frame N1; detecting the output light over a second time window for a second frame N2; calculating a ratiometric signal R which is the ratio of N1 and N2 minus 1; estimating the ratiometric motion signature S = (Sx, Sy) from frames N1 and N2 with S defined as the ratiometric image which would be measured from an invariant sample moving along x and y for a given motion vector m = (mx, my); estimating m as the most consistent vector such that R is approximated using S and m;calculating the corrected ratiometric contrast image R* from R, S and m. An interferometric scattering microscope configured to carry out the method comprises a spatial filter positioned to filter the output light. Figure shows image where motion correction has been applied

20. 发明公开

US20240192477A1 METHODS AND APPARATUS FOR CALCULATING AND MAINTAINING AN OPTIMAL SAMPLE POSITION IN AN INTERFEROMETRIC MICROSCOPE 审中-公开
公开(公告)号：US20240192477A1
公开(公告)日：2024-06-13
申请号：US18287813
申请日：2022-04-22
申请人： REFEYN LTD
发明人： Gavin YOUNG , Daniel COLE
IPC分类号： G02B21/26 , G02B21/00 , G02B21/24
CPC分类号： G02B21/26 , G02B21/0056 , G02B21/006 , G02B21/245
摘要： There is provided a method of calculating a temperature corrected sample position in an interferometric microscope, the method comprising projecting an autofocus beam onto the sample location to form a reflected ring of radiation, detecting an uncalibrated radius. R, of a peak of the annulus of the reflected ring which indicates an uncalibrated sample position, detecting one or more of the width of the annulus or an intensity of the annulus and calculating a calibrated radius Rnorm using at least one of the width of the annulus or the intensity of the annulus to determine the temperature dependent corrected sample position.

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