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    • 11. 发明申请
    • METHOD FOR ABLATING A LAYER
    • 消除层的过程
    • WO2014023798A3
    • 2014-06-12
    • PCT/EP2013066623
    • 2013-08-08
    • FRAUNHOFER GES ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E V
    • NEKARDA JANBRAND ANDREAS
    • B23K26/36B23K26/40
    • B23K26/40B23K26/361B23K2203/172B23K2203/50
    • The invention relates to a method for ablating at least one layer (13) from a substrate (10), wherein laser radiation (210) from at least one first laser (21) acts on at least a sub-area (105) of the surface of the layer (13), wherein the first laser (21) produces pulsed laser radiation (210) having a pulse duration less than approximately 50 ns and at least one second light source (22) is used, which produces pulsed laser radiation (220) having a pulse duration greater than approximately 1 ns or contains a continuous-wave laser or emits incoherent radiation, wherein the light (210) of the first laser (21) hits at a time at which at least the sub-area (105) of the surface is in thermal equilibrium with the surroundings.
    • 本发明涉及一种用于在衬底(10),其激光辐射(210)的至少一个第一激光器(21)作用于该层的表面(13)的至少一个部分的表面(105)中的至少一个层(13)的消融, 其中,与小于约50毫微秒和至少一个第二光源(22)的脉冲持续时间产生的第一激光器(21)脉冲激光辐射(210)被用于产生脉冲激光辐射(220)具有大于大约1纳秒或的脉冲持续时间 包括连续波激光器或写unkohärente辐射,其中所述第一激光器(21)的光(210)入射到与周围环境热平衡一表面的时间在该至少表面部分(105)。
    • 14. 发明申请
    • METHOD AND MEANS FOR MULTISPECTRAL IMAGING
    • 多目标成像的方法和手段
    • WO2015185662A3
    • 2016-07-21
    • PCT/EP2015062448
    • 2015-06-03
    • FRAUNHOFER GES ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E V
    • DIMITRIADIS NIKOLASDELIOLANIS NIKOLAOS
    • G01N21/64A61B1/04A61B1/06A61B5/00G01J3/10G01J3/32G01J3/44G01N21/80G01N21/91
    • G01N21/6456A61B1/043A61B1/0638A61B3/14A61B5/0071A61B5/14551G01J3/10G01J3/32G01J3/4406G01J2003/102G01J2003/106G01N21/6428G01N21/80G01N21/91G01N2021/6417G01N2021/6439
    • The present invention relates to the multispectral imaging of samples, in particular of biological tissues. The invention further relates to a method for acquisition of fluorescence images and reflection images of an object (400) comprising the steps of alternatingly illuminating the object (400) with at least a first light and a second light, wherein the first light and the second light are spectrally shaped such that at least one light has several spectral regions of high light intensity separated by spectral region(s) of low light intensity, wherein the spectral regions of the first light and the second light with high intensity at least partially do not overlap and wherein at least one of the two lights has at least one region of low light intensity that is of longer wavelength to the neighboring region of high light intensity, and recording at least a first image of the object (400) and a second image of the object (400) while illuminating the object (400) with at least one of the lights wherein the light to be recorded as the first image is modified such, that at least one spectral region of high intensity of the second light is attenuated, and wherein the light to be recorded as the second image is modified such, that at least one spectral region of high intensity of the first light is attenuated.
    • 本发明涉及样品,特别是生物组织的多光谱成像。 本发明还涉及一种用于获取物体(400)的荧光图像和反射图像的方法,包括以下步骤:用至少第一光和第二光交替照射物体(400),其中第一光和第二光 光是光谱形状的,使得至少一个光具有由低光强度的光谱区域隔开的几个具有高光强度的光谱区域,其中第一光的光谱区域和具有高强度的第二光线至少部分地不 重叠,并且其中两个光中的至少一个具有至少一个低光强度的区域,其具有比相邻的高光强度区域更长的波长,并且记录至少对象(400)的第一图像和第二图像 (400)中的至少一个光照亮对象(400),其中要被记录为第一图像的光被修改为至少一个光谱reg 第二光的高强度的离子被衰减,并且其中要被记录为第二图像的光被修改为使得第一光的高强度的至少一个光谱区被衰减。
    • 16. 发明申请
    • VACCINE DEVELOPMENT AGAINST THE POULTRY RED MITE DERMANYSSUS GALLINAE
    • 疫苗的发展对家禽红M DER螨的影响
    • WO2016062832A2
    • 2016-04-28
    • PCT/EP2015074542
    • 2015-10-22
    • FRAUNHOFER GES ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E V
    • ULBERT SEBASTIANRODRIGUES MAKERT DOS SANTOS GUSTAVO
    • A61K39/00
    • C07K16/18A61K39/0003A61K2039/552A61K2039/55566C07K14/43531C07K2317/11C07K2317/23
    • The Poultry Red Mite (PRM) Dermanyssus gallinae causes high economic losses and is among the most devastating parasites in poultry farming world-wide. Different chemical, physical and biological strategies try to control the expansion of PRM. However, a solution to this problem still has highest priority. We present here an innovative method for the development of an immunological control strategy, based on the identification of mite protein antigens which elicit antibodies with anti-mite activity in the immunized chicken. Hens were immunized with different PRM protein extracts and IgY-antibodies were extracted from the eggs. A PRM in vitro feeding assay which used chicken blood spiked with these IgY enabled the detection of antibodies which caused PRM mortality. A novel combination of 2D-gel analysis and comparative analysis of antibody binding patterns followed by proteomic approaches led to the identification of candidate antigens responsible for the generation of such protective antibodies. These results show the high potential of this strategy for the development of a vaccine against the poultry mite Dermanyssus gallinae.
    • 家禽红螨(PRM)Dermanyssus gallinae引起高度经济损失,并且是世界范围内家禽养殖中最具破坏性的寄生虫。 不同的化学,物理和生物学策略试图控制PRM的扩展。 但是,解决这个问题仍然是最重要的。 我们在这里介绍了一种创新的免疫控制策略的开发方法,该方法基于鉴定在被免疫的鸡中引发具有抗螨活性的抗体的螨蛋白抗原。 用不同的PRM蛋白提取物免疫母鸡,并从卵中提取IgY抗体。 PRM体外进食测定使用掺入了这些IgY的鸡血来检测导致PRM死亡的抗体。 2D-凝胶分析和抗体结合模式的比较分析的新颖组合随后是蛋白质组学方法,导致鉴定负责产生此类保护性抗体的候选抗原。 这些结果表明这种策略在开发针对家禽螨Dermanyssus gallinae的疫苗方面具有很高的潜力。
    • 17. 发明申请
    • METHOD FOR LASER-PROCESSING A SURFACE BY REPOSITIONING THE SURFACE WITH RESPECT TO THE LASER SCANNER OR BY CONTROLLING A ENCODING INPUT FOR ROTATING A DEFLECTION OF THE LASER BEAM
    • 方法的激光加工使表面与重新定位的表面上激光扫描仪或控制编码器入口处分心的激光束的旋转
    • WO2015169544A3
    • 2016-03-24
    • PCT/EP2015057955
    • 2015-04-13
    • FRAUNHOFER GES ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E V
    • FLEMMER JOHNWILLENBORG EDGAR
    • B23K26/00B23K26/082B23K26/36G02B26/10
    • B23K26/0066B23K26/0006B23K26/082B23K26/36G02B26/105
    • The invention relates to a method for laser-processing a surface. A laser beam is guided over the surface by means of a laser scanner (3), and the surface is moved and/or rotated relative to the laser scanner (3) in a plurality of sequential repositioning processes. During each repositioning process, the laser beam is deflected by the laser scanner (3) along a directional path between a starting direction and an end direction over the surface. The surface is moved during each repositioning process at least in a positive acceleration phase, in which a speed of the surface relative to the laser scanner (3) is increased, and a negative acceleration phase, which is carried out after the positive acceleration phase and in which the speed of the surface relative to the laser scanner is reduced to zero. When the speed reaches zero during the negative acceleration phase before the laser beam has reached the end direction, the speed increase during the positive acceleration phase of the subsequent repositioning process begins at the point in time when the laser beam reaches the end direction, and when the speed reaches zero during the negative acceleration phase after the laser beam has reached the end position, the speed increase during the positive acceleration phase of the subsequent repositioning process begins immediately after the speed has reached zero.
    • 本发明涉及一种激光器的方法处理表面,其特征在于,使用激光扫描器(3)的激光束被引导在表面上和表面在多个相对连续Repositionierungsvorgänge到激光扫描仪移动(3)和/或旋转时,在每个Repositionierungsvorganges的 激光束由激光扫描器(3)沿起始方向和在表面上的最终方向,之间的方向路径偏转,其中,在以正加速度相,其中所述表面的速度相对于激光扫描仪增加至少每个Repositionierungsvorganges的表面上,和一个由 移动执行正加速阶段减速阶段,其中相对于激光扫描器的表面的速度(3)减少到零,并且其中,当在负加速阶段,速度 被indigkeit零实现的激光束已经到达最后的方向之前,启动在后续的Repositionierungsvorgangs到使激光束到达端方向上的时间的正加速阶段的速度增加,并且如果达到零速度在负加速度阶段的激光束之后 已经到达最终位置,在随后的Repositionierungsvorganges的正加速阶段的速度增加达到零速度后立即开始。