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11. 发明申请

WO2003057730A1 LIGAND FOR G-PROTEIN COUPLED RECEPTOR GPR43 AND USES THEREOF 审中-公开
标题翻译： G蛋白偶联受体GPR43的配体及其用途
公开(公告)号：WO2003057730A1
公开(公告)日：2003-07-17
申请号：PCT/EP2003/000042
申请日：2003-01-06
申请人： EUROSCREEN S.A.
发明人： LE POUL, Emmanuel , DETHEUX, Michel , BREZILLON, Stéphane , LANNOY, Vincent , PARMENTIER, Marc
IPC分类号： C07K14/705
CPC分类号： C07K14/70567 , A61K31/00 , A61K31/19 , C07K14/705 , G01N2333/726
摘要： The present invention is related to the G-protein coupled orphan receptor GPR43 and the identification of short chain fatty acids as natural ligands of the receptor. The invention further relates to assays for the identification of agents that modulate GPR43 ligand binding and signalling activity, as well as compositions consisting essentially of an isolated GPR43 polypeptide and an isolated short chain fatty acid. The invention also relates to diagnostic methods and kits that take advantage of the novel interaction of GPR43 with short chain fatty acids.
摘要翻译：本发明涉及G-蛋白偶联孤儿受体GPR43和作为受体天然配体的短链脂肪酸的鉴定。本发明还涉及用于鉴定调节GPR43配体结合和信号传导活性的试剂以及基本上由分离的GPR43多肽和分离的短链脂肪酸组成的组合物的测定。本发明还涉及利用GPR43与短链脂肪酸的新型相互作用的诊断方法和试剂盒。

12. 发明申请

WO2003014731A3 THE NATURAL LIGAND FOR ORPHAN G PROTEIN COUPLED RECEPTOR GPR86 AND METHODS OF USE 审中-公开
公开(公告)号：WO2003014731A3
公开(公告)日：2003-02-20
申请号：PCT/EP2002/008761
申请日：2002-08-06
申请人： EUROSCREEN S.A.
发明人： COMMUNI, Didier , SUAREZ, Nathalie , DETHEUX, Michel , BREZILLON, Stéphane , LANNOY, Vincent , PARMENTIER, Marc , BOEYNAEMS, Jean-Marie
IPC分类号： G01N33/48
摘要： The present invention is related to the G protein coupled receptor GPR86 (P2Y 13 ) and any homologous sequence thereto, recombinant cells comprising the nucleotide sequence encoding the receptor, and the identification of the natural ligand, ADP, and equivalent molecules to be used in screening assays for identification of agonists, inverse agonists or antagonist compounds useful for the development of new drugs and the improvement of various disease diagnostics. The present invention further relates to the identification of ATP, 2MeSATP, 2MeSADP, ADPβS, Ap3A, RB-2, Suramine and PPADS as modulators of GPR86 activity.

13. 发明申请

WO2015069459A1 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO2015069459A1
公开(公告)日：2015-05-14
申请号：PCT/US2014/061868
申请日：2014-10-23
申请人： NOVARTIS AG , EUROSCREEN S.A. , BASSILANA, Frederic , BAUMGARTEN, Birgit Uta , CARTE, Nathalie Marie-Therese , DETHEUX, Michel , FALCHETTO, Rocco , HANNEDOUCHE, Sébastien , LANNOY, Vincent , MANSFIELD, Keith , SEUWEN, Klaus Peter , SUPLY, Thomas
发明人： BASSILANA, Frederic , BAUMGARTEN, Birgit Uta , CARTE, Nathalie Marie-Therese , DETHEUX, Michel , FALCHETTO, Rocco , HANNEDOUCHE, Sébastien , LANNOY, Vincent , MANSFIELD, Keith , SEUWEN, Klaus Peter , SUPLY, Thomas
IPC分类号： G01N33/50 , A01K67/027
CPC分类号： G01N33/566 , C07K16/28 , G01N2333/4719
摘要： The present invention relates to modulators of the interaction between G-protein coupled receptor 15(GPR15) and c10orf99. The modulator maybe a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.
摘要翻译：本发明涉及G蛋白偶联受体15（GPR15）和c10orf99之间相互作用的调节剂。调节剂可能是一种小的化学分子，抗体或其他治疗性蛋白质。还描述了治疗方法和识别调节剂的方法。

14. 发明申请

WO2009010479A2 NOVEL HETEROCYCLIC METHYLENE PIPERIDINE DERIVATIVES AND THEIR USE 审中-公开
标题翻译：新型杂环甲基哌啶衍生物及其用途
公开(公告)号：WO2009010479A2
公开(公告)日：2009-01-22
申请号：PCT/EP2008/059138
申请日：2008-07-11
申请人： EUROSCREEN S.A. , HUCK, Jacques , OOMS, Frédéric , REGEREAU, Yannick
发明人： HUCK, Jacques , OOMS, Frédéric , REGEREAU, Yannick
IPC分类号： C07D413/06 , C07D401/06 , C07D413/14 , A61K31/4523 , A61K31/4525 , A61K31/454 , A61P1/00 , A61P17/00 , A61P19/00 , A61P31/00 , A61P35/00 , A61P11/00
CPC分类号： C07D413/06 , C07D401/06 , C07D413/14
摘要： The present invention is directed to compounds of formula (I) compositions comprising them and their use.
摘要翻译：本发明涉及包含它们的式（I）化合物及其用途。

15. 发明申请

WO2002075273A2 SCREENING, DIAGNOSTIC AND/OR DOSAGE METHOD AND DEVICE OF AN AGONIST AND/OR ANTAGONIST FOR A CALCIUM-COUPLED RECEPTOR 审中-公开
标题翻译：筛选，诊断和/或剂量方法和用于钙联合受体的激动剂和/或拮抗剂的装置
公开(公告)号：WO2002075273A2
公开(公告)日：2002-09-26
申请号：PCT/EP2002/003121
申请日：2002-03-20
申请人： EUROSCREEN S.A. , DUPRIEZ, Vincent , PARMENTIER, Marc
发明人： DUPRIEZ, Vincent , PARMENTIER, Marc
IPC分类号： G01N
CPC分类号： G01N33/5091 , C07K14/705 , G01N33/5008 , G01N33/502 , G01N2333/726
摘要： The present invention relates to a screening, diagnostic and/or dosage method of a known or unknown agonist (full agonist or partial agonist) and/or a known or unknown antagonist (neutral antagonist or inverse agonist) for a calcium-coupled receptor, comprising following steps:incubating one or more cells expressing apoaequorin and said calcium-coupled receptor with "coelenterazine i" having the formula as depicted in Figure 3 or a derivative thereof, in order to reconstitute active aequorin by said cells; contacting said cell(s) with the agonist and/or antagonist of said receptor on a solid support, and,measuring light emitted by said cell(s), allowing the screening, diagnosis and/or dosage of said agonist and/or antagonist of said receptor, and, possibly, recovering said agonist or antagonist of said receptor from the reaction mixture. The present invention also relates to a corresponding device allowing the performance of said method and to the agonist and/or antagonist of said calcium-coupled receptor identified by said method and device.
摘要翻译：本发明涉及用于钙偶联受体的已知或未知的激动剂（全激动剂或部分激动剂）和/或已知或未知的拮抗剂（中性拮抗剂或反向激动剂）的筛选，诊断和/或剂量方法，包括以下步骤：将一种或多种表达载脂蛋白和所述钙偶联受体的细胞与具有如图3所示的配方或其衍生物的“肠培养液i”一起孵育，以便由所述细胞重建活性水母发光蛋白; 使所述细胞与所述受体的激动剂和/或拮抗剂在固体支持物上接触，以及测量由所述细胞发射的光，允许所述激动剂和/或拮抗剂的筛选，诊断和/或剂量所述受体，并且可能从所述反应混合物中回收所述受体的所述激动剂或拮抗剂。本发明还涉及允许所述方法和由所述方法和装置鉴定的所述钙偶联受体的激动剂和/或拮抗剂的表现的相应装置。

16. 发明申请

US20130023530A1 NOVEL NK-3 RECEPTOR SELECTIVE ANTAGONIST COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN NK-3 RECEPTORS MEDIATED DISORDERS 有权
公开(公告)号：US20130023530A1
公开(公告)日：2013-01-24
申请号：US13627091
申请日：2012-09-26
申请人： Euroscreen S.A.
发明人： Hamid R. Hoveyda , Marie-Odile Roy , Graeme Lovat Fraser , Guillaume Dutheuil
IPC分类号： C07D487/04 , A61K31/5377 , A61K31/506 , A61K31/501 , A61P25/24 , A61P25/22 , A61P25/18 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P25/08 , A61P3/04 , A61P1/00 , A61P1/08 , A61P15/00 , A61P11/00 , A61P11/06 , A61P11/08 , A61P11/10 , A61P5/24 , A61P13/08 , A61P35/04 , A61P35/00 , A61P17/10 , A61P17/14 , A61P15/08 , A61K31/4985
CPC分类号： C07D487/04 , A61K31/407 , A61K31/4985
摘要： The present invention is directed to novel compounds of formula I and their use as therapeutic compounds.

17. 发明授权

US07858755B2 Monoclonal antibodies that bind Chemerin polypeptide 有权
标题翻译：结合Chemerin多肽的单克隆抗体
公开(公告)号：US07858755B2
公开(公告)日：2010-12-28
申请号：US10893485
申请日：2004-07-16
申请人： Valerie Wittamer , Jean-François Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franssen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel LePoul , Cecile Loison , Frédéric Ooms
发明人： Valerie Wittamer , Jean-François Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franssen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel LePoul , Cecile Loison , Frédéric Ooms
IPC分类号： C07K16/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4702 , C07K14/575 , C07K16/18 , C07K16/28 , G01N33/74 , G01N2500/02
摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
摘要翻译：本发明涉及G蛋白偶联受体及其新型配体。本发明提供了用于鉴定调节G蛋白偶联受体活性的候选化合物的筛选试验，以及用于诊断和治疗与G蛋白偶联受体信号传导调节异常有关的疾病或病症的测定法。

18. 发明申请

US20090048291A1 Novel Piperidine-4-Acetic Acid Derivatives and Their Use 审中-公开
标题翻译：新型哌啶-4-乙酸衍生物及其用途
公开(公告)号：US20090048291A1
公开(公告)日：2009-02-19
申请号：US12185475
申请日：2008-08-04
申请人： Jacques Huck , Frederic Ooms , Julien Parcq , Regereau Yannick , Hamid R. Hoveyda , Guillaume Dutheuil
发明人： Jacques Huck , Frederic Ooms , Julien Parcq , Regereau Yannick , Hamid R. Hoveyda , Guillaume Dutheuil
IPC分类号： A61K31/439 , C07D211/34 , A61K31/445 , A61K31/4545 , A61P31/18 , A61P29/00 , C07D401/12 , C07D453/02
CPC分类号： A61K31/445 , A61K31/4468 , A61K31/453 , A61K31/4535 , A61K31/4545 , C07D211/34 , C07D401/12 , C07D413/12 , C07D451/02 , Y02A50/411
摘要： The present invention is directed to compounds of formula I compositions comprising them and their use.
摘要翻译：本发明涉及包含它们的式I化合物及其用途。

19. 发明授权

US07094546B2 Inhibitors of the inositol polyphosphate 5-phosphatase SHIP2 molecule 有权
公开(公告)号：US07094546B2
公开(公告)日：2006-08-22
申请号：US10742431
申请日：2003-12-19
申请人： Christopher Erneux , Stephane Schurmans
发明人： Christopher Erneux , Stephane Schurmans
IPC分类号： C12Q1/68 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： A61K31/683 , A61K31/35 , A61K33/24
摘要： The present invention is related to an inhibitor of the inositol polyphosphate 5-phosphatase SHIP2 protein or its encoding nucleotide sequence identified by SEQ ID NO. 1 or of SHIP2 mRNA expression. The present invention is also related to a pharmaceutical composition comprising said inhibitor and an adequate pharmaceutically acceptable carrier or diluent and to a non-human knock-out mammal comprising homozygously or heterozygously a partial or total deletion in its genome of the inositol polyphoshate 5-phosphatase SHIP2 nucleotide sequence.

20. 发明申请

US20060024750A1 Compositions and methods comprising a ligand of Chemerin R 有权
标题翻译：包含Chemerin R的配体的组合物和方法
公开(公告)号：US20060024750A1
公开(公告)日：2006-02-02
申请号：US11134811
申请日：2005-05-20
申请人： Valeria Wittamer , J.F. Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul
发明人： Valeria Wittamer , J.F. Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul
IPC分类号： G01N33/53
CPC分类号： G01N33/74 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/575 , C07K16/18 , C07K16/28 , C07K2317/34 , G01N2500/02
摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
摘要翻译：本发明涉及G蛋白偶联受体及其新型配体。本发明提供了用于鉴定调节G蛋白偶联受体的活性的候选化合物的screeing测定法，以及可用于诊断和治疗与G蛋白偶联受体信号传导调节异常相关的疾病或病症的测定法。

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