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11. 发明授权

US08076352B2 Administration of carboline derivatives useful in the treatment of cancer and other diseases 有权
标题翻译：用于治疗癌症和其他疾病的咔啉衍生物的用途
公开(公告)号：US08076352B2
公开(公告)日：2011-12-13
申请号：US11735069
申请日：2007-04-13
申请人： Liangxian Cao , Samit Hirawat , Langdon Miller , Thomas Davis , Marla L. Weetall
发明人： Liangxian Cao , Samit Hirawat , Langdon Miller , Thomas Davis , Marla L. Weetall
IPC分类号： A61K31/437 , C07D487/04
CPC分类号： A61K31/437 , A61K31/4353 , A61K31/444 , A61K31/5377
摘要： In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and compositions, and methods for the administration and use of those compounds. provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing serum, plasma, and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
摘要翻译：根据本发明，已经鉴定了抑制转录后VEGF表达的化合物，以及这些化合物的给药和使用的组合物和方法。提供。在本发明的一个方面，提供了可用于抑制VEGF产生，治疗实体瘤癌症和降低血清，血浆和/或肿瘤VEGF水平的化合物。在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，治疗癌症以及降低血浆和/或肿瘤VEGF水平的方法。

12. 发明申请

US20110165581A1 METHODS FOR SCREENING FOR COMPOUNDS FOR TREATING CANCER 有权
标题翻译：筛选化合物治疗癌症的方法
公开(公告)号：US20110165581A1
公开(公告)日：2011-07-07
申请号：US13000726
申请日：2009-07-01
申请人： Liangxian Cao , Thomas Davis
发明人： Liangxian Cao , Thomas Davis
IPC分类号： C12Q1/68 , C12N5/10 , C12N15/63 , C07H21/02
CPC分类号： C12Q1/6897
摘要： The methods described herein provide nucleic acid constructs and screening methods for identifying and validating compounds for use in the treatment of cancer, wherein the compounds down-regulate the post-transcriptional expression of Bmi-1.
摘要翻译：本文描述的方法提供用于鉴定和验证用于治疗癌症的化合物的核酸构建体和筛选方法，其中所述化合物下调Bmi-1的转录后表达。

13. 发明申请

US20120129841A1 CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES 审中-公开
标题翻译：用于治疗癌症和其他疾病的碳氢化合物衍生物
公开(公告)号：US20120129841A1
公开(公告)日：2012-05-24
申请号：US13274412
申请日：2011-10-17
申请人： Liangxian Cao , Samit Hirawat , Langdon Miller , Thomas Davis , Marla L. Weetall
发明人： Liangxian Cao , Samit Hirawat , Langdon Miller , Thomas Davis , Marla L. Weetall
IPC分类号： A61K31/551 , A61K31/506 , A61K31/497 , A61K31/5377 , A61K31/541 , A61P35/00 , A61K31/437 , A61K31/496
CPC分类号： A61K31/437 , A61K31/4353 , A61K31/444 , A61K31/5377
摘要： In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and compositions, and methods for the administration and use of those compounds. provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing serum, plasma, and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
摘要翻译：根据本发明，已经鉴定了抑制转录后VEGF表达的化合物，以及这些化合物的给药和使用的组合物和方法。提供。在本发明的一个方面，提供了可用于抑制VEGF产生，治疗实体瘤癌症和降低血清，血浆和/或肿瘤VEGF水平的化合物。在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，治疗癌症以及降低血浆和/或肿瘤VEGF水平的方法。

14. 发明申请

US20080089880A1 Biological bioadhesive compositions and methods of preparation and use 审中-公开
标题翻译：生物生物粘附剂组合物及其制备和使用方法
公开(公告)号：US20080089880A1
公开(公告)日：2008-04-17
申请号：US11799104
申请日：2007-04-30
申请人： Sam Austin , Thomas Davis
发明人： Sam Austin , Thomas Davis
IPC分类号： A61K38/48
CPC分类号： A61K38/363 , A61K31/573 , A61K38/4833 , C12Y304/21005 , A61K2300/00
摘要： The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen or the thrombin component in the presence of biological and/or non-biological agents such as drugs, chemicals, and proteins. Preferably, these agents are introduced in solution, such as for example, a corticosteroid-containing solution like a betamethasone solution containing betamethasone acetate or betamethasone sodium phosphate; a triamcinolone solution; or a methylprednisolone solution. These solutions may be substituted for, or provided as a complement to, other solutions that are typically used in the preparation of fibrin sealants such as, for example, calcium chloride. The invention further relates to a novel method of using the improved fibrin sealant whereby the sealant and accompanying agent(s) are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant. This provides therapeutic value to patients through prolonged presence, and optionally time-released delivery, of the specific agent(s) at the critical site.
摘要翻译：本发明一般涉及依赖于组合纤维蛋白原和凝血酶的生物组织粘合剂的制备和应用。更具体地说，本发明涉及一种制备纤维蛋白密封剂的方法，其中所述密封剂通过在生物和/或非生物制剂如药物，化学品和蛋白质的存在下重构纤维蛋白原或凝血酶组分来形成。优选将这些试剂引入溶液中，例如含有皮质类固醇的溶液，如含有醋酸倍他米松或倍他米松磷酸钠的倍他米松溶液; 曲安奈德溶液; 或甲基强的松龙溶液。这些溶液可以代替通常用于制备纤维蛋白密封剂例如氯化钙的其它溶液的补充，或作为其补充。本发明还涉及使用改进的纤维蛋白密封剂的新方法，其中密封剂和伴随剂直接输送到体内的关键部位并由于密封剂的生物静态质量而被密封就位。这通过在关键部位的特定药剂的长期存在和任选的时间释放的递送来为患者提供治疗价值。

15. 发明申请

US20050152961A1 Biological bioadhesive compositions and methods of preparation and use 有权
标题翻译：生物生物粘附剂组合物及其制备和使用方法
公开(公告)号：US20050152961A1
公开(公告)日：2005-07-14
申请号：US11003106
申请日：2004-12-04
申请人： Sam Austin , Thomas Davis
发明人： Sam Austin , Thomas Davis
IPC分类号： A61L24/00 , A61L24/10 , A61L27/22 , A61L31/04 , A61M37/00
CPC分类号： A61L24/106 , A61L24/0015 , A61L27/225 , A61L31/046 , A61L2300/222 , A61L2300/418 , A61L2300/43 , A61L2300/45
摘要： The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen or the thrombin component in the presence of biological and/or non-biological agents such as drugs, chemicals, and proteins. Preferably, these agents are introduced in solution, such as for example, a corticosteroid-containing solution like a betamethasone solution containing betamethasone acetate or betamethasone sodium phosphate; a triamicinolone solution; or a methylprednisolone solution. These solutions may be substituted for, or provided as a complement to, other solutions that are typically used in the preparation of fibrin sealants such as, for example, calcium chloride. The invention further relates to a novel method of using the improved fibrin sealant whereby the sealant and accompanying agent(s) are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant. This provides therapeutic value to patients through prolonged presence, and optionally time-released delivery, of the specific agent(s) at the critical site.
摘要翻译：本发明一般涉及依赖于组合纤维蛋白原和凝血酶的生物组织粘合剂的制备和应用。更具体地说，本发明涉及一种制备纤维蛋白密封剂的方法，其中所述密封剂通过在生物和/或非生物制剂如药物，化学品和蛋白质的存在下重构纤维蛋白原或凝血酶组分来形成。优选将这些试剂引入溶液中，例如含有皮质类固醇的溶液，如含有醋酸倍他米松或倍他米松磷酸钠的倍他米松溶液; 曲马松醇溶液; 或甲基强的松龙溶液。这些溶液可以代替通常用于制备纤维蛋白密封剂例如氯化钙的其它溶液的补充，或作为其补充。本发明还涉及使用改进的纤维蛋白密封剂的新方法，其中密封剂和伴随剂直接输送到体内的关键部位并由于密封剂的生物静态质量而被密封就位。这通过在关键部位的特定药剂的长期存在和任选的时间释放的递送来为患者提供治疗价值。

16. 发明授权

US06826688B1 Method and apparatus for determining the identity of a digital printer from its output 有权
标题翻译：用于从其输出确定数字打印机的身份的方法和装置
公开(公告)号：US06826688B1
公开(公告)日：2004-11-30
申请号：US09277801
申请日：1999-03-27
申请人： Larry Westerman , Thomas Davis
发明人： Larry Westerman , Thomas Davis
IPC分类号： H04L900
CPC分类号： H04N1/32203 , H04N1/32208 , H04N1/32288 , H04N2201/0082 , H04N2201/3205 , H04N2201/327
摘要： A method for inserting an identification modulation code into a printed image. The method has the steps of inserting a start code modulation sequence, followed by the code modulation sequence, and then a stop code modulation sequence. The code is preferably repeated several times throughout the printed image. The modulation sequence can have several levels of subpixel modulation magnitude.
摘要翻译：一种将识别调制码插入打印图像的方法。该方法具有以下步骤：插入起始码调制序列，随后是码调制序列，然后是停止码调制序列。代码优选在整个打印图像中重复多次。调制序列可以具有多个子像素调制量级。

17. 发明授权

US4824556A Hydrogenation process of unsaturated hydrocarbons employing impregnated alumina containing material 失效
标题翻译：使用含浸氧化铝的材料的不饱和烃的氢化过程
公开(公告)号：US4824556A
公开(公告)日：1989-04-25
申请号：US212838
申请日：1988-06-29
申请人： Karlheinz K. Brandes , Simon G. Kukes , Thomas Davis
发明人： Karlheinz K. Brandes , Simon G. Kukes , Thomas Davis
IPC分类号： B01J37/20 , C10G45/04 , C10G45/00
CPC分类号： B01J37/20 , C10G45/04
摘要： A composition of matter is prepared by a process comprising the steps of impregnating a alumina-containing support material with a thiosulfate (preferably ammonium thiosulfate), drying the thus impregnated material, impregnating the dried material with a transition metal compound, drying and calcining the transition metal impregnated material. This composition of matter is used as catalyst composition for hydrogenating unsaturated hydrocarbon compounds, and as catalyst composition for hydrotreating hydrocarbon-containing feed streams (in particular heavy oils) which contain metal and sulfur compounds as impurities.In another embodiment, a hydrotreating process comprises contacting hydrocarbon-containing feed stream (in particular heavy oils), which contains compounds of sulfur and metals, in the presence of a fixed catalyst bed comprising (X) at least one layer of impregnated substantially spherical alumina-containing particles, which have been prepared by a process comprising the steps of impregnating a specific starting material with (NH.sub.4).sub.2 S.sub.2 O.sub.3 and then heating the thus impregnated material at about 500.degree.-900.degree. C. for improved crush strength retention. In a preferred embodiment, the fixed catalyst bed further comprises at least one layer (Y) of catalyst particles comprising a refractory inorganic carrier and at least one hydrogenation promoter. A composition of matter comprising the impregnated, spherical alumina-containing particles described above, and a process for preparing them are also provided.
摘要翻译：通过包括以下步骤的方法制备物质组合物，所述方法包括用硫代硫酸盐（优选硫代硫酸铵）浸渍含氧化铝的载体材料，干燥如此浸渍的材料，用过渡金属化合物浸渍干燥的材料，干燥和煅烧过渡金属浸渍材料。该物质组合物用作用于氢化不饱和烃化合物的催化剂组合物，以及用作加氢处理含有金属和硫化合物作为杂质的含烃进料流（特别是重油）的催化剂组合物。在另一个实施方案中，加氢处理方法包括在固定的催化剂床存在下使包含硫和金属化合物的含烃进料流（特别是重油）与含有（X）至少一层浸渍的基本上为球形的氧化铝其通过包括以下步骤制备的方法制备，所述方法包括用（NH 4）2 S 2 O 3浸渍特定原料，然后在约500-900℃加热如此浸渍的材料，以改善压碎强度保持性。在优选的实施方案中，固定催化剂床还包含至少一层包含耐火无机载体和至少一种氢化促进剂的催化剂颗粒层（Y）。还提供了包含上述浸渍的含球形氧化铝颗粒的物质组合物及其制备方法。

18. 发明授权

US07338687B2 Method of spray a liner on the inside surface of a pipe 有权
标题翻译：在管道内表面上喷涂衬垫的方法
公开(公告)号：US07338687B2
公开(公告)日：2008-03-04
申请号：US11329708
申请日：2006-01-11
申请人： Thomas Davis
发明人： Thomas Davis
IPC分类号： B05D7/22 , B05B13/06
CPC分类号： B05B13/0636 , B05B3/1014 , B05B12/36 , B05D1/02 , B05D2254/04 , F16L55/1645 , Y10S118/10
摘要： A method for applying a liner to a pipe is disclosed. The methodology includes inserting an apparatus within the pipe and moving the apparatus at a predetermined speed through the pipe. The method sprays a material from a spray head secured to the apparatus. The methodology also includes an oscillation system wherein the spray head assembly will move relative to the base assembly thus creating an over lapping pattern for the spray coating being applied to the interior surface of the pipeline. This oscillation system will allow for a more uniform coating to be applied.
摘要翻译：公开了一种将衬套施加到管道上的方法。该方法包括在管道内插入设备并以预定速度移动设备通过管道。该方法从固定在设备上的喷头喷射材料。该方法还包括振荡系统，其中喷头组件将相对于基座组件移动，从而产生用于将喷涂施加到管道内表面上的过度研磨图案。该振荡系统将允许施加更均匀的涂层。

19. 发明申请

US20070249891A1 Ceiling newsletter system and method 审中-公开
标题翻译：天花板通讯系统和方法
公开(公告)号：US20070249891A1
公开(公告)日：2007-10-25
申请号：US11409160
申请日：2006-04-21
申请人： Thomas Davis
发明人： Thomas Davis
IPC分类号： A61M21/00
CPC分类号： A61M21/0094 , A61M2021/005
摘要： A method for easing stress on a patient in a stressful treatment area, including the steps of: (a) providing at least one page of a periodically issued ceiling newsletter; (b) mounting at least two members of an attachment mechanism on a ceiling of the treatment area; (c) mounting at least two corresponding members of the attachment mechanism on a back side of each ceiling newsletter page; and (d) removably mounting the ceiling newsletter on the treatment area ceiling. Also included herein is a method including the steps of: a) subscribing to a ceiling newsletter; b) transcribing subscriber information to a customer list; c) mailing the ceiling newsletter issues to the subscribers periodically; and d) receiving the issue, affixing corresponding attachment mechanism members to the ceiling and to the back of each page of the ceiling newsletter, and removably attaching the ceiling newsletter to the treatment area ceiling.
摘要翻译：一种在紧张的治疗区域缓解患者压力的方法，包括以下步骤：（a）提供至少一页定期发布的天花板通讯; （b）将至少两个附接机构的构件安装在处理区域的天花板上; （c）将安装机构的至少两个对应的部件安装在每个天花板通讯页的背面; 及（d）将上限通讯录可拆卸地安装在处理区上限。本文还包括一种方法，包括以下步骤：a）订阅上限通讯; b）将用户信息转录给客户列表; c）定期向用户发送上传通讯问题; 和d）收到这个问题，将相应的附属机构成员贴在天花板上的每一页的天花板和背面，并将天花板通讯可拆卸地附着在处理区上限。

20. 发明申请

US20070117530A1 System and Method for Frequency Translation with Harmonic Suppression Using Mixer Stages 有权
标题翻译：使用混频器阶段的谐波抑制的频率转换的系统和方法
公开(公告)号：US20070117530A1
公开(公告)日：2007-05-24
申请号：US11622688
申请日：2007-01-12
申请人： Thomas Davis
发明人： Thomas Davis
IPC分类号： H04B1/26 , H04B15/00
CPC分类号： H03D7/14 , H03C3/40 , H03D7/00
摘要： A method for generating phase signals includes triggering a phase register to output a binary number stored in the phase register, wherein the phase register is triggered based at least in part on a voltage signal provided by a voltage controlled oscillator. The method also includes providing an input signal to a decoder, wherein the input signal is based at least in part on the binary number output by the phase register and the decoder is operable to generate phase signals in response to the input signals. The method further includes incrementing the binary number stored in the phase register and repeating the triggering and providing steps after the binary number is incremented.
摘要翻译：用于产生相位信号的方法包括触发相位寄存器以输出存储在相位寄存器中的二进制数，其中至少部分地基于由压控振荡器提供的电压信号触发相位寄存器。该方法还包括向解码器提供输入信号，其中输入信号至少部分地基于由相位寄存器输出的二进制数，并且解码器可操作以响应于输入信号产生相位信号。该方法还包括增加存储在相位寄存器中的二进制数，并且在二进制数增加之后重复触发和提供步骤。

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