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11. 发明申请

US20080125369A1 SOLUBLE T CELL RECEPTORS 审中-公开
标题翻译：可溶性细胞受体
公开(公告)号：US20080125369A1
公开(公告)日：2008-05-29
申请号：US11926480
申请日：2007-10-29
申请人： Bent Karsten Jakobsen , Meir Glick
发明人： Bent Karsten Jakobsen , Meir Glick
IPC分类号： A61K38/17 , C07K14/435
CPC分类号： C07K14/7051 , A61K38/00
摘要： The present invention provides a soluble T cell receptor (sTCR), which comprises (i) all or part of a TCRα chain, except the transmembrane domain thereof, and (ii) all or part of a TCR β chain, except the transmembrane domain thereof. (i) and (ii) each comprise a functional variable domain and at least a part of the constant domain of the TCR chain, and are linked by a disulphide bond between constant domain residues which is not present in native TCR.
摘要翻译：本发明提供了一种可溶性T细胞受体（sTCR），其包含（i）TCRα链全部或部分，除了其跨膜结构域外，和（ii）全部或部分TCRβ链，除了其跨膜结构域。（i）和（ii）各自包含功能可变结构域和TCR链的恒定结构域的至少一部分，并且通过在天然TCR中不存在的恒定结构域残基之间的二硫键连接。

12. 发明申请

US20070021428A1 Immunomodulating heterocyclic compounds 有权
公开(公告)号：US20070021428A1
公开(公告)日：2007-01-25
申请号：US10547448
申请日：2004-03-10
申请人： Ian Matthews
发明人： Ian Matthews
IPC分类号： A61K31/503 , C07D487/02
CPC分类号： C07D487/04 , C07D519/00
摘要： Compounds of formula (I) are inhibitors of CD80 and useful in immunomodulation therapy: wherein R1 and R3 independently represent H; F; CI; Br; —NO2; —CN; C1-C6 alkyl optionally substituted by F or Cl; or C1-C6 alkoxy optionally substituted by F; R4 represents a carboxylic acid group (—COOH) or an ester thereof, or —C(═O)NR6R7, —NR7C(═O)R6, —NR7C(═O)OR6, —NHC(═O)NR7R6 or —NHC(═S)NR7R6 wherein R6 represents H, or a radical of formula -(Alk)m-Q wherein m is 0 or 1, Alk is an optionally substituted divalent straight or branched C1-C12 alkylene, or C2-C12 alkenylene, or C2-C12 alkynylene radical or a divalent C3-C12 carbocyclic radical, any of which radicals may contain one or more —O—, —S— or —N(R8)— links wherein R8, represents H or C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, or C3-C6 cycloalkyl, and Q represents H; —NR9R10 wherein R9 and R10 independently represents H; C1-C4 alkyl; C3-C4 alkenyl; C3-C4 alkynyl; C3-C6 cycloalkyl; an ester group; an optionally substituted carbocyclic or heterocyclic group; or R9 and R10 form a ring when taken together with the nitrogen to which they are attached, which ring is optionally substituted; and R7 represents H or C1-C6 alkyl; or when taken together with the atom or atoms to which they are attached R6 and R7 form an optionally substituted monocyclic heterocyclic ring having 5, 6 or 7 ring atoms; and X represents a bond or a divalent radical of formula —(Z)n-(Alk)- or -(Alk)-(Z)n— wherein Z represents —O—, —S— or —NH—, Alk is as defined in relation to R6, and n is 0 or 1.

13. 发明申请

US20060155115A1 Multivalent T cell receptor complexes 审中-公开
公开(公告)号：US20060155115A1
公开(公告)日：2006-07-13
申请号：US11321894
申请日：2005-12-29
申请人： Bent Jakobsen , Jonathan Boulter
发明人： Bent Jakobsen , Jonathan Boulter
IPC分类号： C07K14/74
CPC分类号： G01N33/56977 , A61K38/00 , A61K47/6425 , C07K14/7051 , C07K19/00 , C07K2319/00 , C07K2319/02
摘要： The present invention relates to a synthetic multivalent T cell receptor complex for binding to a MHC-peptide complex, which multivalent T cell receptor complex comprises a plurality of T cell receptors specific for the MHC-peptide complex. It is preferred that the T cell receptors are refolded recombinant soluble T cell receptors. The synthetic multivalent T cell receptor complex can be used for delivering therapeutic agents or for detecting MHC-peptide complexes, and methods for such uses are also provided.

14. 发明申请

WO2003020763A3 SOLUBLE T CELL RECEPTOR 审中-公开
公开(公告)号：WO2003020763A3
公开(公告)日：2003-03-13
申请号：PCT/GB2002/003986
申请日：2002-08-30
申请人： AVIDEX LIMITED , JAKOBSEN, Bent, Karsten , GLICK, Meir
发明人： JAKOBSEN, Bent, Karsten , GLICK, Meir
IPC分类号： C07K14/725
摘要： The present invention provides a soluble T cell receptor (sTCR), which comprises (i) all for part of a TCR α chain, except the transmembrane domain thereof, and (ii) all or part of a TCR β chain, except the transmembrane domain thereof. (i) and (ii) each comprise a functional variable domain and at least a part of the constant domain of the TCR chain, and are linked by a disulphide bond between constant domain residues which is not present in native TCR.

15. 发明申请

WO2003016905A2 METHODS 审中-公开
标题翻译：方法
公开(公告)号：WO2003016905A2
公开(公告)日：2003-02-27
申请号：PCT/GB2002/003753
申请日：2002-08-15
申请人： AVIDEX LIMITED , JAKOBSEN, Bent, Karsten
发明人： JAKOBSEN, Bent, Karsten
IPC分类号： G01N33/53
CPC分类号： G01N33/505
摘要： The present invention provides a method for determining whether a T cell reacts with a predetermined Major Histocompatibility Complex (MHC) type. In the method, a sample comprising said T cell is brought into contat with a plurality of molecules of said MHC type, each MHC molecule being complexed with a peptide antigen whose contribution to a T cell receptor binding the MHC-peptide antigen complex is minimised. Whether said plurality of MHC molecules causes activation of the T cell is then determined. The method can assess allo-specific T cell activity, and may be used in matching transplant and donor patients, as well as in monitoring alloreactive responses following a transplant operation.
摘要翻译：本发明提供了一种用于确定T细胞是否与预定的主要组织相容性复合物（MHC）类型反应的方法。在该方法中，将包含所述T细胞的样品与多个所述MHC类型的分子连接，每个MHC分子与肽抗原复合，其对结合MHC-肽抗原复合物的T细胞受体的贡献最小化。然后确定所述多个MHC分子是否导致T细胞的激活。该方法可以评估异体特异性T细胞活性，并且可用于匹配移植和供体患者，以及在移植手术后监测同种异体反应性反应。

16. 发明申请

WO2002102840A2 SUBSTANCES 审中-公开
标题翻译：物质
公开(公告)号：WO2002102840A2
公开(公告)日：2002-12-27
申请号：PCT/GB2002/002866
申请日：2002-06-19
申请人： AVIDEX LIMITED , JAKOBSEN, Bent, Karsten , BOULTER, Jonathan, Michael
发明人： JAKOBSEN, Bent, Karsten , BOULTER, Jonathan, Michael
IPC分类号： C07K14/00
CPC分类号： C07K14/70539 , A61K48/00
摘要： The present invention provides a multimers of class I Major Histocompatibility Complexes (MHCs) having a modified P2-microglobulin whose binding to CD8 is inhibited. Such MHCs are capable of inhibiting CD8 + T cell response, particularly by inducing apoptosis or anergy of the T cell. The invention also provides nucleic acids encoding such molecules, and the use of such multimers and nucleic acids in immunosuppressive therapy, in particular as inhibitors of cytotoxic T cell responses.
摘要翻译：本发明提供具有与CD8结合被抑制的经修饰的P2-微球蛋白的I类主要组织相容性复合物（MHC）的多聚体。这样的MHC能够抑制CD8 + T细胞反应，特别是通过诱导T细胞的凋亡或无反应性。本发明还提供了编码这种分子的核酸，以及这些多聚体和核酸在免疫抑制治疗中的用途，特别是作为细胞毒性T细胞应答的抑制剂。

17. 发明申请

WO2003020763A2 SUBSTANCES 审中-公开
标题翻译：可溶性细胞受体
公开(公告)号：WO2003020763A2
公开(公告)日：2003-03-13
申请号：PCT/GB2002/003986
申请日：2002-08-30
申请人： AVIDEX LIMITED , JAKOBSEN, Bent, Karsten , GLICK, Meir
发明人： JAKOBSEN, Bent, Karsten , GLICK, Meir
IPC分类号： C07K14/705
CPC分类号： C07K14/7051 , A61K38/00
摘要： The present invention provides a soluble T cell receptor (sTCR), which comprises (i) all for part of a TCR α chain, except the transmembrane domain thereof, and (ii) all or part of a TCR β chain, except the transmembrane domain thereof. (i) and (ii) each comprise a functional variable domain and at least a part of the constant domain of the TCR chain, and are linked by a disulphide bond between constant domain residues which is not present in native TCR.
摘要翻译：本发明提供了一种可溶性T细胞受体（sTCR），其包含（i）部分TCRα链，除了其跨膜结构域外，和（ii）全部或部分TCRβ链，除了跨膜结构域它们。（i）和（ii）各自包含功能可变结构域和TCR链的恒定结构域的至少一部分，并且通过在天然TCR中不存在的恒定结构域残基之间的二硫键连接。

18. 发明申请

WO2006016093A1 IMMUNOMODULATING OXOPYRRAZOLOCINNOLINES AS CD80 INHIBITORS 审中-公开
标题翻译：作为CD80抑制剂免疫调节氧化吡咯烷
公开(公告)号：WO2006016093A1
公开(公告)日：2006-02-16
申请号：PCT/GB2004/003422
申请日：2004-08-09
申请人： AVIDEX LIMITED , MATTHEWS, Ian, Richard
发明人： MATTHEWS, Ian, Richard
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： N-(l-Aza-bicyclo[2.2.2]oct-3-yI)-4-(6,9-difluoro-3-oxo-1,3-dihydro-pyrazolo[4,3clcinnolin-2-yI)-benzamide is a CD80 antagonist, useful in the treatment of diseases which benefit from immuno-inhibition.
摘要翻译： N-（1-氮杂 - 二环[2.2.2]辛-3-基）-4-（6,9-二氟-3-氧代-1,3-二氢 - 吡唑并[4,3clcinnolin -2-基） - 苯甲酰胺是可用于治疗受益于免疫抑制的疾病的CD80拮抗剂。

19. 发明申请

WO2004081011A1 IMMUNOMODULATING HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：免疫调节杂环化合物
公开(公告)号：WO2004081011A1
公开(公告)日：2004-09-23
申请号：PCT/GB2004/001008
申请日：2004-03-10
申请人： AVIDEX LIMITED , MATHEWS, Ian, Richard
发明人： MATHEWS, Ian, Richard
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D519/00
摘要： Compounds of formula (I) are inhibitors of CD80 and useful in immunomodulation therapy: wherein R 1 and R 3 independently represent H; F; CI; Br; -NO 2 ; -CN; C 1 -C 6 alkyl optionally substituted by F or Cl; or C 1 -C 6 alkoxy optionally substituted by F; R 4 represents a carboxylic acid group (-COOH) or an ester thereof, or -C(=O)NR 6 R 7 , -NR 7 C(=O)R 6 , -NR 7 C(=O)OR 6 , -NHC(=O)NR 7 R 6 or -NHC(=S)NR 7 R 6 wherein R 6 represents H, or a radical of formula - (Alk) m -Q wherein m is 0 or 1, Alk is an optionally substituted divalent straight or branched C 1 -C 12 alkylene, or C 2 -C 12 alkenylene, or C 2 -C 12 alkynylene radical or a divalent C 3 -C 12 carbocyclic radical, any of which radicals may contain one or more -O-, -S- or -N(R 8 )- links wherein R 8 represents H or C 1 -C 4 alkyl, C 3- C 4 alkenyl, C 3 -C 4 alkynyl, or C 3 -C 6 cycloalkyl, and Q represents H; -NR 9 R 10 wherein R 9 and R 10 independently represents H; C 1 -C 4 alkyl; C 3 -C 4 alkenyl; C 3 -C 4 alkynyl; C 3 -C 6 cycloalkyl; an ester group; an optionally substituted carbocyclic or heterocyclic group; or R 9 and R 10 form a ring when taken together with the nitrogen to which they are attached, which ring is optionally substituted; and R 7 represents H or C 1 -C 6 alkyl; or when taken together with the atom or atoms to which they are attached R 6 and R 7 form an optionally substituted monocyclic heterocyclic ring having 5, 6 or 7 ring atoms; and X represents a bond or a divalent radical of formula - (Z) n -(Alk)- or - (Alk)-(Z) n - wherein Z represents -O-, -S- or -NH-, Alk is as defined in relation to R 6 and n is 0 or 1.
摘要翻译：式（I）化合物是CD80的抑制剂，可用于免疫调节治疗：其中R1和R3独立地表示H; F; CI; BR; NO 2; -CN; 任选被F或Cl取代的C 1 -C 6烷基; 或任选被F取代的C 1 -C 6烷氧基; 或-C（= O）NR 6 R 7，-NR 7 C（= O）R 6，-NR 7 C（= O）OR 6，-NHC（= O）NR 7 R 6或-NHC （= S）NR 7 R 6，其中R 6表示H，或式 - （Alk）mQ基团，其中m为0或1，Alk为任选取代的二价直链或支链C 1 -C 12亚烷基或C 2 -C 12亚烯基， C 12亚炔基或二价C 3 -C 12碳环基团，其中任何基团可以含有一个或多个-O - ， - S-或-N（R 8） - 键，其中R 8表示H或C 1 -C 4烷基，C 3 -C 4烯基，C 3 -C 4炔基或C 3 -C 6环烷基，Q表示H; -NR 9 R 10，其中R 9和R 10独立地表示H; C 1 -C 4烷基; C3-C4烯基; C3-C4炔基; C3-C6环烷基; 酯基; 任选取代的碳环或杂环基; 当与它们所连接的氮一起取代时，R 9和R 10形成环，该环任选被取代; 并且R 7表示H或C 1 -C 6烷基; 或者当与它们所连接的原子或原子一起时，R6和R7形成任选取代的具有5,6或7个环原子的单环杂环; 并且X表示式 - （Z）n-（Alk） - 或 - （Alk） - （Z）n-的键或二价基团，其中Z表示-O - ， - S-或-NH-，Alk为关于R6定义，n为0或1。

20. 发明申请

WO2004044004A3 T CELL RECEPTOR DISPLAY 审中-公开
公开(公告)号：WO2004044004A3
公开(公告)日：2004-05-27
申请号：PCT/GB2003/004636
申请日：2003-10-30
申请人： AVIDEX LIMITED , JAKOBSEN, Bent, Karsten , ANDERSEN, Torben, Bent , MOLLOY, Peter, Eamon , LI, Yi , BOULTER, Jonathan, Michael
发明人： JAKOBSEN, Bent, Karsten , ANDERSEN, Torben, Bent , MOLLOY, Peter, Eamon , LI, Yi , BOULTER, Jonathan, Michael
IPC分类号： C07K14/705
摘要： A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identificaton of high affinity TCRs. Several high affinities are disclosed.

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