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11. 发明授权

US07312198B2 Protein compositions for promoting wound healing and skin regeneration 有权
公开(公告)号：US07312198B2
公开(公告)日：2007-12-25
申请号：US11430574
申请日：2006-05-09
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K38/00 , C07K14/00 , C12N9/00
CPC分类号： A61K38/1741 , A61K38/40 , A61K38/465 , A61K38/57 , C12Y301/03001 , A61K2300/00
摘要： Methods for stimulating proliferation and inhibiting death of cells in the epidermis and dermis of wounded and non-wounded as well as transplanted mammalian skin and transplanted skin cell suspensions are described. The methods include the steps of administering to an area of wounded or non-wounded skin therapeutically effective amounts of α1-antitrypsin, alkaline phosphatase (such as placental alkaline phosphatase), transferrin, and α1-acid glycoprotein in compositions that contain at least two of these proteins, or their active derivatives, as the major active components. The compositions can be administered topically and/or by injection, or both. The invention also provides regimens for restoring or maintaining the strength and thickness of wounded, non-wounded and transplanted skin as well as developing new skin from skin cell suspensions comprising periodically administering one or more compositions topically and/or by injection.

12. 发明申请

US20070010427A1 Use of one or more metal carriers to selectively kill mammalian cells 失效
标题翻译：使用一种或多种金属载体来选择性地杀死哺乳动物细胞
公开(公告)号：US20070010427A1
公开(公告)日：2007-01-11
申请号：US11472763
申请日：2006-06-22
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K38/16
CPC分类号： A61K38/16 , A61K33/24 , A61K33/30 , A61K47/547 , A61K47/665 , A61K47/6929 , B82Y5/00 , A61K2300/00
摘要： Compositions and methods for decreasing the viability of cells, particularly aberrant non-healthy cells, and most particularly cancer cells, are disclosed. The primary agent that causes cell death is a toxic metal atom or ion. Embodiments of the invention provide compositions and methods to ensure that the toxic metal is directed to the desired cell or tissue. In one embodiment, the metal is bound to a sulfur-rich peptide or protein carrier containing a targeting moiety. Such metal-protein complex is targeted to the selected cells or tissues to enrich the cell or tissue site with the metal-containing peptide or protein molecules followed by administering a dithiocarbonyl which carries the metal from the protein inside the cells to induce cell death.
摘要翻译：公开了用于降低细胞，特别是异常非健康细胞，特别是癌细胞活力的组合物和方法。造成细胞死亡的主要原因是毒性金属原子或离子。本发明的实施方案提供了确保有毒金属被引导到期望的细胞或组织的组合物和方法。在一个实施方案中，金属与含有靶向部分的富含硫的肽或蛋白载体结合。这样的金属蛋白复合物被靶向所选择的细胞或组织，以用含金属的肽或蛋白质分子富集细胞或组织部位，然后施用携带来自细胞内的蛋白质的金属的二硫代羰基以诱导细胞死亡。

13. 发明授权

US4657668A Apparatus for the separation of slurry with different grain size into two phases in a tank 失效
标题翻译：用于将不同粒度的浆料分离成两相的装置
公开(公告)号：US4657668A
公开(公告)日：1987-04-14
申请号：US704733
申请日：1985-02-25
申请人： Jozsef Harsanyi , Zoltan Kiss , Ferenc Kukonya , Janos Pinter , Alajos Suri , Andras Toth
发明人： Jozsef Harsanyi , Zoltan Kiss , Ferenc Kukonya , Janos Pinter , Alajos Suri , Andras Toth
IPC分类号： B01D21/34 , B03B5/60 , B03B5/62 , B03B5/64
CPC分类号： B03B5/60 , B03B5/62
摘要： An apparatus for separating a slurry into phases containing larger and smaller grains has an upright tank in which a plurality of downwardly extending inlet pipes open at their lower ends between outlets for the coarse and fine phases located at the bottom and top of the tank, respectively. At the lower end of each inlet pipe, an upwardly widening frustoconical cup is provided with a bottom confronting the open end of the inlet pipe to deflect the slurry upwardly and outwardly. Within the cup swirl vanes impart a swirl to the slurry.
摘要翻译：用于将浆料分离成含有较大和较小颗粒的相的装置具有立式罐，其中多个向下延伸的入口管分别在位于罐的底部和顶部处的粗和细相的出口处的下端开口。在每个入口管的下端，向上变宽的截头圆锥杯设置有与入口管的开口端相对的底部，以使浆料向上和向外偏转。在杯内，涡流叶片给浆料带来漩涡。

14. 发明授权

US08603464B2 Alkaline phosphatase to reduce weight gain or induce weight loss 有权
标题翻译：碱性磷酸酶可减轻体重增加或引起体重减轻
公开(公告)号：US08603464B2
公开(公告)日：2013-12-10
申请号：US12948146
申请日：2010-11-17
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K38/46
CPC分类号： C12N9/16 , A61K9/127 , A61K31/00 , A61K38/00 , A61K38/28 , A61K45/06 , C12Y301/03001 , A61K2300/00
摘要： The present invention provides methods for using human placental alkaline phosphatase or an active derivative to reduce blood glucose level in a mammal. Treatment regimens provided by the invention may be used to control Type 1 and Type 2 forms of diabetes in humans. The methods and treatment regimens may be effective to maintain the human's blood glucose level below about 10 mM, and preferably within the normal range of 4 mM to 7 mM. The methods and treatment regimens may be used in combination with administration of known anti-diabetic medicaments. Also provided by the invention is a method for inducing weight loss or reducing an expected weight gain caused by or associated with obesity or Type 2 diabetes. The invention further provides a preparation for administration to a human, the preparation comprising homogeneous purified human placental alkaline phosphatase in a physiologically acceptable carrier.
摘要翻译：本发明提供使用人胎盘碱性磷酸酶或活性衍生物降低哺乳动物血糖水平的方法。本发明提供的治疗方案可用于控制人类1型和2型糖尿病。方法和治疗方案可能有效地将人的血糖水平维持在低于约10mM，优选在4mM至7mM的正常范围内。方法和治疗方案可以与已知的抗糖尿病药物的给药组合使用。本发明还提供了一种诱导体重减轻或减少由肥胖或2型糖尿病引起或与之相关的预期体重增加的方法。本发明还提供了一种用于给予人的制剂，所述制剂包含在生理上可接受的载体中的均质纯化的人胎盘碱性磷酸酶。

15. 发明授权

US08460654B2 Use of alkaline phosphatase to maintain healthy tissue mass in mammals 有权
标题翻译：使用碱性磷酸酶维持哺乳动物的健康组织
公开(公告)号：US08460654B2
公开(公告)日：2013-06-11
申请号：US12715976
申请日：2010-03-02
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K38/46
CPC分类号： A61K38/465 , C12Y301/03001
摘要： Embodiments of the present invention relate to the use of placental alkaline phosphatase, and other members of the alkaline phosphatase family, to enhance protein synthesis in the muscle as well as the survival of non-cancerous differentiated cells in the muscle, adipose and other tissues. The ability of alkaline phosphatase to selectively enhance the survival of healthy cells and increase protein synthesis has many therapeutic applications. The use of alkaline phosphatase may prevent the loss of body weight and muscle mass typically experienced by diseased (such as cancer) or aging patients, or developing fetuses subjected to harmful conditions, or by patients who are treated with a toxic therapy including chemotherapy.
摘要翻译：本发明的实施方案涉及使用胎盘碱性磷酸酶和碱性磷酸酶家族的其它成员来增强肌肉中的蛋白质合成以及肌肉，脂肪和其它组织中非癌分化细胞的存活。碱性磷酸酶选择性增强健康细胞存活和增加蛋白质合成的能力有很多治疗应用。碱性磷酸酶的使用可以防止患病（例如癌症）或老化患者或发展中的有胎儿患有体重和肌肉量的损失，或通过包括化疗在内的有毒疗法治疗的患者。

16. 发明授权

US07858085B2 Alkaline phosphatase to control diabetes 有权
标题翻译：碱性磷酸酶控制糖尿病
公开(公告)号：US07858085B2
公开(公告)日：2010-12-28
申请号：US12361310
申请日：2009-01-28
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K38/46
CPC分类号： C12N9/16 , A61K9/127 , A61K31/00 , A61K38/00 , A61K38/28 , A61K45/06 , C12Y301/03001 , A61K2300/00
摘要： The present invention provides methods for using human placental alkaline phosphatase or an active derivative to reduce blood glucose level in a mammal. Treatment regimens provided by the invention may be used to control Type 1 and Type 2 forms of diabetes in humans. The methods and treatment regimens may be effective to maintain the human's blood glucose level below about 10 mM, and preferably within the normal range of 4 mM to 7 mM. The methods and treatment regimens may be used in combination with administration of known anti-diabetic medicaments. Also provided by the invention is a method for inducing weight loss or reducing an expected weight gain caused by or associated with obesity or Type 2 diabetes. The invention further provides a preparation for administration to a human, the preparation comprising homogeneous purified human placental alkaline phosphatase in a physiologically acceptable carrier.
摘要翻译：本发明提供使用人胎盘碱性磷酸酶或活性衍生物降低哺乳动物血糖水平的方法。本发明提供的治疗方案可用于控制人类1型和2型糖尿病。方法和治疗方案可能有效地将人的血糖水平维持在低于约10mM，优选在4mM至7mM的正常范围内。方法和治疗方案可以与已知的抗糖尿病药物的给药组合使用。本发明还提供了一种诱导体重减轻或减少由肥胖或2型糖尿病引起或与之相关的预期体重增加的方法。本发明还提供了一种用于给予人的制剂，所述制剂包含在生理上可接受的载体中的均质纯化的人胎盘碱性磷酸酶。

17. 发明授权

US07786082B2 Combinations of human proteins to enhance in vivo viability of stem cells and progenitor cells 有权
标题翻译：人类蛋白质的组合以增强干细胞和祖细胞的体内存活力
公开(公告)号：US07786082B2
公开(公告)日：2010-08-31
申请号：US12189442
申请日：2008-08-11
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K38/00 , C07K14/00 , C12N9/00
CPC分类号： C12N5/0663 , C12N5/0018 , C12N5/0653 , C12N5/0658 , C12N2501/70
摘要： Embodiments of the present invention include the use of placental alkaline phosphatase and other members of the alkaline phosphatase family alone or in combination with human transferrin and, optionally, human α1-antitrypsin to enhance the proliferation and survival of adult or embryonic stem cells and stem cell-derived progenitor cells in vivo.
摘要翻译：本发明的实施方案包括单独使用胎盘碱性磷酸酶和碱性磷酸酶家族的其他成员或与人转铁蛋白和任选的人α1-抗胰蛋白酶组合来增强成人或胚胎干细胞和干细胞的增殖和存活来源的祖细胞。

18. 发明申请

US20100048668A1 COMPOSITIONS AND METHODS TO CONTROL ABNORMAL CELL GROWTH 有权
标题翻译：组合物和控制异常细胞生长的方法
公开(公告)号：US20100048668A1
公开(公告)日：2010-02-25
申请号：US12572793
申请日：2009-10-02
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K31/382 , C07D335/08 , C07D345/00 , A61K31/33
CPC分类号： C07D335/08 , C07D335/16
摘要： A class of compounds commonly containing a trialkylammonium group have been synthesized and characterized as anticancer compounds. They can be used alone or in combination with other therapies to treat cancer and other cell proliferative diseases. Representative compounds of this class, N,N-diethyl-N-methyl-2-[(9-oxo-9H-thioxanthen-2-yl)methoxy]ethanaminium iodide and N,N-diethyl-N-allyl-3-(2-methyl-9H-thioxanthen-9-ylidene)-propane-1-aminium bromide, were shown in various tumor models to decrease tumor volume, enhance the effects of other chemotherapeutic agents including cisplatin, reduce chemotherapy-induced loss of body weight, and increase survival of animals co-treated with toxic amounts of cisplatin. These compounds had even greater effects on tumor volume, body weight, and survival when administered together with the human protein placental alkaline phosphatase.
摘要翻译：通常含有三烷基铵基团的一类化合物已被合成并被表征为抗癌化合物。它们可以单独使用或与其他疗法组合用于治疗癌症和其他细胞增殖性疾病。该类的代表性化合物是N，N-二乙基-N-甲基-2 - [（9-氧代-9H-噻吨-2-基）甲氧基]乙胺碘化物和N，N-二乙基-N-烯丙基-3-（ 2-甲基-9H-噻吨-9-亚基） - 丙烷-1-氨基溴化物，显示在各种肿瘤模型中，以减少肿瘤体积，增强其他化学治疗剂（包括顺铂）的作用，减少化疗引起的体重下降，并增加用有毒量的顺铂共同处理的动物的存活。当与人类蛋白质胎盘碱性磷酸酶一起施用时，这些化合物对肿瘤体积，体重和存活率具有更大的影响。

19. 发明授权

US07589083B2 Compounds and compositions to control abnormal cell growth 失效
标题翻译：控制异常细胞生长的化合物和组合物
公开(公告)号：US07589083B2
公开(公告)日：2009-09-15
申请号：US11458502
申请日：2006-07-19
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K31/352 , A61K31/382
CPC分类号： C07D335/08 , C07D335/16
摘要： A class of compounds commonly containing a trialkylammonium group have been synthesized and characterized as anticancer compounds. A representative of this class, N,N-diethyl-N-methyl-2-[(9-oxo-9H-thioxanthen-2-yl)methoxy]ethanaminium iodide (CCDTHT) was shown in various tumor models to decrease tumor volume, enhance the effects of other chemotherapeutic agents including cisplatin, reduce chemotherapy-induced loss of body weight, and increase survival of animals co-treated with toxic amounts of cisplatin. CCDTHT had even greater effects on tumor volume, body weight, and survival when administered to animals together with the human protein placental alkaline phosphatase. These trialkylammonium group-containing compounds and alkaline phosphatases, particularly in combination with each other and other therapies, may be used to treat cancer and other cell proliferative diseases.
摘要翻译：通常含有三烷基铵基团的一类化合物已被合成并被表征为抗癌化合物。在各种肿瘤模型中显示了该类代表N，N-二乙基-N-甲基-2 - [（9-氧代-9H-噻吨-2-基）甲氧基]乙胺碘化物（CCDTHT）以减少肿瘤体积，增强其他化学治疗剂（包括顺铂）的作用，减少化疗引起的体重减轻，并增加用有毒量的顺铂共同处理的动物的存活。当与人类蛋白质胎盘碱性磷酸酶一起施用于动物时，CCDTHT对肿瘤体积，体重和存活有更大的影响。这些含三烷基铵基的化合物和碱性磷酸酶，特别是彼此组合和其它疗法可用于治疗癌症和其它细胞增殖性疾病。

20. 发明申请

US20080207738A1 DRUG COMBINATIONS TO TREAT DRUG RESISTANT TUMORS 审中-公开
标题翻译：药物联合治疗耐药性肿瘤
公开(公告)号：US20080207738A1
公开(公告)日：2008-08-28
申请号：US11680142
申请日：2007-02-28
申请人： Zoltan Kiss
发明人： Zoltan Kiss
IPC分类号： A61K31/35 , A61K31/382 , C07D311/82
CPC分类号： A61K31/382 , A61K31/35 , C07D311/82
摘要： Embodiments of the invention provide a method and composition for treating or reducing multiple drug resistance in cancers. Embodiments of the invention also provide for a xanthene compound to inhibit multidrug resistance protein 1.
摘要翻译：本发明的实施方案提供了用于治疗或降低癌症中多种耐药性的方法和组合物。本发明的实施方案还提供了呫吨化合物抑制多药耐药性蛋白质1。

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