专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US09656067B2 Medical probe for electro-stimulation and training of pelvic floor musculature 有权
公开(公告)号：US09656067B2
公开(公告)日：2017-05-23
申请号：US14620277
申请日：2015-02-12
申请人： Publiekrechtelijke Rechtspersoon Academisch Ziekenhuis Leiden h.o.d.n. Leids Universitair Medisch Centrum
发明人： Robertus Coenraad Maria Pelger , Theodorus Johannes Ouwerkerk , Pieternella Johanna Voorham-Van Der Zalm
IPC分类号： A61N1/04 , A61N1/36 , A61B5/0488 , A61N1/05 , A63B23/20 , A61B5/00 , A61H19/00 , A61H21/00 , A61N1/08
CPC分类号： A61N1/36007 , A61B5/0488 , A61B5/04882 , A61B5/486 , A61H19/00 , A61H19/44 , A61H21/00 , A61H2205/085 , A61H2205/086 , A61H2230/605 , A61N1/0509 , A61N1/0512 , A61N1/0524 , A61N1/08 , A63B23/20
摘要： A probe system for electro-stimulation and bio-feedback training of muscles in the pelvic floor region, in particular for pelvic floor physiotherapy and diagnosis, includes a probe having a probe body which is insertable into a vagina or a rectum, and a plurality of electrodes which are positioned at several locations along the length and around the circumference on the outer surface of the probe, the probe system further includes a control unit, operationally coupled to the probe, adapted for receiving EMG signals from each of the electrodes and for processing each of the signals for mapping the response of the muscles in the pelvic floor region.

12. 发明授权

US07560105B1 Dendritic cells activated in the presence of glucocorticoid hormones are capable of suppressing antigen-specific T cell responses 失效
标题翻译：在糖皮质激素存在下活化的树突状细胞能够抑制抗原特异性T细胞应答
公开(公告)号：US07560105B1
公开(公告)日：2009-07-14
申请号：US09666430
申请日：2000-09-21
申请人： Delphine Gabrielle Josette Rea , Cornelis Johannes Maria Melief , Rienk Offringa
发明人： Delphine Gabrielle Josette Rea , Cornelis Johannes Maria Melief , Rienk Offringa
IPC分类号： A01N63/00 , A61K39/00 , A61K38/00 , C12N5/00 , C07K2/00
CPC分类号： C12N5/064 , A61K2035/122 , A61K2039/5154 , A61K2039/5158 , C12N2501/052 , C12N2501/22 , C12N2501/23 , C12N2501/39 , C12N2501/505 , C12N2501/52
摘要： The present invention provides novel methods for immunotherapy. The invention provides immune cells and methods to generate them, with the capacity to at least in part reduce an immune response in a host. In one aspect, the invention provides a method for generating a dendritic cell with the capacity to tolerize a T-cell for antigen the T-cell was specific for including culturing peripheral blood monocytes from an individual to differentiate into dendritic cells, activating the dendritic cells in the presence of a glucocorticoid hormone and loading the activated dendritic cell with the antigen the T-cell was specific for.
摘要翻译：本发明提供了新的免疫治疗方法。本发明提供免疫细胞和产生它们的方法，其能力至少部分地降低宿主中的免疫应答。一方面，本发明提供一种产生具有耐受T细胞抗原能力的树突状细胞的方法，所述T细胞特异性包括培养来自个体的外周血单核细胞以分化成树突状细胞，激活树突状细胞在存在糖皮质激素的情况下，用激活的树突状细胞与T细胞特异性的抗原负载。

13. 发明授权

US12059339B2 Arteriovenous graft system, arteriovenous valve device and method to implant an arteriovenous graft system 有权
公开(公告)号：US12059339B2
公开(公告)日：2024-08-13
申请号：US17275326
申请日：2019-09-11
申请人： Academisch Ziekenhuis Leiden h.o.d.n. Leids Universitair Medisch Centrum
发明人： Wouter Jan Geelhoed , Koen Elzert Adriaan van der Bogt , Joris Ivo Rotmans
IPC分类号： A61F2/07 , A61F2/24 , A61M1/36 , A61M39/22
CPC分类号： A61F2/07 , A61F2/2475 , A61M1/3655 , A61M39/228
摘要： A subcutaneous arteriovenous graft system includes an arteriovenous graft having an arterial end, a venous end opposite to the arterial end and an internal volume between the arterial end and the venous end, and a valve device that can be arranged in an open state, in which fluid flow through the graft is possible and a closed state in which the fluid flow through the arteriovenous graft is blocked. The valve device is constructed to decrease, in the closed state of the valve device, the internal volume of the complete graft to substantially zero.

14. 发明授权

US11246947B2 Recombinant AAV-crumbs homologue composition and methods for treating LCA-8 and progressive RP 有权
公开(公告)号：US11246947B2
公开(公告)日：2022-02-15
申请号：US14910302
申请日：2014-08-05
申请人： Academisch Ziekenhuis Leiden H.O.D.N. Leids Universitair Medisch Centrum
发明人： Jan Wijnholds , Lucie Pierrette Francoise Pellissier
IPC分类号： A61K48/00 , C07K14/47 , C12N15/86 , C12N15/864 , C07K14/705 , A61K35/76
摘要： The present invention relates to a Crumbs homologue (CRB) therapeutic for use as a medicament or in a method of treatment or prophylaxis, for example in the treatment or prophylaxis of a retinal disorder due to mutations in the Crumbs homologue-1 (CRB1) gene, such as Leber's congenital amaurosis 8 (LCA8) or retinitis pigmentosa 12 (RP12). In particular, the present invention relates to a recombinant viral vector comprising CRB2 or modified non-toxic forms of either CRB1 or CRB3 that resemble CRB2.

15. 发明授权

US08983627B2 Medical probe for electro-stimulation and bio-feedback training of pelvic floor musculature 有权
标题翻译：盆底肌肉电刺激和生物反馈训练的医学探针
公开(公告)号：US08983627B2
公开(公告)日：2015-03-17
申请号：US12302145
申请日：2007-05-23
申请人： Robertus Coenraad Maria Pelger , Theodorus Johannes Ouwerkerk , Pieternella Johanna Voorham-van der Zalm
发明人： Robertus Coenraad Maria Pelger , Theodorus Johannes Ouwerkerk , Pieternella Johanna Voorham-van der Zalm
IPC分类号： A61N1/04 , A61N1/05 , A61B5/0488 , A61N1/36 , A63B23/20 , A61B5/00 , A61H19/00 , A61H21/00 , A61N1/08
CPC分类号： A61N1/36007 , A61B5/0488 , A61B5/04882 , A61B5/486 , A61H19/00 , A61H19/44 , A61H21/00 , A61H2205/085 , A61H2205/086 , A61H2230/605 , A61N1/0509 , A61N1/0512 , A61N1/0524 , A61N1/08 , A63B23/20
摘要： A probe system for electro-stimulation and bio-feedback training of muscles in the pelvic floor region, in particular for pelvic floor physiotherapy and diagnosis, includes a probe having a probe body which is insertable into a vagina or a rectum, and a plurality of electrodes which are positioned at several locations along the length and around the circumference on the outer surface of the probe, the probe system further includes a control unit, operationally coupled to the probe, adapted for receiving EMG signals from each of the electrodes and for processing each of the signals for mapping the response of the muscles in the pelvic floor region.
摘要翻译：用于骨盆底部区域的肌肉的电刺激和生物反馈训练的探针系统，特别是用于盆底物理治疗和诊断的探针系统包括具有可插入阴道或直肠的探针体的探针，以及多个电极位于探头外表面上的长度和周围的多个位置处，探针系统还包括操作上耦合到探头的控制单元，适于从每个电极接收EMG信号并用于处理每个信号用于映射骨盆底部区域肌肉的反应。

16. 发明申请

US20220305102A1 TREATMENT OF HAEMATOLOGICAL MALIGNANCIES 有权
公开(公告)号：US20220305102A1
公开(公告)日：2022-09-29
申请号：US17744568
申请日：2022-05-13
申请人： ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LEIDS UNIVERSITAIR MEDISCH CENTRUM)
发明人： Marieke GRIFFIOEN , J. H. Frederik FALKENBURG
IPC分类号： A61K39/00 , C07K14/725 , C07K14/47 , C07K7/06 , C12N15/86 , A61P35/02
摘要： Novel nucleic acid sequences, vectors, modified cells, peptides and pharmaceutical compositions are provided that are useful in the treatment of human subjects having a ΔNPM1 positive haematological malignancy. Corresponding methods and uses are also provided.

17. 发明授权

US08012709B2 Method for determining if a subject having type II diabetes has a kidney disorder 有权
标题翻译：用于确定具有II型糖尿病的受试者是否具有肾脏疾病的方法
公开(公告)号：US08012709B2
公开(公告)日：2011-09-06
申请号：US12340994
申请日：2008-12-22
申请人： Johan Hendrikus Verheijen , Jan Roeland Occo Hanemaaijer , Michaela Diamant
发明人： Johan Hendrikus Verheijen , Jan Roeland Occo Hanemaaijer , Michaela Diamant
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , G01N33/573 , G01N2333/96486 , Y10S436/811 , Y10S530/834
摘要： The present invention relates to a method for determining if a subject having Type II diabetes has a kidney disorder by measuring the level of matrix metalloproteinase 8 (MMP-8) in the urine of a subject having Type II diabetes and comparing this level to a reference sample or a sample from a healthy subject and determining if the subject has a kidney disorder base on the presence of increased levels of MMP-8 in the urine compared to the reference values or reference sample.
摘要翻译：本发明涉及通过测量具有II型糖尿病的受试者的尿液中的基质金属蛋白酶8（MMP-8）的水平来确定具有II型糖尿病的受试者是否具有肾脏疾病的方法，并将该水平与参考来自健康受试者的样品或样品，并且与参考值或参考样品相比，基于尿液中MMP-8水平的增加，确定受试者是否患有肾脏疾病。

18. 发明申请

US20100278863A1 Reoviruses 审中-公开
标题翻译：呼肠病毒
公开(公告)号：US20100278863A1
公开(公告)日：2010-11-04
申请号：US12738814
申请日：2008-10-16
申请人： Robert Cornelis Hoeben , Diana Johanna Maria Van Den Wollenberg
发明人： Robert Cornelis Hoeben , Diana Johanna Maria Van Den Wollenberg
IPC分类号： A61K39/15 , C12N15/00 , C12N7/01 , A61K35/76 , A61P35/00 , A61P37/00
CPC分类号： C07K14/005 , A61K35/13 , A61K2039/525 , A61K2039/5256 , C07K2319/21 , C12N7/00 , C12N2720/12222 , C12N2720/12252 , C12N2740/15043 , C12N2810/00 , C12N2810/40
摘要： The present invention provides a reverse genetics system for viruses belonging to the Reoviridae (i.e. Reoviruses), various uses thereof, genetically modified Reoviruses, Reovirus selection/production and propagation systems, medicaments and vaccines.
摘要翻译：本发明提供了用于属于呼肠杆菌科（Reovirirus）的病毒的反向遗传学系统，其各种用途，遗传修饰的呼肠酵毒病毒，呼肠弧病毒选择/生产和繁殖系统，药物和疫苗。

19. 发明授权

US07482135B2 Proteolytic enzymes in urine as diagnostic parameters in diseases involving matrix remodelling 有权
标题翻译：尿中的蛋白水解酶作为涉及基质重塑的疾病的诊断参数
公开(公告)号：US07482135B2
公开(公告)日：2009-01-27
申请号：US10276520
申请日：2001-05-17
申请人： Johan Hendrikus Verheijen , Jan Roeland Occo Hanemaaijer , Michaela Diamant
发明人： Johan Hendrikus Verheijen , Jan Roeland Occo Hanemaaijer , Michaela Diamant
IPC分类号： C12Q1/37 , G01N33/20
CPC分类号： C12Q1/37 , G01N33/573 , G01N2333/96486 , Y10S436/811 , Y10S530/834
摘要： A method for determining whether a urine sample has been obtained from a subject suffering from a kidney disorder involving kidney damage. The method is based on determining the level of a proteolytic enzyme in urine from the subject. Sample and optionally comparing this level with a reference value. The proteolytic enzyme preferably is a matrix metalloproteases, in particular MMP-2 or MMP-9. The method is particularly suitable for subjects with a condition or disorder that is associated with an increased risk of kidney disorders, such as diabetes. The method may adavnatageously be applied for early detection of kidney damage, in particular when the subject does not yet show any sign of microalbuminuria. The method may also be applied to a subject undergoing dialysis for determining whether the subject is suffering from remodelling of the peritoneal membrane. Thus, the method is particularly suited for patients undergoing continuous ambulatory peritoneal dialysis.
摘要翻译：一种用于确定是否从患有涉及肾损伤的肾脏疾病的受试者获得尿样的方法。该方法基于确定来自受试者的尿液中蛋白水解酶的水平。采样并可选地将该级别与参考值进行比较。蛋白水解酶优选是基质金属蛋白酶，特别是MMP-2或MMP-9。该方法特别适用于与肾脏疾病风险增加（如糖尿病）相关的疾病或病症的受试者。该方法可以广泛应用于肾损伤的早期检测，特别是当受试者尚未显示微量白蛋白尿的任何迹象时。该方法还可以应用于经历透析以确定受试者是否患有腹膜的重塑的受试者。因此，该方法特别适用于经历连续不卧床腹膜透析的患者。

20. 发明申请

WO2021251824A1 MEANS AND METHODS FOR THE DIAGNOSIS, CLASSIFICATION AND/OR MONITORING OF PEDIATRIC TUMORS. 审中-公开
公开(公告)号：WO2021251824A1
公开(公告)日：2021-12-16
申请号：PCT/NL2021/050367
申请日：2021-06-09
申请人： STICHTING EUROFLOW , LEIDS UNIVERSITAIR MEDISCH CENTRUM , UNIVERSITY OF SALAMANCA
发明人： DE SA FERREIRA FACIO, Cristiane , DESSANTI BOTAFOGO GONÇALVES, Vitor , SOBRAL DA COSTA, Elaine , VAN DONGEN, Jacobus Johannes Maria , ORFAO DE MATOS CORREIA E VALE, José Alberto
IPC分类号： G01N33/574 , G01N2333/705 , G01N2800/38 , G01N33/57407
摘要： The invention relates to the field of medical diagnostics, in particular to methods and reagents for the detection and monitoring of pediatric tumors by multiparameter flow cytometry (MFC) using a single tube. Provided is a kit-of-parts for the flow cytometric detection of pediatric tumor cells, the kit comprising fluorochrome-conjugated antibodies directed against the cell surface markers CD45, CD56, GD2, CD99, CD8, EpCAM, CD4, smCD3, CD19 and CD271, the cytoplasmic marker cyCD3, and the nuclear marker(s) nuMyogenin and/or nuMyoD1, wherein (i) the antibodies against the markers CD99/CD8 are conjugated to the same fluorochrome and representing a first marker pair CD99/CD8; (ii) the antibodies against the markers EpCAM/CD4 are conjugated to the same fluorochrome and representing a second marker pair EpCAM/CD4; (ii) the antibody against CD271 is conjugated to the same fluorochrome as the antibody against either cyCD3 or smCD3 and representing a third marker pair CD271/cyCD3 or CD271/smCD3; wherein between the first, second and third marker pairs the fluorochromes are distinguishable; and wherein the antibodies against the cytoplasmic and the nuclear markers are physically separated from the antibodies against the cell surface markers.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式